Category: alcohols-buliding-blocks

Shiau, Timothy P. published the artcileSulfonyl-polyol N,N-dichloroamines with rapid, broad-spectrum antimicrobial activity, Name: (R)-Oxiran-2-ylmethanol, the publication is Bioorganic & Medicinal Chemistry Letters (2013), 23(20), 5650-5653, database is CAplus and MEDLINE.

The discovery and development of antimicrobial agents that do not give rise to resistance remains an ongoing challenge. Our efforts in this regard continue to reveal new potential therapeutic agents with differing physicochem. properties while retaining the effective N,N-dichloroamine pharmacophore as the key antimicrobial warhead. In this Letter, disclosed are agents containing polyol units as a water solubilizing group. These sulfonyl-polyol agents show broad spectrum bactericidal and virucidal activity. These compounds show 1h MBC’s of 16-512 μg/mL against Escherichia coli and 4-256 μg/mL against Staphylococcus aureus at neutral pH, and 1-h IC₅₀‘s of 4.5-32 μM against Adenovirus 5 and 0.7-3.0 μM against Herpes simplex virus 1. The lead compounds were tested in a tissue culture irritancy assay and showed only minimal irritation at the highest concentrations tested.

Bioorganic & Medicinal Chemistry Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C14H18BNO2, Name: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Simon-Manso, Yamil published the artcileMetabolite Profiling of a NIST Standard Reference Material for Human Plasma (SRM 1950): GC-MS, LC-MS, NMR, and Clinical Laboratory Analyses, Libraries, and Web-Based Resources, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Analytical Chemistry (Washington, DC, United States) (2013), 85(24), 11725-11731, database is CAplus and MEDLINE.

Recent progress in metabolomics and the development of increasingly sensitive anal. techniques have renewed interest in global profiling, i.e., semiquant. monitoring of all chem. constituents of biol. fluids. In this work, we have performed global profiling of NIST SRM 1950, “Metabolites in Human Plasma”, using GC-MS, LC-MS, and NMR. Metabolome coverage, difficulties, and reproducibility of the experiments on each platform are discussed. A total of 353 metabolites have been identified in this material. GC-MS provides 65 unique identifications, and most of the identifications from NMR overlap with the LC-MS identifications, except for some small sugars that are not directly found by LC-MS. Also, repeatability and intermediate precision analyses show that the SRM 1950 profiling is reproducible enough to consider this material as a good choice to distinguish between anal. and biol. variability. Clin. laboratory data shows that most results are within the reference ranges for each assay. Inhouse computational tools have been developed or modified for MS data processing and interactive web display. All data and programs are freely available online at http://peptide.nist.gov/ and http://srmd.nist.gov/.

Analytical Chemistry (Washington, DC, United States) published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H7BClNO3, Application of (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sciukaite, Agne published the artcileContents of some bioactive compounds in Norway spruce needles as affected by short-term storage at different conditions and implications for their industrial use, Category: alcohols-buliding-blocks, the publication is Industrial Crops and Products (2022), 114919, database is CAplus.

The main aim of the research was to evaluate changes in contents of essential oils and pigments in Norway spruce needles as affected by short-term storage under different conditions as well as to assess the potential resources of winter-harvested foliage obtainable from byproducts of forest felling as a natural source of these bioactives. One- and two-year-old needles were taken for the analyses fresh (control) and after five-week storage at three different conditions: at 4°C in fridge, at -24°C in freezer and in the forest of their origin. Essential oils were isolated from needles by hydrodistillation and analyzed by gas chromatog.-mass spectrometry. Analyses of chlorophylls and carotenoids were performed spectrophotometrically. The study showed that none of the tested storage conditions of P. abies needles had significant influence on the total amounts of essential oils in them varying from 0.16% to 0.20% per dry matter (v/w) in two- and one-year-old needles, resp. Bornyl acetate was the main compound identified in the essential oils amounting to 14.47-40.04%. The mean total contents of chlorophylls amounted to 1.10 mg/g in one-year-old needles and to 1.28 mg/g in two-year-old ones measured in fresh weight Statistically significant differences were established in the levels of all the pigments analyzed between fresh material, and stored under controlled, -24°C and 4°C, conditions both of 1-yr-old and 2-yr-old needles. The highest contents of the pigments were obtained after the storage at 4°C as well as under the natural forest condition. Based on the above data and the national forestry statistics, potential yields of essential oils (6.45 kg), total chlorophylls (9.27 kg) and total carotenoids (1.32 kg) were assessed per ha of a mature sprucewood stand in Lithuania.

Industrial Crops and Products published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C15H18BF3O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nie, Shaozhen published the artcileEnantioselective Hydrothiolation: Diverging Cyclopropenes through Ligand Control, Category: alcohols-buliding-blocks, the publication is Journal of the American Chemical Society (2021), 143(16), 6176-6184, database is CAplus and MEDLINE.

In this article, we advance Rh-catalyzed hydrothiolation through the divergent reactivity of cyclopropenes. Cyclopropenes undergo hydrothiolation to provide cyclopropyl sulfides such as I or allylic sulfides such as II. The choice of bisphosphine ligand dictates whether the pathway involves ring-retention or ring-opening. Mechanistic studies reveal the origin for this switchable selectivity. Our results suggest the two pathways share a common cyclopropyl-Rh(III) intermediate. Electron-rich Josiphos ligands promote direct reductive elimination from this intermediate to afford cyclopropyl sulfides in high enantio- and diastereoselectivities. Alternatively, atropisomeric ligands (such as DTBM-BINAP) enable ring-opening from the cyclopropyl-Rh(III) intermediate to generate allylic sulfides with high enantio- and regiocontrol.

Journal of the American Chemical Society published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xie, Long-Yong published the artcileC(sp²)-H/O-H cross-dehydrogenative coupling of quinoxalin-2(1H)-ones with alcohols under visible-light photoredox catalysis, SDS of cas: 2240-88-2, the publication is Chinese Journal of Catalysis (2020), 41(8), 1168-1173, database is CAplus.

An efficient and practical route to various 3-alkoxylquinoxalin-2(1H)-ones through visible-light photocatalytic C(sp²)-H/O-H cross-dehydrogenation coupling of quinoxalin-2(1H)-ones and alcs. by employing ambient air as an oxidant at room temperature under metal-free conditions was developed.

Chinese Journal of Catalysis published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H9ClOS, SDS of cas: 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Lungang published the artcileSelective Production of 2-Butanol from Hydrogenolysis of Levulinic Acid Catalyzed by the Non-precious NiMn Bimetallic Catalyst, Application In Synthesis of 111-29-5, the publication is ACS Sustainable Chemistry & Engineering (2021), 9(46), 15603-15611, database is CAplus.

Selective production of 2-butanol from levulinic acid (LA) hydrogenolysis over a non-precious catalyst is long desirable. However, the process requires the precious metal Ru, and the yield of 2-butanol was less than 65%. Herein, we prepared Ni-based bimetallic catalysts, among which the NiMn catalyst exhibited the highest efficiency and reached an 84.5% yield of 2-butanol at 100% LA conversion under optimal conditions. The electronic states and surface properties were characterized by various techniques such as X-ray diffraction, XPS, temperature-programmed desorption, temperature-programmed reduction, and SEM/transmission electron microscopy. The high efficiency of the NiMn catalyst was due to the synergy between Ni⁰ and Mn²⁺ species, and the modified surface showed a high basicity and a high affinity to adsorb LA and LA-derived mols. with C=O or COOH. The high affinity of the NiMn catalyst was further confirmed by d. functional theory calculations

ACS Sustainable Chemistry & Engineering published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Application In Synthesis of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ao, Junjie published the artcileBisphenol S exposure induces intestinal inflammation: An integrated metabolomic and transcriptomic study, SDS of cas: 80-09-1, the publication is Chemosphere (2022), 133510, database is CAplus and MEDLINE.

As a typical substitute for bisphenol A (BPA), bisphenol S (BPS) is raising concerns due to the potential adverse effects on human health. Limit evidence is available to understand the toxicity of BPS to the digestive system, especially for intestine. In this study, we aimed to investigate the potential effects and underlying mechanisms of BPS exposure on human colon mucosal epithelial cells (NCM460). Our results showed that BPS exposure significantly increased the production of pro-inflammatory cytokines, including tumor necrosis factor-α (TNF-α), interferon-γ (IFN-γ) and interleukin-17A (IL-17A). The tight junctions of the cells has been destroyed by BPS exposure, which was characterized by a down-regulation of the tight junction proteins (Claudin1 and zonula occluden 1 (ZO1)). A multi-omics study explored the underlying mechanisms based on the metabolomic and transcriptomic responses. A variety of neurotransmitters increased significantly after exposure to BPS. The top enriched pathway was “glutamatergic synapse”;, which was activated by BPS exposure, resulting in the up-regulation of L-glutamine. Links were observed among the altered metabolites, genes and cytokines. Our results indicate that exposure to BPS may disturb the balance of gut-brain axis, leading to the production of inflammatory cytokines and the destruction of tight junction in NCM460 cells. It provides new clue for the development of intestinal inflammation in terms of the environmental pollutants.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, SDS of cas: 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Yinling published the artcileRedox-neutral photocatalytic strategy for selective C-C bond cleavage of lignin and lignin models via PCET process, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol, the publication is Science Bulletin (2019), 64(22), 1658-1666, database is CAplus.

A redox-neutral photocatalytic strategy to accomplish this goal in both β-O-4 and β-1 lignin models at room temperature (RT) via proton-coupled electron transfer (PCET) process without any pretreatments of substrate, by adjusting the alkalinity of base to obtain a lignin models/base PCET pair with a bond dissociation free energy close to 102 kcal/mol was developed. Without breaking down C_β-C_γ bond and any C-O bonds, this PCET method is 100% atom economy and produces exclusive C_α-C_β bond cleavage products, such as benzaldehydes (up to 97%) and Ph ethers (up to 96%), in high to excellent yields and selectivities. Preliminary studies indicated that the PCET strategy was also effective for the depolymerization of native lignin at RT, thus providing significantly important foundation to the depolymerization of lignin.

Science Bulletin published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H22BBrO3, Recommanded Product: 2-Phenoxy-1-phenylpropane-1,3-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gao, Lili published the artcileEfficient optimization of Gluconobacter oxydans based on protein scaffold-trimeric CutA to enhance the chemical structure stability of enzymes for the direct production of 2-keto-L-gulonic acid, Quality Control of 526-98-7, the publication is Journal of Chemistry (2020), 5429409, database is CAplus.

2-Keto-L-gulonic acid (2-KLG), the direct precursor of vitamin C, is produced by a two-step fermentation route from D-sorbitol in industry. However, this route is a complicated mix-culture system which involves three bacteria. Thus, replacement of the conventional two-step fermentation process with a one-step process could be revolutionary in vitamin C industry. The one-step fermentation of 2-keto-L-gulonic acid (2-KLG) has been achieved in our previous study; 32.4 g/L of 2-KLG production was obtained by the one-step strain G. oxydans/pGUC-tufB-sdh-GGGGS-sndh after 168 h. In this study, L-sorbose dehydrogenase (SDH) and L-sorbosone dehydrogenase (SNDH) were expressed in G. oxydans after the codon optimization. Furthermore, the trimeric protein CutA was used to improve the chem. structure stability of SDH and SNDH. The recombinant strain G. oxydans/pGUC-tufB-SH3-sdh-GGGGS-sndh-tufB-SH3lig-(GGGGS)2-cutA produced 40.3 g/L of 2-KLG after 168 h. In addition, the expression levels of the cofactor PQQ were enhanced to further improve 2-KLG production With the stepwise metabolic engineering of G. oxydans, the final 2-KLG production was improved to 42.6 g/L. The efficient one-step production of 2-KLG was achieved, and the final one-step industrial-scale production of 2-KLG is drawing near.

Journal of Chemistry published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C6H10O7, Quality Control of 526-98-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Chen published the artcileHeat-cured concrete: Improving the early strength and pore structure by activating aluminosilicate internal curing agent with triisopropanolamine, Recommanded Product: Triisopropanolamine, the publication is Journal of the American Ceramic Society (2019), 102(10), 6227-6238, database is CAplus.

Although heat-cured concrete (HCC) has received extensive research interests in recent years, it still suffers from problems including coarsened microstructure and low cement hydration degrees, which limited its application. Some of these problems can be solved by internal curing method resulting in low early strength of HCC and low-production efficiency. This study addressed this issue by activating the aluminosilicate internal curing agent (lightweight fine aggregate, LWFA) with triisopropanolamine (TIPA). More Al³⁺ and Fe³⁺ ions were dissolved from LWFA by TIPA, which assisted the formation of hydrates with cement ions in interfacial transition zone (ITZ), and enhanced the d. of ITZ in the early stage. The introduction of TIPA increased the early compressive strength of HCC, by ∼15.3%, 25.9%, and 28.0%, resp. for the cement cured for 1, 3, and 7 days compared with control samples. Moreover, the results of rapid chloride migration and water absorption depth also suggested that coupling the aluminosilicate internal curing agent with TIPA improved the pore structure of HCC.

Journal of the American Ceramic Society published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Recommanded Product: Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts