Category: alcohols-buliding-blocks

Gao, Xiaozhong published the artcilePassive sampling hydrophilic and hydrophobic bisphenol analogues using hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane in surface waters, SDS of cas: 80-09-1, the publication is Science of the Total Environment (2022), 156239, database is CAplus and MEDLINE.

Bisphenol analogs (BPs) are ubiquitous emerging contaminants in water environments and have wide polarity ranges (1.65 < log K_OW< 7.2). Integrated passive sampling strategy rarely contains hydrophilic and hydrophobic organics simultaneously, while the method has good application perspective in monitoring organic contaminants. This work evaluated passive sampling performance for fifteen BPs in a newly developed passive sampler, i.e., hydrophilic-lipophilic balance sorbent-embedded cellulose acetate membrane (HECAM). In the dynamic accumulation experiments, both hydrophilic and hydrophobic BPs (including moderately hydrophilic BPs) well followed first-order kinetic uptake in the HECAMs. The estimated uptake rate constants, elimination rate constants, and equilibrium partition coefficients for BPs ranged from 4.4 L g^-1 d^-1 to 14.7 L g^-1 d^-1, 0.22 d^-1 to 0.72 d^-1, and 3.99 to 4.64, resp. The kinetic parameters for BPs in HECAM show limited correlations to log K_OW values, which the rule differs from traditional passive sampler. In the study of elimination kinetics, three deuterium labeled compounds showed incomplete elimination in HECAM and did not follow first-order isotropic exchange kinetics. Dual sorption mechanisms including both adsorption and partition were found for chems. in HECAM, which the partitioned part could release to water and the adsorbed part could not easily release to water from HECAM. As a result, performance reference compounds (PRCs) calibration may be inapplicable to HLB sorbent-based passive sampler. The field deployment of HECAM in coastal waters of Guangdong, China resulted in the detection of eleven BPs, which indicated that the waters have been polluted by various BPs. Finally, monitoring strategy of simultaneous passive sampling hydrophobic and hydrophilic organic contaminants in surface waters was recommended.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ho, Steven Sai Hang published the artcileSeasonal behavior of water-soluble organic nitrogen in fine particulate matter (PM_2.5) at urban coastal environments in Hong Kong, Quality Control of 96-20-8, the publication is Air Quality, Atmosphere & Health (2019), 12(4), 389-399, database is CAplus.

Water-soluble organic nitrogen (WSON) in fine particulate matter (PM_2.5) was determined at urban coastal environments in China based on 1-yr measurement. The WSON concentrations were in a range of 14.3-257.6 nmol N m^-3 and accounted for 22.0-61.2% of the water-soluble nitrogen (WSN) in composition The average total concentration of free amino acid (FAA) was 1264.5 ± 393.0 pmol m^-3, which was lower than those in continental urban cities but nevertheless comparable to the rural area of Pearl River Delta (PRD) in China. The total quantified amines and amino compounds ranged from 223.8 to 806.0 pmol m^-3 in which methylamine, ethylamine, and ethanolamine were the most abundant compounds The average concentration of urea was 7.8 ± 3.0 nmol m^-3 and at least one order of magnitude higher than those in marine and rural areas but comparable to other continental cities in China during non-dust period. Summer showed the highest average concentration of WSON (95.0 ± 66.6 nmol N m^-3) and composition in WSN (49.3%) compared to other seasons (27.9-37.0%). The results were consistent with previous findings that the inorganics can contribute more than the organics in secondary aerosol formation. There were no distinctive seasonal variations of organic compositions of FAA, amine and amino compounds, and urea. This observation was possibly attributed to a mix of original sources in urban and different prevailing wind directions. Fair correlations (r < 0.4) between WSON compounds and atm. oxidants [ozone (O₃) and nitrogen oxides (NO_x)] suggest that biogenic oxidation is possibly not a major contributing factor in atm. coastal urban location.

Air Quality, Atmosphere & Health published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Quality Control of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Guo, Zhiruo published the artcileSize effect of Ru particles on the self-reforming-driven hydrogenolysis of a lignin model compound, Recommanded Product: 4-Propylphenol, the publication is Catalysis Science & Technology (2022), 12(16), 5143-5151, database is CAplus.

Particle size always has a great influence on catalytic performance. In this study, we investigated the size effect of Ru colloids on the self-reforming-driven hydrogenolysis of a lignin model compound by taking 4-(3-hydroxypropyl)-2-methoxyphenol (PG-OH) as the substrate and NiAl₂O₄ spinel as the support. This reaction provides a strategy to produce alkylphenols from lignin without the consumption of exogenous hydrogen. Three catalysts with different Ru particle sizes (Ru^1.5, Ru^2.6, and Ru^3.3) were prepared, and the catalytic results showed that the reaction activity presented a volcanic curve with the increase in the Ru particle sizes, in which Ru^2.6/NiAl₂O₄ possessed the best performance. Reaction pathway studies showed two different reaction routes over small (Ru^1.5 and Ru^2.6) and large (Ru^3.3) Ru particles. The reforming-driven hydrogenolysis of the methoxy group dominated over small Ru particles, with 4-ethylphenol (4-EP) as the main product; while the hydrogenation of hydroxypropyl and hydrolysis of the methoxy group dominated over the larger particles, with 4-propylcatechin (4-PC) as the main product. Comprehensive investigations indicates the difference in catalytic performance came from the interaction between Ru colloids and the NiAl₂O₄ spinel support, which led to different Ru^δ+/Ru⁰ ratios and finally changed the reaction routes or reaction rate in these three catalysts. This study proves that the particle size really affects catalytic reactions, and indeed, the self-reforming-driven hydrogenolysis of lignin (the model compound) to alkylphenols is structure-sensitive.

Catalysis Science & Technology published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Recommanded Product: 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huang, Ting published the artcileSpatiotemporal distribution of Streptococcus agalactiae attenuated vaccine strain YM001 in the intestinal tract of tilapia and its effect on mucosal associated immune cells, COA of Formula: C13H19Br2ClN2O, the publication is Fish & Shellfish Immunology (2019), 714-720, database is CAplus and MEDLINE.

In the current study, the tilapia was orally vaccinated by the attenuated Streptococcus agalactiae(S. agalactiae) strain YM001, and the distribution and the pathol. effect of strain YM001 in different intestinal segments of tilapia were evaluated by real-time PCR(qPCR), immunohistochem.(IHC) and histomorphol. The qPCR results showed that the number of bacteria was the highest in the intestinal tracts at 12 h post oral gavage in the YM001 group, then began to decrease sharply and eliminated at 7 d. And the number of bacteria was highest in the foregut, hindgut, and rectum at 12 h, 24 h, and 3 d, resp. IHC indicated that bacteria mainly distributed in the margin epithelium and the goblet cells at 12 h – 24 h, and in the submucosa and muscle layer in the YM001 group in 3 d post gavage, then almost disappeared at 7 d. Histol. examination of intestines post gavage displayed that an inflammation was observed at 7 d in the YM001 group and the intestinal structure was fully recovered at 15 d. and the intestinal structure was fully recovered at 15 d. The attenuated S. agalactiae vaccine strain YM001 could enter the intestinal tissue after oral gavage and had a strong spatial and temporal selectivity in the intestinal tract, which could cause obvious mucosal immune response and mild pathol. reaction, but the pathol. change could be gradually repaired with the extinction of bacteria in the body.

Fish & Shellfish Immunology published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, COA of Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mazellier, Patrick published the artcileTransformation of 4-tert-octylphenol by UV irradiation and by an H₂O₂/UV process in aqueous solution, Recommanded Product: 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, the publication is Photochemical & Photobiological Sciences (2003), 2(9), 946-953, database is CAplus and MEDLINE.

The transformation of 4-(1,1,3,3-tetramethylbutyl)phenol (4-tert-octylphenol; OP) upon irradiation at 253.7 nm and by hydroxyl radicals generated by the photolysis (λ_exc =253.7 nm) of H₂O₂ in wastewater was studied. The quantum yield of direct OP photolysis in pure aqueous solution was 0.058±0.004 in aerated conditions ([O₂] =272μM). The rate of photoreaction depends on O concentration; it increases with increasing [O₂]. 4-Tert-octylcatechol was identified as one of the degradation products, together with a dimeric structure. The probable mechanism of OP photolysis involves photoejection of an electron from the singlet state, leading to the formation of the 4-tert-octylphenoxyl radical. In the presence of H₂O₂, the degradation of octylphenol by hydroxyl radicals was observed The 2nd-order rate constant was (6.4±0.5) × 10⁹/M-s by direct measurement at various high concentrations of H₂O₂ and competitive kinetic measurements using atrazine as the competitor. The degradation products are 4-tert-octylcatechol and 2-hydroxy-5-tert-octylbenzoquinone. The later product may arise from the oxidation of 4-tert-octylcatechol by H₂O₂ or from a subsequent reaction of hydroxyl radicals with 4-tert-octylcatechol. Kinetic modeling when using either pure water or natural water simulated the elimination of 4-tert-octylphenol by UV and H₂O₂/UV processes.

Photochemical & Photobiological Sciences published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, Recommanded Product: 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Supranovich, Vyacheslav I. published the artcileGeneration of Alkyl Radicals from Thiols via Zinc Thiolates: Application for the Synthesis of gem-Difluorostyrenes, Synthetic Route of 4410-99-5, the publication is Advanced Synthesis & Catalysis (2021), 363(11), 2888-2892, database is CAplus.

Reaction of thiols with α-(trifluoromethyl)styrenes under photocatalytic conditions led to desulfurative allylic fluorine substitution was described. The reaction was performed by treatment of thiols with benzyl zinc chloride to generate zinc thiolates followed by visible light induced desulfurization by means of triphenylphosphine. Radicals formed after the C-S bond cleavage react with the double bond afforded gem-difluorostyrenes.

Advanced Synthesis & Catalysis published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C10H18O4, Synthetic Route of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Yu Ra published the artcileAlterations in pattern baldness according to sex: hair metabolomics approach, Application of 4-Propylphenol, the publication is Metabolites (2021), 11(3), 178, database is CAplus and MEDLINE.

Pattern baldness has been associated with the male hormone, dihydrotestosterone. In this study, we tried to determine how the overall metabolic pathways of pattern baldness differ in patients and in normal controls. Our study aimed to identify alterations in hair metabolomic profiles in order to identify possible markers of pattern baldness according to sex. Untargeted metabolomics profiling in pattern baldness patients and control subjects was conducted using ultra-performance liquid chromatog.-mass spectrometry. To identify significantly altered metabolic pathways, partial least squares discriminant anal. was performed. Our anal. indicated differences in steroid biosynthesis pathway in both males and females. However, there was a remarkable difference in the androgen metabolic pathway in males, and the estrogen metabolic and arachidonic acid pathways in females. For the first time, we were able to confirm the metabolic pathway in pattern baldness patients using hair samples. Our finding improves understanding of pattern baldness and highlights the need to link pattern baldness and sex-related differences.

Metabolites published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Application of 4-Propylphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morgan, William Raymond published the artcileNitrogen inversion of tertiary amines in aqueous acid, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of the American Chemical Society (1970), 92(15), 4527-31, database is CAplus.

The kinetics of the N inversion of 3 tertiary amines was studied in aqueous acid by high-resolution NMR. Line-shape anal. of the AB NMR pattern of methylene protons on each compound provided a measure of the rate of interchange of the magnetic environments of these protons, which results upon the reprotonation of the free base following an odd number of inversions. The inversion rate followed a modification of the first-order protolysis reaction given by Grunwald. Inversion rate constants of 108-109 sec-1 are estimated These are compared to inversion rate constants for N atoms in ring systems. A second-order dependence of inversion on the concentration of amine was also found. The rate law for this inversion process follows very closely the second-order proton exchange reaction for the amine in question. Application of solvent isotope effects to the protolysis rate parameters predicted the observed results of N inversion in D2O.

Journal of the American Chemical Society published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Montanaro, Sara published the artcilePhotonucleophilic Addition of the ε-Amino Group of Lysine to a Triflusal Metabolite as a Mechanistic Key to Photoallergy Mediated by the Parent Drug, Related Products of alcohols-buliding-blocks, the publication is ChemMedChem (2009), 4(7), 1196-1202, database is CAplus and MEDLINE.

A mechanism for triflusal-induced photoallergy involving complexation of 2-hydroxy-4-trifluoromethylbenzoic acid with site I of human serum albumin and subsequent formation of a covalent adduct by photoreaction between a metabolite and a neighboring lysine residue is proposed. This is supported by the observed photobinding to poly-L-lysine. Thereby, a photoantigen is generated, which is a likely trigger of the immune response. The goal of the work presented herein is to gain deeper insight into the mol. basis of photoallergy mediated by triflusal through its active metabolite, 2-hydroxy-4-trifluoromethylbenzoic acid (HTB). For this purpose, the interaction between HTB and human serum albumin (HSA) was investigated by fluorescence and laser flash photolysis to monitor inclusion into the protein binding sites through variation in the excited-state properties. A remarkable lengthening of HTB triplet lifetime in the presence of HSA was observed The use of oleic acid as a displacement probe clearly suggests the preference for dark binding in site I. The mechanism of photobinding was studied by irradiation of HTB in the presence of amino acids, and, in the case of lysine, a photoadduct was detected that arises from nucleophilic attack by the ε-amino group to the trifluoromethyl substituent of HTB. Accordingly, photobinding of the metabolite to poly-L-lysine was also observed Overall, these results are consistent with a mechanism for triflusal photoallergy involving complexation of HTB to site I of HSA and subsequent formation of a covalent photoadduct with one neighboring lysine residue.

ChemMedChem published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pal, Vineet Kumar published the artcileDiurnal variability in urinary volatile organic compound metabolites and its association with oxidative stress biomarkers, Synthetic Route of 90-64-2, the publication is Science of the Total Environment (2022), 151704, database is CAplus and MEDLINE.

Volatile organic compounds (VOCs) are ubiquitous environmental pollutants that are associated with birth defects, leukemia, neurocognitive deficits, reproductive impairment and cancer in humans exposed to these compounds Exposure to VOCs can be assessed by measuring their metabolites in urine. Little is known, however, about the temporal variability in urinary VOC metabolite (VOCM) concentrations within- and between-individuals. In this study, we determined the variability in the concentrations of 38 VOCMs in urine samples collected from 19 healthy individuals across a period of 44 days. We also measured seven biomarkers of oxidative stress (lipid, protein and DNA damage) in urine to assess the relationship of VOC exposure to oxidative stress. Seventeen VOCMs had detection frequencies (DFs) of >60% in urine, and we limited further data anal. to those compounds The creatinine-adjusted geometric mean concentrations of VOCMs ranged from 2.70 μg/g to 327 μg/g in spot and 2.60 μg/g to 551 μg/g in first morning void (FMV) urine samples. Calculation of the intra-class correlation coefficients (ICCs) for 17 VOCM concentrations to assess their predictability and repeatability in urinary measurements showed ranges of 0.080-0.425 in spot and 0.050-0.749 in FMV urine samples, revealing notable within-individual variability. Our results suggest that taking only single measurements of VOCM concentrations in urine in epidemiol. investigations may lead to exposure misclassification. In addition, VOCM concentrations were significantly and pos. correlated with oxidative stress biomarkers. This study thus provides important information for formulating sampling strategies in the biomonitoring of VOC exposure in human populations.

Science of the Total Environment published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts