Category: alcohols-buliding-blocks

Daldrup, T. published the artcileA screening test for pharmaceuticals, drugs and insecticides with reversed-phase liquid chromatography – retention data of 560 compounds, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Chromatography Newsletter (1982), 10(1), 1-7, database is CAplus.

High-performance reversed-phase liquid chromatog. retention data are given. The relative retention times were calculated as the ratio of retention times of compound and reference compound 5-(p-methylphenyl)-5-phenylhydantoin. The UV detector wavelength was 220 nm, where most of the compounds gave a good response. The sensitivity of the method for each compound is rated from very good to bad. Two solvent programs and a prepacked column C-18 SIL-X-10 were used for the anal.

Chromatography Newsletter published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yuan, Yuping published the artcileEnergy level tuning of polythiophene derivative by click chemistry-type postfunctionalization of side-chain alkynes, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2011), 49(1), 225-233, database is CAplus.

A polythiophene derivative substituted with electron-rich alkynes as a side chain was synthesized using the Suzuki polycondensation reaction. The electron-rich alkynes underwent the “click chem.”-type quant. addition reaction with strong acceptor mols., such as tetracyanoethylene (TCNE) and 7,7,8,8-tetracyanoquinodimethane (TCNQ), resulting in the formation of donor-acceptor chromophores. All polymers showed excellent solubilities in the common organic solvents as well as good thermal stabilities with their 5% decomposition temperatures exceeding 230 °C. The TCNE-/TCNQ-adducted polymers displayed well-defined charge-transfer (CT) bands in the low energy region. The CT energy of the TCNE-adducted polymer was 2.56 eV (484 nm), which was much greater than that of the TCNQ-adducted polymer [1.65 eV (750 nm)]. This result was supported by the electrochem. measurements. The electrochem. band gaps of the TCNE-adducted polymers were much greater than those of the corresponding TCNQ-adducted polymers. Furthermore, the HOMO and LUMO energy levels, determined from the first oxidation and first reduction peak potentials, resp., decreased with the increasing acceptor addition amount All these results suggested that the energy levels of the polythiophene derivative can be tuned by varying the species and amount of the acceptor mols. using this postfunctionalization method. © 2010 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2010.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C12H14S, Safety of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Derrien, Daniele published the artcileMuramyl dipeptide bound to poly-L-lysine substituted with mannose and gluconoyl residues as macrophage activators, SDS of cas: 96345-79-8, the publication is Glycoconjugate Journal (1989), 6(2), 241-55, database is CAplus and MEDLINE.

Poly(L-lysine) modified with mannose derivatives, the residual cationic charges of which being neutralized by N-acylation, were synthesized and used as carriers of a macrophage activator (N-acetylmuramyl dipeptide, MDP). The effect of the acylating agent on the targeting efficiency was investigated: a hydrosolubilizing group such as a gluconoyl moiety led to very efficient carrier conjugates, while an acetyl group did not. The effect of sugar and acyl content of the polymers was assessed using these compounds as inhibitors of red blood cell agglutination by Con A. The binding and specific endocytosis of poly(L-lysine) substituted with several mannose derivatives and gluconoyl residues (GlcA_x-, Man_y-PLK) were determined by a quant. flow cytometry anal. MDP bound to these conjugates was much more efficient in vitro than free MDP in macrophage cytostasis assays.

Glycoconjugate Journal published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, SDS of cas: 96345-79-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Olechowska, Karolina published the artcileThe effect of selected bisphenols on model erythrocyte membranes of different cholesterol content, Category: alcohols-buliding-blocks, the publication is Chemistry and Physics of Lipids (2022), 105224, database is CAplus and MEDLINE.

Bisphenols belong to the group of environmental pollutants with proven harmful impact on human red blood cells. However, the exact effect of these substances may vary depending on the lipid composition of the cell membrane, since this structure is the first barrier between the cell interior and the external environment. The aim of this work was to analyze the influence of bisphenol A (BPA), bisphenol S (BPS) and their 1:1 mixture on model human erythrocyte membranes, composed of sphingomyelin (SM), phospatidylcholine (PC) and cholesterol (Chol). Due to the postulated correlation between the content of cholesterol in biomembranes and the toxic effect of bisphenols the model systems of different sterol concentrations (10, 20 and 40 mol% of Chol) were used in the studies. In the experiments, Langmuir monolayer technique accompanied with Brewster Angle Microscopy were applied and liposome properties were investigated. The obtained findings reveal that, in the investigated range of the sterol content, the effect of BPA, namely the changes of the organization and stability of model membranes and weakening of the attractive lipid-lipid interactions, is strongly dependent on the concentration of Chol in the system. The higher the sterol content, the stronger the BPA-induced alterations in membrane properties. However taking into account the results reported previously for the system containing 33.3% of cholesterol, it seems that the relationship between the effect of BPA and the amount of Chol is not linear for higher sterol concentrations In contrast, BPS shows a much weaker influence on model erythrocyte membranes and does not act selectively on the systems studied. The effect of a mixture of BPA and BPS is intermediate between that of BPA and BPS used sep., however, the observed effects appear to be determined only by the presence of BPA in the system. Thus, the concentration of cholesterol in human erythrocyte membranes, which depends on factors such as age or health status, may play a key role in the toxic effects of BPA but not BPS.

Chemistry and Physics of Lipids published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Landge, Vinod G. published the artcilePalladium-Catalyzed Regioselective Arylation of Unprotected Allylamines, Recommanded Product: 2-Aminobutan-1-ol, the publication is JACS Au (2021), 1(1), 13-22, database is CAplus and MEDLINE.

A simple protocol for the arylation of cinnamylamines and the diarylation of terminal allylamines to generate a of 3,3-diarylallylamine products using a Pd^II precatalyst was described. Key features of the method were the ability to access relatively mild conditions that facilitate a broad substrate scope as well as direct diarylation of terminal allylamine substrates. In addition, several complex and therapeutically relevant mols. were included to demonstrate the utility of the transformation.

JACS Au published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fent, Kenneth W. published the artcileFirefighters′ urinary concentrations of VOC metabolites after controlled-residential and training fire responses, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is International Journal of Hygiene and Environmental Health (2022), 113969, database is CAplus and MEDLINE.

Firefighters are exposed to volatile organic compounds (VOCs) during structural fire responses and training fires, several of which (e.g., benzene, acrolein, styrene) are known or probable carcinogens. Exposure studies have found that firefighters can absorb chems. like benzene even when self-contained breathing apparatus (SCBA) are worn, suggesting that dermal absorption contributes to potentially harmful exposures. However, few studies have characterized VOC metabolites in urine from firefighters. We quantified VOC metabolites in firefighters urine following live firefighting activity across two field studies. In two sep. controlled field studies, spot urine was collected before and 3 h after firefighters and firefighter students responded to simulated residential and training fires. Urine was also collected from instructors from the training fire study before the first and 3 h after the last training scenario for each day (instructors led three training scenarios per day). Samples were analyzed for metabolites of VOCs to which firefighters may be exposed. In the residential fire study, urinary metabolites of xylenes (2MHA), toluene (BzMA), and styrene (MADA) increased significantly (at 0.05 level) from pre- to post-fire. In the training fire study, MADA concentrations increased significantly from pre- to post-fire for both firefighter students and instructors. Urinary concentrations of benzene metabolites (MUCA and PhMA) increased significantly from pre- to post-fire for instructors, while metabolites of xylenes (3MHA+4MHA) and acrolein (3HPMA) increased significantly for firefighter students. The two highest MUCA concentrations measured post-shift from instructors exceeded the BEI of 500 μg/g creatinine. Some of the metabolites that were significantly elevated post-fire are known or probable human carcinogens (benzene, styrene, acrolein); thus, exposure to these compounds should be eliminated or reduced as much as possible through the hierarchy of controls. Given stringent use of SCBA, it appears that dermal exposure contributes in part to the levels measured here.

International Journal of Hygiene and Environmental Health published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Palomino-Schatzlein, Martina published the artcileCombining metabolic profiling of plasma and faeces as a fingerprint of insulin resistance in obesity, Safety of 3-Hydroxyphenylacetic acid, the publication is Clinical Nutrition (2020), 39(7), 2292-2300, database is CAplus and MEDLINE.

Insulin resistance (IR) is one of the main risk factor for type 2 diabetes mellitus (T2DM). Nevertheless, its underlying pathophysiol. is not completely established because IR is triggered by a complex interconnection of numerous factors impairing metabolism, promoting metabolome changes. We used a metabolomics approach to identify plasma and faecal metabolites related to IR and obesity. We explored a cohort of 44 subjects at baseline, with 30 of them followed two years thereafter in a longitudinal study after an hypocaloric diet in the obese subjects. In all individuals as a whole, 11 plasma metabolites pos. associated with BMI (acetoacetate, creatinine, glycerol, glycerol of lipids, VLDL, fatty esters, myo-inositol, phenylalanine, threonine, tyrosine and valine) and one neg. (phosphocholine), with similar associations at baseline and follow-up. Four of these metabolites (myo-inositol, valine, acetoacetate and phosphocholine) remained significant within obese and non-obese groups. Thirteen faecal metabolites pos. associated with BMI at baseline and one neg. (glutamine). However, these correlations did not remain significant at follow-up. The correlations were not always consistent at baseline and at follow-up and the metabolites that showed significant correlations were different for the obese group compared with the control group. The percent change in plasma Δethanolamine, Δglucose, Δuracil and Δhypoxanthine were pos. associated with ΔBMI. The percent change in plasma Δphosphocholine and of faecal Δhydroxyphenylacetate, and Δ2-hydroxyphenylacetate were associated with ΔHOMA-IR in those patients that lost weight Faecal branched chain amino acids (BCAAs) in faeces were associated with IR, following a similar pattern to that described for plasma BCAAs. Choline derivates had an opposite behavior. The integration of plasma and faecal metabolites represents a valuable fingerprint that could help in the identification of patients at risk for IR and in the design of novel therapeutic strategies to prevent IR and the development of overt T2DM in the context of obesity. The results are coherent with diet having a much greater impact on faecal metabolomic profile than on plasma metabolome.

Clinical Nutrition published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Safety of 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Danielski, Renan published the artcileA non-conventional approach for obtaining phenolic antioxidants from red guava (Psidium guajava L.) by-products, Related Products of alcohols-buliding-blocks, the publication is Journal of Food Processing and Preservation (2022), 46(6), e16502, database is CAplus.

The recovery of phenolic antioxidants from agro-industrial byproducts using non-conventional techniques is a powerful tool to explore the bioactive potential of natural sources. Therefore, it is imperative to analyze the most suitable method to investigate a plant material’s phenolic composition This study used ultra-turrax (UTE), ultrasonic bath (BUAE), and pressurized liquid (PLE) for soluble phenolic extraction from guava’s pulp and processing waste. UTE at 25°C for 1 h yielded the highest concentration of total phenolics and flavonoids from guava pulp, while PLE for 30 min at 60°C/10 MPa presented the best performance for flavonoids and condensed tannins recovery from guava waste. PLE produced extracts with 39 phenolics and high antioxidant capacity. Besides, scopoletin, resveratrol, and naringin are being reported for the first time in this fruit. These results suggest possible alternatives for the recovery of bioactive compound, which may be used to develop nutraceuticals and/or functional foods. Practical applications : Upon guava processing, 30% of fruit’s total volume is lost in the form of byproducts (seeds, peels, and pulp leftovers). Evidence points out that this fraction, along with guava’s pulp, is rich in phenolics with antioxidant properties. An extraction procedure should be conducted to recover these compounds However, conventional techniques are laborious, time-consuming, and they generally use a large amount of toxic organic solvent. Ultra-turrax-UTE, ultrasonic bath-BUAE, and pressurized liquid-PLE are non-conventional approaches that make possible the reduction of solvents and the recovery of selected phenolics not possible with conventional techniques. These extracts could be further applied to lipid-rich foods as a natural antioxidant system and/or as an ingredient in the development of nutraceuticals and functional foods.

Journal of Food Processing and Preservation published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Torres, Talyta Mayara Silva published the artcilePhenolic compounds recovered from ora-pro-nobis leaves by microwave assisted extraction, Application of 2-Hydroxy-2-phenylacetic acid, the publication is Biocatalysis and Agricultural Biotechnology (2022), 102238, database is CAplus.

Ora-pro-nobis is an ornamental plant, often used as food in some regions of Brazil, and Pereskia grandifolia is one of the less explored specie of this nutritional plant. To understand the antioxidant potential and phenolic profile of ora-pro-nobis leaves, the micro-wave assisted extraction (MAE) was held using the green solvents ethanol and water. An optimization was made using Box-Behnken exptl. design (32), with process time, temperature and solvent (% of water/ethanol) as variables. The evaluated responses were the process yield, combined with antioxidant capacity (DPPH, ABTS and FRAP methods) and total phenolic content (TPC) of the recovered extracts Soxhlet method with ethanol was performed for comparison purpose. The phenolic profile of extract samples was assessed by LC-ESI-MS/MS anal. High yield values were provided by 50% ethanol as solvent at 150°C. Best antioxidant potential from DPPH and FRAP methods were provided by ethanolic extracts at 110°C, while water extracts at 150°C provided best ABTS results. High TPC recovery was found in 50% ethanol samples at 70°C. Overall, 24 phenolic compounds were identified, within caffeic acid, ellagic acid, p-anisic acid, p-coumaric acid kaempferol and quercetin as the main components. Ellagic acid and p-anisic acid were firstly reported associated to ora-pro-nobis leaves. The optimization of the results indicates that 150°C, 12.5 min of MAE and ethanol as solvent provided the best combined responses. The use of MAE for ora-pro-nobis leaves is a novelty that must be followed to explore green methods to value natural products.

Biocatalysis and Agricultural Biotechnology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C18H34N4O5S, Application of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

McAfee, Seth M. published the artcileUtility of a heterogeneous palladium catalyst for the synthesis of a molecular semiconductor via Stille, Suzuki, and direct heteroarylation cross-coupling reactions, Synthetic Route of 239075-02-6, the publication is RSC Advances (2015), 5(33), 26097-26106, database is CAplus.

The com. available silica-supported heterogeneous catalyst SiliaCat DPP-Pd has proven to be highly active, robust, and reusable for the synthesis of a thiophene-phthalimide-based mol. semiconductor under microwave-irradiation reaction conditions. A Stille reaction protocol demonstrated that SiliaCat DPP-Pd outperformed well-known homogeneous catalysts, Pd(PPh₃)₄ and Pd(PPh₃)₂Cl₂, in terms of performance and catalyst loading, while also exhibiting tolerance to ambient reaction conditions and two-fold recyclability for the formation of product. The success established for SiliaCat DPP-Pd catalyzed Stille reactions via microwave irradiation was extended to optimize Suzuki coupling and direct heteroarylation protocols. Notably, direct heteroarylation with SiliaCat DPP-Pd exhibited excellent selectivity and perturbed the formation of homo-coupled aryl bromides, two side reactions that are known to plague this type of cross-coupling reaction.

RSC Advances published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Synthetic Route of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts