Category: alcohols-buliding-blocks

Yamaguchi, Mutsuo published the artcileMitochondrial NADH:ubiquinone oxidoreductase (complex I): Proximity of the subunits of the flavoprotein and the iron-sulfur protein subcomplexes, Related Products of alcohols-buliding-blocks, the publication is Biochemistry (1993), 32(8), 1935-9, database is CAplus and MEDLINE.

The proximities of the three subunits (51, 24, and 9 kDa) of the flavoprotein subcomplex (FP) and five subunits (75, 49, 30, 18, and 13) of the iron-sulfur protein subcomplex (IP) of the bovine NADH: ubiquinone oxidoreductase (complex I) were investigated by crosslinking studies. The crosslinking reagents used were disuccinimidyl tartrate and ethylene glycol bis(succinimidyl succinate). The cross-linked products were identified by sodium dodecyl sulfate gel electrophoresis and immunoblotting with antibodies specific for each subunit. Results showed that the three FP subunits are juxtaposed to one another, and only the 51 kDa subunit of FP is in close proximity to only the 75-kDa subunit of IP. The 75-kDa subunit cross-linked to the 30- and the 13-kDa subunits, the 49-kDa subunit cross-linked to the 30-, 18-, and 13-kDa subunits, and the 30-kDa subunit cross-linked to the 18- and the 13-kDa subunits. No cross-linked products of 75+49-, 75+18-, or 18+13-kDa subunits were detected. These results are consistent with the occurrence of potential electron carriers in FP and IP subunits. These electron carriers are FMN and one iron-sulfur cluster in the 51-kDa subunit, one iron-sulfur cluster in the 24-kDa subunit, and apparently two iron-sulfur clusters in the 75-kDa subunit.

Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C5H10N2OS, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fejes, Zsolt published the artcileSynthesis of ether-linked [60]fullerene glycoconjugates by nucleophilic cyclopropanation, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Chemical Papers (2015), 69(6), 896-900, database is CAplus.

Et acetoacetate-sugar derivatives were prepared by standard alkylation of primary or secondary hydroxyls of diacetonide-protected sugars with Et 4-chloroacetoacetate. The obtained D-fructose, D-galactose, D-glucose and F-allose derivatives were conjugated to C₆₀ using the Bingel reaction to afford hydrolytically stable, ether-linked fullerene-carbohydrates. Conjugation of an ester-protected mannose derivative to the C₆₀ scaffold was carried out by the combination of the acetoacetate chem. with the azide-alkyne click reaction.

Chemical Papers published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Safety of ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Al Farraj, Dunia A. published the artcileCharacterization of pyrene and chrysene degradation by halophilic Hortaea sp. B15, SDS of cas: 86-48-6, the publication is Bioprocess and Biosystems Engineering (2019), 42(6), 963-969, database is CAplus and MEDLINE.

Polycyclic aromatics hydrocarbons (PAHs) are ubiquitous and toxic pollutants that are dangerous to humans and living organism in aquatic environment. Normally, PAHs has lower mol. weight such as phenanthrene and naphthalene that are easy and efficient to degrade, but high-mol.-weight PAHs such as chrysene and pyrene are difficult to be biodegraded by common microorganism. This study investigated the isolation and characterization of a potential halophilic bacterium capable of utilizing two high-mol.-weight PAHs. At the end of the experiment (25-30 days of incubation), bacterial counts have reached a maximum level (over 40 × 10¹⁶ CFU/mL). The highest biodegradation rate of 77% of chrysene in 20 days and 92% of pyrene in 25 days was obtained at pH 7, temperature 25°C, agitation of 150 rpm and Tween 80 surfactant showing to be the most impressive parameters for HMWPAHs biodegradation in this research. The metabolism of initial compounds revealed that Hortaea sp. B15 utilized pyrene to form phthalic acid while chrysene was metabolized to form 1-hydroxy-2-naphthoic acid. The result showed that Hortaea sp. B15 can be promoted for the study of in situ biodegradation of high mol. weight PAH.

Bioprocess and Biosystems Engineering published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, SDS of cas: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marzenell, Paul published the artcileAminoferrocene-Based Prodrugs and Their Effects on Human Normal and Cancer Cells as Well as Bacterial Cells, Product Details of C14H21BO3, the publication is Journal of Medicinal Chemistry (2013), 56(17), 6935-6944, database is CAplus and MEDLINE.

Aminoferrocene-based prodrugs are activated under cancer-specific conditions (high concentration of reactive oxygen species, ROS) with the formation of glutathione scavengers (p-quinone methide) and ROS-generating iron complexes. Herein, the authors explored three structural modifications of these prodrugs to improve their properties: (a) the attachment of a -COOH function to the ferrocene fragment leads to the improvement of water solubility and reactivity in vitro but also decreases cell-membrane permeability and biol. activity, (b) the alkylation of the N-benzyl residue does not show any significant affect, and (c) the attachment of the second arylboronic acid fragment improves the toxicity (IC₅₀) of the prodrugs toward human promyelocytic leukemia cells (HL-60) from 52 to 12 μM. Finally, the authors demonstrated that the prodrugs are active against primary chronic lymphocytic leukemia (CLL) cells, with the best compounds exhibiting an IC₅₀ value of 1.5 μM. The most active compounds were found to not affect mononuclear cells and representative bacterial cells.

Journal of Medicinal Chemistry published new progress about 1370732-71-0. 1370732-71-0 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester, name is (3-Methyl-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl)methanol, and the molecular formula is C14H21BO3, Product Details of C14H21BO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mascharak, P. K. published the artcileStructural distortions of the [Fe₄S₄]²⁺ core of [Fe₄S₄(S-tert-C₄H₉)₄]^2- in different crystalline environments and detection and instability of oxidized ([Fe₄S₄]³⁺) clusters, Name: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Inorganica Chimica Acta (1983), 80(3), 157-70, database is CAplus.

The structural and redox chem. of the clusters [Fe₄S₄(SR)₄]^2- with R = tert-alkyl were investigated for the purpose of determining the structures of the same cluster in different environments and the stability of the oxidized species [Fe₄S₄(SR)₄]^1-. (Me₃NCH₂Ph)₂[Fe₄S₄(S-tert-Bu)₄] crystallizes in the monoclinic space group P2₁/c with no imposed symmetry. (Et₄N)₂[Fe₄S₄(S-tert-Bu)₄] crystallizes in the tetragonal space group I4̅2m with D_2d symmetry imposed on the cluster. The [Fe₄S₄]²⁺ cluster cores in both compounds exhibit compressed tetragonal structures with different extents of distortion from T_d symmetry. These structures are compared to those of other [Fe₄S₄]²⁺ clusters by means of core shape parameters. Clusters with R = tert-alkyl (tert-Bu, C(CH₃)₂CH₂OH, C(CH₃)₂CH₂NHPh) in DMF exhibit, in addition to the usual 2-/3- and 3-/4- redox reactions common to all [Fe₄S₄(SR)₄]^2- species, discrete 1-electron oxidations near -0.1 V vs. SCE. Cyclic voltammetry of [Fe₄S₄(S-tert-Bu)₄]^2- reveals an essentially reversible 1-/2- couple with E_1/2 = -0.12 V, supporting the authenticity of clusters containing an oxidized ([Fe₄S₄]³⁺) core. This couple cannot be electrochem. resolved from multi-electron oxidation in the case of clusters in DMF with other types of R substituents, a behavior apparently due to cathodic potential shifts by tert-alkyl groups. Stability of oxidized clusters is low, and [Fe₄S₄(S-tert-Bu)₄]^1- could not be generated in appreciable concentrations at longer times by coulometric or chem. oxidation The relative stabilities of analog and protein [Fe₄S₄]³⁺ clusters are discussed. Preparations of 4 new [Fe₄S₄(SR)₄]^2- cluster salts are described including water-soluble (Et₄N)₂[Fe₄S₄(SC(CH₃)₂CH₂OH)₄].

Inorganica Chimica Acta published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Name: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smoum, Reem published the artcileFenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential, Application In Synthesis of 645-56-7, the publication is Molecules (2022), 27(4), 1382, database is CAplus and MEDLINE.

A series of novel cannabinoid-type derivatives was synthesized by the coupling of (1S,4R)-(+) and (1R,4S)-(-)-fenchones I (R = H, Me, n-pentyl, 2-methylbutan-2-yl, etc.; R¹ = H, hexyl; R² = H, OMe) with various resorcinols RC₆H₃(OH)₂/phenols RC₆H₄OH. The fenchone-resorcinol derivatives I were fluorinated using Selectfluor and demethylated using sodium ethanethiolate in DMF (DMF). The absolute configurations of four compounds were determined by X-ray single crystal diffraction. The fenchone-resorcinol analogs I possessed high affinity and selectivity for the CB2 cannabinoid receptor. One of the analogs synthesized, I (R = 2-methyloctan-2-yl, R¹ = H, R² = OMe (II)), had a high affinity (K_i = 3.51 nM) and selectivity for the human CB2 receptor (hCB2). In the [³⁵S]GTPγS binding assay, the lead compound was found to be a highly potent and efficacious hCB2 receptor agonist (EC₅₀ = 2.59 nM, E_(max) = 89.6%). Two of the fenchone derivatives I were found to possess anti-inflammatory and analgesic properties. Mol.-modeling studies elucidated the binding interactions of (II) within the CB2 binding site.

Molecules published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C3H6BrNaO3S, Application In Synthesis of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Karpati, Levente published the artcileThe sequenced structure of amino-alcohol-based random poly(ester amide)s, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of Thermal Analysis and Calorimetry (2019), 136(2), 737-747, database is CAplus.

Random amino-alc.-based poly(ester amide)s were synthesized using adipic acid and differently substituted amino-alcs., namely 2-amino-ethan-1-ol, 1-amino-propan-2-ol, 2-amino-butan-1-ol and 2-amino-2-methyl-propan-1-ol. The effect of substitution on the yield and fine structure was investigated using residual functional group anal., SEC and NMR. The functional group anal. and SEC proved the blocking effect of small substituents on direct polycondensation. The NMR data suggested a sequenced structure that could cause the formation of different crystalline phases in linear amino-alc.-based poly(ester amide)s. Three different crystalline phases with different thermal stability and crystallization rate were observed with DSC and WAXS. The crystalline nature of the poly(ester amide)s proves the sequenced organization along the backbone.

Journal of Thermal Analysis and Calorimetry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tan, Y. L. published the artcileDeoxygenation of pyrolysis vapour derived from durian shell using catalysts prepared from industrial wastes rich in Ca, Fe, Si and Al, Product Details of C4H11NO, the publication is Science of the Total Environment (2020), 134902, database is CAplus and MEDLINE.

Catalysts prepared from industrial wastes rich in Fe, Ca, Si, and Al were used in catalytic upgrading of pyrolysis vapor derived from durian shell and their effect on product yield and properties were compared. With same SiO₂-to-alumina ratio, catalyst prepared from oil palm ash (AS-OPA) with lower Fe and Ca contents gave higher liquid yield (8.32%) with alcs. (28.90%), hydrocarbons (46.00%), and N-containing compounds (21.46%) while catalyst prepared from elec. arc furnace slag (AS-EAF) with higher Fe and Ca contents produced lower liquid yield (50.21%) with high amount of esters (25.80%) and hydrocarbons (72.82%). The presence of AS-OPA and AS-EAF catalysts enhanced deoxygenation degree of bio-oil to 81.13% and 85.49%, resp. The catalytic performance of AS-EAF at different temperatures (400-600°) and AS-EAF/durian shell ratios (1:30, 2:30, 3:30) was studied. Increasing catalytic temperature enhanced production of bio-oil, reduced oxygenates and enhanced formation of esters. The liquid yield and yield of esters decreased with increasing catalyst loading. Hydrocarbons (mainly neopentane) were the major chem. compounds found in bio-oil produced over AS-EAF. Besides that, AS-EAF showed good deoxygenation performance with highest selectivity of hydrocarbons at 500° and AS-EAF/durian shell ratio of 2:30. Catalytic fast pyrolysis of durian shell using waste-derived catalysts is an effective waste management strategy as the bio-oil produced can be a potential alternative source of energy or chem. feedstocks.

Science of the Total Environment published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C10H9NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Novotny, Chris J. published the artcileFarnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras, Application In Synthesis of 57044-25-4, the publication is ACS Chemical Biology (2017), 12(7), 1956-1962, database is CAplus and MEDLINE.

Mutationally activated Ras is one of the most common oncogenic drivers found across all malignancies, and its selective inhibition has long been a goal in both pharma and academia. One of the oldest and most validated methods to inhibit overactive Ras signaling is by interfering with its post-translational processing and subsequent cellular localization. Previous attempts to target Ras processing led to the development of farnesyltransferase inhibitors, which can inhibit H-Ras localization but not K-Ras due to its ability to bypass farnesyltransferase inhibition though alternative prenylation by geranylgeranyltransferase. Here the authors present the creation of a neo-substrate for farnesyltransferase that prevents the alternative prenylation by geranylgeranyltransferase and mislocalizes oncogenic K-Ras in cells.

ACS Chemical Biology published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Junghoon published the artcileSiloxane-Based Hybrid Semiconducting Polymers Prepared by Fluoride-Mediated Suzuki Polymerization, Computed Properties of 239075-02-6, the publication is Angewandte Chemie, International Edition (2015), 54(15), 4657-4660, database is CAplus and MEDLINE.

Siloxane-containing materials are a large and important class of organic-inorganic hybrids. In this report, a practical variation of the Suzuki polymerization to generate semiconducting polymeric hybrids based on siloxane units, which proceeds under essentially nonbasic conditions, is presented. This method generates solution-processable poly(diketopyrrolopyrrole-alt-benzothiadiazole) (PDPPBT-Si) consisting of the hybrid siloxane substituents, which could not be made using conventional methods. PDPPBT-Si exhibits excellent ambipolar transistor performance with well-balanced hole and electron FET mobilities. The siloxane-containing DPP-thiophene polymer classes (PDPP3T-Si and PDPP4T-Si), synthesized by this method, exhibit high hole mobility of up to 1.29 cm² V^-1 s^-1. This synthetic approach should provide access to a variety of novel siloxane-containing conjugated semiconductor classes by using a variety of aryldihalides and aryldiboronic acids/esters.

Angewandte Chemie, International Edition published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts