Category: alcohols-buliding-blocks

Balandin, A. A. published the artcileCatalytic properties of zirconium phosphate, Formula: C5H11BrO, the publication is Doklady Akademii Nauk SSSR (1965), 161(4), 851-2, database is CAplus.

Catalytic properties of Zr phosphate prepared according to the method described formerly (Amphlett, et al., CA 52, 14281b), were studied. The sp. surface of the catalyst was 335 sq. m./g. and the total acidity 1.2 milliequivalents/g. The kinetics of the dehydration of C₂-C₄ paraffinic alcs. and of cyclohexanol was measured. The conversions at 350-450° were 93-4%. Part of the olefins formed during the dehydration was isomerized. The experiments proved that Zr phosphate is an active catalyst for the reactions, where redistribution of H takes place: isomerization, alkylation, and etherification. Through the changes in preparation of this catalyst it is possible to obtain catalysts of convenient selectivity.

Doklady Akademii Nauk SSSR published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C5H11BrO, Formula: C5H11BrO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vaghela, Chetana published the artcileSelective electrochemical sensing of bisphenol derivatives using novel bioelectrode of agarose-guar gum-graphene oxide immobilized with tyrosinase, Category: alcohols-buliding-blocks, the publication is Journal of Environmental Chemical Engineering (2022), 10(3), 107360, database is CAplus.

Bisphenols (BPs) are widely used in manufacturing of recyclable plastic products that are potentially toxic to human beings. In the current investigation, an electrochem. sensor based on a novel bioelectrode of agarose-guar gum-graphene oxide (A-G-GO) immobilized with tyrosinase was developed for bisphenols detection. The sensor was responsive toward six BP derivatives (A, F, E, B, Z and AP) while being non-responsive toward bisphenols S and AF. Formation of A-G-GO composites was confirmed by various anal. techniques. The electrochem. characterization indicated enhanced charge transfer abilities of the composites that helped in improving sensitivity. Mechanism of sensing involved enzymic oxidation of bisphenols to corresponding o-bisphenols and subsequently their reduction on designed bioelectrodes at a potential of 80 mV. The sensor exhibited differential sensitivity toward varied BPs with linear dynamic response in the concentration range of 50-1000 μM and limit of detection ranging from 5 to 50 μM. Based on apparent Km values exhibited by tyrosinase, differential sensitivity toward BPs could be explained. The biosensor was found to be highly selective for bisphenol detection over other tyrosinase substrates with enhanced storage stability of 150 d. The proposed bioelectrode could successfully be used for measurement of bisphenols from plastic food packing material thus demonstrating its practical utility.

Journal of Environmental Chemical Engineering published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C31H25F2N5O7S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Monton, Chaowalit published the artcileCharacterization of crosslinked hard gelatin capsules for a structural assembly of elementary osmotic pump delivery system, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Journal of Pharmaceutical Investigation (2019), 49(6), 655-665, database is CAplus.

The objective of this study was to characterize the crosslinked hard gelatin capsules (HGCs) for use as a structural assembly of elementary osmotic pumps (EOP). HGCs were crosslinked in formaldehyde vapor for 6, 12, and 24 h. Weight loss after immersing in various mediums, water soluble protein fraction, loss on drying, and formaldehyde residue were investigated. Fourier transform IR (FTIR) spectra were used to detect the crosslinking formation. The EOP capsules were prepared for delivery of diltiazem hydrochloride (DIL HCl) and ambroxol hydrochloride (AMB HCl), which are freely and sparingly water soluble drugs, resp. Physicochem. stability of storage crosslinked HGC shells was investigated. All crosslinked HGC shells were water insoluble FTIR spectra exhibited intermediate lysine methylol and arginine methylol peaks. Storage time increased, moisture content increased and formaldehyde residue decreased. The developing EOP capsules were more appropriate for delivery of high water soluble rather than low water soluble drug. EOP capsule contained 100 mg DIL HCl using HGCs crosslinked for 12 h provided release profiles for 12 h with a lag time of 2.6-3.1 h. It was also found that DIL HCl EOP capsules prepared using crosslinked HGC shells stored for 90 days maintained the similar drug release profiles. AMB HCl EOP capsules exhibited low drug release. In summary, the crosslinked HGCs were applicable as a structural assembly of the osmotic controlled drug delivery system.

Journal of Pharmaceutical Investigation published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Oleszek, Sylwia published the artcileMitigation of bromine-containing products during pyrolysis of polycarbonate-based tetrabromobisphenol A in the presence of copper(I) oxide, Name: 4-Propylphenol, the publication is Journal of Hazardous Materials (2021), 124972, database is CAplus and MEDLINE.

Polycarbonate (PC) is an engineering thermoplastic that is widely used in elec. and electronic equipment. This plastic often contains tetrabromobisphenol A (TBBA), the most common brominated flame retardant. Thermal degradation of the PC-TBBA leads to generation of numerous bromo-organic products in the pyrolytic oil, hindering its appropriate utilization, as well as corrosive hydrogen bromide gas. The purpose of this study was to exptl. investigate and compare the pyrolysis products of PC-TBBA and PC-TBBA + Cu₂O at various temperatures, with an emphasis on the yield and distribution of brominated compounds In pyrolysis of PC-TBBA + Cu₂O, at the maximum degradation temperature (600 °C), as much as 86% of total Br was trapped in the residue, while 3% and 11% were distributed in the condensate and gas fractions, resp. In contrast, the distribution of Br from non-catalytic pyrolysis of PC-TBBA (600 °C) was 0.5% residue, 40% condensate, and 60% gas. The results of this study revealed that in the presence of Cu₂O, organo-bromine products were most likely involved in Ullman-type coupling reactions, leading to early crosslinking of the polymer network that efficiently hinders their vaporization. HBr in the gas fraction was suppressed due to effective fixation of bromine in residue in the form of CuBr.

Journal of Hazardous Materials published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Name: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Daw, Prosenjit published the artcileSynthesis of Pyrazines and Quinoxalines via Acceptorless Dehydrogenative Coupling Routes Catalyzed by Manganese Pincer Complexes, Safety of 2-Aminobutan-1-ol, the publication is ACS Catalysis (2018), 8(9), 7734-7741, database is CAplus and MEDLINE.

Base-metal catalyzed dehydrogenative self-coupling of 2-amino alcs. to selectively form functionalized 2,5-substituted pyrazine derivatives is presented. Also, 2-substituted quinoxaline derivatives are synthesized by dehydrogenative coupling of 1,2-diaminobenzene and 1,2-diols. In both cases, water and hydrogen gas are formed as the sole byproducts. The reactions are catalyzed by acridine-based pincer complexes of earth-abundant manganese.

ACS Catalysis published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Safety of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Manjunatha, N. K. published the artcileSolid state and Computational studies of Ambroxol hydrochloride drug, COA of Formula: C13H19Br2ClN2O, the publication is Chemical Data Collections (2020), 100377, database is CAplus.

The title compound Ambroxol hydrochloride salt or 4-[(2-amino-3, 5-dibromophenyl) Me amino] cyclohexan-1-olhydrochloride (A) have been crystallized, characterized using FT-IR and confirmed by single crystal X-ray diffraction method. In addition, the intercontacts in the crystal structure are analyzed using Hirshfeld surfaces computational method. The A crystallizes in a monoclinic crystal system (space group C2/c) with cell parameters a = 25.1946(14) Å, b = 15.5139(9) Å, c = 8.1636(5) Å, β = 94.664(6)°, V = 3180.3(3) ų and Z = 8. An intermol. interaction of the type O-H… O, N-H… Cl, C-H… Br, C-H… Cg and C-Br… Cg stabilizes the crystal structure. The intercontacts in the crystal structures are visualized using 2D finger print plots. The electrostatic potential surfaces and topol. surfaces (shape index (S) and curvedness (C)) are plotted over the Hirshfeld surfaces to identify the potentials (pos. and neg.) and mol. surface topol., resp. Intercontacts are evaluated for the propensity of forming contacts in the crystal packing by enrichment ration (E) values. The presence of C-Br… Br-C intermol. interactions are confirmed using E values and is categorized as Type I halogen…halogen intermol. interactions.

Chemical Data Collections published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Vijayasree, P. published the artcileA simple RP-HPLC method for quantitation of carboprost tromethamine in injection dosage form, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Journal of Global Trends in Pharmaceutical Sciences (2014), 5(4), 2012-2016, database is CAplus.

A new simple, precise, accurate and rapid method was developed for determination of Carboprost Tromethamine from its pharmaceutical dosage form. The separation was carried out on a Waters C18 column (Symmetry -C18, 3.5μm, and 4.6×100mm) in isocratic mode with mobile phase comprising acetate buffer pH 3.7 and methanol (30:70, %volume/volume) by using Agilent 1100 series HPLC system with Agilent Chemstation software. The flow rate was 1 mL/min and Ultra-Violet detection was carried out at 200 nm. Every part of determination was performed at ambient column temperature The retention time was 6.827 min for Carboprost Tromethamine. The developed method was validated for parameters like specificity, accuracy, precision, robustness as per International Conference on Harmonization guidelines. Linearity for Carboprost Tromethamine was in the range of 83-249μg/mL and Correlation coefficient was found to be 0.999. The percentage recovery was found to be in the limit of 98.4-99.3 %. Statistical anal. of the results has been carried out revealing high accuracy and good precision. Hence this method can be of use and value for the quality control department of pharmaceutical companies manufacturing these formulations without any interference due its sensitivity, simplicity and selectivity.

Journal of Global Trends in Pharmaceutical Sciences published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H5F3N4, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Anantram, Aarti published the artcileMolecular dynamic simulations on an inhibitor of anti-apoptotic Bcl-2 proteins for insights into its interaction mechanism for anti-cancer activity, Quality Control of 518303-20-3, the publication is Journal of Biomolecular Structure and Dynamics (2019), 37(12), 3109-3121, database is CAplus and MEDLINE.

The first anticancer agents targeting this family of proteins were aimed primarily toward inhibition of Bcl-2. An elevated level of Mcl-1, despite Bcl-2 inhibition, continues to be a cause for resistance in most cancers. However, in silico exploration of Mcl-1 specific drugs and their associated mechanisms have not been clearly elucidated. In order to understand the same, we have carried out docking and mol. dynamic simulations on ABT-263 (Navitoclax), an orally active inhibitor of Bcl-2, Bcl-xL, and Bcl-w proteins; Obatoclax, a pan-Bcl-2 inhibitor as well as Maritoclax, an Mcl-1 specific inhibitor. Docking studies revealed that binding to the hydrophobic grooves is a prerequisite for action on the BCL protein and the binding mechanism and chem. space utilization dictates stability as well as specificity of the inhibitor mol. dynamic simulations showed that on binding, the a-helixes of these proteins exhibited less fluctuations than loop regions, also hydrophobic contacts and hydrogen bonding were observed to be the predominant interactions in the drug-receptor complexes.Communicated by Ramaswamy H. Sarma.

Journal of Biomolecular Structure and Dynamics published new progress about 518303-20-3. 518303-20-3 belongs to alcohols-buliding-blocks, auxiliary class Apoptosis,Bcl-2, name is 2-((4-(4-Bromophenylsulfonamido)-1-hydroxynaphthalen-2-yl)thio)acetic acid, and the molecular formula is C18H14BrNO5S2, Quality Control of 518303-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Le, Thuy G. published the artcileStructure-activity relationship studies of tolfenpyrad reveal subnanomolar inhibitors of Haemonchus contortus development, Product Details of C3H5F3O, the publication is Journal of Medicinal Chemistry (2019), 62(2), 1036-1053, database is CAplus and MEDLINE.

Recently, we have discovered that the registered pesticide, tolfenpyrad, unexpectedly and potently inhibits the development of the L4 larval stage of the parasitic nematode Haemonchus contortus with an IC₅₀ value of 0.03 μM while displaying good selectivity, with an IC₅₀ of 37.9 μM for cytotoxicity. As a promising mol. template for medicinal chem. optimization, we undertook anthelmintic structure-activity relationships for this chem. Modifications of the left-hand side (LHS), right-hand side (RHS), and middle section of the scaffold were explored to produce a set of 57 analogs. Analogs I, II, and III were shown to be the most potent compounds of the series, with IC₅₀ values at a subnanomolar level of potency against the chemotherapeutically relevant fourth larval (L4) stage of H. contortus. Selected compounds from the series also showed promising activity against a panel of other different parasitic nematodes, such as hookworms and whipworms.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Product Details of C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Galloway, John M. published the artcileSynthesis and characterization of bifunctional surfaces with tunable functional group pairs, Name: Triethylsilanol, the publication is Surface Science (2016), 284-290, database is CAplus.

Grafting of pairs of functional groups onto a silica surface was demonstrated by tethering both terminals of an organochlorosilane precursor mol., Cl₂(CH₃)Si(CH₂)₄(CO)(OSi(i-Pr)₂)(CH₂)₂Si(CH₃)Cl₂, that possess a cleavable silyl ester bond, onto a silica surface. Hydrolytic cleavage of the silyl ester bond of the grafted mol. resulted in the generation of organized pairs of carboxylic acid and organosilanol groups. This organosilanol moiety was easily transformed into other functional groups through condensation reactions to form, together with the neighboring acid group, pairs such as carboxylic acid/secondary amine, carboxylic acid/pyridine, and carboxylic acid/phosphine. In the case of carboxylic acid/amine pairing, there was evidence of the formation of amide. A sample grafted with amine-carboxylic acid pairs was three times more active (per free amine) than a sample without such pairs for the nitroaldol condensation of 4-nitrobenzaldehyde and nitromethane.

Surface Science published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts