Category: alcohols-buliding-blocks

Rozi, Parhat published the artcileSequential extraction, characterization and antioxidant activity of polysaccharides from Fritillaria pallidiflora Schrenk, Application In Synthesis of 59-23-4, the main research area is Fritillaria polysaccharide extraction antioxidant activity property; Antioxidant activity; Characterization; Fritillaria pallidiflora schrenk; Polysaccharide.

In this paper, Fritillaria pallidiflora schrenk polysaccharides were extracted with different methods and isolated by anion-exchange and gel-permeation chromatog. Physicochem. properties, structural characteristics and antioxidant activities were investigated for the first time. The polysaccharides composed of glucose, galactose, arabinose, xylose, mannose and rhamnose with different molar ratio and mol. weight Fourier transform IR spectroscopy and NMR anal. exhibited the presence of key functional groups of polysaccharides whereas SEM anal. revealed the characteristic morphol. of different fractions. The thermogravimetric anal. manifested the thermal stability of polysaccharides. The reducing power and antioxidant activities of polysaccharides were evaluated in vitro. Among them, the acidic fraction FPSP-H2-1 has a strong antioxidant effect against DPPH, hydroxyl and ABTS free radicals. The results revealed the polysaccharide’s important role as potential natural antioxidant agents during the investigation and application of bioactive polysaccharide.

International Journal of Biological Macromolecules published new progress about Anion exchange. 59-23-4 belongs to class alcohols-buliding-blocks, name is (2R,3S,4S,5R)-2,3,4,5,6-Pentahydroxyhexanal, and the molecular formula is C6H12O6, Application In Synthesis of 59-23-4.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Matsumiya, Masahiko published the artcileSeparation of palladium by solvent extraction with methylamino-bis-N,N-dioctylacetamide and direct electrodeposition from loaded organic phase, Synthetic Route of 111-87-5, the main research area is palladium solvent extraction methylaminodioctylacetamide formed organic phase direct electrodeposition.

The development of solvent extraction and direct electrodeposition processes is an important task to reduce the volume of secondary wastes. In this study, the extraction of Pd(II) from hydrochloric/chloride media using methylimino-bis-N,N-dioctylacetamide (MIDOA) in three diluents (acetophenone; AP, 1,2-dichloroethane; DCE, or 1-octanol; OC) was investigated. Slope anal. revealed that the extraction reaction of Pd(II) was based on the following anion exchange: [PdCl42-]aq + n[MIDOA]org ↔ [Pd(Cl)4-2n(MIDOA)2]2n-2org + 2n[Cl-]aq . The electrochem. behavior of the extracted Pd(II) complex in the MIDOA/AP bath was investigated using an electrochem. quartz crystal microbalance (EQCM). Pd(II) was found to be reduced to Pd(0) metal via a two-electron transfer, and the cathodic reaction [Pd(MIDOA)2]2+ + 2e- → Pd(0) + 2[MIDOA] was found to proceed in the region between -2.38 V and -3.40 V based on the apparent molar mass of 105.22 evaluated by EQCM. Moreover, the alternation of Δηρ corresponded to the local decrease in the viscosity of the organic phase near the electrode. The potentiostatic electrodeposition of the extracted Pd(II) complex enabled us to recover the blackish electrodeposits, which were identified as Pd metal through SEM/EDX, XPS, and XRD analyses.

Separation and Purification Technology published new progress about Anion exchange. 111-87-5 belongs to class alcohols-buliding-blocks, name is n-Octanol, and the molecular formula is C8H18O, Synthetic Route of 111-87-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Dybczynski, Rajmund S. published the artcileSeparation of Rare Earth Elements (REE) by Ion Interaction Chromatography (IIC) Using Diglycolic Acid (ODA) as a Complexing Agent, Quality Control of 110-99-6, the main research area is separation rare earth element ion interaction chromatog; diglycolic acid complexing agent.

Abstract: The possibility of rare earth elements (REE) separation by ion interaction chromatog. (IIC) employing their complexes with diglycolic acid (ODA) in anion exchange mode has been studied theor. and exptl. Calculations, assuming that only trivalent complex is significantly uptaken by the stationary phase, indicated that at at pH 4-6, the retention in the lanthanide series should increase from La to the Tb-Dy-Ho region with yttrium showing apparent at. number (ApparatusAt.Number) of 671/2 and then decrease with further increase of at. number Chromatog. experiments in the system: Column: Eternity C18-mobile phase 5 mM ODA/8.6 mM TBAOH/0.6 mM HNO3; pH 4.60 confirmed theor. predictions. It was found that scandium at pH ≥ 4.0 elutes in front of the whole REE group but at low pH enters the region of light lanthanides. The non-monotonical change of affinity of the REE with the increase of at. number results in quite unusual order of elution of REE namely: Sc < La < Ce < Lu < Pr < Yb < Nd < Tm < Sm < Eu < Er≈Y < Gd < Ho < Tb≈Dy. Chromatographia published new progress about Anion exchange. 110-99-6 belongs to class alcohols-buliding-blocks, name is 2,2'-Oxydiacetic acid, and the molecular formula is C4H6O5, Quality Control of 110-99-6.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Heffernan, Michele L. R. published the artcileUlotaront: A TAAR1 Agonist for the Treatment of Schizophrenia, COA of Formula: C4H11NO2, the main research area is structure TAAR1 agonist ulotaront preparation schizophrenia.

Ulotaront (SEP-363856) is a trace-amine associated receptor 1 (TAAR1) agonist with 5-HT1A receptor agonist activity in Phase 3 clin. development, with FDA Breakthrough Therapy Designation, for the treatment of schizophrenia. TAAR1 is a G-protein-coupled receptor (GPCR) that is expressed in cortical, limbic, and midbrain monoaminergic regions. It is activated by endogenous trace amines, and is believed to play an important role in modulating dopaminergic, serotonergic, and glutamatergic circuitry. TAAR1 agonism data are reported herein for ulotaront and its analogs in comparison to endogenous TAAR1 agonists. In addition, a human TAAR1 homol. model was built around ulotaront to identify key interactions and attempt to better understand the scaffold-specific TAAR1 agonism structure-activity relationships.

ACS Medicinal Chemistry Letters published new progress about Antipsychotics. 22483-09-6 belongs to class alcohols-buliding-blocks, name is 2,2-Dimethoxyethanamine, and the molecular formula is C4H11NO2, COA of Formula: C4H11NO2.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Lima, Nayana F. published the artcileOral nitazoxanide treatment of experimental neurocysticercosis induces gluconeogenesis in Taenia crassiceps cysticerci, Name: (S)-2-hydroxysuccinic acid, the main research area is nitazoxanide antiprotozoal agent oral drug delivery gluconeogenesis Taenia neurocysticercosis; Experimental neurocysticercosis; Fatty acids oxidation; Metabolism; Nitazoxanide; Taenia crassiceps.

Neurocysticercosis is the most frequent helminthiasis of the central nervous system and is caused by the presence of Taenia solium cysticerci. Nitazoxanide (NTZ) is an antifolate containing the pyrrolopyrimidine-based nucleus that exerts its antiprotozoal activity due to interference with the pyruvate:ferredoxin oxidoreductase (PFOR) enzyme which is essential to anaerobic energy metabolism The aim of this work was to determine the effect of NTZ on the energetic metabolism of Taenia crassiceps cysticerci intracranially inoculated BALB /c mice. The infected animals were treated with a single oral dose of NTZ 30 days after the inoculation. Anal. of the organic acids was performed through high performance liquid chromatog. Glucose was detected only in the treated groups, alongside with a significant decrease in lactate, pyruvate and oxaloacetate concentrations which indicate an increase in gluconeogenesis. The non-detection of alpha-ketoglutarate indicated the use of the fumarate reductase pathway in all groups. It was possible to confirm the drugs mode of action due to the non-detection of acetate in the treated groups. There was an increase in the fatty acids oxidation Therefore it was possible to observe that NTZ induces gluconeogenesis as well as the increase of alternative energetic pathways such as fatty acids oxidation in T. crassiceps cysticerci.

Acta Tropica published new progress about Gluconeogenesis. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Name: (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Yasuzawa, Mikito published the artcileCharacterization of N-substituted polypyrrole thin-film electrode having immobilized glucose oxidase, SDS of cas: 50966-69-3, the main research area is polypyrrole electrode glucose oxidase.

The authors describe the properties of a glucose sensor prepared by the electropolymerization or pyrrole derivatives, 1-pyrrole propionic acid (PPA) and 1-pyrrole propanol (PPO), which have a carboxyl group and hydroxyl group, resp. Since these derivatives have substituents that can possibly make a hydrogen bond with GO, these electrodes are expected to afford higher electrode stability and reproducibility compared with that of unsubstituted pyrrole.

Sensors and Actuators, B: Chemical published new progress about Glucose sensors. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, SDS of cas: 50966-69-3.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Polshettiwar, Vivek published the artcileMagnetic nanoparticle-supported glutathione: a conceptually sustainable organocatalyst, Safety of 3-(1H-Pyrrol-1-yl)propan-1-ol, the main research area is primary amine dimethoxytetrahydrofuran organocatalyst water microwave Paal Knorr reaction; pyrrole derivative preparation; magnetic nanoparticle supported glutathione recoverable Paal Knorr catalyst.

A conceptually novel nanoparticle-supported and magnetically recoverable organocatalyst has been developed, which is readily prepared from inexpensive starting materials in a truly sustainable manner; which catalyzes the Paal-Knorr reaction with high yield in pure aqueous medium that avoids the use of toxic organic solvents, even in the workup step.

Chemical Communications (Cambridge, United Kingdom) published new progress about Green chemistry. 50966-69-3 belongs to class alcohols-buliding-blocks, name is 3-(1H-Pyrrol-1-yl)propan-1-ol, and the molecular formula is C7H11NO, Safety of 3-(1H-Pyrrol-1-yl)propan-1-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Kamarauskaite, Justina published the artcileIncreased succinate accumulation induces ROS generation in in vivo ischemia/reperfusion-affected rat kidney mitochondria, Safety of (S)-2-hydroxysuccinic acid, the main research area is rotenone renoprotectant cytochrome c kidney ischemia.

Mitochondria are recognized as main reactive oxygen species (ROS) producers, involving ROS generation by mitochondrial complexes I and III. Lately, the focus has been shifting to the ROS generation by complex II. Contribution of complex II (SDH) to ROS generation still remains debatable, espectaly in in vivo settings. Moreover, it is not completely defined at what time of ischemia the first alterations in mitochondria and the cell begin, which is espectaly important with renal arterial clamping in vivo during kidney surgery, as it predicts the postischemic kidney function. The aim of this study on an in vivo rat kidney ischemia/reperfusion model was to determine if there is a connection among (a) duration of kidney ischemia and mitochondrial dysfunction and (b) succinate dehydrogenase activity, succinate accumulation, and ROS generation in mitochondria at low and satg succinate concentrations Our results point out that mitochondrial disturbances can occur even after 30 min of kidney ischemia/reperfusion in vivo and increase progressively with the prolonged time of ischemia; accumulation of succinate in cytosol after ischemia/reperfusion correlated with increased H2O2 generation mediated by complex II, which was most noticeable with physiol. succinate concentrations; and ischemia/reperfusion induced cell necrosis, indicated by the changes in LDH activity. In conclusion, our new findings on the accumulation of succinate in cytosol and changes in SDH activity during kidney ischemia/reperfusion may be important for energy production after reperfusion, when complex I activity is suppressed. On the other hand, an increased activity of succinate dehydrogenase is associated with the increased ROS generation, espectaly with physiol. succinate concentrations All these observations play an important role in understanding the mechanisms which occur in the early phase of ischemia/reperfusion injury in vivo and may provide new ideas for novel therapeutic approaches or injury prevention; therefore, more detailed studies are necessary in the future.

BioMed Research International published new progress about Kidney ischemia. 97-67-6 belongs to class alcohols-buliding-blocks, name is (S)-2-hydroxysuccinic acid, and the molecular formula is C4H6O5, Safety of (S)-2-hydroxysuccinic acid.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Maertens, Christophe published the artcileSynthesis and characterization of end-functionalized oligo(vinylthiophenes) with liquid crystal properties, Computed Properties of 6214-45-5, the main research area is end functionalized vinylthiophene liquid crystal property.

A general scheme for the synthesis of end-functionalized conjugated (E)-vinylthiophene oligomers with liquid crystal and potential 2nd-order nonlinear optical properties is described. These push-pull thiophene-containing aromatic mols. show mesogenic properties over different temperature ranges depending on the chain length and the functional end-groups.

Journal of the Chemical Society, Perkin Transactions 2: Physical Organic Chemistry published new progress about Liquid crystals. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Computed Properties of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Johansson, Gary published the artcileMolecular recognition directed self-assembly of tubular liquid crystalline and crystalline supramolecular architectures from Taper Shaped (15-crown-5)methyl 3,4,5-tris(p-alkyloxybenzyloxy)benzoates and (15-crown-5)methyl 3,4,5-tris(p-dodecyloxy)benzoate, Computed Properties of 6214-45-5, the main research area is crown ether hydroxymethyl benzoate derivative; liquid crystalline hydroxymethyl crown benzoate; supramol architecture hydroxymethyl crown benzoate; mol recognition hydroxymethyl crown benzoate.

The syntheses and characterization of title crown ether derivatives I [R = p-Me(CH2)nOC6H4CH2, where n = 3, 5, or 11 (27); R = Me(CH2)11 (28)] are described. Complexation of the crown ether endo-receptor with CF3SO3Na destabilizes the crystalline phase of I and induces for the case of 27 and 28 the self-assembly of a supramol. cylindrical channel-like architecture which displays a thermotropic hexagonal columnar (Φh) mesophase. Most remarkably, in the crystalline phase of the complexes of 27 with CF3SO3Na the cylindrical structure of the Φh mesophase is maintained. Characterization of these supramol. architectures was performed by a combination of differential scanning calorimetry, thermal optical polarized microscopy, X-ray scattering and mol. modeling. A model is proposed in which a stratum of the column is formed by six mols. of 27 and 28 with the crown ether receptors residing in the column center and the alkyl tails radiating toward the column periphery. Endo-Recognition generated via the (15-crown-5)methyl receptor upon complexation, and exo-recognition provided by the tapered 3,4,5-tris(p-dodecyloxybenzyloxy)benzoate and 3,4,5-tris(p-dodecyloxy)benzoate fragments of 27 and 28 provide the driving force for the self-assembly of this cylindrical supramol.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry published new progress about Liquid crystals. 6214-45-5 belongs to class alcohols-buliding-blocks, name is (4-Butoxyphenyl)methanol, and the molecular formula is C11H16O2, Computed Properties of 6214-45-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts