Category: alcohols-buliding-blocks

Wang, Di published the artcileAntimicrobial activity and mechanism of action of oregano essential oil against Morganella psychrotolerans and potential application in tuna, Category: alcohols-buliding-blocks, the publication is LWT–Food Science and Technology (2022), 113758, database is CAplus.

Morganella psychrotolerans is a psychrotolerant histamine producer capable of accumulating large amounts of histamine at low temperatures Oregano essential oil (OEO) is a natural antimicrobial agent used widely in the food industry, however, its antimicrobial effectiveness against M. psychrotolerans has not been studied. In this study, the inhibitory activity of OEO against M. psychrotolerans, causing damage to the membrane structure of the cell with 0.025% (volume/volume) min. inhibitory concentration (MIC) has been revealed. Metabolomics anal. revealed changes of 161 significant metabolites in ESI+ and ESI- modes, which involved in carbohydrates metabolism, amino acid metabolism, metabolism of cofactors and vitamins, nucleotides metabolism, lipids metabolism, and energy metabolism Furthermore, challenge tests revealed the OEO exhibited a significant inhibitory effect on M. psychrotolerans in tuna. These results provided new insights into the inhibition action of OEO on M. psychrotolerans and suggested that OEO had the potential to control M. psychrotolerans in the seafood industry.

LWT–Food Science and Technology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C4H6BrFO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Masferrer-Rius, Eduard published the artcileExploration of highly electron-rich manganese complexes in enantioselective oxidation catalysis; a focus on enantioselective benzylic oxidation, Quality Control of 645-56-7, the publication is Catalysis Science & Technology (2021), 11(23), 7751-7763, database is CAplus.

The direct enantioselective hydroxylation of benzylic C-H bonds to form chiral benzylic alcs. represents a challenging transformation. Herein, the authors report on the exploration of new biol. inspired manganese and iron complexes bearing highly electron-rich aminopyridine ligands containing 4-pyrrolidinopyridine moieties ((S,S)-1, (R,R)-1, 2 and 5) in combination with chiral bis-pyrrolidine and N,N-cyclohexanediamine backbones in enantioselective oxidation catalysis with aqueous H₂O₂. The current manganese complexes outperform the analogous manganese complexes containing 4-dimethylaminopyridine moieties (3 and 4) in benzylic oxidation reactions in terms of alc. yield while keeping similar ee values (~60% ee), which is attributed to the higher basicity of the 4-pyrrolidinopyridine group. A detailed investigation of different carboxylic acid additives in enantioselective benzylic oxidation provides new insights into how to rationally enhance enantioselectivities by means of proper tuning of the environment around the catalytic active site, and has resulted in the selection of Boc-L-tert-leucine as the preferred additive. Using these optimized conditions, manganese complex 2 was shown to be effective in the enantioselective benzylic oxidation of a series of arylalkane substrates with up to 50% alc. yield and 62% product ee. A final set of experiments also highlights the use of the new 4-pyrrolidinopyridine-based complexes in the asym. epoxidation of olefins (up to 98% epoxide yield and >99% ee).

Catalysis Science & Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Quality Control of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ma, Shaoping published the artcileRecyclable aqueous two-phase system formed by two temperature-responsive polymers for the chiral resolution of mandelic acid enantiomers, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Molecular Liquids (2022), 118738, database is CAplus.

Aqueous two-phase systems (ATPSs) have been used in the chiral resolution of various enantiomers in recent years. However, it is difficult to recycle and reuse the phase-forming components and chiral selectors in these applications. Therefore, a completely recyclable ATPS that is based on two temperature-responsive polymers, viz., poly(MAH-β-CD-co-NIPAAm-DMAEMA-BMA) (PNDB-CD) and poly(NVCL-AM) (PVAm), was employed for the chiral separation of mandelic acid (MA) enantiomers. The two polymers can be recovered by simply adjusting the temperature; meanwhile, the polymer PNDB-CD can be used as a chiral selector. The factors that affect the chiral resolution process were also investigated. A maximum separation factor (α) of 1.49 was achieved via a one-step extraction under the following conditions: PVAm concentration of 14.0 wt%, PNDB-CD concentration of 9.0 wt%, MA concentration of 5.0 mg/g, and system p^H of 4.0. Moreover, the two polymers can be easily recycled after the chiral separation process. The recyclable ATPS used for enantioseparation in the current study can provide new ideas for other applications by using enantioselective liquid-liquid extraction (ELLE).

Journal of Molecular Liquids published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiao-Gen published the artcileHydrogenation of Esters by Manganese Catalysts, Formula: C5H12O2, the publication is Advanced Synthesis & Catalysis (2022), 364(4), 744-749, database is CAplus.

The hydrogenation of esters catalyzed by a manganese complex of phosphine-aminopyridine ligand was developed. Using this protocol, a variety of (hetero)aromatic and aliphatic carboxylates including biomass-derived esters and lactones were hydrogenated to primary alcs. R¹CH₂OH [R¹ = Me, Ph, 2-furyl, etc.] with 63-98% yields. The manganese catalyst was found to be active for the hydrogenation of Me benzoate, providing benzyl alc. with turnover numbers (TON) as high as 45,000. Investigation of catalyst intermediates indicated that the amido manganese complex was the active catalyst species for the reaction.

Advanced Synthesis & Catalysis published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Choi, Younghun published the artcileIdentification, quantification, and prioritization of new emerging pollutants in domestic and industrial effluents, Korea: Application of LC-HRMS based suspect and non-target screening, Application of Triisopropanolamine, the publication is Journal of Hazardous Materials (2021), 123706, database is CAplus and MEDLINE.

The present study was designed to identify recently (or rarely) recognized or unreported substances (RRS or URS) contained in the effluents from water treatment plants in two industrialized urban areas, Gumi and Daegu, in Korea. In addition to 30 initial targets, 72 substances were identified through suspect and non-target screening (SNTS). Among them were 4 RRSs and 22 URSs, resp. The quant. analyses were applied to 35 pharmaceuticals, 15 pesticides, 13 poly-/perfluorinated alkyl substances (PFASs), 2 organophosphate flame retardants (OPFRs), 2 corrosion inhibitors, and 3 metabolites. The highest average concentration was observed for benzotriazole, followed by those for niflumic acid, and metformin. Effluents from Gumi mainly contained benzotriazole and metformin whereas niflumic acid and tramadol were the major components in effluents from Daegu. According to a scoring system based on risk relevant parameters, higher priorities were given to telmisartan, PFOA, and cimetidine. Yet, priorities for some substances were area specific (e.g., benzotriazole from Gumi, PFASs from Daegu), reflecting differences in industry profiles and populations. Many of the RRSs and URSs were recognized as potential hazards. The new identifications and evaluations should be taken into consideration for constant monitoring and management, as do the previously recognized contaminants.

Journal of Hazardous Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Seo Yoon published the artcilepH-Dependent interaction mechanism of lignin nanofilms, Recommanded Product: 2-Phenylethanethiol, the publication is Nanoscale (2021), 13(46), 19568-19577, database is CAplus and MEDLINE.

Lignin has been spotlighted as an abundant renewable bioresource for use in material technologies and applications such as biofuels, binders, composites, and nanomaterials for drug delivery. However, owing to its complex and irregular structure, it is difficult to investigate its fundamental interaction mechanism, which is necessary to promote its use. In this study, a surface forces apparatus (SFA) was used to investigate the pH-dependent mol. interactions between a lignin nanofilm and five functionalized self-assembled monolayers (SAMs). The lignin nanofilm adhered most strongly to the amine-functionalized SAM, indicating that the mol. interactions with lignin were mainly electrostatic and cation-π interactions. The force-distance profile between lignin and a methyl-functionalized SAM revealed pH-dependent interactions similar to those between two lignin nanofilms. This finding indicates that the dominant cohesion mechanism is hydrophobic interactions. A quartz crystal microbalance with dissipation was used to investigate the adsorption of free lignin mols. on functionalized SAMs. Lignin mols., which were free in solution, were most effectively adsorbed to the phenyl-functionalized SAM. To investigate whether the nanoscopic interaction forces could be extended to macroscopic properties, the compressive strength of activated carbon-lignin composites prepared at different pH values was evaluated. As the pH increased, the compressive strength decreased owing to the reduced hydrophobic interactions between the activated carbon and lignin, consistent with the SFA results. These quant. results regarding lignin interactions can advance the potential use of lignin as an eco-friendly biomaterial.

Nanoscale published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Seung Koo published the artcileHighly fluorinated and photocrosslinkable liquid prepolymers for flexible optical waveguides, Quality Control of 129301-42-4, the publication is Journal of Materials Chemistry (2011), 21(6), 1755-1761, database is CAplus.

We evaluate highly fluorinated liquid prepolymers and their UV-cured films for flexible optical waveguide applications. Two liquid prepolymers, 2,3,5,6,2′,3′,5′,6′-octafluoro-4,4′-bis-[2-{2-[1,1-difluoro-2-(2,3,5,6-tetrafluoro-4-vinyl-phenoxy)-ethoxy]-1,1,2,2-tetrafluoro-ethoxy}-2,2-difluoro-ethoxy]-biphenyl (7) and 2,3,5,6,2′,3′,5′,6′-octafluoro-4,4′-bis-[2-(2-{2-[1,1-difluoro-2-(2,3,5,6-tetrafluoro-4-vinyl-phenoxy)-ethoxy]-1,1,2,2-tetrafluoro-ethoxy}-1,1,2,2-tetrafluoro-ethoxy)-2,2-difluoro-ethoxy]-biphenyl (8), are synthesized with decafluorobiphenyl, 2,3,4,5,6-pentafluoro styrene, and fluorinated triethylene glycol or fluorinated tetraethylene glycol. The prepolymers are photocurable to give flexible and transparent films. The refractive indexes of the films made from the prepolymers are controlled with their blending composition, 1.417-1.437 at a wavelength of 1.31 μm. The optical losses of the films prepared from prepolymers 7 and 8 are 0.25 and 0.23 dB cm^-1 at a wavelength of 1.31 μm, resp. The films are thermostable at temperatures over 400°. The ultimate stress, initial modulus, and elongation of the films prepared from prepolymers 7 and 8 are 17.1 MPa, 1.25 GPa, and 1.5% and 12.3 MPa, 0.44 GPa, and 6.9%, resp. Optical waveguides fabricated from the prepolymers are flexible without any substrate film and the optical losses at a bending radius of 1.5 mm are under 0.2 dB. We identify the liquid prepolymers as possible good candidate materials for flexible optical waveguide applications by studying the optical transmission in flexible optical waveguides fabricated from them.

Journal of Materials Chemistry published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Quality Control of 129301-42-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Park, Sung Min published the artcilePopulation pharmacokinetic and pharmacodynamic modeling of transformed binary effect data of triflusal in healthy Korean male volunteers: a randomized, open-label, multiple dose, crossover study, Computed Properties of 328-90-5, the publication is BMC Pharmacology and Toxicology (2014), 75/1-75/21, 21 pp., database is CAplus and MEDLINE.

Background Triflusal is a drug that inhibits platelet aggregation. In this study we investigated the dose-exposure- response relationship of a triflusal formulation by population pharmacokinetic (PK) and pharmacodynamic (PD) modeling of its main active metabolite, hydroxy-4-(trifluoromethyl) benzoic acid (HTB). Methods This study was a randomized, open-label, multiple-dose, two-period, two-treatment, comparative crossover design. All volunteers received a single oral loading dose of 900 mg of triflusal on Day 1, followed by a dose of 600 mg/day from Day 2 to 9. Using data from 34 healthy volunteers, 476 HTB plasma concentration data points and 340 platelet aggregation data points were used to construct PK and PD models resp. using NONMEM (version 6.2). As the PD endpoint was qual., we implemented binary anal. of ‘inhibition’ and ‘non-inhibition’ rather than using the actual value of the test. The final PK-PD model was evaluated using a visual predictive check (VPC) and bootstrap. Results The time-concentration profile of HTB over the entire dosing period was described by a one-compartment model with a first-order formation rate constant for HTB. Weight was selected as a covariate for clearance and volume of triflusal, resp. The structure and the population estimates for triflusal PK were as follows: oral clearance (CL/F) = 0.2 · (weight/71.65)0.845 L/h, oral volume of distribution (V/F) = 8.3 · (weight/71.65) L, and kf = 0.341 h-1. A sigmoid relationship between triflusal concentration and the probability of significant inhibition with shape factor was chosen as the final PD model. No time delay between concentration and response was identified. The final structure between predicted concentration (Cpred,ij γ) and the probability of inhibition of platelet aggregation (IPA) relationship was as follows: Probability of IPA = Cpred,ij19 / (84.9 μg/mL19 + Cpred,ij19). Thus, we concluded this relationship is more like quantal concentration-response relationship. The current dosing regimen was considered to be efficacious based on the EC50 estimate of 84.9 μg/mL obtained in this study. Conclusions A PK and binary probability PD model of triflusal was successfully developed for Korean healthy volunteers. The model may be used to further prediction inhibition of platelet aggregation by triflusal.

BMC Pharmacology and Toxicology published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Computed Properties of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shin, Seoungwoo published the artcileAnti-skin-aging activity of a standardized extract from Panax ginseng leaves in vitro and in human volunteer, Synthetic Route of 70445-33-9, the publication is Cosmetics (2017), 4(2), 18/1-18/12, database is CAplus.

Ginseng leaves contain high saponin composition and content, but are used less often than the root part. To develop a use for the leaves that exploits their properties, we studied ginseng leaves as the raw material of anti-aging cosmetics. This study highlights an assessment of the cellular activity and clin. efficacy of ginseng leaf extract, providing necessary information relevant to the development of new cosmetic products. Panax ginseng leaf purified extracts (PGLE) were shown to have high contents of Rb3 and Rb2. Rb3, the major chem. components of PGLE, promoted collagen synthesis though the activation of transforming growth factor-β (TGF-β) in human skin fibroblast cells. In addition, the possibility of PGLE as an anti-skin-aging agent has also been clin. validated. Our anal. of the crow’s feet wrinkle showed that there was a decrease in the depth of deep furrows in the region of interest (RI) treated with PGLE lotion over an eight-week period. Based on these results, we suggest the possibility that PGLE, having high levels of Rb3, be considered as an attractive, wrinkle-reducing candidate for topical application.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C15H14O, Synthetic Route of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gerard, Baudouin published the artcileSynthesis of Stereochemically and Skeletally Diverse Fused Ring Systems from Functionalized C-Glycosides, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2013), 78(11), 5160-5171, database is CAplus and MEDLINE.

A diversity-oriented synthesis (DOS) strategy was developed for the synthesis of stereochem. diverse fused-ring systems containing a pyran moiety. Each scaffold contains an amine and Me ester for further diversification via amine capping and amide coupling. Scaffold diversity was evaluated in comparison to previously prepared scaffolds by a shape-based principal moments of inertia (PMI) anal.

Journal of Organic Chemistry published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts