Category: alcohols-buliding-blocks

Dashti, Amir published the artcileQuantitative structure property relationship schemes for estimation of autoignition temperatures of organic compounds, Synthetic Route of 122-20-3, the publication is Journal of Molecular Liquids (2020), 111797, database is CAplus.

We have extended a quant. structure-property relationship (QSPR) scheme to estimate the auto-ignition temperatures (AIT) of organic compounds by employing GA-ANFIS, PSO-ANFIS, DE-ANFIS and GP methods. The average absolute relative deviations (%AARD) are 7.96, 6.29, 8.85 and 8.26, resp. The range of these values appears to match that of exptl. error in AIT measurements, suggesting strong models. For organic compounds, the AIT can be estimated using the above-mentioned methods, from mol. structure. This goal is possible using only 9 theor. descriptors.

Journal of Molecular Liquids published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Synthetic Route of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Jinshu published the artcileLignin-derived layered 3D biochar with controllable acidity for enhanced catalytic upgrading of Jatropha oil to biodiesel, COA of Formula: C9H12O, the publication is Catalysis Today, database is CAplus.

Biochar materials have wide applications in soil improvement/remediation, water pollution control, gas storage, and heterogeneous catalysis, while usually suffering from low surface areas and harsh preparation conditions. In this study, a green, environmentally friendly, and low-cost biochar catalyst (PAP-MEPP-C) was prepared by thermochem. treatment of lignin-derived monomers at a low temperature (80 °C), and further developed for high-efficiency production of biodiesel from non-edible Jatropha oil (JO). The characterization results showed that the structure of the PAP-MEPP-C biochar catalyst was layered and 3D structure, and its acidity could be controlled by changing the monomeric composition The reaction conditions of preparing biodiesel catalyzed by PAP-MEPP-C were optimized by the response surface method, and the obtained maximum biodiesel yield was 97.2%. The kinetics of the (trans)esterification reaction over the developed biochar catalyst PAP-MEPP-C was studied, and its superior catalytic performance to other tested acid catalysts could be supported by a relatively lower activation energy (36 kJ mol^-1). In addition, the biochar catalyst was highly stable and could be recycled four times with more than 90% biodiesel yield.

Catalysis Today published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, COA of Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liao, Liping published the artcileSynthesis and biological evaluation of 1,2,4-triazole derivatives as potential neuroprotectant against ischemic brain injury, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is European Journal of Medicinal Chemistry (2020), 112114pp., database is CAplus and MEDLINE.

A series of 1,2,4-triazole derivatives I (R¹ = H, OH; R² = H, F, CF₃, etc.; R³ = H, Me, F, CF₃ ) was synthesized to investigate their neuroprotective effects and mechanisms of action. Some compounds noticeably protected PC12 cells from the cytotoxicity of H₂O₂ or sodium nitroprusside (SNP). Compound I (R¹ = OH; R² = OMe; R³ = H) was the most effective derivative Compound I (R¹ = OH; R² = OMe; R³ = H) chelated Fe (II) iron, scavenged reactive oxygen species (ROS), and restored the mitochondrial membrane potential (MMP). Moreover, it enhanced the activity of the antioxidant defense system by increasing the serum level of superoxide dismutase (SOD) and promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2). Compound I (R¹ = OH; R² = OMe; R³ = H) caused certain improvements in behavior, the cerebral infarction area, and serum levels of biochem. indicators (TNF-α, IL-1β, SOD and MDA) in a rat MCAO model. The LD (LD₅₀) of compound I (R¹ = OH; R² = OMe; R³ = H) in mice receiving i.p. injections was greater than 400 mg/kg. Meanwhile, pharmacokinetic experiments revealed high bioavailability of this compound after both oral and i.v. administration (F = 60.76%, CL = 0.014 mg/kg/h) and a longer half-life (4.26 and 5.11 h after oral and i.v. administration, resp.). Based on these findings, compound I (R¹ = OH; R² = OMe; R³ = H) may be a promising neuroprotectant for the treatment of ischemic stroke.

European Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, NaJung published the artcileSynthesis and characterization of mannosylated pegylated polyethylenimine as a carrier for siRNA, Quality Control of 96345-79-8, the publication is International Journal of Pharmaceutics (Amsterdam, Netherlands) (2012), 427(1), 123-133, database is CAplus and MEDLINE.

Regulation of gene expression using small interfering RNA (siRNA) is a promising strategy for research and treatment of numerous diseases. In this study, we develop and characterize a delivery system for siRNA composed of polyethylenimine (PEI), polyethylene glycol (PEG), and mannose (Man). Cationic PEI complexes and compacts siRNA, PEG forms a hydrophilic layer outside of the polyplex for steric stabilization, and mannose serves as a cell binding ligand for macrophages. The PEI-PEG-mannose delivery system was constructed in two different ways. In the first approach, mannose and PEG chains are directly conjugated to the PEI backbone. In the second approach, mannose is conjugated to one end of the PEG chain and the other end of the PEG chain is conjugated to the PEI backbone. The PEI-PEG-mannose delivery systems were synthesized with 3.45-13.3 PEG chains and 4.7-3.0 mannose mols. per PEI. The PEI-PEG-Man-siRNA polyplexes displayed a coarse surface in SEM images. Polyplex sizes were found to range from 169 to 357 nm. Gel retardation assays showed that the PEI-PEG-mannose polymers are able to efficiently complex with siRNA at low N/P ratios. Confocal microscope images showed that the PEI-PEG-Man-siRNA polyplexes could enter cells and localized in the lysosomes at 2 h post-incubation. Pegylation of the PEI reduced toxicity without any adverse reduction in knockdown efficiency relative to PEI alone. Mannosylation of the PEI-PEG could be carried out without any significant reduction in knockdown efficiency relative to PEI alone. Conjugating mannose to PEI via the PEG spacer generated superior toxicity and gene knockdown activity relative to conjugating mannose and PEG directly onto the PEI backbone.

International Journal of Pharmaceutics (Amsterdam, Netherlands) published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Quality Control of 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kim, T. H. published the artcileReceptor-mediated gene delivery using chemically modified chitosan, SDS of cas: 96345-79-8, the publication is Biomedical Materials (Bristol, United Kingdom) (2007), 2(3), S95-S100, database is CAplus and MEDLINE.

Chitosan has been investigated as a non-viral vector because it has several advantages such as biocompatibility, biodegradability and low toxicity with high cationic potential. However, the low specificity and low transfection efficiency of chitosan need to be solved prior to clin. application. In this paper, we focused on the galactose or mannose ligand modification of chitosan for enhancement of cell specificity and transfection efficiency via receptor-mediated endocytosis in vitro and in vivo.

Biomedical Materials (Bristol, United Kingdom) published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, SDS of cas: 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Jie published the artcileSimultaneous determination of the main components in carboprost tromethamine injection by HPLC-UV-CAD, Quality Control of 58551-69-2, the publication is Zhongguo Xinyao Zazhi (2015), 24(1), 22-26, 51, database is CAplus.

Objective: To establish an HPLC-UV-CAD method for the simultaneous determination of carboprost, tromethamine and benzyl alc. in carboprost tromethamine injection. Methods: Carboprost, tromethamine and benzyl alc. were separated on a CAPCELL PAK CR 1:4 column (150 mm×4.6 mm, 5 μm). The mobile phase was composed of ultrapure water, 0.1 mol·L^-1 ammonium acetate buffer (pH 6.2) and methanol with gradient elution mode at a flow about 1.0 mL·min^-1; the injection volume was 10 μL and column temperature was 40 °C. CAD was used to detect carboprost and tromethamine, in which nebulization temperature was 35 °C and collection frequency was 30 Hz. UV was used to detect benzyl alc., in which detection wavelength was set at 258 nm and collection frequency was 5 Hz. Results: The linear range of carboprost was 9.38-56.2 μg·mL^-1 (r = 0.997 1, n = 6); the lowest limit of detection was 0.3 μg·mL^-1; LOQ was 0.6 μg·mL^-1; average recovery was 104.7%. The linear range of tromethamine was 5.19-23.3 μg·mL^-1 (r = 0.999 2, n = 6); the lowest limit of detection was 1 μg·mL^-1; LOQ was 2.5 μg·mL^-1; average recovery was 95.5%. The linear range of benzyl alc. was 0.297-1.78 mg·mL^-1 (r = 1, n = 6), the lowest limit of detection was 5.0 μg·mL^-1; LOQ was 10.0 μg·mL^-1; average recovery was 100.1%. The actual measurement results of the sample were consistent with the standard method currently used. Conclusion: The HPLC method established does not require derivative operations, and is cheap, sensitive, simple, accurate, reproducible and accurate. This method can simultaneously detect carboprost, tromethamine and benzyl alc. in carboprost tromethamine injection.

Zhongguo Xinyao Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C5H6BNO2, Quality Control of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Li published the artcileCarboprost tromethamine prevents caesarean section associated postpartum hemorrhage, Category: alcohols-buliding-blocks, the publication is Tropical Journal of Pharmaceutical Research (2020), 19(4), 899-904, database is CAplus.

To investigate the effect of carboprost tromethamine on post-partum hemorrhage associated with caesarean section. One hundred patients with postpartum hemorrhage induced by cesarean section who were admitted to Binzhou People’s Hospital from Oct. 2016 to August 2018 were selected. They were randomly assigned to two groups: control group and treatment group. Patients in the control group were administered oxytocin, while those in the treatment group received oxytocin in combination with carboprost tromethamine. The incidence of hemorrhage and adverse reactions were compared for the two groups. The two groups showed gradually increasing degrees of postpartum hemorrhage within 24 h, but the treatment group had significantly lower volume of postpartum hemorrhage than the control group at different time points (p < 0.05). At the 1st, 3rd and 5th days after delivery, the height of the uterine fundus decreased gradually in the two groups, but was smaller in the treatment group than in the oxytocin group at all time points (p < 0.05). Total response in the treatment group was 98%, which was significantly higher than 78% in the control group (p < 0.05). The incidence of adverse reactions in the treatment group (12%) was significantly lower than that in the control group (24%, p < 0.05). Carboprost tromethamine prevents postpartum hemorrhage after cesarean section. It effectively reduces bleeding and promotes uterine involution, without obvious adverse reactions.

Tropical Journal of Pharmaceutical Research published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C10H10CoF6P, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Xiaozhen published the artcileEffects of different combination therapy to reduce the adverse reactions of patients with cesarean section caused by carboprost tromethamine, Computed Properties of 58551-69-2, the publication is Linchuang Mazuixue Zazhi (2015), 31(6), 612-613, database is CAplus.

The effects of different combination therapy to reduce the adverse reactions of patients with cesarean section caused by carboprost tromethamine were studied. One hundred fifty cases of cesarean section were divided into A group (dexamethasone 5 mg, tropisetron 5 mg), B group (dexamethasone 10 mg, penehyclidine hydrochloride 1 mg), and C group (dexamethasone 10 mg, tropisetron 5 mg, penehyclidine hydrochloride 1 mg). The results showed that the combined application of dexamethasone, tropisetron and penehyclidine hydrochloride could reduce the adverse reactions of patients with cesarean section caused by carboprost tromethamine.

Linchuang Mazuixue Zazhi published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C48H47FeP, Computed Properties of 58551-69-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jingwu published the artcileReaction-activated palladium catalyst for dehydrogenation of substituted cyclohexanones to phenols and H₂ without oxidants and hydrogen acceptors, Computed Properties of 27292-49-5, the publication is Chemical Science (2015), 6(8), 4674-4680, database is CAplus and MEDLINE.

It was widely believed that the dehydrogenation of organic compounds was a thermodynamically unfavorable process, and thus required stoichiometric oxidants such as dioxygen and metal oxides or sacrificial hydrogen acceptors to remove the hydrogen from the reaction mixture to drive the equilibrium towards the products. A previously unappreciated combination of common com. Pd/C and H₂ which dehydrogenated a wide range of substituted cyclohexanones and 2-cyclohexenones to their corresponding phenols with high isolated yields, with H₂ as the only byproduct was reported. The reaction requires no oxidants or hydrogen acceptors because instead of removing the generated hydrogen with oxidants or hydrogen acceptors, it was used as a cocatalyst to help power the reaction. The method for phenol synthesis manifested a high atom economy, and was inherently devoid of the complications normally associated with oxidative dehydrogenations.

Chemical Science published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C38H24F4O4P2, Computed Properties of 27292-49-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Da-Liang published the artcileVisible-light-driven C(sp²)-H arylation of phenols with arylbromides enabled by electron donor-acceptor excitation, Related Products of alcohols-buliding-blocks, the publication is Chemical Communications (Cambridge, United Kingdom) (2022), 58(22), 3637-3640, database is CAplus and MEDLINE.

A catalyst-free visible-light-driven C(sp²)-H arylation of unprotected phenols ROH (R = Ph, naphthalen-2-yl, 3,5-dibromophenyl, etc.) with arylbromides R¹Br (R¹ = 4-cyclopropanecarbonylbenzen-1-yl, 2-cyanobenzen-1-yl, 3-cyano-5-(trifluoromethyl)phenyl, etc.) to give 2-arylated phenols RR¹ have been developed. This reaction proceeds through the excitation of an electron donor-acceptor complex between a phenolate and arylbromide, electron transfer, and debrominative C(sp²)-C(sp²) coupling.

Chemical Communications (Cambridge, United Kingdom) published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C8H10BNO3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts