Category: alcohols-buliding-blocks

Nelson, Jade D. published the artcilePhoto-induced ring expansion of 1-triisopropylsilyloxy-1-azidocyclohexane: preparation of ε-caprolactam, Recommanded Product: Triisopropylsilanol, the publication is Organic Syntheses (2003), 165-175, database is CAplus.

The synthesis of lactams has attracted considerable attention in recent years. Despite the wide range of methodologies that have been examined for the synthesis of lactams, the Beckmann and Schmidt rearrangements still remain by far the most convenient and general methods. The strongly acidic conditions required for the Schmidt rearrangement often lead to undesired byproducts. This is a major limitation particularly with acid-labile substrates. A convenient and environmentally benign Schmidt rearrangement is reported in which the azidohydrin is prepared using a recyclable acid catalyst and trimethylsilyl azide. Photolysis of the azidocyclohexane results in the ring expansion, probably through the formation of a reactive nitrene. The byproducts from this reaction are gases or innocuous silanes. The main limitation with the method is that at present the ring expansion is not regioselective.

Organic Syntheses published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Recommanded Product: Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kovacic, Ana published the artcileDegradation of bisphenol A and S in wastewater during cold atmospheric pressure plasma treatment, Application In Synthesis of 80-09-1, the publication is Science of the Total Environment (2022), 155707, database is CAplus and MEDLINE.

Developing novel, fast and efficient ecol. benign processes for removing organic contaminants is important for the continued development of water treatment. For this reason, this study investigates the implementation of Cold Atm. pressure Plasma (CAP) generated in ambient air as an efficient tool for the removal of Bisphenol A (BPA) and Bisphenol S (BPS)-known endocrine disrupting compounds in water and wastewater, by monitoring degradation kinetics and its transformation products. The highest removal efficiencies of BPA (>98%) and BPS (>70%) were obtained after 480 s of CAP exposure. A pseudo-first-order kinetic revealed that BPA (-k_t = 4.4 – 9.0 ms^-1) degrades faster than BPS (-k_t = 0.4 – 2.4 ms^-1) and that the degradation is also time- and CAP power-dependent, while the initial concentration or matrix type had a negligible effect. This study also tentatively identified three previously reported and one novel transformation product of BPA and four novel transformation products of BPS. Their postulated structures suggested similar breakdown mechanisms, i.e., hydroxylation followed by ring cleavage. The results demonstrate that CAP technol. is an effective process for the degradation of both BPA and BPS without the need for addnl. chems., indicating that CAP is a promising technol. for water and wastewater remediation worthy of further investigation and optimization.

Science of the Total Environment published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Application In Synthesis of 80-09-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khajavi-Shojaei, Shila published the artcileBiodegradation and phytotoxicity assessment of phenanthrene by biosurfactant-producing Bacillus pumilus 1529 bacteria, Product Details of C11H8O3, the publication is Chemistry and Ecology (2020), 36(5), 396-409, database is CAplus.

Phenanthrene is a toxic and mutagenic pollutant that can cause severe environmental and human health issues. The bioremediation of these polyaromatic hydrocarbons (PAHs) is possible with a biosurfactant by enhancing hydrophobicity. In this study, the production of a biosurfactant by Bacillus pumilus 1529 and its effects on the phenanthrene biodegradation pathway were examined Biosurfactant production was determined using hemolytic activity, emulsification index, and surface tension. For phenanthrene metabolite detection, samples at 0, 7, 14, and 21 incubation days were analyzed by gas chromatog.-mass (GC-mass) spectrometry. The results showed that Bacillus pumilus 1529 can reduce surface tension to 22.83 ± 1.1 mN m-1. Furthermore, the GC-mass spectrometry anal. showed that 1-hydroxy-2-naphthoic acid, benzaldehyde, o-phthalic acid, and phenylacetic acid were notable phenanthrene metabolites produced during phenanthrene biodegradation Biodegraded phenanthrene and its metabolites have a less toxic effect on the germination of safflower seeds than non-biodegraded phenanthrene. The IC50 of phenanthrene on seed germination after biodegradation was increased to approx. 113 mg L-1. In general, biodegradation aided by biosurfactant producing bacteria contributed to turning the toxic phenanthrene into less harmful metabolites with lower phytotoxicity effects, indicating that its application in the bioremediation of PAHs is promising.

Chemistry and Ecology published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Product Details of C11H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Prasad, Durga published the artcileR-VAPOL-phosphoric acid based ¹H and ¹³C-NMR for sensing of chiral amines and acids, SDS of cas: 96-20-8, the publication is RSC Advances (2020), 10(4), 2303-2312, database is CAplus and MEDLINE.

Enantiomers have significant importance in pharmaceuticals, biol. and modern chem. and therefore distinguishing and quantifying the enantiomeric forms is of utmost importance. Herein, we propose diphenyl-3,3′-biphenanthryl-4,4′-diyl phosphate (R-VAPOL-PA) as a promising chiral solvating agent to discriminate amines and acids of poly-functional groups such as chiral amines, amino alcs. and hydroxy acids. The methodol. approach involves using the nature of hydrogen bonds and ion pairs as a mode of weak interactions to form diastereomers where the probe is associated with enantiomers. The resulting diastereomer difference in the NMR spectrum enables the chiral discrimination with a complete baseline peak separation and an accurate enantiomeric excess (ee) anal. We also carried out d. functional theory (DFT) calculations to understand the complex formation to explain enantiodiscrimination by analyzing the formation and stability of different chiral complexes. The binding energy differences between enantiomeric forms revealed by DFT calculations are qual. in agreement with the diastereomer difference in the NMR spectrum and unequivocally establishes the suggested exptl. protocol of R-VAPOL-PA-based enantiomeric discrimination.

RSC Advances published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, SDS of cas: 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ferreira Azevedo, L. published the artcileThe alternative analog plasticizer BPS displays similar phenotypic and metabolomic responses to BPA in HepG2 and INS-1E cells, COA of Formula: C12H10O4S, the publication is Food and Chemical Toxicology (2022), 167(Suppl._1), 113266, database is CAplus and MEDLINE.

Bisphenols A (BPA) and S (BPS) are endocrine-disrupting chems. that affect energy metabolism, leading to impairment of glucose and lipid homeostasis. We aimed at identifying metabolic pathways regulated by both compounds in human liver cells and rat pancreatic β-cells that could impair energy homeostasis regulation. We assessed the effects on growth, proliferation, and viability of hepatocarcinoma (HepG2) and insulinoma (INS-1E) cells exposed to either BPA or BPS in a full range concentration between 0.001 and 100μM. Both the dose and duration of exposure caused a differential response on growth and viability of both cells. Effects were more pronounced on HepG2, as these cells exhibited non-linear dose-responses following exposure to xenobiotics. For INS-1E, effect was observed only at the highest concentration In addition, we profiled their intracellular state by untargeted metabolomics at 24, 48, and 72 h of exposure. This anal. revealed time- and dose-dependently mol. changes for HepG2 and INS-1E that were similar between BPA and BPS. Both increased levels of inflammatory mediators, such as metabolites pertaining to linolenic and linoleic acid metabolic pathway. In summary, this study shows that BPS also disrupts mol. functions in cells that regulate energy homeostasis, displaying similar but less pronounced responses than BPA.

Food and Chemical Toxicology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, COA of Formula: C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kinosita, Yoshiaki published the artcileMotile ghosts of the halophilic archaeon, Haloferax volcanii, Application of Triisopropanolamine, the publication is Proceedings of the National Academy of Sciences of the United States of America (2020), 117(43), 26766-26772, database is CAplus and MEDLINE.

Archaea swim using the archaellum (archaeal flagellum), a reversible rotary motor consisting of a torque-generating motor and a helical filament, which acts as a propeller. Unlike the bacterial flagellar motor (BFM), ATP (adenosine-5a²-triphosphate) hydrolysis probably drives both motor rotation and filamentous assembly in the archaellum. However, direct evidence is still lacking due to the lack of a versatile model system. Here, we present a membrane-permeabilized ghost system that enables the manipulation of intracellular contents, analogous to the triton model in eukaryotic flagella and gliding Mycoplasma. We observed high nucleotide selectivity for ATP driving motor rotation, neg. cooperativity in ATP hydrolysis, and the energetic requirement for at least 12 ATP mols. to be hydrolyzed per revolution of the motor. The response regulator CheY increased motor switching from counterclockwise (CCW) to clockwise (CW) rotation. Finally, we constructed the torque-speed curve at various [ATP]s and discuss rotary models in which the archaellum has characteristics of both the BFM and F1-ATPase. Because archaea share similar cell division and chemotaxis machinery with other domains of life, our ghost model will be an important tool for the exploration of the universality, diversity, and evolution of biomol. machinery.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application of Triisopropanolamine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Marinov, B published the artcile[Some possibilities for application of “Pfizer” medicines–Prostin 15m, Prostin E2, Prepidil gel, Dostinex, Synarel–in the obstetrician practice]., Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Akusherstvo i ginekologiia (2007), 57-60, database is MEDLINE.

The authors make a clinical and pharmacological overview of the possibilities of application in the obstetrician practice of part of the medicines of the company Pfiser. Some of these medicines have no analogue in Bulgaria–i.e. Prostin 15M. The authors outline the advantages of the Pfiser medicines in comparison with other medicines with similar action.

Akusherstvo i ginekologiia published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C25H47NO8, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Skorenski, Marcin published the artcilePhosphonate inhibitors of West Nile virus NS2B/NS3 protease, Application of 4,4-Diethoxybutan-1-amine, the publication is Journal of Enzyme Inhibition and Medicinal Chemistry (2019), 34(1), 8-14, database is CAplus and MEDLINE.

West Nile virus (WNV) is a member of the flavivirus genus belonging to the Flaviviridae family. The viral serine protease NS2B/NS3 has been considered an attractive target for the development of anti-WNV agents. Although several NS2B/NS3 protease inhibitors have been described so far, most of them are reversible inhibitors. Herein, we present a series of α-aminoalkylphosphonate di-Ph esters and their peptidyl derivatives as potent inhibitors of the NS2B/NS3 protease. The most potent inhibitor identified was Cbz-Lys-Arg-(4-GuPhe)^P(OPh)₂ displaying K_i and k₂/K_i values of 0.4 μM and 28 265 M^-1s^-1, resp., with no significant inhibition of trypsin, cathepsin G, and HAT protease.

Journal of Enzyme Inhibition and Medicinal Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C15H14O3, Application of 4,4-Diethoxybutan-1-amine.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Startek, Justyna B. published the artcileThe agonist action of alkylphenols on TRPA1 relates to their effects on membrane lipid order: implications for TRPA1-mediated chemosensation, Application In Synthesis of 645-56-7, the publication is International Journal of Molecular Sciences (2021), 22(7), 3368, database is CAplus and MEDLINE.

The Transient Receptor Potential Ankyrin 1 cation channel (TRPA1) is a broadly-tuned chemosensor expressed in nociceptive neurons. Multiple TRPA1 agonists are chem. unrelated non-electrophilic compounds, for which the mechanisms of channel activation remain unknown. Here, we assess the hypothesis that such chems. activate TRPA1 by inducing mech. perturbations in the plasma membrane. We characterized the activation of mouse TRPA1 by non-electrophilic alkylphenols (APs) of different carbon chain lengths in the para position of the aromatic ring. Having discarded oxidative stress and the action of electrophilic mediators as activation mechanisms, we determined whether APs induce mech. perturbations in the plasma membrane using dyes whose fluorescence properties change upon alteration of the lipid environment. APs activated TRPA1, with potency increasing with their lipophilicity. APs increased the generalized polarization of Laurdan fluorescence and the anisotropy of the fluorescence of 1,6-diphenyl-1,3,5-hexatriene (DPH), also according to their lipophilicity. Thus, the potency of APs for TRPA1 activation is an increasing function of their ability to induce lipid order and membrane rigidity. These results support the hypothesis that TRPA1 senses non-electrophilic compounds by detecting the mech. alterations they produce in the plasma membrane. This may explain how structurally unrelated non-reactive compounds induce TRPA1 activation and support the role of TRPA1 as an unspecific sensor of potentially noxious compounds

International Journal of Molecular Sciences published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C34H33ClN6O7, Application In Synthesis of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jorge, Miguel published the artcileNew Force-Field for Organosilicon Molecules in the Liquid Phase, Recommanded Product: Triethylsilanol, the publication is ACS Physical Chemistry Au (2021), 1(1), 54-69, database is CAplus and MEDLINE.

In this paper, we present a new mol. model that can accurately predict thermodn. liquid state and phase-change properties for organosilicon mols. including several functional groups (alkylsilane, alkoxysilane, siloxane, and silanol). These mols. are of great importance in geol. processes, biol. systems, and material science, yet no force field currently exists that is widely applicable to organosilicates. The model is parametrized according to the recent Polarization-Consistent Approach (PolCA), which allows for polarization effects to be incorporated into a nonpolarizable model through post facto correction terms and is therefore consistent with previous parametrizations of the PolCA force field. Alkyl groups are described by the United-Atom approach, bond and angle parameters were taken from previous literature studies, dihedral parameters were fitted to new quantum chem. energy profiles, point charges were calculated from quantum chem. optimizations in a continuum solvent, and Lennard-Jones dispersion/repulsion parameters were fitted to match the d. and enthalpy of vaporization of a small number of selected compounds Extensive validation efforts were carried out, after careful collection and curation of exptl. data for organosilicates. Overall, the model performed quite well for the d., enthalpy of vaporization, dielec. constant, and self-diffusion coefficient, but it slightly overestimated the magnitude of self-solvation free energies. The modular and transferable nature of the PolCA force field allows for further extensions to other types of silicon-containing compounds

ACS Physical Chemistry Au published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts