Category: alcohols-buliding-blocks

Nakanishi, Masako published the artcileDietary walnut supplementation alters mucosal metabolite profiles during DSS-induced colonic ulceration, Application of Triisopropanolamine, the publication is Nutrients (2019), 11(5), 1118, database is CAplus and MEDLINE.

Walnuts contain a complex array of natural compounds and phytochems. that exhibit a wide range of health benefits, including protection against inflammation and colon cancer. In this study, we assess effect of dietary supplementation with walnuts on colonic mucosal injury induced in mice by ulcerogenic agent, dextran sodium sulfate (DSS). C57Bl/6J mice were started on the Total Western Diet supplemented with freshly-ground whole walnuts (0, 3.5, 7 and 14% g/kg) 2 wk prior to a 5-day DSS treatment and walnut diets were continued throughout the entire exptl. period. In a sep. study, a discovery-based metabolite profiling anal. using liquid chromatog. tandem mass spectrometry was performed on fecal samples and colonic mucosa following two weeks of walnut supplementation. Dietary walnut supplementation showed significant effects in the 10-day post-DSS recovery-phase study, in which the extent of ulceration was significantly reduced (7.5% vs. 0.3%, p < 0.05) with 14% walnuts. In the metabolite-profiling anal., walnuts caused a significant increase in several polyunsaturated fatty acids, including docosahexaenoic acid and 9-oxo-10(E),12(E)-octadecadienoic acid (9-oxoODA), as well as kynurenic acid. In colon tissue samples, walnuts caused a significant increase in the levels of S-adenosylhomocysteine and betaine, important components of fatty acid β-oxidation These metabolite changes may contribute in part to the observed protection against DSS-induced inflammatory tissue injury.

Nutrients published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mathis-Noel, Raymonde published the artcileSpectroscopic studies of hydrogen bonding in aliphatic and aromatic amino alcohols, Application of 2-(Benzyl(methyl)amino)ethanol, the publication is Bulletin de la Societe Chimique de France (1970), 3047-56, database is CAplus.

Inter- and intramol. H bonds were studied for a series of amino alcs., which included some aromatic substituted compounds The ir frequencies of the OH and NH bonds were observed for the pure compound and for several dilutions in CCl4. Further, the NMR shifts of these bonds were observed All compounds studied, with the one exception of 1-phenyl-2-N-methyl-N-ethylaminoethanol, showed various intermol. H-bonds in the pure phase, i.e., OH..A, NH…O, NH…N. Compounds with electron donor substituents on N showed intramol. H bonds (C. F. Douberet and Pariand, 1962). Such bonds are also observed for primary amines; they increase as the number of electron donors on the adjacent C increases. Substitution of an electron source or sink for a H on the C bearing the OH will always favor intramol. association Chelation will be suppressed by substitution of a H atom on N; this increases the H-bonding to the π-electrons of an aromatic system, observed at about 3541 cm-1.

Bulletin de la Societe Chimique de France published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Application of 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alexis, Michael N. published the artcileSubunit composition of the untransformed glucocorticoid receptor in the cytosol and in the cell, Related Products of alcohols-buliding-blocks, the publication is European Journal of Biochemistry (1992), 204(1), 75-84, database is CAplus and MEDLINE.

Bifunctional reagents were used to exam. the subunit composition of the non-DNA-binding form of the rat and human glucocorticoid receptor. Treatment of intact cells and cell extracts with a reversible cross-linker, followed by electrophoretic anal. of immunoadsorbed receptor revealed that 3 proteins of apparent approx. mol. masses, 90, 53, and 14 kDa are associated with the receptor. The 1st of these was identified immunochem. as a 90-kDa heat-shock protein (hsp90). The complex isolated from HeLa cells contained 2.2 mol hsp90/mol steroid-binding subunit. Crosslinking of the receptor complex in the cytosol completely prevented salt-induced dissociation of the subunits. The cross-linked receptor was electrophoretically resolved into 2 oligomeric complexes of apparent mol. mass 288 kDa and 347 kDa, reflecting the association of the 53-kDa protein with a fraction of the receptor. Since no higher oligomeric complexes could be generated by crosslinking cell extracts under different conditions, it was concluded that most of the untransformed cytosolic receptor is devoid of addnl. components.

European Journal of Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Buta, Andriy published the artcileNovel Potent Orthosteric Antagonist of ASIC1a Prevents NMDAR-Dependent LTP Induction, Name: 3-(Methylamino)phenol, the publication is Journal of Medicinal Chemistry (2015), 58(11), 4449-4461, database is CAplus and MEDLINE.

Acid sensing ion channels 1a (ASIC1a) are of crucial importance in numerous physiol. and pathol. processes in the brain. Here we demonstrate that novel 2-oxo-2H-chromene-3-carboxamidine derivative 5b, designed with mol. modeling approach, inhibits ASIC1a currents with an apparent IC₅₀ of 27 nM when measured at pH 6.7. Acidification to 5.0 decreases the inhibition efficacy by up to 3 orders of magnitude. The 5b mol. not only shifts pH dependence of ASIC1a activation but also inhibits its maximal evoked response. These findings suggest that compound 5b binds to pH sensor of ASIC1a acting as orthosteric noncompetitive antagonist. At 100 nM, compound 5b completely inhibits induction of long-term potentiation (LTP) in CA3-CA1 but not in MF-CA3 synapses. These findings support the knockout data indicating the crucial modulatory role of ASIC1a channels in the NMDAR-dependent LTP and introduce a novel type of ASIC1a antagonists.

Journal of Medicinal Chemistry published new progress about 14703-69-6. 14703-69-6 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Phenol, name is 3-(Methylamino)phenol, and the molecular formula is C7H9NO, Name: 3-(Methylamino)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sindhu, S. published the artcileGC-MS determination of bioactive components of Polycarpaea corymbosa Lams. (Caryophyllaceae), Application of Triisopropylsilanol, the publication is Hygeia (2013), 5(1), 5-9, database is CAplus.

Plan: The investigation was carried out to determine the possible chem. components from Polycarpaea corymbosa Lam. root and aerial parts. Methodol.: GC-MS was analyzed using Agilent (Model 5975C) Gas Chromatog.-Mass Spectrometry. Outcome: GC-MS anal. of methanolic extract of root and aerial part led to identification of 30 and 24 compounds resp. The components were identified by comparing their retention indexes and mass spectra fragmentation patterns with those stored in the National Institute of Standards and Technol. (NIST) library. The major constituents reported are n-Hexadecanoic acid in methanolic aerial extract and 5-Hydroxymethyl furfural in methanolic root extract

Hygeia published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C5H5N3S, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Paalasmaa, Sanna published the artcileSynthesis and characterization of three homoleptic bismuth silanolates: [Bi(OSiR₃)₃] (R = Me, Et, iPr), Quality Control of 17877-23-5, the publication is Zeitschrift fuer Anorganische und Allgemeine Chemie (2005), 631(12), 2433-2438, database is CAplus.

The bismuth tris(triorganosilanolates) [Bi(OSiR₃)₃] (1, R = Me; 2, R = Et; 3, R = iPr) were prepared by reaction of R₃SiOH with [Bi(OtBu)₃]. Compound 1 crystallizes in the triclinic space group P1̅ with Z = 2 and a 10.323(1), b 13.805(1), c 21.096(1) Å and α 91.871(4), β 94.639(3), γ 110.802(3)°. In the solid state compound 1 is a trimer as result of weak intermol. bismuth-oxygen interactions with Bi-O distances in the range 2.686(6)-3.227(3) Å. The coordination at the bismuth atoms Bi(1) and Bi(3) is best described as 3 + 2 coordination whereas Bi(2) shows a 3 + 3 coordination. The intramol. Bi-O distances fall in the range 2.041(3)-2.119(3) Å. Compound 3 crystallizes in the orthorhombic space group Pbcm with Z = 4 and a 7.201(1), b 23.367(5) and c 20.893(1) Å whereas the triethylsilyl-derivative 2 is liquid In contrast to [Bi(OSiMe₃)₃] (1), compound 3 is monomeric in the solid state, but shows similar intramol. Bi-O distances in the range 1.998(2)-2.065(5) Å. The bismuth silanolates are highly soluble in common organic solvents and strongly moisture sensitive. Compound 1 shows the lowest thermal stability.

Zeitschrift fuer Anorganische und Allgemeine Chemie published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Quality Control of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chang, Wei-chen published the artcileReaction of HppE with Substrate Analogues: Evidence for Carbon-Phosphorus Bond Cleavage by a Carbocation Rearrangement, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Journal of the American Chemical Society (2013), 135(22), 8153-8156, database is CAplus and MEDLINE.

(S)-2-Hydroxypropylphosphonic acid ((S)-2-HPP) epoxidase (HppE) is an unusual mononuclear non-heme iron enzyme that catalyzes the oxidative epoxidation of (S)-2-HPP in the biosynthesis of the antibiotic fosfomycin. Recently, HppE has been shown to accept (R)-1-hydroxypropylphosphonic acid as a substrate and convert it to an aldehyde product in a reaction involving a biol. unprecedented 1,2-phosphono migration. In this study, a series of substrate analogs were designed, synthesized, and used as mechanistic probes to study this novel enzymic transformation. The resulting data, together with insights obtained from d. functional theory calculations, are consistent with a mechanism of HppE-catalyzed phosphono group migration that involves the formation of a carbocation intermediate. As such, this reaction represents a new paradigm for biol. C-P bond cleavage.

Journal of the American Chemical Society published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Goncalves, Leticia C. P. published the artcileBoosting photobioredox catalysis by morpholine electron donors under aerobic conditions, Recommanded Product: 2-Morpholinoethanol, the publication is Catalysis Science & Technology (2019), 9(10), 2682-2688, database is CAplus.

Light-driven reduction of flavins, e.g. FAD or FMN, by sacrificial electron donors emerged as a convenient method to promote biocatalytic transformations. However, flavin activation has been restricted to oxygen-free conditions to prevent enzyme deactivation caused by reactive oxygen species (ROS). Herein, we show that the photoreduction of FMN by morpholines, including 3-(N-morpholino)propanesulfonic acid (MOPS), lessens the deactivation of the enoate reductase XenB from Pseudomonas sp. during the stereoselective asym. enzymic reduction of a model α,β-unsaturated diketone under aerobic conditions, leading to a 91% GC-yield and a stereoselectivity greater than 94%. The kinetic stability of the thermolabile XenB was increased by more than 20-fold in MOPS buffer compared to that in Tris-HCl buffer, and a pronounced pos. effect on the transition midpoint temperature was observed The reactive form of the FMN photocatalyst is stabilized by the formation of a ³[FMN^–̇-MOPS⁺̇] ensemble, which reduces the formation of hydrogen peroxide and other ROS in the presence of oxygen. These results contribute to broaden the application of photobiocatalytic transformations using flavin-dependent reductases.

Catalysis Science & Technology published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Recommanded Product: 2-Morpholinoethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chunarrom, Wannida published the artcileThe dielectric and polarization behavior of polyurethane-based polycarbonate diols with different content levels of fluorinated hard segments, Synthetic Route of 129301-42-4, the publication is Polymer Chemistry (2021), 12(8), 1136-1146, database is CAplus.

A novel series of polyurethane-based polycarbonate diols containing fluorinated hard segments in the main chain (FPU) were synthesized using a prepolymer method. The fluorinated hard segment content was varied to study the effects on the dielec. and polarization behaviors under an applied elec. field (P-E loop). The addition of a fluorinated chain notably improved the polarization via an induced dipole moment in the PU films and higher dielec. constant, including allowing the relaxation peak to move to a lower frequency. Paraelec. loop behavior was observed with thinner loops as the fluorinated group content was increased. The nature of the solvent used for the synthesis affected the H-bonding capabilities and fluorinated group content. FPU synthesized in DMF showed a higher dielec. constant than that synthesized in dimethylsulfoxide due to its higher fluorine content.

Polymer Chemistry published new progress about 129301-42-4. 129301-42-4 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Aliphatic hydrocarbon chain,Alcohol,Ether, name is 2,2′-((Perfluoroethane-1,2-diyl)bis(oxy))bis(2,2-difluoroethanol), and the molecular formula is C6H6F8O4, Synthetic Route of 129301-42-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhou, Xin published the artcileSynthesis of 2-oxazolines from ring opening isomerization of 3-amido-2-phenyl azetidines, Product Details of C11H8O3, the publication is Molecules (2021), 26(4), 857, database is CAplus and MEDLINE.

In this paper, an efficient synthesis of 2-oxazolines I (R = Me, Ph, furan-2-yl, 1-hydroxynaphthalen-2-yl, etc.) has been achieved via the stereospecific isomerization of 3-amido-2-Ph azetidines II. The reactions were studied in the presence of both Bronsted and Lewis acids, and Cu(OTf)₂ were found to be the most effective.

Molecules published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C2H3N3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts