Category: alcohols-buliding-blocks

Ito, Motoki published the artcileSynthesis of Boron-Substituted Diaryliodonium Salts and Selective Transformation into Functionalized Aryl Boronates, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Angewandte Chemie, International Edition (2012), 51(50), 12555-12558, database is CAplus and MEDLINE.

Diaryliodonium salts were synthesized from aryl boronate derivatives according to two alternative general methods with hypervalent iodine(III) reagents and fluoroalc. solvents: transformation of an aryl C-H bond and boron-iodine(III) exchange. The salts could be functionalized by both catalyst-free and metal-catalyzed reactions without loss of the boron functionality.

Angewandte Chemie, International Edition published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ito, Masaki published the artcileSelective Boryl Silyl Ether Formation in the Photoreaction of Bisboryloxide/Boroxine with Hydrosilane Catalyzed by a Transition-Metal Carbonyl Complex, Safety of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Journal of the American Chemical Society (2014), 136(17), 6183-6186, database is CAplus and MEDLINE.

Selective B-O-Si bond formation was achieved in the reaction of bisboryloxide O(Bpin)₂ (pin = (OCMe₂)₂)/boroxine (MeBO)₃ system with tertiary silane R₃SiH in the presence of stoichiometric water and a catalytic amount of [M](CO)₅ ([M] = Mo(CO), W(CO), Fe) to give boryl silyl ethers. Moreover, this reaction can be applied to various hydrosilanes (disilyl compounds and secondary silanes) and hydrogermane. Some of the boryl silyl ethers thus formed were confirmed by X-ray anal.

Journal of the American Chemical Society published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Safety of 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shimizu, Kuniaki published the artcileReductive cleavage reaction of N,N’-, N,O- and N,S-linked alkylidene compounds by sodium borohydride, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Chemical & Pharmaceutical Bulletin (1974), 22(6), 1256-60, database is CAplus.

NaBH4 reduction was undertaken with a variety of N,n’-, N,O-, and N,S-linked alkylidene compounds (e.g. I-III) in aqueous ethanolic medium at room temperature Reductive cleavage of one of these two alkylidene carbon-heteroatom bonds is generally effected in this reduction The alkylidene bond initially cleaved when the two bonds were different was also determined

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C14H12O2, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, M. B. published the artcileSynthesis of 4-(dibromomethyl)benzenecarbaldehyde and its reactions with N- and O-nucleophiles, Product Details of C8H19NO2, the publication is Russian Chemical Bulletin (2016), 65(1), 191-194, database is CAplus.

4-(Dibromomethyl)benzenecarbaldehyde (4-Br₂CHC₆H₄CHO, I) was prepared chemoselectively by debromination of 1,4-bis(dibromomethylbenzene) with tri-Me phosphate; reaction with primary amines RNH₂ [R = i-Pr, 4-MeOC₆H₄, (EtO)₂CHCH₂, (EtO)₂CH₂CH₂CH₂] yielded benzaldimines 4-Br₂CHC₆H₄CH:NR [R = i-Pr, 4-MeOC₆H₄, (EtO)₂CHCH₂, (EtO)₂CH₂CH₂CH₂], while reaction with tri-Me and tri-Et orthoformates in the presence of H₂SO₄ yielded the acetals 4-Br₂CHC₆H₄CH(OR¹)₂ (R¹ = Me, Et).

Russian Chemical Bulletin published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Product Details of C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, M. B. published the artcile4-(Dibromomethyl)benzaldehyde and its reactions with primary amines, Synthetic Route of 6346-09-4, the publication is Russian Journal of General Chemistry (2015), 85(9), 2209-2211, database is CAplus.

The title compound, 4-Br₂CHC₆H₄CHO (1) was prepared by reaction of 1,4-(Br₂CH)₂C₆H₄ with tri-Me phosphate with 42% yield, the side product being di-Me phosphorobromidate (MeO)₂P(O)Br. The process shows advantages over usual acid hydrolysis, being selective and leaving less aggressive hydrogen bromide waste. The aldehyde 1 reacts with primary amines RNH₂, giving aldimines 4-Br₂CHC₆H₄CH:NR [13a–d; R = ⁱPr, 4-MeOC₆H₄, CH₂CH(OEt)₂, (CH₂)₃CH(OEt)₂].

Russian Journal of General Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gazizov, Mukattis B. published the artcileSynthesis and properties of 4-(dibromomethyl)benzenecarbaldehyde, SDS of cas: 6346-09-4, the publication is Tetrahedron Letters (2016), 57(2), 210-212, database is CAplus.

The 4-(dibromomethyl)benzenecarbaldehyde was synthesized for the first time using a new method, which also allowed the co-preparation of terephthalic aldehyde. The reaction of this aldehyde with primary amines RNH₂ [R = CH(CH₃)₂, 4-OCH₃C₆H₄, CH₂CH(O(C₂H₅)₂), etc.] resulted in the formation of imines RN=CHC₆H₄CHBr₂, including those containing an addnl. acetal group, while the reaction with trialkyl orthoformates HC(OR¹)₃ (R¹ = Me, Et) led to the formation of acetals R¹O(OR¹)CHC₆H₄CHBr₂. The latter compounds were transformed into 4-(dibromomethyl)-substituted benzenes containing a phosphorus functional group in the side chain via consecutive reactions with phosphorus trichloride and the esters of P(III) acids.

Tetrahedron Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, SDS of cas: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shibanuma, Tadao published the artcileSynthesis of optically active 2-(N-benzyl-N-methylamino)ethyl methyl 2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate (nicardipine), HPLC of Formula: 101-98-4, the publication is Chemical & Pharmaceutical Bulletin (1980), 28(9), 2809-12, database is CAplus and MEDLINE.

(+)- And (-)-nicardipine (I) were prepared from (-)- and (+)-1-ethoxymethyl-5-methoxycarbonyl-2,6-dimethyl-4-(m-nitrophenyl)-1,4-dihydropyridine-3-carboxylic acid (II). Resolution of II was carried out using cinchonidine and cinchonine. The vertebral vasodilating activity of (+)-I.HCl was about 3 times that of (-)-I.HCl.

Chemical & Pharmaceutical Bulletin published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C4H6BrFO2, HPLC of Formula: 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pestova, S. V. published the artcileSynthesis and membrane protective activity of bis-sulfides derived from monoterpenoids and monosaccharides, Product Details of C12H20O6, the publication is Russian Journal of Bioorganic Chemistry (2017), 43(3), 302-310, database is CAplus.

Hydroxyl- and chloroethyl derivatives of neomenthane- and isobornanethiol in yields of to 80% were synthesized. They served as the basis for the preparation of new bis-sulfides with diacetone-protected galacto- and fructopyranose fragments in yields up to 98%. The bis-sulfides synthesized were screened for membrane protective and antioxidant properties in a model cell system (in vitro) based on their ability to inhibit the H₂O₂-induced hemolysis of erythrocytes and retard the oxy-Hb oxidation

Russian Journal of Bioorganic Chemistry published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Product Details of C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pestova, S. V. published the artcileSynthesis and membranoprotective properties of new disulfides with monoterpene and carbohydrate fragments, Computed Properties of 20880-92-6, the publication is Russian Chemical Bulletin (2015), 64(3), 723-731, database is CAplus.

A cooxidn. of carbohydrate and terpene thiols gives mixtures of disulfides containing 51-90% of the unsym. product. Membranoprotective and antioxidant properties of obtained unsym. and sym. disulfides were evaluated based on their ability to inhibit the H₂O₂-induced hemolysis of erythrocytes, as well as the accumulation of secondary products of the peroxy oxidation of lipids and the oxidation of Hb.

Russian Chemical Bulletin published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C12H20O6, Computed Properties of 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ge, Jun published the artcileSustained release of nucleic acids from polymeric nanoparticles using microemulsion precipitation in supercritical carbon dioxide, Related Products of alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2010), 46(47), 9034-9036, database is CAplus and MEDLINE.

A general approach for producing biodegradable nanoparticles for sustained nucleic acid release is presented. The nanoparticles are produced by precipitating a water-in-oil microemulsion in supercritical CO₂. The microemulsion consists of a tRNA aqueous solution (water phase), dichloromethane containing poly(L-lactic acid)-poly(ethylene glycol) (oil phase), the surfactant n-octyl β-D-glucopyranoside, and the cosurfactant n-butanol.

Chemical Communications (Cambridge, United Kingdom) published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts