Category: alcohols-buliding-blocks

Araki, Naohiro published the artcileScreening for androgen receptor activities in 253 industrial chemicals by in vitro reporter gene assays using AR-EcoScreen cells, Safety of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, the publication is Toxicology in Vitro (2005), 19(6), 831-842, database is CAplus and MEDLINE.

Recently, there has been great concern about the potential of industrial chems. to act as endocrine disrupters. In this report, we conducted a pilot study to validate the use of AR-EcoScreen cells for tier 1 screening of androgen receptor (AR) agonist and antagonist activities. From 253 test compounds, we identified two AR agonists and nine antagonists. The two agonists, 2-tert-butylanthraquinone and benzoanthrone, were relatively weak (10% maximal activation of the pos. control, 5α-dihydrotestosterone, at 2.54×10^-7 and 4.46×10^-6 M, resp.). The most potent antagonist was 3,3′-dichlorobenzidine dihydrochloride (IC₅₀ = 2.28×10^-7 M). The order of the anti-androgenic activities was 3,3′-dichlorobenzidine dihydrochloride > 4-diethylaminobenzaldehyde > 4,4′-[1-[4-[1-(4-hydroxyphenyl)-1-methylethyl]phenyl]ethylidene]bis[phenol] > 2,4,6-trichlorophenylhydrazine = 4-(phenylpropyl)pyridine > 2-hydroxy-4-methoxybenzophenone > 2,2-bis(4-cyanophenyl)propane > 4-methoxy-2-methyldiphenylamine = 2,4-diphenyl-4-methylpentene-1. These results suggest that AR-EcoScreen cell line has the potential to be used as a tool for the large scale tier 1 screening of chems. for androgen receptor agonist and antagonist activity.

Toxicology in Vitro published new progress about 903-19-5. 903-19-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol, and the molecular formula is C22H38O2, Safety of 2,5-Bis(2,4,4-trimethylpentan-2-yl)benzene-1,4-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ohnishi, Ryuhei published the artcileCationic Dirhodium Complexes Bridged by 2-Phosphinopyridines Having an Exquisitely Positioned Axial Shielding Group: A Molecular Design for Enhancing the Catalytic Activity of the Dirhodium Core, Formula: C9H12O, the publication is Organometallics (2021), 40(15), 2678-2690, database is CAplus.

This report describes a strategy to create highly electrophilic dirhodium catalysts. The electrophilicity of lantern-type dirhodium complexes is generally decreased by the coordination of a ligand to the axial site, which often causes a reduction in the catalytic activity. The authors designed and synthesized cationic dirhodium complexes bridged by 2-diarylphosphinopyridines having a bulky 2,4,6-triisopropylphenyl (Tip) group that can prevent the attack of external mols. to the closest axial site. Theor. calculations indicated that the Tip group weakly interacts with the axial site but hardly reduces the electrophilicity of the dirhodium core. The complexes served as excellent catalyst precursors for the dehydrogenative silylation of alcs. using hydrosilanes under mild conditions and a low metal loading, producing the silyl ethers in higher yields in comparison to conventional dirhodium complexes.

Organometallics published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Formula: C9H12O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ochiai, Hiroshi published the artcileOrally active PDE4 inhibitor with therapeutic potential, Application of 3,3,3-Trifluoropropan-1-ol, the publication is European Journal of Medicinal Chemistry (2004), 39(7), 555-571, database is CAplus and MEDLINE.

Based on the promising results obtained by the clin. trial of Ariflo (I), further optimization of the spatial arrangement of the three pharmacophores (the carboxylic acid moiety, nitrile moiety and 3-cyclopentyloxy-4-methoxyphenyl moiety) in the structure of I was attempted using a bicyclo[3 3 0]octane template with more stereochem. diversity than the cyclohexane template of I. Biol. evaluation of the decyanated analogs and further optimization of the cyclopentyloxy moiety of II (R = cyclopentyl; X = OH, NHOH) were also performed. Among the compounds tested, II [R = cyclopentyl; X = OH (III)], IV and II (X = OH, R = 2,3-dihydro-1H-indene-2-yl) were found to be orally active and were estimated to have therapeutic potential based on cross-species and same-species comparisons. The structure-activity relationships (SARs) of these compounds were investigated and pharmacokinetic data for III and IV (X = NHOH) were also obtained by single-dose studies in rats.

European Journal of Medicinal Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zheng, Yijun published the artcileOptical and redox properties of phenyl-capped cyclohexa[c]-oligothiophenes, Application In Synthesis of 239075-02-6, the publication is Synthetic Metals (2013), 1-9, database is CAplus.

A series of phenyl-capped cyclohexa[c]thiophene derivatives (nCHT-TEG, n = 2, 4, or 6) have been synthesized. NCHT-TEG are well-soluble in common organic solvents. The absorption spectra of neutral nCHT-TEG oligomers indicated a shorter effective conjugation length than conventional oligothiophenes based on the non-coplanarity of the thiophene rings. NCHT-TEG can be oxidized/reduced reversibly. The results of cyclic voltammetry and UV-Vis-NIR spectroscopy of the oxidized nCHT-TEG revealed that the effective conjugation length increases at the higher oxidation state. D. functional theory (DFT) calculations indicate that the quinoidal structure of the oxidized nCHT contributes to the improved effective conjugation length. NCHT-TEG radical cations and dications were characterized by ESR and NMR spectroscopies, resp. NMR results of nCHT-TEG dication revealed that 2CHT-TEG²⁺ have closed-shell bipolaron structure, while 4CHT-TEG²⁺ and 6CHT-TEG²⁺ are the mixture of closed-shell bipolaron and open-shell two-polaron structures.

Synthetic Metals published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C5H6BNO3, Application In Synthesis of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cherkasov, Rafael A. published the artcileThiophosphorylation of Pharmacophoric Phenols, Diols, and Triols, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol, the publication is Phosphorus, Sulfur and Silicon and the Related Elements (2013), 188(1-3), 24-26, database is CAplus.

Novel organyldithiophosphonic and bis(aryldithiophosphonic) acids were obtained by the reaction of 2,4-diorganyl 1,3,2,4-dithiadiphosphetane-2,4-disulfides with paracetamol, 4-(1H-pyrrol-1-yl)phenol, ethambutol dihydrochloride, vitamin B₆, and its acetonide derivatives

Phosphorus, Sulfur and Silicon and the Related Elements published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Recommanded Product: 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Qilei published the artcileCatalytic C(β)-O Bond Cleavage of Lignin in a One-Step Reaction Enabled by a Spin-Center Shift, Related Products of alcohols-buliding-blocks, the publication is ACS Catalysis (2021), 11(22), 14181-14187, database is CAplus.

A challenge to the utilization of lignin as a feedstock for aromatic fine chems. lies in selective cleavage of copious β-O-4 linkages. A photocatalytic strategy for the selective cleavage of the C(β)-O bonds of model substrates and natural lignin extracts is achieved by a redox-neutral, catalytic cycle that does not require stoichiometric reagents. Mechanistic studies reveal the generation of a thiyl radical, which is derived from a cystine-derived H-atom transfer catalyst, initiates a spin-center shift (SCS) that leads to C(β)-O bond cleavage. The SCS reactivity is reminiscent of the C(β)-O bond cleavage chem. that occurs in the active site of ribonucleotide reductase.

ACS Catalysis published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kuge, Souichi published the artcileIdentification of peptide fragments chemically cross-linked in cytochrome c oxidase from thermophilic Bacillus PS3, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, the publication is Biochemistry and Molecular Biology International (1996), 38(1), 181-188, database is CAplus and MEDLINE.

In order to study steric arrangement of subunits in cytochrome c oxidase isolated from thermophilic Bacillus PS3, we developed a simple procedure including chem. crosslinking, two consecutive runs of electrophoresis, proteolytic digestion, and peptide sequencing for simultaneous identification of two cross-linked fragments. By this procedure, the cytochrome c domain of subunit 2 was found cross-linked to the C-terminal region of subunit 1 including two hydrophobic transmembrane segments, suggesting that these two regions were located close each other. The present simple procedure might be applicable to proteins whose crystal structures are not revealed.

Biochemistry and Molecular Biology International published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Application of Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sutili, Felipe K. published the artcileLipase immobilized in microemulsion based organogels (MBGs) as an efficient catalyst for continuous-flow esterification of protected fructose, COA of Formula: C12H20O6, the publication is RSC Advances (2015), 5(47), 37287-37291, database is CAplus.

Sugar-based organogels are important esters for the cosmetic, food and pharmaceutical industries due to their intrinsic properties. Chem. routes to obtain these mols. suffer from low yields and undesirable side products. In this way, biocatalysis can be an interesting and efficient alternative, which meets the green chem. principles. Herein we report our results on the development of a continuous flow process for the production of sugar-based surfactants mediated by immobilized enzymes in microemulsion based organogels, leading to the desired product in high productivities (66.8 to 88.1 g of ester per h per g of lipase).

RSC Advances published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C17H19N3O7S, COA of Formula: C12H20O6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shon, Jong Cheol published the artcileThe impact of phenanthrene on membrane phospholipids and its biodegradation by Sphingopyxis soli, Related Products of alcohols-buliding-blocks, the publication is Ecotoxicology and Environmental Safety (2020), 110254, database is CAplus and MEDLINE.

The direct interactions of bacterial membranes and polycyclic aromatic hydrocarbons (PAHs) strongly influence the biol. processes, such as metabolic activity and uptake of substrates due to changes in membrane lipids. However, the elucidation of adaptation mechanisms as well as membrane phospholipid alterations in the presence of phenanthrene (PHE) from α-proteobacteria has not been fully explored. This study was conducted to define the degradation efficiency of PHE by Sphingopyxis soli strain KIT-001 in a newly isolated from Jeonju river sediments and to characterize lipid profiles in the presence of PHE in comparison to cells grown on glucose using quant. lipidomic anal. This strain was able to resp. utilize 1-hydroxy-2-naphthoic acid and salicylic acid as sole carbon source and approx. 90% of PHE (50 mg/L) was rapidly degraded via naphthalene route within 1 day incubation. In the cells grown on PHE, strain KIT-001 appeared to dynamically change profiles of metabolite and lipid in comparison to cells grown on glucose. The levels of primary metabolites, phosphatidylethanolamines (PE), and phosphatidic acids (PA) were significantly decreased, whereas the levels of phosphatidylcholines (PC) and phosphatidylglycerols (PG) were significantly increased. The adaptation mechanism of Sphingopyxis sp. regarded mainly the accumulation of bilayer forming lipids and anionic lipids to adapt more quickly under restricted nutrition and toxicity condition. Hence, these findings are conceivable that strain KIT-001 has a good adaptive ability and biodegradation for PHE through the alteration of phospholipids, and will be helpful for applications for effective bioremediation of PAHs-contaminated sites.

Ecotoxicology and Environmental Safety published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C2H8Cl2N4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Drouet, Fleur published the artcileA Convenient Method for the Asymmetric Synthesis of Fluorinated α-Amino Acids from Alcohols, Synthetic Route of 2240-88-2, the publication is European Journal of Organic Chemistry (2014), 2014(6), 1195-1201, database is CAplus.

Due to their numerous applications, fluorinated amino acids have recently attracted significant attention. The preparation of fluorine-containing phenylalanines and aliphatic fluorinated amino acids using Mitsunobu-Tsunoda alkylation of a chiral nucleophilic glycine equivalent with readily available alc. substrates is described. The reaction proceeds in high yields and with excellent diastereoselectivity. This method provides an efficient synthetic route to fluorinated amino acids for which asym. approaches are scarce.

European Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Synthetic Route of 2240-88-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts