Category: alcohols-buliding-blocks

Seitz, Ann-Katrin published the artcileConcentrated Aqueous Peroxodicarbonate: Efficient Electrosynthesis and Use as Oxidizer in Epoxidations, S-, and N-Oxidations, Related Products of alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2022), 61(25), e202117563, database is CAplus and MEDLINE.

Peroxodicarbonates are of substantial interest as potentially powerful and sustainable oxidizers but have so far been accessible only in low concentrations with unsatisfactory energy efficiency. Concentrated (> 0.9 mol L^-1) peroxodicarbonate solutions have now been made accessible by the electrolysis of aqueous K₂CO₃/Na₂CO₃/KHCO₃ solutions at high c.d. of 3.33 A cm^-2 in an efficiently cooled circular flow reactor equipped with a boron-doped diamond anode and a stainless-steel cathode. Their synthetic potential as platform oxidizers was clearly demonstrated in transformations including sulfoxidation, N-oxidation, and epoxidation

Angewandte Chemie, International Edition published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C8H11NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Maness, Peter published the artcileSubstituent Effects on Temperature Dependence of Kinetic Isotope Effects in Hydride-Transfer Reactions of NADH/NAD⁺ Analogues in Solution: Reaction Center Rigidity Is the Key, Synthetic Route of 596-38-3, the publication is Organic Letters (2020), 22(15), 5963-5967, database is CAplus and MEDLINE.

Substituent effects on the temperature dependence of primary kinetic isotope effects, characterized by ΔE_a = E_aD – E_aH, for two series of the title reactions in acetonitrile were studied. The change from ΔE_a â‰?0 for a highly rigid system to ΔE_a > 0 for systems with reduced rigidities was observed The rigidities were controlled by the electronic and steric effects. This work replicates the observations in enzymes and opens a new research direction that studies structure-ΔE_a relationship.

Organic Letters published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Synthetic Route of 596-38-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Limnios, Dimitris published the artcileOrganocatalytic Oxidation of Organosilanes to Silanols, Synthetic Route of 17877-23-5, the publication is ACS Catalysis (2013), 3(10), 2239-2243, database is CAplus.

The oxidation of organosilanes to silanols constitutes an attractive transformation for both industry and academia. Bypassing the need for stoichiometric oxidants or precious metal catalytic complexes, the first organocatalytic oxidation of silanes has been accomplished. Catalytic amounts of 2,2,2-trifluoroacetophenone, in combination with the green oxidant H₂O₂, lead to excellent to quant. yields in a short reaction time. A variety of alkyl, aryl, alkenyl, and alkynyl substituents can be tolerated, providing an easy, cheap, efficient, and practical solution to a highly desirable transformation.

ACS Catalysis published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Synthetic Route of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Limnios, Dimitris published the artcileOrganocatalytic Oxidation of Organosilanes to Silanols, Related Products of alcohols-buliding-blocks, the publication is ACS Catalysis (2013), 3(10), 2239-2243, database is CAplus.

The oxidation of organosilanes to silanols constitutes an attractive transformation for both industry and academia. Bypassing the need for stoichiometric oxidants or precious metal catalytic complexes, the first organocatalytic oxidation of silanes has been accomplished. Catalytic amounts of 2,2,2-trifluoroacetophenone, in combination with the green oxidant H₂O₂, lead to excellent to quant. yields in a short reaction time. A variety of alkyl, aryl, alkenyl, and alkynyl substituents can be tolerated, providing an easy, cheap, efficient, and practical solution to a highly desirable transformation.

ACS Catalysis published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Spiliopoulou, Nikoleta published the artcilePhotochemical metal-free aerobic oxidation of thiols to disulfides, SDS of cas: 4410-99-5, the publication is Green Chemistry (2021), 23(1), 546-551, database is CAplus.

A mild, inexpensive and green photochem. approach for the synthesis of both sym. and non-sym. disulfides, using metal-free and environmentally friendly conditions was reported. Utilizing phenylglyoxylic acid as the photoinitiator, common household bulbs as the light source and a simple inorganic salt as the additive, a versatile oxidation of thiols leading to products in excellent yields was described.

Green Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C11H14O4, SDS of cas: 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gangireddy, Ramana published the artcileDesign and evaluation of gastroretentive floating matrix tablets of ambroxol hydrochloride, COA of Formula: C13H19Br2ClN2O, the publication is International Journal of Pharmacy and Biological Sciences (2019), 9(2), 1386-1396, database is CAplus.

Gastro retentive drug delivery is a special approach which remains in the gastric region for a prolonged period to increase gastric residence time and also have the advantage of site-specific drug delivery especially in the upper gastrointestinal tract (GIT) for local or systemic effects. Ambroxol hydrochloride is a systemically active mucolytic agent with a half-life of 3-4 h. It acts by breakdown of acid muco polysaccharide fibers which make the sputum thinner and less viscous as long as treatment is maintained and therefore more easily sputum was removed by coughing. The main aim of the present work is to develop the oral controlled release floating matrix tablets of Ambroxol hydrochloride by direct compression method, using various hydrophilic polymers such as HPMCK100M, Carbopol971P, Polyethylene oxide. FT-IR studies revealed that there was no incompatibility between the drug and polymers used. All the formulations remained buoyant without any disintegration. The formulations F4, F9, F15 have shown the extended drug release close to that of marketed formulation for a period of 12 h. To ascertain the mechanism of drug release in-vitro data was fitted into various release kinetic models like zero order, first order, Higuchi and Peppas. The values indicated the non-fickian diffusion with slow erosion of polymer matrix followed by drug diffusion and resulted in linear drug release profile over a prolonged period of time.

International Journal of Pharmacy and Biological Sciences published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Grabosch, Carsten published the artcileGlycoarrays by a New Tandem Noncovalent-Covalent Modification of Polystyrene Microtiter Plates and their Interrogation with Live Cells, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is ChemBioChem (2012), 13(13), 1874-1879, S1874/1-S1874/18, database is CAplus and MEDLINE.

Thiourea bridging was used for fabrication of glycoarrays on polystyrene microtiter plates, to allow assaying of carbohydrate recognition in a optimally easy and flexible way. For the noncovalent modification of polystyrene microtiter plates, dodecylamine and dodecyl isothiocyanate were selected. This first immobilization step was followed by thiourea bridging with a suitable carbohydrate derivative and subsequent carbohydrate-specific read out. For the testing system, mannose-specific bacterial adhesion was employed with green fluorescent protein (GFP)-tagged Escherichia coli bacteria (pPKLl 162). A selection of inhibitors of type 1 fimbriae-mediated bacterial adhesion was used. Tandem noncovalent-covalent modification of polystyrene microtiter plates led to stable glycoarrays that yield valuable and valid data in adhesion inhibition tests with live bacterial cells. Nonspecific adhesion to polystyrene is excluded in this protocol. In addition to polystyrene plates, polypropylene (PP) microtiter plates were tested by the same approach and showed results that were in good accordance with the assays on analogously modified polystyrene plates.

ChemBioChem published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Recommanded Product: (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Jing published the artcileEnantioselective synthesis of an octahydroindolizine (indolizidine) alcohol using an enzymatic resolution, Synthetic Route of 6346-09-4, the publication is Organic & Biomolecular Chemistry (2017), 15(14), 2953-2961, database is CAplus and MEDLINE.

A homo-chiral synthesis of (7R,8aS)-octahydro-5,5-dimethylindolizin-7-amine 8 and (7S, 8aS)-octahydro-5,5-dimethylindolizin-7-ol 9, amine building blocks which have found applications within the pharmaceutical industry, is presented. The approach uses a Novozym 435-mediated kinetic resolution of racemic octahydroindolizine (indolizidine) alc. 13 as a key step (up to 100 g scale).

Organic & Biomolecular Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H5F3O2S, Synthetic Route of 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Janak, J. published the artcileSeparation and analysis of dihydric phenols by gas chromatography, Recommanded Product: 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, the publication is Collection of Czechoslovak Chemical Communications (1959), 1960-6, database is CAplus.

Specific elution volumes (chromatographic spectra) of some dihydric phenols (pyrocatechol, 3-methyl-, 4-methyl-, 4-ethyl-, 4-tert-butyl-, 4-tert-octyl-, 3,4-dimethyl-, 3,5-dimethyl-, 4,5-dimethyl-, 3,5-di-tert-butylpyrocatechol, resorcinol, 4-ethylresorcinol, quinol, and ethylquinol) were determined on nonpolar (dimethyl polysiloxane) or (better) on polar stationary phases (mannitol at temperature 170-90°, dulcitol at 200°, inositol at 230-45°, and galactonic acid lactone at 190°). As the carrier, Celite C 545 was used. The relation between chem. structure of the (substituted) dihydric phenol and chromatographic behavior is discussed on the basis of the interaction with the stationary phase (H bonding). The method was applied for the analysis of raw pyrocatechol from Northern Bohemia brown coal tar used in the manufacture of tanning materials.

Collection of Czechoslovak Chemical Communications published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Recommanded Product: 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Malviya, Yogendra published the artcileFormulation development and evaluation of gastroretentive floating tablets of ambroxol hydrochloride, Formula: C13H19Br2ClN2O, the publication is Journal of Drug Delivery and Therapeutics (2019), 9(4Suppl.), 1016-1021, database is CAplus.

The present study is focused on the development of gastroretentive floating drug delivery system of ambroxol hydrochloride, which acts as a mucolytic agent that is reported to be useful in gastric neoplasms which are designed to increase the gastric residence time, thus prolonging the drug release in the stomach. Gastro retentive floating tablets of ambroxol hydrochloride were prepared by direct compression method using altered concentrations of HPMC K4, HPMC K15 and PVP K30 as polymers. Sodium bicarbonate and citric acid was used as gas releasing agent. The prepared tablets of ambroxol hydrochloride were evaluated for hardness, thickness, friability, weight variation, drug content uniformity, buoyancy lag time, total floating time, in-vitro dissolution study, etc. All the compositions were resulted in adequate Pharmacopoeial limits. Compatibility studies was execution during FTIR shown that there was absence of probable chem. interaction between pure drug and excipients. The varying concentration of gas generating agent and polymers was found to affect on in-vitro drug release and floating lag time. In vitro drug release of floating gastro retentive tablet of ambroxol hydrochloride shown that the formulation F6 was found to be the best formulation as it releases 99.87% in a controlled manner for an extended period of time (up to 12 h). The release data was fitted to various math. models such as Higuchi, Korsmeyer-Peppas, First order and Zero order to evaluate the kinetics and mechanism of the drug release. The optimized formulation (F6) showed no significant change in phys. parameters such as, hardness, friability, weight variation and %drug content for accelerated stability condition at 40±2°C temperature and 75±5% relative humidity for a period 3 mo. Prepared floating tablets of ambroxol hydrochloride may prove to be a potential candidate for safe and effective controlled drug delivery over an extended period of time for gastro retentive drug delivery system.

Journal of Drug Delivery and Therapeutics published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts