Category: alcohols-buliding-blocks

Ru, Xiangli published the artcileSynthesis and characterization of new coenzyme NADH model compound, Name: 9-Phenyl-9H-xanthen-9-ol, the publication is Henan Shifan Daxue Xuebao, Ziran Kexueban (2013), 41(3), 103-104, 129, database is CAplus.

BNAH and 9-Ph xanthene(9-PhXnH) are new nicotinamide coenzyme NADH model compounds, and they have been becoming more and more important in green synthesis of drugs. In this paper, the coenzyme NADH model compounds of BNAH and 9-Ph xanthene were synthesized with nicotinamide and 9-Ph xanthene ethanol as raw materials, and by 1H NMR, elemental anal., UV and other anal. methods, n BNAH and 9-Ph xanthene were characterized. This synthetic route had easily available raw materials, mild reaction conditions, simple operation, high yield, high product purity.

Henan Shifan Daxue Xuebao, Ziran Kexueban published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Name: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Jing published the artcileMetabolic and microbial modulation of phenolic compounds from raspberry leaf extract under in vitro digestion and fermentation, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is International Journal of Food Science and Technology (2021), 56(10), 5168-5177, database is CAplus.

Raspberry leaves, byproducts in raspberry production, are also a rich source of bioactive phytochems. In this study, the changes of phenolic compounds in raspberries leaf extract (RLE) under in vitro digestion and colonic fermentation were further studied by HPLC-MS anal. and 16S rRNA. The results showed that the phenolic compounds in RLE were relatively stable during in vitro gastric digestion; however, in the subsequent intestinal digestion and colonic fermentation, their content decreased sharply. A large amount of hydroxyphenylpropionic acid, hydroxyphenylacetic acid and urolithins were produced under the action of gut microbiota. Moreover, compared with corresponding control, RLE significantly reduced the ratio of Firmicutes/Bacteroidetes in all volunteers, increased the relative abundances of some beneficial bacteria, Enterococcus, Prevotella, and decreased the relative abundances of potential pathogens, Clostridium and Faecalibacterium. These findings suggest that RLE during in vitro digestion and fermentation has pos. effects on gut microbiota and potential value of maintaining intestinal health.

International Journal of Food Science and Technology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C15H20O6, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Xiao-xia published the artcileNew highly phosphorescent heteroleptic tris-cyclometalated iridium(III) complexes: Synthesis and photophysical characterization, Product Details of C8H5F3O3, the publication is Guangpuxue Yu Guangpu Fenxi (2010), 30(1), 170-173, database is CAplus and MEDLINE.

New heteroleptic tris-cyclometalated iridium(III) complexes (ppy)₂Ir(LX) [ppy = 2-phenylpyridine, LX = Sal (salicylic acid), MSal (4-methylsalicylic acid), FSal (4-trifluoromethylsalicylic acid)] was synthesized and characterized. The mol. structure, photophys. properties and thermal stability were tested and analyzed. The results show that the absorption peaks were located around 270, 370, 450 and 484 nm resp. at room temperature The two former peaks at 270 and 370 nm should belong to ¹π^–π^* transition at ppy and transition from salicylic acid ligands to 2-phenylpyridine. The peaks around 450 and 484 nm can be assigned to the charge transfer transition from Ir to ligand (¹MLCT and ³MLCT) and ³π^–π^* transition resp. The PL emission peaks were located at 520, 522, and 510 nm, resp. The emission of (ppy)₂Ir(Sal) and (ppy)₂Ir(MSal) was mainly ascribed to the radiation transition of triple state ³MLCT, while the emission of (ppy)₂ Ir(FSal) was mainly from the radiation transition between Sal and ppy, partly from the radiation transition of single state ¹MLCT and triple state ³MLCT. The quantum efficiencies of these complexes were 0.37, 0.33 and 0.29 resp. The thermal decomposition temperature was from 306 to 328°C. (ppy)₂Ir(LX), being efficient phosphorescent materials with good thermal stability, can be used in organic electroluminescent devices.

Guangpuxue Yu Guangpu Fenxi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Product Details of C8H5F3O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Jian-ning published the artcileA new type of iridium (III) phenylpyrazole complexes: synthesis, photophysical characterization, Category: alcohols-buliding-blocks, the publication is Guangpuxue Yu Guangpu Fenxi (2010), 30(9), 2424-2427, database is CAplus and MEDLINE.

New heteroleptic iridium(III) complexes (ppz)₂Ir(LX), which consist of two cyclometalated ligands ppz(1-pheny-lpyrazole) together with an ancillary ligand LX (LX=2-(2′-hydroxylphenyl)benzothiazole (BTZ),2-(3′-methyl-2′-hydroxyl-phenyl) benzothiazole (3-MeBTZ), 2-(4′-methyl-2′-hydroxylphenyl)benzothiazole (4-MeBTZ) and 2-(4′-Trifluoromcthyl-2′-hydroxylphenyl)benzothiazole (4-tfmBTZ)), were synthesized and characterized. The mol. structures and photophys. properties were characterized and analyzed comparatively. The results show that the four complexes have basically similar UV-Vis absorption spectra, fluorescence excitation and emission spectra. Their maximum emission peaks are located at 583-615 nm, and accompanied by a lower intensity emission band around 400 nm. The weak emissions around 400 nm are ascribed to the radiation transition of single state excition from ancillary ligand BTZ perturbed by metallic ion, and light emission around long-wavelength to the radiation transition of ³MLCT of Ir(BTZ) fragment. While the triplet state ³MLCT of Ir(ppz)₂ fragment might be quenched at room temperature For all complexes, the excitations with maximum efficiency are located at 250-310 nm, which indicates that main contributor to light emitting is ligand-centered absorption(¹π-π^*) of ppz and BTZ rather than ³MLCT transitions, and thus provides a striking evidence that there is intersystem crossing from ¹π-π^* state to ³MLCT state in these complexes. Compared with Ir(ppz)₃, these complexes not only have stronger phosphorescence at room temperature but also their emission color can be tuned by modifying ancillary ligand.

Guangpuxue Yu Guangpu Fenxi published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C10H2F12NiO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pitcher, Noel P. published the artcileDevelopment of 1,2,4-Oxadiazole Antimicrobial Agents to Treat Enteric Pathogens within the Gastrointestinal Tract, Name: 3-Hydroxyphenylacetic acid, the publication is ACS Omega (2022), 7(8), 6737-6759, database is CAplus and MEDLINE.

Colonization of the gastrointestinal (GI) tract with pathogenic bacteria is an important risk factor for the development of certain potentially severe and life-threatening healthcare-associated infections, yet efforts to develop effective decolonization agents have been largely unsuccessful thus far. Herein, we report modification of the 1,2,4-oxadiazole class of antimicrobial compounds with poorly permeable functional groups in order to target bacterial pathogens within the GI tract. We have identified that the quaternary ammonium functionality of analog 26a (I) results in complete impermeability in Caco-2 cell monolayers while retaining activity against GI pathogens Clostridioides difficile and multidrug-resistant (MDR) Enterococcus faecium. Low compound recovery levels after oral administration in rats were observed, which suggests that the analogs may be susceptible to degradation or metabolism within the gut, highlighting a key area for optimization in future efforts. This study demonstrates that modified analogs of the 1,2,4-oxadiazole class may be potential leads for further development of colon-targeted antimicrobial agents.

ACS Omega published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Name: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shi, Da-Hua published the artcileSynthesis of 3-(alkylamino)-, 3-(alkoxy)-, 3-(aryloxy)-, 3-(alkylthio)-, and 3-(arylthio)-1,2,4-triazines by using a unified route with 3-(methylsulfonyl)-1,2,4-triazine, COA of Formula: C3H5F3O, the publication is European Journal of Organic Chemistry (2016), 2016(16), 2842-2850, database is CAplus.

In our attempts to synthesize 3-(alkylthio)- and 3-(alkoxy)-1,2,4-triazines without substituents at the 5- or 6-position, the synthesis of their anticipated precursor 3-(methylsulfonyl)-1,2,4 triazine was also optimized. The reactivity of 3-(methylsulfonyl)-1,2,4-triazine towards alkyl and aryl thiols, primary and secondary alkylamines, phenols, and alcs. was explored, and the reactions were optimized to maximize the isolation of the corresponding 3-substituted 1,2,4-triazine. Good yields were obtained for the products of the reactions with all of the aforementioned nucleophiles, with the exception of alcs., by using alkali metal carbonates. Higher yields of 3-(alkoxy)-1,2,4-triazines were obtained by using the appropriate magnesium alkoxide as the nucleophile.

European Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C16H12O, COA of Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghosh, Kousik published the artcileA triple alkoxo bridged dinuclear cobalt(III) complex mimicking phosphatase and showing ability to degrade organic dye contaminants by photocatalysis, COA of Formula: C4H11NO, the publication is Journal of Organometallic Chemistry (2019), 52-64, database is CAplus.

A dinuclear Co(III) complex, [(N₃)L¹Co^IIIL²Co^IIIL¹] (1), was synthesized and characterized {H₂L¹ = 2-((1-hydroxybutan-2-ylimino)methyl)-4-bromophenol and HL² = 2-amino-1-butanol}. Single crystal x-ray diffraction anal. confirmed its structure. Extended supra-mol. architectures were generated in the complex through weak noncovalent interactions. The energetic features of significant supramol. interactions were studied using DFT calculation and further corroborated with NCI plot index computational tool. The complex was found to mimic the role of phosphatase enzyme efficiently by transforming 4-nitrophenylphosphate to 4-nitrophenolate at room temperature The reaction follows Michaelis-Menten enzymic reaction kinetics with turnover numbers of ∼1.4 s^-1 in aqueous DMF (98% DMF, volume/volume) medium. The complex also acts as an efficient photocatalyst for degradation of organic pollutants. Methylene blue (MB), a widely used dye in various industries, was selected as a model pollutant in aqueous media to evaluate the photocatalytic effectiveness of the complex.

Journal of Organometallic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Pinjing published the artcileInsertions of Ketones and Nitriles into Organorhodium(I) Complexes and β-Hydrocarbyl Eliminations from Rhodium(I) Alkoxo and Iminyl Complexes, Formula: C19H14O2, the publication is Organometallics (2008), 27(18), 4749-4757, database is CAplus.

Tris(triethylphosphine)-ligated organorhodium(I) complexes were prepared, and their reactions with electron-poor arylnitriles and diaryl ketones were studied. [(PEt₃)₃Rh(Ar)] (Ar = Ph (1a) or o-anisyl (1e)) reacted with an excess of electron-poor arylnitriles Ar’CN (Ar’ = p-CF₃C₆H₄ or 3,5-bis(CF₃)C₆H₃) to form Rh(I) iminyl complexes {(PEt₃)₃Rh[N:C(Ar)(Ar’)]} (2h–j). In contrast, 3,5-(CF₃)₂C₆H₃CN did not insert into the M-C bond of the arylrhodium(I) complexes [(PEt₃)₃Rh(Ar)] (Ar = p-CF₃C₆H₄ (1f) or 3,5-(CF₃)₂C₆H₃ (1g)), containing more electron-poor aryl groups. The kinetic data for nitrile insertions were most consistent with a pathway involving initial ligand dissociation, followed by a classic migratory insertion. Some iminyl complexes decomposed at higher temperatures via β-aryl eliminations with selective migration of the more electron-poor aryl Group 3,5-(CF₃)₂C₆H₃ to form 1g and the corresponding nitriles. Migratory aptitudes of various aryl groups were assessed by studying β-aryl eliminations from a variety of iminyl complexes. Kinetic data for these β-aryl eliminations were most consistent with initial phosphine dissociation and C-C bond cleavage of the resulting 14-electron intermediate. Insertions of diaryl ketones Ar(Ar’)C:O (Ar = 3,5-(CF₃)₂C₆H₃, Ar’ = Ph or 3,5-(CF₃)₂C₆H₃) into 1a also occurred, although the resulting Rh(I) alkoxides {(PEt₃)₂Rh[OC(Ph)(Ar)(Ar’)]} (3f–g) were not stable under the reaction conditions and could not be directly identified. Instead, a mixture of {(PEt₃)₃Rh[3,5-(CF₃)₂C₆H₃]} (1g) and the ketone Ph(Ar’)C:O (Ar’ = Ph or 3,5-(CF₃)₂C₆H₃) were detected as the major products, indicating that decomposition of alkoxides 3f–g occurred by β-elimination of the more electron-poor aryl group. Independent preparation of 3f–g and studies on their thermal decomposition with added PEt₃ confirmed that selective β-aryl elimination occurs to generate aryl complex 1g and the corresponding ketones. Analogous β-aryl eliminations from bis-phosphine Rh(I) alkoxo complexes 3a–e and trisphosphine Rh(I) alkoxo complexes 4b–e were also studied, and the kinetic results were most consistent with irreversible β-Ph elimination from bis(phosphine) alkoxo complexes. Insertion of 3,5-(CF₃)₂C₆H₃CN into an alkylrhodium(I) complex [(PEt₃)₃Rh(Me)] did not occur; however, the electron-poor ketone Ar₂C:O (Ar = 3,5-(CF₃)₂C₆H₃) inserted into 1h, as judged by the detection of the corresponding alc. HOC(Me)[3,5-(CF₃)₂C₆H₃]₂ as the major organic product after quenching with Et₃N·HCl. Vinylrhodium(I) complex [(PEt₃)₃Rh(CH:CH₂)] also reacted with ketones Ar₂C:O (Ar = 3,5-(CF₃)₂C₆H₃) to form a Rh(I) alkoxo complex (PEt₃)₂Rh{OC(CH:CH₂)[3,5-(CF₃)₂C₆H₃]₂} (3h), which was stabilized by the intramol. coordination of the vinyl moiety to the Rh center. The alkynylrhodium(I) complex [(PEt₃)₃Rh(CCPh)] (1j) did not react with ketones or nitriles. Instead, the propargylic alkoxides {(PEt₃)₂Rh[OC(R)₂(CCPh)]} (R = Me or Ph) that would have resulted from insertion react rapidly in the presence of added PEt₃ to form the alkynyl complex 1j and the corresponding ketones via β-alkynyl eliminations. The crystal and mol. structures of [(PEt₃)₃Rh(2-MeOC₆H₄)] and [(PEt₃)₂Rh(OCPh₃)] were determined by x-ray crystallog.

Organometallics published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H13N3O2, Formula: C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

El-Sayed, Heba M. published the artcileQuality by Design Strategy for Simultaneous HPLC Determination of Bromhexine HCl and Its Metabolite Ambroxol HCl in Dosage Forms and Plasma, Application In Synthesis of 23828-92-4, the publication is Chromatographia (2020), 83(9), 1075-1085, database is CAplus.

Abstract: The quality by design strategy was applied for the simultaneous chromatog. quantification of a binary mixture of bromhexine HCl and its pharmacol. active metabolite ambroxol HCl in dosage forms as well as in human plasma. In this study, five independent parameters were screened by fractional factorial design to specify the critical ones. The optimal conditions were determined by a response surface methodol. using a central composite design. Response surface methodol. enabled the best separation in minimal run time, as well as, prediction of separation and retention parameters with min. error. Separation and quantitation were carried out on BDS Hypersil C₈ (250 × 4.6 mm, 5μm) RP-column at 1.1 mL min^-1 flow rate, 25 mM of KH₂PO₄ (pH 3.5) in aqueous mobile phase, 65% MeOH, 210 nm wavelength of detection and 10μL injection volume After optimization of the chromatog. parameters, validation of the method was achieved according to ICH guidelines. Linearity ranged from 0.195 to 100μg mL^-1 ambroxol HCl, and 0.391-100μg mL^-1 bromhexine HCl, with R² values of 0.9998 and 0.9999 and limits of detection of 0.098 and 0.195μg mL^-1, resp. Recovery results ranged from 98.06 to 100.18 and 97.88 to 100.68 for bromhexine HCl and ambroxol HCl, resp., with RSD less than 1.80.

Chromatographia published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Doura, Tomohiro published the artcileAn adhesive ¹⁹F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(97), 11421-11423, database is CAplus and MEDLINE.

We report a new strategy for designing a signal off-to-on-type ¹⁹F MRI chem. probe that operates in biol. environments. The present strategy is based on the control of adherence of a ¹⁹F MRI chem. probe to certain blood proteins, accompanied by a change in transverse relaxation time of ¹⁹F nuclei.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts