Category: alcohols-buliding-blocks

Katiyar, R. D. published the artcileThiabendazole as an anthelmintic of outstanding efficiency, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Veterinary Journal (1964), 41(12), 803-9, database is CAplus.

Four trials are described in which thiabendazole [2-(4-thiazolyl)benzimidazole] (I) efficiency is tested against nematodes. Frantin (bephenium hydroxynaphthoate) (II), Promintic (Methrydine) (III), and phenothiazine (IV) were used as comparisons. Lambs naturally parasitized with Haemonchus, Trichostrongyles, Ostertagia, Nematodirus, Oesophagostomum, Cooperia, and Bunostomum spp. were treated with I (50 mg./kg. body weight), II (4 g./lamb), III (200 mg./kg. body weight), IV (600 mg./kg.) and no treatment. The reductions in egg counts were 95.7, 82.1, 78.7, 76.2, and 39.2%, resp. Against individual nematode species in sheep, I was 85-100% effective. It was 97.7% effective against nematodes causing gastroenteritis in crossbred Angora kids, while IV was only 76.5% effective. Romney Marsh rams with a heavy infestation of Strongloides papillosus were treated with IV with no effect, while treatment with I reduced the ova count by 91-95% over 15 days. In all trials, treatment with I increased the body weight

Indian Veterinary Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Castineiras, Alfonso published the artcileMulticomponent Solids of DL-2-Hydroxy-2-phenylacetic Acid and Pyridinecarboxamides, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Crystals (2022), 12(2), 142, database is CAplus.

We prepared cocrystals of DL-2-Hydroxy-2-phenylacetic acid (D, L-H2ma) with the pyridinecarboxamide isomers, picolinamide (pic) and isonicotinamide (inam). They were characterized by elemental anal., single crystal and powder X-ray, IR spectroscopy and ¹H and ¹³C NMR. The crystal and mol. structures of (pic)-(D-H₂ma) (1), (nam)-(L-H₂ma) (2) and (inam)-(L-H₂ma) (3) were studied. The crystal packing is stabilized primarily by hydrogen bonding and in some cases through π-πstacking interactions. The anal. of crystal structures reveals the existence of the characteristic heterosynthons with the binding motif R²₂(8) (primary amide-carboxilic acid) between pyridinecarboxamide mols. and the acid. Other synthons involve hydrogen bonds such as O-H(carboxyl)···N(pyridine) and O-H(hydroxyl)···N(pyridine) depending on the isomer. The packing of 1 and 3 is formed by tetramers, for whose formation a crystallization mechanism based on two stages is proposed, involving an amide-acid (1) or amide-amide (3) mol. recognition in the first stage and the formation of others, and interdimeric hydrogen bonding interactions in the second. The thermal stability of the cocrystals was studied by differential scanning calorimetry and thermogravimetry. Further studies were conducted to evaluate other physicochem. properties of the cocrystals in comparison to the pure coformers. D.-functional theory (DFT) calculations (including NCIplot and QTAIM analyses) were performed to further characterize and rationalize the noncovalent interactions.

Crystals published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Minguez-Alarcon, Lidia published the artcilePregnancy urinary concentrations of bisphenol A, parabens and other phenols in relation to serum levels of lipid biomarkers: Results from the EARTH study, Related Products of alcohols-buliding-blocks, the publication is Science of the Total Environment (2022), 155191, database is CAplus and MEDLINE.

The epidemiol. literature on associations between urinary phenol concentrations and lipid profiles during pregnancy is limited. We examined whether urinary concentrations of phenol and phenol replacement biomarkers were associated with serum lipid levels among pregnant women. This cross-sectional study included 175 women attending the Massachusetts General Hospital Fertility Center who enrolled in the Environment and Reproductive Health (EARTH) Study between 2005 and 2017 and had data available on urinary phenol biomarkers and serum lipids during pregnancy. We used linear regression models to assess the relationship between groups of urinary phenol and phenol replacement biomarkers and serum lipid levels [total cholesterol, high d. lipoprotein (HDL), non-HDL, low-d. lipoprotein (LDL) cholesterol, and triglycerides], while adjusting for age at sample collection, pre-pregnancy BMI, education, race, infertility diagnosis, cycle type, number of fetuses, trimester and sp. gr. In adjusted models, pregnant women with urinary propylparaben concentrations in the highest tertile had 10% [22 (95% CI = 5, 40) mg/dL], 12% [19 (95% CI = 2, 36) mg/dL] and 16% [19 (95% CI = 3, 35) mg/dL] higher mean total, non-HDL and LDL cholesterol, resp., compared to women with concentrations in the lowest tertile. Similar elevations were observed for urinary bisphenol A concentrations Urinary bisphenol S, benzophenone-3, triclosan, methylparaben, ethylparaben, and butylparaben were unrelated to serum lipids. Among pregnant women, urinary concentrations of bisphenol A and propylparaben were associated with higher serum levels of total, non-HDL and LDL cholesterol.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yan, Yan published the artcileMetabolic profile and underlying antioxidant improvement of Ziziphi Spinosae Folium by human intestinal bacteria, Related Products of alcohols-buliding-blocks, the publication is Food Chemistry (2020), 126651, database is CAplus and MEDLINE.

Ziziphi Spinosae Folium, the leaf of Ziziphus jujuba Mill. Var. spinosa (Bunge) Hu ex H. F. Chou (LZJS), is currently used as a healthy tea in China. This study evaluated the chem. components and antioxidant activities of LZJS flavonoid (LZJSF) and fermented LZJSF (FLZJSF) using human intestinal bacteria (HIB) through dynamic fermentation Eighteen flavonoids were simultaneously identified in LZJSF using UHPLC-Q-Orbitrap-MS method, nine of which were targeted for a HIB metabolism study. Seven small phenolic acids were identified in FLZJSF. Not only at chem. level but also at PC12 cell level, FLZJSF samples fermented for 4 and 6 h showed significant pos. correlation between their activities and flavonoid aglycons, which were transformed from LZJSF. However, FLZJSF samples (8 h and longer time) mainly contained phenolic acids and indicated weak activities. Thus, LZJSF was found to result in increased antioxidant activity and could be com. utilized as a novel functional food.

Food Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C4HN5, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hu, Xiao-Ling published the artcileNetwork pharmacology study on mechanism of Zhen-Wu decoction for chronic heart failure treatment, Recommanded Product: 2-Phenylethanethiol, the publication is Drug Combination Therapy (2021), 3(1), 1, database is CAplus.

To explore and predict the mechanism of classic ancient prescription of Chinese medicine Zhen-Wu decoction for chronic heart failure treatment based on network pharmacol. Traditional Chinese medicine systems pharmacol. database was used to search the effective components and targets of herbs in classic ancient prescription of Chinese medicine Zhen-Wu decoction. Relevant target genes of chronic heart failure were obtained from GeneCards and Online Mendelian Inheritance in Man databases. Then we obtained the intersection target genes of classic ancient prescription of Chinese medicine Zhen-Wu decoction in treating chronic heart failure, constructing the classic ancient prescription of Chinese medicine Zhen-Wu decoction-active ingredient-chronic heart failure-targets network using Cytoscape, and performing network anal. using a network ananlyzer plug-in to acquire hub compounds and key targets. Proton pump inhibitor network was constructed through STRING database. Gene ontol. function and Kyoto Encyclopedia of Genes and Genomes pathway enrichment anal. were carried out in Database for Annotation, Visualization and Integrated Discovery. There are 61 active ingredients and 134 action targets in classic ancient prescription of Chinese medicine Zhen-Wu decoction, among which 49 target genes and 11 important compounds related to the chronic heart failure treatment. After network anal., we obtained 12 key targets, 77 gene ontol. entries and 22 signal pathways, including tumor necrosis factor signaling pathway, NF-kappaB signal pathway, PI3K-Akt signal pathway, et al. Classic ancient prescription of Chinese medicine Zhen-Wu decoction was used for chronic heart failure treatment for the multi-component, multi-target and multi-channel interaction. The components such as kaempferol and β-sitosterol were combined with target proteins such as CHRM1 and AChE, involving biol. processes such as DNA transcription regulation, cholinergic synaptic transmission and apoptosis regulation, as well as signal pathways such as tumor necrosis factor signaling pathway, NF-kappa B signal pathway, PI3K-Akt signal pathway, et al.

Drug Combination Therapy published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Haitao published the artcileHighly and homogeneously conductive conjugated polyelectrolyte hole transport layers for efficient organic solar cells, Computed Properties of 239075-02-6, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2017), 5(28), 14689-14696, database is CAplus.

High mobility, stable and thick hole-transporting layer (HTL) materials are highly desirable for organic solar cells (OSCs). Two pH neutral conjugated polyelectrolytes (CPEs), PCPDT-T and PCPDT-2T, based on 3,4-dithia-7H-cyclopenta[a]pentalene and thienyl units with a self-doping effect were designed and synthesized. Between the 2 CPEs, the PCPDT-T exhibits higher, more homogeneous mobility and appropriate work function, which makes it an ideal HTL material for OSCs. The single-junction OSCs modified with the PCPDT-T HTL showed an outstanding power conversion efficiency of 9.3%, which is much higher than that of the PEDOT:PSS-modified devices (8.0%). Notably, the PCPDT-T HTL exhibits excellent thickness insensitivity in fabricating OSC devices, i.e. OSC devices with very thick PCPDT-T interlayers over 50 nm still demonstrated high power conversion efficiencies over 7.1%, which is very compatible to meet the requirement for future roll-to-roll printing.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is Al2H32O28S3, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Satoh, Yasushi published the artcileA catalyst- and additive-free synthesis of alkoxyhydrosiloxanes from silanols and alkoxyhydrosilanes, Safety of Triethylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(59), 8218-8221, database is CAplus and MEDLINE.

A convenient method for the selective synthesis of alkoxyhydrosiloxanes that bear SiH and SiOR² groups on the same silicon atom, R¹₃Si-O-SiR³_2-n(OR²)_nH (n = 0, 1, or 2), via a simple catalyst- and additive-free dealcoholization reaction between silanols and alkoxyhydrosilanes has been developed. These alkoxyhydrosiloxanes can be easily converted into Si(OR²)₃-containing siloxanes by zinc catalyzed alkoxylation and alkoxy-containing silphenylene polymers by platinum catalyzed hydrosilylation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Safety of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nagasawa, Shota published the artcileChromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols, Product Details of C9H11NO4, the publication is Journal of Organic Chemistry (2021), 86(9), 6952-6968, database is CAplus and MEDLINE.

We describe an aerobic intramol. dearomative coupling reaction of tethered phenols such as I using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products such as II including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

Journal of Organic Chemistry published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Product Details of C9H11NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeong, Jaeyoung published the artcileSelective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium-Catalyzed Borrowing Hydrogen Pathway, Quality Control of 111-29-5, the publication is ChemCatChem (2022), 14(3), e202101499, database is CAplus.

A new system was developed for the selective synthesis of bisdimethylamine derivatives using a diol and dimethylamine as starting materials and an iridium complex bearing an N-heterocyclic carbene ligand as catalyst. The starting materials were easily available, less toxic, inexpensive and easy to handle. The reaction proceeded efficiently through a borrowing hydrogen pathway under aqueous conditions, without any addnl. organic solvent, to afford various bisdimethylamine derivatives in good to excellent yields.

ChemCatChem published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hirose, Yuta published the artcileStereoselective synthesis of the A-ring of armatol A from a bromo-substituted chiral building block based on Ireland-Claisen rearrangement and ring-closing olefin metathesis, Product Details of C9H22OSi, the publication is Heterocycles (2015), 91(1), 76-103, database is CAplus.

The stereoselective synthesis of the A-ring (I) of armatol A, a natural polycyclic ether triterpene from the red alga Chondria armata, was achieved in a non-biomimetic way. The synthesis employed Ireland-Claisen rearrangement of an ester, prepared from a bromo-substituted chiral building block, for the construction of C6 and C7 stereocenters and a relay ring-closing olefin metathesis for the seven-membered ring formation.

Heterocycles published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts