Category: alcohols-buliding-blocks

Konidala, Praveen published the artcileMolecular dynamics characterization of n-octyl-β-D-glucopyranoside micelle structure in aqueous solution, SDS of cas: 85618-21-9, the publication is Journal of Molecular Graphics & Modelling (2006), 25(1), 77-86, database is CAplus and MEDLINE.

N-Octyl-β-D-glucopyranoside (OG) is a non-ionic glycolipid, which is used widely in biotech. and biochem. applications. All-atom mol. dynamics simulations from two different initial coordinates and velocities in explicit solvent have been performed to characterize the structural behavior of an OG aggregate at equilibrium conditions. Geometric packing properties determined from the simulations and small angle neutron scattering experiment state that OG micelles are more likely to exist in a non-spherical shape, even at the concentration range near to the critical micelle concentration (0.025 M). Despite few large deviations in the principal moment of inertia ratios, the average micelle shape calculated from both simulations is a prolate ellipsoid. The deviations at these time scales are presumably the temporary shape change of a micelle. However, the size of the micelle and the accessible surface areas were constant during the simulations with the micelle surface being rough and partially elongated. Radial distribution functions computed for the hydroxyl oxygen atoms of an OG show sharper peaks at a min. van der Waals contact distance than the acetal oxygen, ring oxygen, and anomeric carbon atoms. This result indicates that these atoms are pointed outwards at the hydrophilic/hydrophobic interface, form hydrogen bonds with the water mols., and thus hydrate the micelle surface effectively.

Journal of Molecular Graphics & Modelling published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, SDS of cas: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Song, Chengwen published the artcileRole of carboprost tromethamine in laparoscopic myomectomy, COA of Formula: C25H47NO8, the publication is Xuzhou Yixueyuan Xuebao (2013), 33(2), 139-140, database is CAplus.

Hemostatic effect of carboprost tromethamine in laparoscopic myomectomy was discussed. One hundred patients with uterine fibroids were randomly divided into treatment group and control group, they were injected with 1 mL carboprosttromethamine (250 μg) and oxytocin 20 U during operation to prevent bleeding. Bleeding amount, operation time and abdominal drainage in treatment group were less than those in control group (P<0.05). Temperature recovery time and evacuation time by anus had no statistical significance. Application of carboprost tromethamine in laparoscopic myomectomy could significantly decrease bleeding time, shorten operation time, with less adverse reaction and worth popularizing.

Xuzhou Yixueyuan Xuebao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H10N2O2, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Lei published the artcileExperimental study on multi-component corrosion inhibitor for steel bar in chloride environment, SDS of cas: 122-20-3, the publication is Construction and Building Materials (2021), 125533, database is CAplus.

This paper investigates one type of multi-component corrosion inhibitor for steel bars in chloride environment. Triethanolamine (TEA), tri-isopropanolamine (TIPA), sodium monofluorophos-phate (MFP) and sodium molybdate (T-4) were proportioned to prepare this multi-component corrosion inhibitor. Corrosion behavior of steel bar was evaluated using the polarization curve, electrochem. impedance spectroscopy (EIS) and SEM (SEM). The polarization curves were fitted using the adsorption isotherm models. Exptl. results indicated that the steel bar corrosion in chloride solution can be reduced by the addition of either organic or inorganic corrosion inhibitors. This is attributed to the fact that organic corrosion inhibitor can form an adsorption film on the steel bar surface and inorganic corrosion inhibitor abates electrochem. reaction of steel bars. Compared to single component corrosion inhibitors, the corrosion rate of steel bars in simulated pore solution was significantly restrained by the multi-component corrosion inhibitor. The adsorption of multi-component corrosion inhibitor on the surface of steel bar can significantly reinforce the passive film by means of phys. (organic) or chem. (inorganic) process. For all the investigated corrosion inhibitors, the adsorption isotherms were in good agreement with exptl. results. The EIS result and equivalent electrochem. circuit confirmed the chem. reaction and phys. adsorption process of the multi-component corrosion inhibitor. Therefore, the chloride induced corrosion of steel bars can be effectively controlled by the multi-component corrosion inhibitor.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Minghui published the artcileInhibition effect of different corrosion inhibitors on steel bars corrosion and improvement effect after double doped, Application In Synthesis of 122-20-3, the publication is Science Journal of Chemistry (2021), 9(4), 105-112, database is CAplus.

Reinforced concrete structures are easily corroded in the Salt Lake areas of China, especially in harsh environmental circumstance, such as freezing-thawing cycles, wetting-dry, et al, thus causing a lot of damage problems (concrete deterioration and steel bars corrosion). This research investigation was a research study which was to solve the corrosion problem of reinforced concrete structures under the chloride environmental circumstance through the electrochem. performance and mech. properties test of the reinforced mortar specimens, the effect of single or compound doping of two organic and two inorganic corrosion inhibitors to the electrode potential, electrochem. impedance spectroscopy and mech. properties of the reinforced mortar were investigated. The exptl. conclusion demonstrated that the organic or inorganic corrosion inhibitors after single and compound doping showed some degree influence on the electrode potential and mech. properties of the reinforced mortar specimens. Meanwhile, when the ratio of triethanolamine (TEA):triisopropanolamine (TIPA) was 7:3, sodium monofluorophosphate (MFP):sodium molybdate was 5:5, the compressive strength and flexural strength of mortar after curing for 28 days were greater than 90, it indicated that these proportions showed the best corrosion resistance performance of steel bars. Therefore, these proportions of corrosion inhibitors could be used in reinforced concrete structures. The significant was that these results could provide theor. guidance and tech. basis for the study of corrosion damage of reinforced concrete structures in the future.

Science Journal of Chemistry published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application In Synthesis of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ervin, Samantha M. published the artcileTargeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases, SDS of cas: 622-40-2, the publication is ACS Chemical Biology (2019), 14(12), 2737-2744, database is CAplus and MEDLINE.

Regorafenib (Stivarga) is an oral small mol. kinase inhibitor used to treat metastatic colorectal cancer, hepatocellular carcinomas, and gastrointestinal stromal tumors. Diarrhea is one of the most frequently observed adverse reactions associated with regorafenib. This toxicity may arise from the reactivation of the inactive regorafenib-glucuronide to regorafenib by gut microbial β-glucuronidase (GUS) enzymes in the gastrointestinal tract. We sought to unravel the mol. basis of regorafenib-glucuronide processing by human intestinal GUS enzymes and to examine the potential inhibition of these enzymes. Using a panel of 31 unique gut microbial GUS enzymes derived from the 279 mapped from the human gut microbiome, we found that only four were capable of regorafenib-glucuronide processing. Using crystal structures as a guide, we pinpointed the mol. features unique to these enzymes that confer regorafenib-glucuronide processing activity. Furthermore, a pilot screen identified the FDA-approved drug raloxifene as an inhibitor of regorafenib reactivation by the GUS proteins discovered. Novel synthetic raloxifene analogs exhibited improved potency in both in vitro and ex vivo studies. Taken together, these data establish that regorafenib reactivation is exclusively catalyzed by gut microbial enzymes and that these enzymes are amenable to targeted inhibition. Our results unravel key mol. details of regorafenib reactivation in the GI tract and provide a potential pathway to improve clin. outcomes with regorafenib.

ACS Chemical Biology published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, SDS of cas: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dreiling, Alena published the artcileEarly cleavage of ethylene glycol bis(succinimidylsuccinate) (EGS)-linker moieties during enzymatic digestion of cross-linked proteins, Quality Control of 70539-42-3, the publication is Rapid Communications in Mass Spectrometry (2014), 28(21), 2385-2388, database is CAplus and MEDLINE.

It has become popular to combine the crosslinking of proteins with mass spectrometry (MS) to study their tertiary structure or interactions. There are several difficulties with the method which make it a challenge. They include the limited availability of crosslinked peptides for MS anal. due to low yield of the crosslinking reaction and unwanted side chem. Recently, the authors have pointed out the uncontrolled quenching of azide linkers by buffer components rendering them almost useless for the intended task. Here, the authors describe a phenomenon involving cleavable crosslinkers. They have been designed to overcome the drawback that crosslinked peptides provide poor gas-phase fragmentation mass spectra because of their branched structure. Moreover, isotope coding on such linkers may assist in finding the low-abundance crosslinked peptides in mass spectra as described for ethylene glycol bis(succinimidylsuccinate) (EGS). In some of the authors’ experiments, this compound provided better crosslinking yields compared to other N-hydroxysuccinimide-derived reagents as detected by one-dimensional sodium dodecyl sulfate PAGE. For best results from crosslinking experiments using cleavable agents such as EGS, careful control of sample preparation protocols for early hydrolysis products is advisable.

Rapid Communications in Mass Spectrometry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Quality Control of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Szabo, Lajos Z. published the artcilePreparation of S-glycoside surfactants and cysteine thioglycosides using minimally competent Lewis acid catalysis, Category: alcohols-buliding-blocks, the publication is Carbohydrate Research (2016), 1-4, database is CAplus and MEDLINE.

Here we report a method for the preparation of anomerically pure β-S-glycopyranosides (1,2-trans-glycosides) from the corresponding peracetate donors. S-glycosylation was performed in CHCl₃ at reflux in the presence of a catalytic amount of InBr₃. Deacylation of the intermediate peracetates were achieved under Zemplén conditions. Five pyranose examples, monosaccharides D-glucose and D-galactose and disaccharides cellobiose, maltose, and lactose, were used as donors, and five thiols including an α/ω dithiol and Fmoc-L-cysteine were used as acceptors. M.ps., high res MS, [α]_D and NMR data (¹H and ¹³C, including COSY, HSQC and HMBC) are reported for compounds not previously described.

Carbohydrate Research published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H17BF3NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oppegard, Martin published the artcileDetermination of C₀-C₉ alkyl phenols in produced-water-exposed fish eggs using gas chromatography/tandem mass spectrometry, Recommanded Product: 4-Propylphenol, the publication is Rapid Communications in Mass Spectrometry (2020), 34(24), e8950, database is CAplus and MEDLINE.

Rationale: Produced water (PW) discharge from the oil and gas industry represents the largest intentional marine waste volume Alkyl phenols (APs) are one of the main toxic component groups found in PW, with concentration of APs in discharged PW from the Norwegian Sector of the North Sea up to >16 mg/L. Several species of fish spawn in direct proximity to offshore production platforms and may be at risk of AP exposure. Therefore, a sensitive method to determine the potential for bioaccumulation of APs in fish eggs is needed. Methods: Fish eggs were extracted using liquid-solid extraction followed by gel permeation chromatog. cleanup. Anal. was performed by gas chromatog. coupled to triple quadrupole mass spectrometry. Extraction and anal. conditions were optimized for anal. of phenol and 30 APs (C₁-C₉) with different degrees of branching in the alkyl chain. The method was verified and applied to analyze the body residue of APs in PW-exposed marine fish (Atlantic cod, Gadus morhua) eggs. Results: A comprehensive and sensitive method for the determination of C₀-C₉ APs was developed. Detection limits were in the range 0.03-8 ng. Apart from a few compounds with poor recovery, the method generally provided reliable results with good precision (<15%). Conclusions: We demonstrate the successful application of an optimized extraction method for APs in fish eggs and show first results of AP accumulation in cod embryos exposed to PW in the laboratory

Rapid Communications in Mass Spectrometry published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cheng, Qiuhong published the artcileEutectogels as Matrices to Manipulate Supramolecular Chirality and Circularly Polarized Luminescence, Product Details of C8H8O3, the publication is ACS Nano (2022), 16(4), 6825-6834, database is CAplus and MEDLINE.

The occurrence and manipulation of supramol. chirality in deep eutectic solvents (DESs) was explored. Transfer from inherent chiral DES to solutes in either aggregated or monomeric building units is blocked. The chiral assembly of π-conjugated amino acids was realized. Compared to aqueous media, self-assembly in DES hinders the spontaneous structural and chirality evolution that benefit from efficient solvation, where the π-conjugated amino acids were involved as H bonding donors. DES performs as a dye-friendly matrix to afford chiroptical eutectogels with tunable circularly polarized luminescence, whereby a large dissymmetry g-factor of ≤0.015 was realized. DES behaves as feasible and flexible solvents to fabricate and stabilize functional soft chiral self-assemblies with controllable chiroptical properties.

ACS Nano published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Bowen published the artcileFluorinated paclitaxel prodrugs for potentiated stability and chemotherapy, SDS of cas: 2240-88-2, the publication is Journal of Materials Chemistry B: Materials for Biology and Medicine (2021), 9(48), 9971-9979, database is CAplus and MEDLINE.

Robust colloidal stability is an essential prerequisite for effective drug delivery. Herein, a series of fluorinated paclitaxel prodrugs bridged with redox-responsive linkages were synthesized, and the effect of fluorination on the assembly behavior and physiol. stability was investigated. The 17-fluorinated ethanol-modified paclitaxel prodrug could self-assemble into stable nanoparticles without the addition of any surfactants. Fluorinated paclitaxel prodrug nanoparticles possessed potent cytotoxicity toward cancer cells and superior antitumor activity. This study offers a universal fluorination approach to improve drug delivery efficacy by enhancing the self-assembly capability and improving the colloidal stability of prodrugs for potentiating chemotherapy.

Journal of Materials Chemistry B: Materials for Biology and Medicine published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts