Category: alcohols-buliding-blocks

Yu, Mengmeng published the artcileVisible-light-promoted generation of hydrogen from the hydrolysis of silanes catalyzed by rhodium(III) porphyrins, Recommanded Product: Triethylsilanol, the publication is Organometallics (2015), 34(24), 5754-5758, database is CAplus.

Visible-light-promoted hydrolysis of hydrosilanes catalyzed by iodo[meso-tetrakis(4-methoxyphenyl)porphyrinato]rhodium [(TAP)Rh-I] to produce silanols and dihydrogen efficiently under mild conditions was reported. (TAP)Rh-H was observed as the key intermediate through stoichiometric activation of the Si-H bond by (TAP)Rh-I. Addition of water drove the stoichiometric activation of Si-H into catalysis.

Organometallics published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C38H24F4O4P2, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Quan published the artcileCarboalumination-epoxide ring opening for the formation of 1,4-disubstituted (Z)-3,6-alkadienols, Related Products of alcohols-buliding-blocks, the publication is Chinese Journal of Chemistry (2013), 31(6), 773-778, database is CAplus.

Allylalumination of alkynes, i.e. forming Negishi’s (Z)-alkenyl dialkylalane, followed by alkenylation of epoxides provides 1,4-disubstituted (Z)-3,6-alkadienols. The alkenylation can be facilitated by the presence of a neighboring coordinating group in the epoxides. This “one-pot” approach was successfully applied in the large-scale production of the C(10)-C(15) fragment of 9,10-dehydroepothilone D, a synthetic epothilone analog as an anticancer agent in phase-2 clin. trials.

Chinese Journal of Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H5BN2O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Walker, Brandon published the artcileMolecular dynamics free energy simulations of ATP:Mg²⁺ and ADP:Mg²⁺ using the polarisable force field AMOEBA, Formula: C9H21NO3, the publication is Molecular Simulation (2021), 47(5), 439-448, database is CAplus and MEDLINE.

ATPases and GTPases are two important classes of protein that play critical roles in energy transduction, cellular signalling, gene regulation and catalysis. These proteins use cofactors such as nucleoside di and tri-phosphates (NTP, NDP) and can detect the difference between NDP and NTP which then induce different protein conformations. Mechanisms that drive proteins into the NTP or NDP conformation may depend on factors such as ligand structure and how Mg²⁺ coordinates with the ligand, amino acids in the pocket and water mols. Here, we have used the advanced electrostatic and polarisable force field AMOEBA and mol. dynamics free energy simulations (MDFE) to examine the various binding mechanisms of ATP:Mg²⁺ and ADP:Mg²⁺. We compared the ATP:Mg²⁺ binding with previous studies using non-polarisable force fields and exptl. data on the binding affinity. It was found that the total free energy of binding for ATP:Mg²⁺ (-7.00 2.13 kcal/mol) is in good agreement with exptl. values (-8.6 .2 kcal/mol) [1]. In addition, parameters for relevant protonation states of ATP, ADP, GTP and GDP have been derived. These parameters will allow for researchers to investigate biochem. phenomena involving NTP’s and NDP’s with greater accuracy than previous studies involving non-polarisable force fields.

Molecular Simulation published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C8H6ClN, Formula: C9H21NO3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Skvorcova, M. published the artcileIntramolecular cyclopropylmethylation via non-classical carbocations, Formula: C3H6O2, the publication is Organic & Biomolecular Chemistry (2017), 15(33), 6909-6912, database is CAplus and MEDLINE.

Cyclopropyl-cyclopropyl rearrangement was achieved selectively by intramol. trapping of cyclopropylmethyl carbenium ions with an internal nucleophile. This was exploited as a useful method for the introduction of a cyclopropyl group into complex mols. using readily accessible disubstituted cyclopropane intermediates.

Organic & Biomolecular Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C4H6O3, Formula: C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fadilah, Nurul Q. published the artcileVirucidal Activity of Essential Oils From Citrus x aurantium L. Against Influenza A Virus H1N1:Limonene as a Potential Household Disinfectant Against Virus, Category: alcohols-buliding-blocks, the publication is Natural Product Communications (2022), 17(1), 1934578X211072713, database is CAplus.

This work explored the compositions of a crude extract of peels of Citrus x aurantium using a gas chromatog.-mass spectrometry (GC-MS) technique. The crude extract of peels of C. x aurantium was analyzed by GC-MS revealing the presence of limonene as the major compound, accounting for 93.7% of the total. Virucidal activity of the oil of C. x aurantium peels against influenza A virus H1N1 was evaluated by the ASTM E1053-20 method. Moreover, the virucidal activity was also investigated of D-limonene, the major terpene in essential oils of C. x aurantium, and its enantiomer L-limonene. The essential oil of the C. x aurantium peels produced a log reduction of 1.9 to 2.0, accounting for 99% reduction of the virus, while D- and L-limonene exhibited virucidal activity with a log reduction of 3.70 to 4.32 at concentrations of 125 and 250.0μg/mL, thus reducing the virus by 99.99%. Previous work found that D-limonene exhibited antiviral activity against herpes simplex virus, but L-limonene, an enantiomer of D-limonene, has never been reported for antiviral activity. This work demonstrates the antiviral activity of L-limonene for the first time. Moreover, this work suggests that concentrations of 0.0125% to 0.025% of either D- or L-limonene can possibly be used as a disinfectant against viruses, probably in the form of essential oil sprays, which may be useful disinfectants against the airborne transmission of viruses, such as influenza and COVID-19.

Natural Product Communications published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maya, R. J. published the artcileA bentonite-gold nanohybrid as a heterogeneous green catalyst for selective oxidation of silanes, Safety of Triisopropylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2016), 52(70), 10625-10628, database is CAplus and MEDLINE.

A highly efficient, environmentally benign and reusable heterogeneous bentonite-gold nanohybrid catalyst was designed and synthesized. This heterogeneous catalyst could efficaciously catalyze the oxidation of organosilanes to silanols. The reaction is 98.7% atom economical and the products were obtained in excellent yield without the formation of disiloxanes as byproducts. The catalyst was also well applicable for the gram scale preparation of silanols.

Chemical Communications (Cambridge, United Kingdom) published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Safety of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hill, Michael S. published the artcileSingle-source AACVD of composite cobalt-silicon oxide thin films, Category: alcohols-buliding-blocks, the publication is Inorganica Chimica Acta (2014), 47-56, database is CAplus.

A series of cobalt(II) complexes comprising either triorganosiloxide or tris(tert-butoxy)siloxide ligands were synthesized and characterized. A mononuclear constitution is enforced through the incorporation of bi- and tridentate N-donor ligands. The resultant 4- or 6-coordinate complexes were identified by single-crystal x-ray diffraction anal. and were assessed for their potential as mol. precursors to hybrid cobalt/silicon oxide thin film materials by TGA. A TMEDA adduct of the bis-ligated Co(II) tris(tert-butoxy)siloxide species was used as a single-source precursor for the AACVD of aesthetically attractive blue composite films. Anal. by PXRD, SEM, EDS and XPS indicated the production of amorphous, continuous films with the bulk compositions reflecting the cobalt, silicon and oxygen stoichiometry of the mol. precursor complex.

Inorganica Chimica Acta published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Barker, Graeme published the artcileChirality Transfer in Gold(I)-Catalysed Direct Allylic Etherifications of Unactivated Alcohols: Experimental and Computational Study, Safety of 3,3,3-Trifluoropropan-1-ol, the publication is Chemistry – A European Journal (2015), 21(39), 13748-13757, database is CAplus and MEDLINE.

Gold(I)-catalyzed direct allylic etherifications have been successfully carried out with chirality transfer to yield enantioenriched, γ-substituted secondary allylic ethers. Our investigations include a full substrate-scope screen to ascertain substituent effects on the regioselectivity, stereoselectivity and efficiency of chirality transfer, as well as control experiments to elucidate the mechanistic subtleties of the chirality-transfer process. Crucially, addition of mol. sieves was found to be necessary to ensure efficient and general chirality transfer. Computational studies suggest that the efficiency of chirality transfer is linked to the aggregation of the alc. nucleophile around the reactive π-bound Au-allylic ether complex. With a single alc. nucleophile, a high degree of chirality transfer is predicted. However, if three alcs. are present, alternative proton transfer chain mechanisms that erode the efficiency of chirality transfer become competitive.

Chemistry – A European Journal published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Safety of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sguazzin, Matthew A. published the artcileHexafluoroisopropyl Sulfamate: A Useful Reagent for the Synthesis of Sulfamates and Sulfamides, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Organic Letters (2021), 23(9), 3373-3378, database is CAplus and MEDLINE.

Sulfamates and sulfamides were most often synthesized from alcs. and amines with sulfamoyl chloride, which was an unstable reagent. Hexafluoroisopropyl sulfamate (HFIPS) as a bench-stable solid that reacts readily with a wide variety of alcs., amines, phenols, and anilines under mild reaction conditions was identified. The sole byproduct of the reaction was hexafluoroisopropanol (HFIP) and reaction products was often isolated in high purity after an aqueous workup (optional) and removal of solvents by evaporation

Organic Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C15H21BO2, Name: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Graves, Brian M. published the artcileComprehensive characterization of mainstream marijuana and tobacco smoke, Application of 4-Propylphenol, the publication is Scientific Reports (2020), 10(1), 7160, database is CAplus and MEDLINE.

Recent increases in marijuana use and legalization without adequate knowledge of the risks necessitate the characterization of the billions of nanoparticles contained in each puff of smoke. Tobacco smoke offers a benchmark given that it has been extensively studied. Tobacco and marijuana smoke particles are quant. similar in volatility, shape, d. and number concentration, albeit with differences in size, total mass and chem. composition Particles from marijuana smoke are on average 29% larger in mobility diameter than particles from tobacco smoke and contain 3.4 times more total mass. New measurements of semivolatile fractions determined that >97% of the mass and volume of the particles from either smoke source are comprised of semivolatile compounds For tobacco smoke and marijuana smoke, resp., 4350 and 2575 different compounds are detected, of which 670 and 536 (231 in common) are tentatively identified, and of these, 173 and 110 different compounds (69 in common) are known to cause neg. health effects through carcinogenic, mutagenic, teratogenic, or other toxic mechanisms. This study demonstrates striking similarities between marijuana and tobacco smoke in terms of their phys. and chem. properties.

Scientific Reports published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Application of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts