Category: alcohols-buliding-blocks

Yang, Daqian published the artcileTris (2-chloroethyl) phosphate (TCEP) induces obesity and hepatic steatosis via FXR-mediated lipid accumulation in mice: Long-term exposure as a potential risk for metabolic diseases, Product Details of C8H8O3, the publication is Chemico-Biological Interactions (2022), 110027, database is CAplus and MEDLINE.

Tris (2-chloroethyl) phosphate (TCEP) is the most commonly detective organophosphate flame retardant in surroundings. TCEP is also evidenced as endocrine disrupting chems. and has potential adverse effects on metabolic diseases. In this study, we hypothesized that metabolic diseases are adverse outcomes of TCEP exposure. Adult ICR mice was daily treated with TCEP (20 mg/kg and 60 mg/kg, higher than expected level in people) by gavage administration for 9 wk. The results demonstrate that TCEP promoted body weight gain, hypertriglyceridemia, and hepatic steatosis, consistent with upregulation of hepatic lipogenesis-related gene expression. Moreover, TCEP altered the levels of several hepatic metabolites, especially bile acids and downregulated bile acid synthesis pathways. Intriguingly, we found a marked downregulation of the bile acid nuclear reporter, FXR, in TCEP-exposed livers. Mechanistically, TCEP directly interacted with FXR at Lys335 and Lys336. Further studies in this work elucidate the mechanisms of long-term TCEP exposure on hepatic steatosis and obesity in mice via FXR-mediated lipid accumulation. Our results provide insight into the possibility of intermediate TCEP exposure in causing metabolic diseases.

Chemico-Biological Interactions published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C19H15NO3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Tao published the artcilePhotoinduced Nickel-Catalyzed Deaminative Cross-Electrophile Coupling for C(sp²)-C(sp³) and C(sp³)-C(sp³) Bond Formation, Synthetic Route of 96-20-8, the publication is ACS Catalysis (2021), 11(11), 6519-6525, database is CAplus.

The N-alkylpyridinium salts, e.g., pyridinium, 1-cycloheptyl-2,4,6-triphenyl-, tetrafluoroborate can be efficiently merged with aryl or alkyl halides RX (R = 4-NCC₆H₄, 2-cyanopyridin-4-yl, 1-oxo-2,3-dihydro-1H-inden-5-yl, etc.; X = Br, I) in an intermol. fashion, affording products, e.g., 2-(4-cycloheptylbutyl)isoindoline-1,3-dione in up to 92% yield at ambient temperature These reactions harness the ability of N-alkylpyridinium salts to form electron donor-acceptor complexes with Hantzsch esters, enabling photoinduced single-electron transfer and fragmentation to afford alkyl radicals that are subsequently trapped by a Ni-based catalytic species to promote C(sp₂)-C(sp₃) and C(sp₃)-C(sp₃) bond formation. The operationally simple protocol is applicable to site-selective cross-coupling and tolerates diverse functional groups, including those that are sensitive toward metal reductants.

ACS Catalysis published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C6H13I, Synthetic Route of 96-20-8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mishra, Ratan K. published the artcileEnergy-effective grinding of inorganic solids using organic additives, Application In Synthesis of 122-20-3, the publication is Chimia (2017), 71(7-8), 451-460, database is CAplus and MEDLINE.

We present our research findings related to new formulations of the organic additives (grinding aids) needed for the efficient grinding of inorganic solids. Even though the size reduction phenomena of the inorganic solid particles in a ball mill is purely a phys. process, the addition of grinding aids in milling media introduces a complex physicochem. process. In addition to further gain in productivity, the organic additive helps to reduce the energy needed for grinding, which in the case of cement clinker has major environmental implications worldwide. This is primarily due to the tremendous amounts of cement produced and almost 30% of the associated elec. energy is consumed for grinding. In this paper, we examine the question of how to optimize these grinding aids linking mol. insight into their working mechanisms, and also how to design chem. additives of improved performance for industrial comminution.

Chimia published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application In Synthesis of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Herzig, Maryanne C. S. published the artcileSynthesis and characterization of N-hydroxysuccinimide ester chemical affinity derivatives of asialoorosomucoid that covalently crosslink to galactosyl receptors on isolated rat hepatocytes, Related Products of alcohols-buliding-blocks, the publication is Biochemistry (1989), 28(2), 600-10, database is CAplus and MEDLINE.

Asialoorosomucoid (ASOR) was derivatized with 5 homobifunctional N-hydroxysuccinimide (NHS) ester crosslinkers. NHS/ASOR derivatives were synthesized, purified, and applied within 10 min to isolated rat hepatocytes at 4°. Specific binding of these ^125I-labeled derivatives was ∼90% in the presence of either EGTA or excess ASOR. Specific crosslinking, assessed by the resistance of specifically bound NHS/¹²⁵I-ASOR to release by EGTA, was 50-75% of the specifically bound ligand. The extent of specific crosslinking correlated with the average number of NHS groups per ASOR and was controlled by varying the molar ratio of crosslinker to ASOR during the synthesis. Crosslinking proceeded rapidly at 4° as a 1st-order process (k = 0.25 min^-1, t_1/2 = 2.8 min). After being crosslinked with any of the NHS/¹²⁵I-ASOR derivatives, cells were washed with EGTA, solubilized in Triton X 100, and analyzed by SDS-PAGE and autoradiog. Major bands were observed at M_r ≃ 83, 94, and 105 kilodaltons corresponding to the expected size of 1:1 adducts between NHS/ASOR (M_r ≃ 41.3 kilodaltons) and the 3 subunits of the receptor, M_r ≃ 43, 50, and 60 kilodaltons. The 3 subunits, rat hepatic lectin (RHL) 1, 2, and 3, were labeled in the ratio of about 1.0:1.2:1.0, resp. After crosslinking, a polyclonal goat antibody to the receptor immunoprecipitated up to 100% of the specifically crosslinked NHS/¹²⁵I-ASOR. Preimmune IgG immunoprecipitated <1% of the radiolabeled ligand. Cell surface receptors were crosslinked to NHS-ASOR, extracted with Triton X 100, immunoprecipitated with anti-orosomucoid-Sepharose, and subjected to Western blot anal. By use of antisera specific for RHL 1 or RHL 2/3 (from K. Drickamer), crosslinked complexes of M_r ∼85 kilodaltons or ∼90-115 kilodaltons, resp., were detected as were uncrosslinked native subunits. The ratio of free to crosslinked subunits was ∼10:1 for RHL 1 and ∼0.5:1 for RHL 2/3. Apparently, all 3 receptor subunits can crosslink to ligand. A model is proposed in which the native receptor is a heterohexamer composed of 4 subunits of RHL 1 and 2 subunits of RHL 2 and/or RHL 3.

Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bai, Xinxin published the artcileRemediation of phenanthrene contaminated soil by coupling soil washing with Tween 80, oxidation using the UV/S₂O₈^2- process and recycling of the surfactant, Application of 1-Hydroxy-2-naphthoic acid, the publication is Chemical Engineering Journal (Amsterdam, Netherlands) (2019), 1014-1023, database is CAplus.

Surfactant-enhanced soil washing was applied to phenanthrene (PHE)-polluted soil, followed by a sulfate radical-based advanced oxidation process. Soil washing experiments were conducted using the nonionic surfactant Tween 80 (TW 80), assessing the effect of washing temperature, TW 80 concentration, and liquid:soil ratio on PHE removal. Maximum PHE removal (90.0%) was achieved with 15 g/L TW 80 and a 10:1 (mL/g) liquid:soil ratio at 20°. A UV/S₂O₈^2- process was used to selectively oxidize PHE in the effluent and recover TW 80. The regenerated effluent was re-used for soil washing; results showed PHE removal efficiency was nearly the same as with fresh surfactant solution The UV/S₂O₈^2- oxidation reaction was also assessed, including possible intermediate products detection by liquid chromatog./mass spectrometry; a corresponding degradative pathway of target pollutants was proposed. Overall result indicated toil washing with TW 80 and subsequent selective UV/S₂O₈^2- oxidation may provide a potential option to remediate polycyclic aromatic hydrocarbon-polluted soil.

Chemical Engineering Journal (Amsterdam, Netherlands) published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Application of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shi, Jinguo published the artcileSynthesis and biological evaluation of 1,2,4-oxadiazole core derivatives as potential neuroprotectants against acute ischemic stroke, Category: alcohols-buliding-blocks, the publication is Neurochemistry International (2021), 105103, database is CAplus and MEDLINE.

Here, we report the synthesis and neuroprotective capacity of 27 compounds with a bisphenol hydroxyl-substituted 1,2,4-triazole core or 1,2,4-oxadiazole core for stroke therapy. In vitro studies of the neuroprotective effects of compounds 1-27 on sodium nitroprusside (SNP)-induced apoptosis in PC12 cells indicate that compound 24 is the most effective compound conferring potent protection against oxidative injury. Compound 24 inhibits reactive oxygen species (ROS) accumulation and restores the mitochondrial membrane potential (MMP). Moreover, further anal. of the mechanism showed that compound 24 activates the antioxidant defense system by promoting the nuclear translocation of nuclear factor erythroid 2-related factor 2 (Nrf2) and increasing the expression of haem oxygenase 1 (HO-1). An in vivo study was performed in a rat model of transient focal cerebral ischemia generated by the intraluminal occlusion of the middle cerebral artery (MCAO). Compound 24 significantly reduced brain infarction and improved neurol. function. Overall, compound 24 potentially represents a promising compound for the treatment of stroke.

Neurochemistry International published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C12H13F2N3O4S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shang, Yong-Jia published the artcileSynthesis of isoxazolines and isoxazoles using poly(ethylene glycol) as support, Product Details of C10H8ClNO2, the publication is Synthesis (2002), 1663-1668, database is CAplus.

A general method for the liquid-phase syntheses of isoxazoles and isoxazolines through a 1,3-dipolar cycloaddition is described. The poly(ethylene glycol) (PEG)-supported alkyne or alkene reacted with nitrile oxides generated in situ from aldoximes, followed by cleavage from the PEG, to give isoxazoles or isoxazolines in good yield and purity.

Synthesis published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C4H3Cl2N3, Product Details of C10H8ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shang, Yong-Jia published the artcileSoluble polymer-supported synthesis of isoxazoles, Product Details of C10H8ClNO2, the publication is Tetrahedron Letters (2002), 43(12), 2247-2249, database is CAplus.

The first soluble polymer-supported synthesis of isoxazoles through a 1,3-dipolar cycloaddition is described. A soluble polymer-supported alkyne reacts with nitrile oxides generated in situ to give isoxazoles in good yield.

Tetrahedron Letters published new progress about 438565-33-4. 438565-33-4 belongs to alcohols-buliding-blocks, auxiliary class Isoxazole,Chloride,Benzene,Alcohol, name is 3-(2-Chlorophenyl)-5-isoxazolemethanol, and the molecular formula is C10H10O2, Product Details of C10H8ClNO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qiu, Qianqian published the artcileDesign, synthesis, and biological evaluation of novel FXR agonists based on auraptene, Related Products of alcohols-buliding-blocks, the publication is Bioorganic Chemistry (2021), 105198, database is CAplus and MEDLINE.

Farnesoid X receptor (FXR) has been considered as an attractive target for metabolic disorder and liver injury, while many current FXR agonists suffer from undesirable side effects, such as pruritus. Therefore, it is urgent to develop new structure types different from current FXR agonists. In this study, a series of structural optimizations were introduced to displace the unstable coumarin and geraniol scaffolds of auraptene (AUR), a novel and safe FXR agonist. All of these efforts led to the identification of compound 14 (I), a potent FXR agonist with nearly fourfold higher activity than AUR. Mol. modeling study suggested that compound 14 fitted well with binding pocket, and formed the key ionic bond with His291 and Arg328. In acetaminophen-induced acute liver injury model, compound 14 exerts better therapeutic effect than that of AUR, which highlighting its pharmacol. potential in the treatment of drug-induced liver injury.

Bioorganic Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yamaguchi, Kazuya published the artcileHeterogeneously Catalyzed Aerobic Cross-Dehydrogenative Coupling of Terminal Alkynes and Monohydrosilanes by Gold Supported on OMS-2, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2013), 52(21), 5627-5630, database is CAplus and MEDLINE.

Aerobic cross-dehydrogenative coupling of terminal alkynes, e.g., RCCH (R = 1-naphthyl, 4-XC₆H₄, X = Me, F, Br, CF₃, NO₂, NH₂), with monohydrosilanes, e.g., R’₃SiH (R’₃ = Et₃, PhMe₂, iPr₃, tBuMe₂, tBuPh₂, (EtO)₃) gave alkynylsilanes, RCCSiR’₃ in the presence of gold catalyst supported on a cryptomelane-type manganese oxide-based octahedral mol. sieve OMS-2 (Au/OMS-2, average particle size of gold: 4.5 nm).

Angewandte Chemie, International Edition published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C14H12N2S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts