Category: alcohols-buliding-blocks

Jagia, Moksh published the artcileNovel Co-crystals and Eutectics of Febuxostat: Characterization, Mechanism of Formation, and Improved Dissolution, Category: alcohols-buliding-blocks, the publication is AAPS PharmSciTech (2022), 23(1), 43, database is CAplus and MEDLINE.

Co-crystallization studies were undertaken to improve the solubility of a highly water-insoluble drug febuxostat (FXT), used in the treatment of gout and hyperuricemia. The selection of co-crystal former (CCF) mols. such as 1-hydroxy 2-naphthoic acid (1H-2NPH), 4-hydroxy benzoic acid (4-HBA), salicylic acid (SAC), 5-nitro isophthalic acid (5-NPH), isonicotinamide (ISNCT), and picolinamide (PICO) was based on the presence of complementary functional groups capable of forming hydrogen bond and the ΔpKa difference between FXT and CCF. A liquid-assisted grinding (LAG) method was successfully employed for the rapid screening of various pharmaceutical adducts. These adducts were characterized based on their unique thermal (differential scanning calorimetry) and spectroscopic (Fourier transform IR and Raman spectroscopy) profiles. Binary phase diagrams (BPD) were plotted to establish a relationship between the thermal events and adduct formed. Powder X-ray diffraction (PXRD) studies were carried out to confirm the formation of eutectic/co-crystal. Thermogravimetric anal. (TGA) was also performed for the novel co-crystals obtained. The propensity for strong homo-synthons over weak hetero-synthons and strong hetero-synthons over weak homo-synthons during supramol. growth resulted in the formation of eutectics and co-crystals resp. FXT:1H-2NPH (1), FXT:4-HBA (1), FXT:SAC (1, 2), and FXT:5-NPH (2-1) gave rise to pure eutectic systems, while FXT:ISNCT (2-1) and FXT:PICO (1) gave rise to novel co-crystals with characteristic DSC heating curves and PXRD pattern. Addnl., the impact of microenvironmental pH and microspeciation profile on the improved dissolution profile of the co-crystals was discussed.

AAPS PharmSciTech published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Songwen published the artcileDiscovery of 4-Methylquinazoline Based PI3K Inhibitors for the Potential Treatment of Idiopathic Pulmonary Fibrosis, Synthetic Route of 622-40-2, the publication is Journal of Medicinal Chemistry (2019), 62(19), 8873-8879, database is CAplus and MEDLINE.

Idiopathic pulmonary fibrosis (IPF) is a progressive and fatal lung disease, and its mol. pathogenesis remains poorly understood. Recently, emerging evidence demonstrates that the PI3K signaling transduction pathway is linked to the pathol. of IPF. In this work, we rationally designed a new series of 4-methylquinazoline derivatives as highly potent PI3K inhibitors that significantly suppress the phosphorylation of the main PI3K downstream effectors and displays marked antiproliferative activity in mouse MLg2908 lung fibroblasts. In a bleomycin-induced mouse pulmonary fibrosis model, 5d from the series improved mouse lung function and slowed the progression of pulmonary fibrosis. Overall, this work promises a therapeutic potential for PI3K inhibitors to treat IPF.

Journal of Medicinal Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Synthetic Route of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jia, Yaya published the artcileEnhancing mechanical, thermal property and flame retardancy of optical polythiourethane with self-assembly phosphazene nanoparticles, Quality Control of 80-09-1, the publication is Polymer Composites (2022), 43(4), 2010-2021, database is CAplus.

Polythiourethane (PTU) has attracted considerable attention in engineering building materials. Here, based on phosphazene nanoparticles (PZS-1 and PZS-2) prepared by water-triggered and ultrasonic self-assembly method, phosphazene/polythiourethane (PZS/PTU) composites with excellent mech. strength, high flame retardancy and good transparency was obtained. Then, the comprehensive properties of both composites were evaluated, where PZS-2 endowed PTU with better overall performance. Due to the good dispersibility of PZS and its strengthed interfacial interaction with PTU matrix, both PZS significantly enhanced mech. and thermal property of PTU, where the tensile strength and glass transition temperature of PZS/PTU composites reached to 84.34 MPa and 59.94°C resp. More importantly, compared to pure PTU, the values of peak heat release rate (HRR), total heat release rate (THR), smoke production rate (SPR), and total smoke production (TSP) of composites were decreased by 10.5%, 13.3%, 30.6% and 18.0%, resp. The limiting oxygen index of composites was improved to 21.39% due to the catalytic carbonization of PZS, the expanded carbon layer and the incombustible gases released during combustion. Meanwhile, the PZS/PTU composite exhibited the high refractive index of 1.6580 and good transparency (not less than 85% at 500 nm). The PZS/PTU composite was promising candidates for optical flame retardant coatings and engineering building materials.

Polymer Composites published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Quality Control of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jia, Yaya published the artcileZirconium dioxide@phosphazene for enhancing mechanical property, flame retardancy, and thermal property of polythiourethane composites, Application In Synthesis of 80-09-1, the publication is Journal of Applied Polymer Science (2022), 139(22), 52230, database is CAplus.

Introducing high strength inorganic nanoparticles has emerged as an effective strategy to optimize the comprehensive properties of polymers, but good dispersion must be maintained to avoid clustering of inorganic nanoparticles. We report a novel phosphazene-coated ZrO₂ nanoparticles (ZrO₂@PZS) prepared by a simple ultrasonic method to further enhance thermal, mech., optical properties and flame retardancy of polythiourethane (PTU). ZrO₂@PZS nanoparticles presented good dispersion in composites, with regular spherical core-shell structures exhibiting significant enhancement effects for overall performance of PTU composites, through strong interfacial interaction. Studies revealed that regular spherical ZrO₂@PZS strengthened thermal and tensile properties of PTU, which reached 62.8°C and 79.28 MPa resp. More importantly, PTU composites showed good flame retardancy through catalytic carbonization, condensed phase shielding and gas phase dilution effect of ZrO₂@PZS, where the limiting oxygen index was increased to 25.39% from 20.39%. Moreover, the peak heat release rate, total heat release and smoke production rate could be reduced by 23.5%, 27.7% and 40.0%, resp. In brief, PTU composites show excellent potential in high strength special fireproof lenses.

Journal of Applied Polymer Science published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Application In Synthesis of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tan, Xuerong published the artcileDevelopment and Validation of a Modified QuEChERS Method for the Analysis of Bisphenols in Meats by UPLC-MS/MS, Recommanded Product: 4,4′-Sulfonyldiphenol, the publication is Chromatographia (2022), 85(5), 433-445, database is CAplus.

Abstract: A reliable and affordable QuEChERS (quick, easy, cheap, effective, rugged, and safe) methodol. in combination with ultra-high performance liquid chromatog.-tandem mass spectrometry (UPLC-MS/MS) was successfully developed and validated for the determination of eight bisphenols (BPs) residues containing in meats (chicken, duck, beef, pork, fish, shrimp, and mutton). A novel QuEChERS method optimization was carried out in terms of process efficiency (PE), matrix effect (ME), and extraction recovery (RE). After a simple vortex extraction of the samples with acetonitrile, 1 g sodium acetate was used for salting out (NaAC), and 100 mg primary secondary amine (PSA) purifying reagents were used for purification The properties of the sorbents were assessed by the obtained parameters, such as matrix effect (ME), linearity, sensitivity, accuracy, and precision. Under the optimal conditions, BPs were well separated on an ACQUITY UPLC BEH C₁₈ column in 8 min by gradient elution, and exhibited a good linear relationship (R² > 0.9988) in the linear range. Moreover, the limits of detection (LODs) and the limits of quantification (LOQs) were located in the range of 0.01- 0.11μg/kg and 0.03 – 0.37μg/kg, resp. The developed method was satisfactory in terms of accuracy (relative recoveries: 76.1% – 113.7%) and precision (relative standard deviations below 10.3%). Finally, the developed method was successfully employed to identify and quantify BPs residues in 28 real meat samples. The proposed QuEChERS-UPLC-MS/MS method is simple, high efficiency, cost-effective, practical, and susceptible to being implemented in routine laboratories to quickly detect the BPs in meats (chicken, duck, beef, pork, fish, shrimp, and mutton). In this sense, the method is useful for obtaining BPs residue data to evaluate the contamination status of BPs in meat food and provide scientific support for scientific supervision.

Chromatographia published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C10H2F12NiO4, Recommanded Product: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Shengping published the artcileNickel-catalyzed oxidative dehydrogenative coupling of alkane with thiol for C(sp³)-S bond formation, SDS of cas: 4410-99-5, the publication is Tetrahedron Letters (2021), 152950, database is CAplus.

A nickel-catalyzed oxidative dehydrogenative coupling reaction of alkanes RH (R = 1-phenylethan-1-yl, cyclohexyl, tetrahydrofuran-2-yl, 1,4-dioxan-2-yl, etc.) with thiols R¹SH (R¹ = 4-methylphenyl, 2-naphthyl, octan-1-yl, benzo[d]thiazol-2-yl, etc.) for the construction of C(sp³)-S bond has been established, affording more than 50 alkyl thioethers RSR¹. Notably, pharmaceutical and agrochems., such as Provigil, Chlorbenside and Pyridaben, were readily synthesized by this approach. The sterically hindered ligand bathocuproine (BC) and disulfide which was formed in situ oxidation of thiol, efficiently avoiding nickel-catalyst poisoning. A set of mechanistic experiments disclose both Ni-catalyzed and Ni-free HAA processes.

Tetrahedron Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, SDS of cas: 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hayashi, Ryuji published the artcileSynthesis and evaluation of novel heterocyclic MMP inhibitors, Synthetic Route of 17236-59-8, the publication is Bioorganic & Medicinal Chemistry Letters (2007), 17(24), 6864-6870, database is CAplus and MEDLINE.

A variety of novel heterocyclic compounds, e.g., I, were synthesized and evaluated for MMP inhibition. Broad spectrum inhibition of MMPs 1, 2, 9, and 12 was found with pyridinone-based compounds while N-heterocyclic triazoles and tetrazoles were largely ineffective. A highly selective tetrazole inhibitor for MMP-2 was discovered.

Bioorganic & Medicinal Chemistry Letters published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Synthetic Route of 17236-59-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xufeng published the artcileEfficacy and safety of ambroxol hydrochloride in the treatment of secretory otitis media: a systematic review and meta-analysis, COA of Formula: C13H19Br2ClN2O, the publication is Annals of Translational Medicine (2022), 10(3), 142, database is CAplus and MEDLINE.

Secretory otitis media is a very common nonsuppurative inflammatory disease in otorhinolaryngol. Ambroxol hydrochloride helps to improve ciliary movement in the ear canal and promote the dissolution and discharge of secretions. However, its effect still lacks systematic evaluation. We conducted a meta-anal. of clin. studies to systematically evaluate the application effect of ambroxol hydrochloride. A computer-based search of the Chinese Biomedical Database (CBM), China National Knowledge Infrastructure (CNKI), PubMed, and Web of Science databases was conducted using the keywords “Ambroxol hydrochloride” & “secretory otitis media”. Randomized controlled trials published after 2015 were selected and then screened and analyzed using RevMan 5.4 software. Ten studies involving a total of 998 patients were included. Meta-anal. showed that adding ambroxol hydrochloride to the original glucocorticoid treatment improved therapeutic efficacy [odds ratio (OR) = 4.95, 95% confidence interval (CI): 3.27, 7.50, P<0.00001], reduced tympanic pressure after treatment [mean difference (MD) = -19.04, 95% CI: -22.72, -15.36, P<0.00001], and increased the pure tone threshold (MD =6.37, 95% CI: 5.36, 7.37, P<0.00001), without increasing adverse reactions (OR = 0.51, 95% CI: 0.14, 1.85, P=0.30). On the basis of the original treatment of secretory otitis media, adding ambroxol hydrochloride treatment improved the therapeutic effect, reduced tympanic pressure after treatment, and improved the pure tone threshold (hearing), without increasing adverse reactions.

Annals of Translational Medicine published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C25H23NO4, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Li published the artcileDifferent photodegradation behavior of 4-tert-octylphenol under UV and VUV irradiation in aqueous solution, Related Products of alcohols-buliding-blocks, the publication is Journal of Photochemistry and Photobiology, A: Chemistry (2013), 69-77, database is CAplus.

Comparative study on 4-tert-octylphenol degradation under UV (253.7 nm) and VUV (combined 253.7 nm and 184.9 nm) radiation in aqueous solution was performed in laboratory scale(coating process) in this paper. Excitation light played the key role on 4-tert-octylphenol photodegradation 93.5% 4-tert-Octylphenol was decomposed after 20-min VUV radiation while only 49.5% degradation efficiency was achieved after 4-tert-octylphenol received UV radiation for the same irradiation time. Other factors influencing 4-tert-octylphenol degradation efficiency included solution pH, initial concentration and natural water constituents. Initial 4-tert-octylphenol concentration and pH exhibited different influence pattern on 4-tert-octylphenol degradation under UV and VUV radiation. 4-tert-Octylphenol photodegradation products were discerned by HPLC and GC-MS. 4-tert-octylcatechol was recognized as predominant photoproducts under both UV and VUV radiation. Trace amount of phenol was also detected when 4-tert-octylphenol was subjected to VUV radiation. Degradation of 4-tert-octylphenol upon UV radiation was, therefore, predicted to be initiated by the photoejection of an electron from excited 4-tert-octylphenol, whereas 4-tert-octylphenol photolysis upon VUV radiation may also involve the direct CC bond cleavage from excited 4-tert-octylphenol. No matter the excitation light wavelength, photopolymization process was found to occur at high initial 4-tert-octylphenol concentration Special attention should be paid to the photopolymerization phenomena during practical application of 4-tert-octylphenol photodegradation

Journal of Photochemistry and Photobiology, A: Chemistry published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Mengmeng published the artcileHighly Efficient Generation of Hydrogen from the Hydrolysis of Silanes Catalyzed by [RhCl(CO)₂]₂, Computed Properties of 597-52-4, the publication is Inorganic Chemistry (2013), 52(19), 10741-10743, database is CAplus and MEDLINE.

Catalytic hydrolysis of silanes mediated by chlorodicarbonylrhodium(I) dimer [RhCl(CO)₂]₂ to produce silanols and dihydrogen efficiently under mild conditions is reported. Second-order kinetics and activation parameters are determined by monitoring the rate of dihydrogen evolution. The mixing of [RhCl(CO)₂]₂ and HSiCl₃ results in rapid formation of a rhodium silane σ complex.

Inorganic Chemistry published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C11H14O2, Computed Properties of 597-52-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts