Category: alcohols-buliding-blocks

Zhao, Kang-He published the artcileRefractory organic compounds in coal chemical wastewater treatment by catalytic ozonation using Mn-Cu-Ce/Al₂O₃, Application In Synthesis of 2588-77-4, the publication is Environmental Science and Pollution Research (2021), 28(30), 41504-41515, database is CAplus and MEDLINE.

A composite Mn-Cu-Ce tri-metal oxide supported on γ-Al₂O₃ (Mn-Cu-Ce/Al₂O₃) catalyst was prepared by an impregnation-calcination method and investigated in the catalytic ozonation treatment of real coal chem. wastewater (CCW). The catalyst was characterized by XRD, SEM, TEM, XRF, BET, and XPS techniques. The results showed that Mn, Cu, and Ce metal oxides were evenly distributed on the Al₂O₃ surface and the catalyst maintained a large surface area and a high pore volume compared with the pristine Al₂O₃. The synergy between Mn, Cu, and Ce oxides greatly enriched the catalytic active sites and enhanced the ozonation performance. The catalytic ozonation process with Mn-Cu-Ce/Al₂O₃ increased the removal rate of total organic carbon (TOC) by 31.6% compared with ozonation alone. The ketones, aromatic compounds, phenols, and nitrogen-containing heterocyclic compounds in CCW have been effectively degraded and mineralized by Mn-Cu-Ce/Al₂O₃ catalytic ozonation process, and its biodegradability has also been significantly improved. The exptl. results of ·OH scavengers revealed that the mechanism of Mn-Cu-Ce/Al₂O₃ catalytic ozonation was to promote the generation of ·OH radicals. The catalytic activity of Mn-Cu-Ce/Al₂O₃ was only a slight decrease in six consecutive catalytic ozonation treatments, showing good stability. Therefore, Mn-Cu-Ce/Al₂O₃ can be used as a candidate catalyst for the advanced treatment of refractory organic wastewaters upon catalytic ozonation.

Environmental Science and Pollution Research published new progress about 2588-77-4. 2588-77-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 2-Methyl-3-bromo-2-butanol, and the molecular formula is C24H20Ge, Application In Synthesis of 2588-77-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xia, Lisha published the artcileEvaluation of chemical cross-linkers for in-depth structural analysis of G protein-coupled receptors through cross-linking mass spectrometry, Related Products of alcohols-buliding-blocks, the publication is Analytica Chimica Acta (2020), 53-62, database is CAplus and MEDLINE.

Chem. crosslinking would conceivably cause structural disruption of a protein, but few cross-linkers have been fully evaluated in this aspect. Furthermore, integral membrane proteins may differ from soluble proteins in the selection of suitable cross-linkers, which has never been investigated. In this study, we systematically evaluated the impact of five conventional cross-linkers targeting Lys, Asp and Glu, and two Arg-reactive cross-linkers on the structural and functional integrity of two G protein-coupled receptors (GPCRs). Perturbation of the receptor structure and ligand-binding activity was observed, depending on the receptor and crosslinking conditions. In particular, our study demonstrated that the concentrations of PDH and KArGO need to be fine-tuned in order to minimize the structural and functional disturbance of specific GPCRs. A set of amenable cross-linkers was selected to acquire the most comprehensive cross-link maps for two GPCRs. Our in-depth crosslinking mass spectrometry (CXMS) anal. has revealed dynamic features of structural regions in GPCRs that are not observable in the crystal structures. Thus, CXMS anal. of GPCRs using the expanded toolkit would facilitate structural modeling of uncharacterized receptors and gain new insights into receptor-ligand interactions.

Analytica Chimica Acta published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C11H20N2O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Belhachemi, Asma published the artcileGC-MS and GC-FID analyses of the essential oil of Eucalyptus camaldulensis grown under greenhouses differentiated by the LDPE cover-films, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol, the publication is Industrial Crops and Products (2022), 114606, database is CAplus.

The chem. composition of essential oils (EOs) can vary from one plant to another of the same species and can be affected by several factors including the environment of growth. The research was carried out on the EOs of Eucalyptus camaldulensis leaves grown in three sep. greenhouses differentiated by their low-d. polyethylene (LDPE) covering material. This study aimed to compare the impact of the type of the greenhouse cover film on the internal microclimate, light intensity, and chem. composition of E. camaldulensis EOs. Eucalyptus species was initially cultivated from the seeds and the EOs were extracted from the leaves of 14 wk aged trees. The extraction was performed by hydrodistillation using a Clevenger-type apparatus Qual. and quant. analyses of the extracted EOs were performed using gas chromatog. coupled with mass spectrometry (GC-MS) and gas chromatog. coupled with a flame ionization detector (GC-FID). The analyzed samples were rich in terpenes with a total of 66 identified compounds The oxygenated monoterpenes pinocarvone and -carvone were only identified in the essential oils from multilayered greenhouses. cis-1-Methyl-4-(1-methylethyl-)-2-cyclohexen-1-ol was absent in eucalyptus EOs from the three-layer greenhouse, unlike the others that had it. Different compound contents were detected in the extracted essential oils, according to their greenhouse cover conditions. 1,8-Cineol was the compound present in a higher amount as expected, with the highest value of c.a 164.78 mg/gdw from the leaves of E. camaldulensis cultivated in the ordinary greenhouse. Contents of 51.55 mg/gdw and 42.11 mg/gdw were obtained from E. camaldulensis cultivated in the three-layers and monolayer greenhouses, resp. In contrast, the EOs of E. camaldulensis grown under the monolayer greenhouse presented the highest content of some aromadendranes family compounds This study shows that the greenhouse cover-film should be chosen thoughtfully because it plays a major function regarding its effect on the chem. composition of the EOs of E. camaldulensis cultivated in greenhouse environments.

Industrial Crops and Products published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Recommanded Product: cis-3,7-Dimethyl-2,6-Octadien-1-Ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gupta, Sharad published the artcileSynthesis of structurally diverse bis-peptide oligomers, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2006), 71(23), 8691-8695, database is CAplus and MEDLINE.

The authors have developed second-generation monomers I (n = 1, 2) and improved conditions for rapidly and simultaneously closing multiple diketopiperazines on solid support. These new conditions involve either the microwave heating of a suspension of solid-supported amino-tetrafluoropropyl esters in acetic acid/triethylamine catalyst solution or continuous flow of catalyst solution through the resin, heated in a flow cell apparatus The authors demonstrate that monomers I and II can be combined with the new conditions easily to synthesize previously inaccessible hetero and homo spiro ladder oligomers III and IV.

Journal of Organic Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shareef, Afzaal M. published the artcileComparison of RNA synthesis initiation properties of non-segmented negative strand RNA virus polymerases, SDS of cas: 122-20-3, the publication is PLoS Pathogens (2021), 17(12), e1010151, database is CAplus and MEDLINE.

It is generally thought that the promoters of non-segmented, neg. strand RNA viruses (nsNSVs) direct the polymerase to initiate RNA synthesis exclusively opposite the 3′ terminal nucleotide of the genome RNA by a de novo (primer independent) initiation mechanism. However, recent studies have revealed that there is diversity between different nsNSVs with pneumovirus promoters directing the polymerase to initiate at positions 1 and 3 of the genome, and ebolavirus polymerases being able to initiate at position 2 on the template. Studies with other RNA viruses have shown that polymerases that engage in de novo initiation opposite position 1 typically have structural features to stabilize the initiation complex and ensure efficient and accurate initiation. This raised the question of whether different nsNSV polymerases have evolved fundamentally different structural properties to facilitate initiation at different sites on their promoters. Here we examined the functional properties of polymerases of respiratory syncytial virus (RSV), a pneumovirus, human parainfluenza virus type 3 (PIV-3), a paramyxovirus, and Marburg virus (MARV), a filovirus, both on their cognate promoters and on promoters of other viruses. We found that in contrast to the RSV polymerase, which initiated at positions 1 and 3 of its promoter, the PIV-3 and MARV polymerases initiated exclusively at position 1 on their cognate promoters. However, all three polymerases could recognize and initiate from heterologous promoters, with the promoter sequence playing a key role in determining initiation site selection. In addition to examining de novo initiation, we also compared the ability of the RSV and PIV-3 polymerases to engage in back-priming, an activity in which the promoter template is folded into a secondary structure and nucleotides are added to the template 3′ end. This anal. showed that whereas the RSV polymerase was promiscuous in back-priming activity, the PIV-3 polymerase generated barely detectable levels of back-primed product, irresp. of promoter template sequence. Overall, this study shows that the polymerases from these three nsNSV families are fundamentally similar in their initiation properties, but have differences in their abilities to engage in back-priming.

PLoS Pathogens published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C4H10BBrO2, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Caliskan, Burcu published the artcilePyrazol-3-propanoic acid derivatives as novel inhibitors of leukotriene biosynthesis in human neutrophils, Application of 4-(1H-Pyrrol-1-yl)phenol, the publication is European Journal of Medicinal Chemistry (2011), 46(10), 5021-5033, database is CAplus and MEDLINE.

Thirty-six title compounds were synthesized and led to potent inhibition of leukotriene (LT) biosynthesis in activated human neutrophils. Some examples showed IC₅₀ values in the range of 1.6-3.5 μM. Moreover, several compounds showed a substantial inhibition of platelet COX-1 activity with IC₅₀ of 2.5, 0.041, 0.3, 0.9 and 0.014 μM, resp., leading up to dual acting inhibitors. On the basis of their high potency in cellular environment, these straightforward pyrazole-3-propanoic acid derivatives may possess potential in the design of more potent compounds for intervention with inflammatory and allergic diseases.

European Journal of Medicinal Chemistry published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Application of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kluczyk, Alicja published the artcileArgireline: Needle-Free Botox as Analytical Challenge, Computed Properties of 70445-33-9, the publication is Chemistry & Biodiversity (2021), 18(3), e2000992, database is CAplus and MEDLINE.

Argireline-containing cosmetics attract public interest due to their confirmed reduction of facial wrinkles. Argireline is a peptide that works by inhibiting the release of neurotransmitters in the neuromuscular junction, producing a botox-like effect. Therefore, it is used as a safe needle-free alternative to botox treatment. In this work we investigated the presence of Argireline in cosmetic creams and sera by application of reversed phase liquid chromatog. and tandem mass spectrometry (RP-HPLC/MS and MS/MS). The anal. revealed the presence of argireline and its oxidized form in several different cosmetics. The methionine residue in Argireline sequence was indicated as oxidation point according to neutral loss MS studies. The developed sample preparation strategy minimizes and monitors methionine oxidation, bringing to our attention the question of impact of ingredients on the stability of cosmetic product.

Chemistry & Biodiversity published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Computed Properties of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Siewert, Riko published the artcileNon-covalent interactions in molecular systems: thermodynamic evaluation of the hydrogen bond strength in aminoalcohols, Recommanded Product: 2-Aminobutan-1-ol, the publication is Physical Chemistry Chemical Physics (2021), 23(44), 25226-25238, database is CAplus and MEDLINE.

In mols. with two functional groups that form hydrogen bonds, the structure-property relationship can depend significantly on the strength of intra-mol. hydrogen bonding. This bonding can cause a substantial conformational change that is accompanied by a frequency shift in the IR spectrum, which provides the basis for exptl. studies. Despite its great importance in biol. systems, the available literature data for the strength of this bonding are scarce and not in agreement. In this work, we present the results of four thermodn. methods for the determination of the strength of intramol. hydrogen bonds. Comprehensive thermochem. anal. of 1-amino-2-alcs. and 2-amino-1-alcs. was performed with Fourier-transform IR spectroscopy, high-level G4 quantum-chem. calculations, the homomorph scheme with enthalpies of vaporization and a group contribution method. With the combination of these four thermodn. methods, the strength of intramol. hydrogen bonding in 1,2-aminoalcs. and 2,1-aminoalcs. was evaluated quant. The results were correlated with NBO parameters to find an explanation for the different strengths of intramol. hydrogen bonds in total charge transfer and second order stabilization energies.

Physical Chemistry Chemical Physics published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C7H14N4, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rueeger, Heinrich published the artcileDiscovery of Cyclic Sulfone Hydroxyethylamines as Potent and Selective β-Site APP-Cleaving Enzyme 1 (BACE1) Inhibitors: Structure-Based Design and in Vivo Reduction of Amyloid β-Peptides, Related Products of alcohols-buliding-blocks, the publication is Journal of Medicinal Chemistry (2012), 55(7), 3364-3386, database is CAplus and MEDLINE.

Structure-based design of a series of cyclic hydroxyethylamine BACE1 inhibitors allowed the rational incorporation of prime- and nonprime-side fragments to a central core template without any amide functionality. The core scaffold selection and the structure-activity relationship development were supported by mol. modeling studies and by x-ray anal. of BACE1 complexes with various ligands to expedite the optimization of the series. The direct extension from P1-aryl- and heteroaryl moieties into the S3 binding pocket allowed the enhancement of potency and selectivity over cathepsin D. Restraining the design and synthesis of compounds to a physicochem. property space consistent with central nervous system drugs led to inhibitors with improved blood-brain barrier permeability. Guided by structure-based optimization, highly potent compounds were obtained, such as I, with enzymic and cellular IC₅₀ values of 2 and 50 nM, resp., and with >200-fold selectivity over cathepsin D. Pharmacodynamic studies in APP51/16 transgenic mice at oral doses of 180 μmol/kg demonstrated significant reduction of brain Aβ levels.

Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xie, Yun published the artcileExcited-state hydroxide ion transfer from a model xanthenol photobase, Category: alcohols-buliding-blocks, the publication is Journal of Physical Chemistry B (2015), 119(6), 2498-2506, database is CAplus and MEDLINE.

This article reports a study of excited-state hydroxide ion release from a model xanthenol photobase, XanOH. The driving force for the reaction was tuned using solvent mixtures with varying water/acetonitrile ratios, and the kinetics of the reaction was monitored using ultrafast pump-probe spectroscopy. The intrinsic barrier for the heterolysis was evaluated using Marcus and bond-energy bond-order (BEBO) models. The obtained value (ΔG^#_o = 10.17-10.80 kcal/mol) is significantly higher than the intrinsic barriers found for the proton release from previously studied photoacids. These results were discussed in terms of the difference in structures of solvated H⁺ and OH^– ions.

Journal of Physical Chemistry B published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C9H10O3S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts