Category: alcohols-buliding-blocks

Zeng, Ying-Jie published the artcileStructure and immunomodulatory activity of polysaccharides from Fusarium solani DO7 by solid-state fermentation, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is fermentation polysaccharide Fusarium solani; Polysaccharides from Fusarium solani DO7; Solid-state fermentation; Structure-activity relationship.

Two polysaccharides, DGS1 and DGS2, were obtained by solid-state fermentation (SSF) of Fusarium solani DO7, an endophytic fungus isolated from the orchid Dendrobium officinale. Structural characterizations revealed that DGS1 consisted of arabinose, glucose, mannose and galactose with a molar ratio of 2.9:13.4:3.0:1, resp., and contained (1 → 5)-Araf, (1 → 4)-Glcp, (1 → 6)-Glcp, (1 → 3)-Manp, (1 → 2,6)-Manp and (1 → 6)-Galp glycosidic linkages, while DGS2 was composed of arabinose, glucose, mannose and galactose in a molar ratio of 3.5:8.1:2.1:1, resp., and contained (1 → 5)-Araf, (1 → 4)-Glcp, (1 → 6)-Glcp, (1 → 3)-Manp and (1 → 6)-Galp glycosidic linkages. Neither polysaccharide was toxic to human embryonic kidney cells or mouse RAW 264.7 macrophage cells. An immunomodulatory activity assay indicated that both polysaccharides could significantly enhance the levels of TNF-α, IL-6 and NO by activating TNF-α, IL-6 and iNOs gene expression, resp., especially DGS2. Interestingly, DGS2 also possessed relatively high antioxidant activity. These results illustrate that, due to its cost-effectiveness and environmentally friendly features, SSF has significant potential as a com. competitive source of natural products, including fungal polysaccharides, with immunomodulatory activity.

International Journal of Biological Macromolecules published new progress about Fusarium solani. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application of (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jingjing published the artcileDetermination and Correlation of Solubility of Borneol, Camphor, and Isoborneol in Different Solvents, Computed Properties of 124-76-5, the main research area is correlation solubility borneol camphor isoborneol solvent.

The solubility of borneol, camphor, and isoborneol in four solvents (i.e., acetone, ethanol, p-cymene, and p-xylene) was measured by the static equilibrium method within the temperature range of 296.65-348.85 K under the atm. The fusion points and fusion enthalpies of borneol and isoborneol were determined by differential scanning calorimetry. The Apelblat equation, Wilson model, and NRTL model were employed to correlate the measured solubility data, and the NRTL model fits the measured data better. Mixing properties of each solute-solvent pair are calculated by the NRTL model.

Journal of Chemical & Engineering Data published new progress about Fusion enthalpy. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Peng, Ke published the artcileGelled non-toxic microemulsions: phase behavior & rheology, Category: alcohols-buliding-blocks, the main research area is gelled non toxic microemulsion phase diagram rheol.

Bicontinuous microemulsions gelled with a low mol. weight gelator have been shown to be an orthogonally self-assembled system. With the mech. stability provided by the gel network, gelled non-toxic bicontinuous microemulsions have the potential to be an efficient transdermal drug delivery carrier. However, up to now no suitable system has been formulated for transdermal drug delivery. To fill this gap, we formulated and characterized a gelled non-toxic bicontinuous microemulsion suitable for the mentioned application. Starting from a previously studied scouting system, namely, H2O-n-octane-n-octyl β-D-glucopyranoside (β-C8G1)-1-octanol, the co-surfactant and the oil were replaced by non-toxic components. Subsequently, the expensive pure surfactant was replaced by cheap tech.-grade surfactants (Plantacare series) to make the system economical. Having formulated the non-toxic microemulsion H2O-IPM-Plantacare 1200 UP-1,2-octanediol, three low mol. weight gelators were studied with regard to the gelation of both the scouting system and the non-toxic system. The chosen gelators were 12-hydroxyoctadecanoic acid (12-HOA), 1,3:2,4-dibenzylidene-D-sorbitol (DBS), and N,N’-dibenzoyl-L-cystine (DBC). We found that only DBS gels the non-toxic microemulsion. The gelled non-toxic bicontinuous microemulsion H2O-IPM-Plantacare 1200 UP-1,2-octanediol was characterized with oscillatory shear rheometry and small-angle neutron scattering (SANS) at a DBS concentration of 0.3 wt% to verify that the system is indeed a gel and that the microstructure of the microemulsion is not altered by the gel network.

Soft Matter published new progress about Gelation agents. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xia, Long published the artcileStructural characterization and anticomplement activity of an acidic polysaccharide containing 3-O-methyl galactose from Juniperus tibetica, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, the main research area is Juniperus twig leaf anticomplement agent methyl galactose; Complement inhibitor; Juniperus tibetica Kom.; Polysaccharide.

A water-soluble acidic polysaccharide containing 3-O-Me galactose, named YB-PS4, was isolated from the twigs and leaves of Juniperus tibetica Kom. Its structure was characterized by monosaccharide composition anal., methylation, and NMR spectroscopy. It was concluded that YB-PS4 had a backbone composed of (2,4)-a-Rhap-(1, 3,5)-a-Araf-(1, 2,4)-a-Galp-(1 and 4)-a-GalpA-(1, with branches of 2)-a-Rhap-(1,3)-a-Araf-(1 and 2)-3-O-Me-a-Galp-(1). The possible repetitive units were speculated and further analyzed by oligosaccharide anal. YB-PS4 showed inhibitory effects on complement activation through the classical pathway (CH50 = 94.23 ± 8.90 mug/mL) and alternative pathway (AP50 = 194.76 ± 9.20 mug/mL). Preliminary mechanism study indicated that it interacted with C1q, C2, C3, C4 and C5. These studies pointed a way to understand the active constituents of J. tibetica and provided scientific bases for YB-PS4 as a complement inhibitor.

International Journal of Biological Macromolecules published new progress about Genetic linkage. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Recommanded Product: (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yan, Bo published the artcilePluronic F127 gels fabricated by thiol-ene click chemistry: preparation, gelation dynamics, swelling behaviors and mechanical properties, Application In Synthesis of 7575-23-7, the main research area is Pluronic F127 fabricated thiol ene click chem gelation swelling.

Click chem. is an effective tool to fabricate three-dimensional gel network in an accurate way. In this work, Pluronic F127 gels are prepared by thiol-ene click chem., utilizing double-bond end-capped Pluronic F127 (F127DA) and pentaerythritol tetras-mercaptopropionate (PETMP) as the starting materials and triethylamine as the catalyst. Both the mass fraction of F127DA and the initial concentration of PETMP have effects on the properties of the resulting F127 gels. The optimized F127 gel prepared under a F127DA mass fraction of 15 wt% and a PETMP concentration of 17.62 mmol/L exhibits the highest swelling ratio (10) and has the largest elongation at break (194%). When the F127DA mass fraction and PETMP concentration are fixed at 15 wt% and 48.26 mmol/L, resp., the resulting F127 gel has a high stress of 0.25 MPa. The present example has presented a method to fabricate three-dimensional gel network in a controlled way.

Polymer Bulletin (Heidelberg, Germany) published new progress about Click chemistry. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Application In Synthesis of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Wu, Chia-Hui published the artcileSimple and Practical Real-Time Analysis of Solid-Phase Reactions by Thin-Layer Chromatography, Application In Synthesis of 87905-98-4, the main research area is glycoside solid phase preparation TLC reaction analysis; triazole solid phase preparation TLC reaction analysis; amino acid solid phase preparation TLC reaction analysis.

Solid-phase synthesis is a practical approach for simplifying the time-consuming and routine purification steps in the preparation of numerous naturally occurring mols.; however, studying such reactions is difficult due to the lack of a convenient monitoring method. By using thin-layer chromatog. in conjunction with a photolabile linker on a resin, we developed a convenient and simple method for monitoring solid-phase reactions in real time by thin-layer chromatog. This method provides a user-friendly protocol for examining reaction conditions for solid-state syntheses.

Synlett published new progress about Click chemistry. 87905-98-4 belongs to class alcohols-buliding-blocks, name is Benzyl (5-hydroxypentyl)carbamate, and the molecular formula is C13H19NO3, Application In Synthesis of 87905-98-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shin, Jaeman J. published the artcileEffect of site-specific functionalization on the shape of nonspherical block copolymer particles, Synthetic Route of 7575-23-7, the main research area is nonspherical butadiene styrene diblock copolymer particle functionalization shape; block copolymer; particle shape; site-specific functionalization; thiol-ene.

Shape-anisotropic polymeric colloids having chem. distinct compartments are promising materials, however, introducing site-sp. surface functionality to block copolymer particles has not yet been actively investigated. The current contribution demonstrates the selective surface functionalization of nanostructured, ellipsoidal polystyrene-b-polybutadiene (PS-b-PB) particle and investigate their effects on the particle shape. Photo-induced thiol-ene click reaction was used as a selective functionalization chem. for modifying the PB block, which was achieved by controlling the feed ratio of functional thiols to the double bonds in PB. Importantly, the controlled particle elongation was observed as a function of the degree of PB functionalization. Such an increase in the aspect ratio is attributed to the (i) increased incompatibility of the PS and modified PB block and (ii) the reduced surface tension between the particles and surrounding aqueous medium, both of which contributes to the further elongation of ellipsoids. Further tunability of the elongation behavior of ellipsoids was further demonstrated by controlling the particle size and chem. structure of functional thiols, showing the versatility of this approach for controlling the particle shape. Finally, the utility of surface functionality was demonstrated by the facile complexation of fluorescent dye on the modified surface of the particle via favorable interaction, which showed stable fluorescence and colloidal dispersity.

Polymers (Basel, Switzerland) published new progress about Click chemistry. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Synthetic Route of 7575-23-7.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Newell, Grace E. published the artcilePreparation of a clickable monomer compatible with automated PNA synthesis, Category: alcohols-buliding-blocks, the main research area is peptide nucleic acid thymine monomer synthesis; reductive amination PNA monomer incorporation PNA Click chem.

A propargyl-containing Fmoc-protected (Fmoc = 9-fluorenylmethoxycarbonyl) thymine monomer was synthesized for possible use in the pre- or post-functionalization of PNA oligomers via Click chem. The monomer should be suitable for incorporation in normal automated solid phase PNA synthesis. The synthesis is suitable for the preparation of gram-quantities of monomers and uses reductive amination as the key step.

Tetrahedron Letters published new progress about Click chemistry. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Xu, Can published the artcileA class of azocarbazole-based carboxylates: high-efficiency ionic unimolecular photobase generators for thiol-epoxy click polymerization under blue light, Related Products of alcohols-buliding-blocks, the main research area is azocarbazole carboxylate ionic unimol photobase generator; thiol epoxy click polymerization blue light.

Two new unimol. azocarbazole-based visible photobase generators (Ac-C-Base) with different strong bases such as 1,5,7-triazabicyclo[4.4.0]dec-5-ene (TBD) and 1,1,3,3-tetramethylguanidine (TMG) as the potential active species were prepared Their structures were confirmed by 1H NMR, 13C NMR, and HR-MS. According to the photolysis and EPR results, Ac-C-Base could generate free radicals and strong bases simultaneously through the photodecarboxylation mechanism under 455 nm LED irradiation Thus they can effectively catalyze the thiol-epoxy polymerization without post exposure baking under light exposure. In addition, the Ac-C-TBD containing a stronger base shows a faster polymerization rate and higher epoxy conversion.

Journal of Polymer Science (Hoboken, NJ, United States) published new progress about Click chemistry. 7575-23-7 belongs to class alcohols-buliding-blocks, name is Pentaerythritol tetra(3-mercaptopropionate), and the molecular formula is C17H28O8S4, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kumar, Anil published the artcileRotational Diffusion of Medium Sized 7-[Diethylamino]-2H-1-Benzopyran-2-One Molecule in Alcohols: Study of Temperature and Solvent Viscosity Effect, Related Products of alcohols-buliding-blocks, the main research area is diethylamino benzopyranone dipole moment dielec relaxation rotational diffusion fluorescence; Hydrodynamic theories; Laser dye; Point dipole dielectric theories; Reorientation times; Super slip.

The rotational re-orientations times of the 7-[diethylamino]-2H-1-benzopyran-2-one (7-DHB) dye mol. have been examined in ethanol and octanol solvents when macroscopic solvent viscosity parameter is varied by varying the temperature, by employing the steady-state fluorescence depolarisation and Time-Correlated Single Photon Counting (TCSPC) techniques. Exptl. observation shows that 7-DHB probe is experiencing higher friction in octanol compared to ethanol and rotates slower by a factor of 7.3. The hydrodynamic Stokes Einstein’s Debye theory (SED) with a stick, slip boundary conditions parameters, quasi-hydrodynamic models (Dote-Kivelson-Schwartz and Geirer-Wirtz) were used to determine mech. friction and found an interesting towards super slip trend. Dielec. frictional theories of point dipole, Nee-Zwanzig and van der Zwan-Hynes both models fail to describe exptl. observe dielec. friction trends. Evidently, both hydrodynamic and dielec. models failed to explain the examined behavior, even in the qual. way in alcs.

Journal of Fluorescence published new progress about C-N bond length. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts