Category: alcohols-buliding-blocks

Rodriguez-Alba, Efrain published the artcileSynthesis, characterization and optical properties of novel oligothiophenes bearing pyrene units attached via well defined oligo(ethylene glycol) spacers, Quality Control of 239075-02-6, the publication is Synthetic Metals (2015), 92-105, database is CAplus.

Two new thiophene monomers bearing pyrene units attached via di(ethylene glycol) and tetra(ethylene glycol) spacers were synthesized, 3-methyl-4-(diethoxy) thiophene (M2) and 3-methyl-4-(tetraethoxy) thiophene (M4). These monomers were linked to thiophene and bithiophene via a Suzuki coupling reaction to give the corresponding terthiophenes and quaterthiophenes: [3,3-(di (diethoxypyrene)), 4,4”’dimethyl-2,2: 5#14-15#-terthiophene (TT2)], [3,3-(di(tetraethoxypyrene)), 4,4”’dimethyl-2,2:5#14-15#-terthiophene (TT4)], [3,3”’-di(diethoxypyrene), 4,4”’methyl-2,2′:5′: 2”:5”,2”’-quaterthiophene (QT2)], and [3,3”’-di(tetraethoxypyrene), 4,4”’methyl -2,2′:5′:2”:5”,2”’-quaterthiophene (QT4)]. The obtained oligothiophenes were characterized by ¹H, ¹³C NMR spectroscopies and MALDI-TOF mass spectrometry. The optical properties of these compounds were studied by absorption and fluorescence spectroscopy. The absorption spectra of these compounds exhibited a broad absorption band at λ_max = 350 nm arising from the S₀ → S₂ transition of the pyrene group. This broadening is an indication of the presence of pyrene-pyrene interactions in the ground state. A discrete band at ca λ = 385 due to the S₀ → S₁ transition (n-π*) of the oligothiophene backbone was also observed The emission spectra of oligomers TT2, TT4, QT2 and QT4 showed a “monomer emission” band at λ_M = 379-450 nm followed by an intense excimer emission band at λ_E = 570 nm due to intramol. pyrene-pyrene interactions. The effect of the flexible spacer length and that of the oligomer backbone influences significantly the formation of pyrene-pyrene complexes.

Synthetic Metals published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rodriguez-Alba, Efrain published the artcileDesign of novel well-defined oligothiophenes bearing donor-acceptor groups (pyrene-porphyrin): Synthesis, characterization, optical properties and energy transfer, Quality Control of 239075-02-6, the publication is Journal of Molecular Structure (2019), 28-36, database is CAplus.

Novel thiophene monomers containing porphyrin units attached via di(ethylene glycol) and tetra(ethylene glycol) spacers were synthesized: 3-methyl-4-(4-(1-(5-phenyl-10,15,20-triphenylporphyrin)) diethoxy) thiophene (M2PPh) and 3-methyl-4-(4-(1-(5-phenyl-10,15,20-triphenylporphyrin)) tetraethoxy) thiophene (M4PPh). These monomers and other co-monomers with pyrene units 3-methyl-4-(diethoxy) thiophene (M2) and 3-methyl-4-(tetraethoxy) thiophene (M4) previously reported by us, were linked to thiophene and bithiophene via a Suzuki coupling reaction to give the corresponding terthiophenes and quaterthiophenes: [3-diethoxypyrene, 3-diethoxyporphyrin, 4,4”’ di-Me – 2,2:5’2″- terthiophene (TT2PY-PPh)], [3-tetraethoxypyrene, 3-tetraethoxyporphyrin, 4, 4”’dimethyl-2,2:5’2″-terthiophene (TT4PY-PPh)], [3′-diethoxypyrene, 3′-diethoxyporphyrin, 4,4”’methyl-2,2′:5′:2”:5”,2”’-quaterthiophene (QT2PY-PPh)], and [3′-tetraethoxypyrene, 3′-tetraethoxyporphyrin,4,4”’methyl-2,2′:5′:2”:5”,2”’-quaterthiophene (QT4PY-PPh)]. The synthesized compounds were characterized by ¹H NMR, ¹³C NMR and MALDI-TOF mass spectrometry; their optical properties were studied by absorption and fluorescence spectroscopy. The emission spectra of the oligothiophenes bearing pyrene-porphyrin units showed a significant decrease in the pyrene monomer emission and the appearance of a new emission band at 650 nm, arising from the porphyrin, which revealed that a FRET phenomenon is occurring from the excited pyrene to the porphyrin. The obtained FRET efficiencies were between 93 and 98% depending on the oligomer structure.

Journal of Molecular Structure published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Quality Control of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Katane, Masumi published the artcileIdentification of Novel d-Amino Acid Oxidase Inhibitors by in Silico Screening and Their Functional Characterization in Vitro, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Journal of Medicinal Chemistry (2013), 56(5), 1894-1907, database is CAplus and MEDLINE.

D-Amino acid oxidase (DAO) is a degradative enzyme that is stereospecific for d-amino acids, including d-serine and d-alanine, which are potential coagonists of the N-methyl-d-aspartate (NMDA) receptor. Dysfunction of NMDA receptor-mediated neurotransmission has been implicated in the onset of various mental disorders such as schizophrenia. Hence, a DAO inhibitor that augments the brain levels of d-serine and/or d-alanine and thereby activates NMDA receptor function is expected to be an antipsychotic drug, for instance, in the treatment of schizophrenia. In the search for potent DAO inhibitor(s), a large number of compounds were screened in silico, and several compounds were estimated as candidates. These compounds were then characterized and evaluated as novel DAO inhibitors in vitro. The results reported in this study indicate that some of these compounds are possible lead compounds for the development of a clin. useful DAO inhibitor and have the potential to serve as active site probes to elucidate the structure-function relationships of DAO.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Michinobu, Tsuyoshi published the artcileSynthesis and properties of 1,8-carbazole-based conjugated copolymers, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Polymers (Basel, Switzerland) (2010), 2(3), 159-173, database is CAplus.

A new series of conjugated carbazole polymers based on the 1,8-carbazolylene unit was synthesized by the Pd-catalyzed polycondensation between the 1,8-diiodocarbazole derivative and various bifunctional counter comonomers. An alkyne spacer was found to be a key to increasing the mol. weight of the resulting polymers. All the obtained polymers showed good solubilities in the common organic solvents, and they were fully characterized by Gel permeation chromatog. (GPC), and ¹H NMR and IR spectroscopies. The UV-vis absorption and fluorescence spectra revealed the relationship between the chem. structure and effective conjugation length. The efficiency order of the carbazole connectivity was 2,7-carbazolylene > 1,8-carbazolylene > 3,6-carbazolylene. The electrochem. properties of these polymers suggested the relatively facile oxidation at ca. +0.5-0.7 V vs. Fc/Fc⁺ or a high potential as p-type semiconductors. The combination of the electrochem. oxidation potentials and the optical band gaps allowed us to estimate the HOMO and LUMO levels of the polymers. It was shown that the energy levels of the 1,8-carbazole-based conjugated polymers can be tunable by selecting the appropriate comonomer structures.

Polymers (Basel, Switzerland) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Name: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kobenan, Koffi Christophe published the artcileChemical Composition, Antioxidant Activity, Cholinesterase Inhibitor and in Vitro Insecticidal Potentiality of Essential Oils of Lippia multiflora Moldenke and Eucalyptus globulus Labill. on the Main Carpophagous Pests of Cotton Plant in Ivory Coast, Application In Synthesis of 106-25-2, the publication is Chemistry & Biodiversity (2022), 19(4), e202100993, database is CAplus and MEDLINE.

The abusive and repeated use of synthetic chem. insecticides has proven to be harmful to human health and the viability of the cotton production system in Ivory Coast, so it is imperative to find alternatives. . Thus, the objective of this study was to study the chem. composition and biol. activity of essential oils of Lippia multiflora (Verbenaceae) and Eucalyptus globulus (Myrtaceae) and to evaluate their insecticidal potential in the laboratory on three main pests of cotton. After essential oils extraction, their chem. composition was determined Also, antioxidant activity and cholinesterase inhibitor of essential oils were evaluated. After that, different concentrations of the two essential oils were prepared and applied by contact on groups of insects constituted by ten. The essential oil of L. multiflora was the most toxic for the three pests tested. Indeed, the lethal concentrations (LC50) were 1.74 %, 1.39 and 7.20 %, resp., on Pectinophora gossypiella, Thaumatotibia leucotreta and Helicoverpa armigera. In contrast, the values obtained with E. globulus essential oil were nine to two times greater (16.05 %, 10.23 % and 16.32 %, resp. on these pests). With respect to the chem. composition of the essential oils, E. globulus essential oil was the richest in oxygenated monoterpenes (65 %) with 1,8-cineole or eucalyptol as the majority compound (61.6 %). The essential oil of L. multiflora was distinguished by a lower proportion of oxygenated monoterpenes (44.3 %), but it contained more terpene elements (24 vs. 15 for the essential oil of E. globulus). The essential oils of L. multiflora and E. globulus also showed significant inhibition of acetyl (2.13 and 2.16 mg galantamine equivalent (GALAE)/g, resp.) and butyryl cholinesterase (4.03 and 3.61 mg GALAE, resp.). L. multiflora was differentiated by its good inactivation of tyrosinases (163.46 vs. 58.95 mg kojic acid equivalent (KAE)/g in E. globulus). Better antioxidant activity was observed with L. multiflora essential oil relative to DPPH (7.05±0.34 mg trolox equivalent (TE)/g). Biopesticides based on L. multiflora essential oil could be developed for the phytosanitary protection of cotton plant.

Chemistry & Biodiversity published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C10H18O, Application In Synthesis of 106-25-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ishidate, Motoi Jr. published the artcileChromosome tests with 134 compounds on Chinese hamster cells in vitro – a screening for chemical carcinogens, Formula: C8H19NO, the publication is Mutation Research, Genetic Toxicology Testing (1977), 48(3-4), 337-53, database is CAplus.

Chromosomal aberration tests in vitro were carried out on Chinese hamster cells grown in culture with various chems., including carcinogenic N-nitroso compounds and their related derivatives, food additives, medical drugs, pesticides and other chems. commonly used in laboratories or industries. Of the 134 chems. tested, 63 gave neg. results in the test system even with doses at which the cell growth was markedly inhibited. Nearly all compounds known to be mutagenic in bacteria were also pos. in this system. Both urethane [51-79-6] and diethylstilbestrol [56-53-1] were pos., even though they are known to be carcinoenic but not mutagenic in bacteria. Compounds such as N-alkyl-N’-nitrogunidines, barbital [57-44-3], Na benzoate [532-32-1], saccharin sodium [128-44-9], NaNO2, NaNO3, and 4-aminoquinoline-1-oxide [2508-86-3] were pos. in the chromosome tests, but they have not been conclusively tested for their carcinogenicity.

Mutation Research, Genetic Toxicology Testing published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, Formula: C8H19NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Okunlola, Adenike published the artcileMicrosphere formulations of ambroxol hydrochloride: influence of Okra (Abelmoschus esculentus) mucilage as a sustained release polymer, SDS of cas: 23828-92-4, the publication is Progress in Biomaterials (2020), 9(1-2), 65-80, database is CAplus and MEDLINE.

Ambroxol hydrochloride (AH), a secretion-releasing expectorant, is a good candidate for sustained delivery. Mucilages are biodegradable, inexpensive carriers in microsphere formulations. The study aimed to prepare microspheres of AH using Okra mucilage obtained from pods of Abelmoschus esculentus combined with sodium alginate at various polymer/drug ratios. Okra mucilage was characterized for morphol., swelling, viscosity and flow properties. AH microspheres were prepared by ionic emulsification method and characterized using size, entrapment efficiency, swelling index and dissolution time (t₅₀). A full 2 by 3 factorial exptl. design using three factors (Okra mucilage/alginate ratio X₁; drug/polymer ratio X₂; and polymer concentration X₃), each at two levels, was used to determine the effects of formulation variables on the responses. Optimized formulations of AH microspheres had sizes ranging from 250.91 ± 16.22 to 462.10 ± 23.85μm; swelling index 1.35 ± 0.05 and 3.20 ± 0.03 and entrapment 55.70 ± 3.55-94.11 ± 4.50%. The microspheres exhibited sustained release of AH over a prolonged period as revealed by the dissolution time (t₅₀) 2.85 ± 1.03-7.50 ± 0.96 h. Drug release kinetics generally followed zero order, implying that the process is constant and independent of the initial concentration of drug. Polymer concentration had the highest influence on microsphere size, entrapment efficiency and dissolution time while Okra/alginate ratio had the highest influence on swelling. Okra mucilage was a suitable polymer that could serve as an alternative to synthetic polymers in sustaining the release of ambroxol hydrochloride.

Progress in Biomaterials published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, SDS of cas: 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hermida-Merino, Daniel published the artcileEnhancement of microphase ordering and mechanical properties of supramolecular hydrogen-bonded polyurethane networks, Quality Control of 622-40-2, the publication is Polymer Chemistry (2018), 9(24), 3406-3414, database is CAplus.

The improvement of the mech. properties of supramol. polymer networks is currently receiving significant interest both within academic and industrial circles in order to enable the application of these desirable stimuli-responsive materials in real world situations. In this study, structural units within phase separated supramol. polyurethane (SPU) networks have been changed to assess the role of the hard segment composition on the mech. characteristics of the resultant materials. Notably, increasing the degrees of conformational freedom within the hard segment component of a SPU was found to improve the phase separation and as a consequence also increase the storage modulus of the polymer network. Specifically, replacing 4,4′-methylene di-Ph diisocyanate with 4,4′-dibenzyl diisocyanate within a SPU improved the packing efficiency of the isocyanate derived hard segments and improved the phys. properties of the supramol. polymer network. This study utilized a combination of SAXS, WAXS and AFM anal. to assess the degree of crystallinity within the hard segment component of the polymer network while rheol. anal. was used to establish the mech. characteristics of the polymers.

Polymer Chemistry published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, Quality Control of 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chelcea, Ioana published the artcilePhysiologically Based Toxicokinetic Modeling of Bisphenols in Zebrafish (Danio rerio) Accounting for Variations in Metabolic Rates, Brain Distribution, and Liver Accumulation, Name: 4,4′-Sulfonyldiphenol, the publication is Environmental Science & Technology (2022), 56(14), 10216-10228, database is CAplus and MEDLINE.

Bisphenol A (BPA) is an industrial chem., which has raised human health and environmental concerns due to its endocrine-disrupting properties. BPA analogs are less well-studied despite their wide use in consumer products. These analogs have been detected in water and aquatic organisms around the world, with some analogs showing toxic effects in various species including fish. Here, we present novel organ-specific time-course distribution data of bisphenol Z (BPZ) in female zebrafish (Danio rerio), including concentrations in the ovaries, liver, and brain, a rarely sampled organ with high toxicol. relevance. Furthermore, fish-specific in vitro biotransformation rates were determined for 11 selected bisphenols. A physiol. based toxicokinetic (PBTK) model was adapted for four of these bisphenols, which was able to predict levels in the gonads, liver, and brain as well as the whole body within a 2-5-fold error with respect to exptl. data, covering several important target organs of toxicity. In particular, predicted liver concentrations improved compared to currently available PBTK models. Predicted data indicate that studied bisphenols mainly distribute to the carcass and gonads and less to the brain. Our model provides a tool to increase our understanding on the distribution and kinetics of a group of emerging pollutants.

Environmental Science & Technology published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Name: 4,4′-Sulfonyldiphenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Colleary, Sandra published the artcileStability and catalytic properties of chemically modified pig trypsin, Related Products of alcohols-buliding-blocks, the publication is Biocatalysis and Biotransformation (2009), 27(5-6), 309-317, database is CAplus.

Pig trypsin was chem. modified with the bifunctional compound ethylene glycol-bis(succinic acid N-hydroxysuccinimide ester) to yield EG-trypsin. EG-trypsin showed greater thermal stability (100% active beyond 100 min at 55°C; native only 53% active at 100 min) together with slightly increased tolerance toward some organic solvents. Arg/Lys hydrolysis ratio changed little. Esterase/amidase activity ratio of EG-trypsin in buffer was 11-fold greater than that of native pig trypsin, but 5-fold less in 30% volume/volume acetonitrile. In buffer, EG-trypsin synthesized the dipeptide benzoyl-Arg-Leu-NH₂ at a 3-fold higher rate than native trypsin, but native trypsin outperformed EG-trypsin in 30% volume/volume acetonitrile.

Biocatalysis and Biotransformation published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts