Category: alcohols-buliding-blocks

Miao, Hua published the artcile1-Hydroxypyrene mediates renal fibrosis through aryl hydrocarbon receptor signalling pathway, Recommanded Product: 3-Hydroxyphenylacetic acid, the publication is British Journal of Pharmacology (2022), 179(1), 103-124, database is CAplus and MEDLINE.

In chronic kidney disease (CKD), patients inevitably reach end-stage renal disease and require renal transplant. Evidence suggests that CKD is associated with metabolite disorders. However, the mol. pathways targeted by metabolites remain enigmatic. Here, we describe roles of 1-hydroxypyrene in mediating renal fibrosis. We analyzed 5406 urine and serum samples from patients with Stage 1-5 CKD using metabolomics, and 1-hydroxypyrene was identified and validated using longitudinal and drug intervention cohorts as well as 5/6 nephrectomized and adenine-induced rats. We identified correlations between the urine and serum levels of 1-hydroxypyrene and the estimated GFR in patients with CKD onset and progression. Moreover, increased 1-hydroxypyrene levels in serum and kidney tissues correlated with decreased renal function in two rat models. Up-regulated mRNA expression of aryl hydrocarbon receptor and its target genes, including CYP1A1, CYP1A2 and CYP1B1, were observed in patients and rats with progressive CKD. Further we showed up-regulated mRNA expression of aryl hydrocarbon receptor and its three target genes, plus up-regulated nuclear aryl hydrocarbon receptor protein levels in mice and HK-2 cells treated with 1-hydroxypyrene, which caused accumulation of extracellular matrix components. Treatment with aryl hydrocarbon receptor short hairpin RNA or flavonoids inhibited mRNA expression of aryl hydrocarbon receptor and its target genes in 1-hydroxypyrene-induced HK-2 cells and mice. Metabolite 1-hydroxypyrene was demonstrated to mediate renal fibrosis through activation of the aryl hydrocarbon receptor signalling pathway. Targeting aryl hydrocarbon receptor may be an alternative therapeutic strategy for CKD progression.

British Journal of Pharmacology published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhu, Ya-rui published the artcileEffects of ambroxol hydrochloride combined with pulmicorin on changes of airway inflammation and allergic reaction EOS, ECP and IL-4 indexes in patients with bronchial asthma, Formula: C13H19Br2ClN2O, the publication is Xiandai Zhenduan Yu Zhiliao (2021), 32(5), 707-708, database is CAplus.

Objective: To investigate the effect of ambroxol hydrochloride combined with pulmicorin on airway inflammation and the changes of EOS, ECP and IL-4 indexes in patients with bronchial asthma. Methods: A total of 60 patients with bronchial asthma who were admitted to our hospital from Feb. 2019 to Dec. 2019 were selected and divided into a control group and an exptl. group with 30 cases in each group according to the method of tossing a coin. The control group was given routine treatment, and the exptl. group was given ambroxol hydrochloride combined with pulmicoride on this basis. The levels of eosinophils (EOS), eosinophil cationic protein (ECP), interleukin-4 (IL-4) and adverse reactions were observed in the two groups. Results: Before treatment, there was no significant difference in the levels of IL-4, ECP and EOS between the two groups (P>0.05). After treatment, the levels of IL-4, ECP and EOS in the two groups were lower than those before treatment, and the exptl. group was significantly lower than the control group (P<0.05). The incidence of adverse reactions in the exptl. group was significantly lower than that in the control group (P<0.05). Conclusion: Ambroxol hydrochloride combined with pulmicoride has pos. effect on airway inflammation and allergic reaction EOS, ECP and IL-4 levels in patients with bronchial asthma, with high safety, which is worthy of clin. application.

Xiandai Zhenduan Yu Zhiliao published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C38H74Cl2N2O4, Formula: C13H19Br2ClN2O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Tao published the artcilePromoted Production of Phenolic Monomers from Lignin-First Depolymerization of Lignocellulose over Ru Supported on Biochar by N,P-co-Doping, Category: alcohols-buliding-blocks, the publication is ACS Sustainable Chemistry & Engineering (2022), 10(7), 2343-2354, database is CAplus.

Co-doping of heteroatoms into the support of metal-supported catalysts is a prevalent method to improve the catalytic performance by adjusting metal-support interactions. This paper investigated the catalytic performances of Ru supported on biomass-derived char (Ru@Char), N-doped char (Ru@N-Char), and N,P-co-doped char (Ru@NP-Char) in the emerging lignin-first depolymerization for both poplar (hardwood) and pine (softwood) samples, with an emphasis on the production of phenolic monomers. Various characterizations of the prepared catalysts showed that the codoping of N,P not only facilitated the formation of micropores in the char, but also introduced weak and moderate acid sites. Furthermore, the sizes of Ru nanoparticles on the codoped char became smaller and the proportion of metallic Ru species was increased, resulting from electron transfer from Ru to the codoped char. The yields of the phenolic monomers from poplar and pine over Ru@NP-Char were as high as 57.98 and 17.53 weight %-Klason lignin, resp., which were improved by factors of 1.4-2.5 in comparison to Ru@Char and Ru@N-Char. Full delignification during the depolymerization of both poplar and pine was also achieved over Ru@NP-Char.

ACS Sustainable Chemistry & Engineering published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bremner, John B. published the artcileAnnulation of Eight- to Ten-Membered Oxaza Rings to the Benzo[b]thiophene System by Intramolecular Nucleophilic Displacement, COA of Formula: C8H19NO2, the publication is Australian Journal of Chemistry (2014), 67(8 & 9), 1217-1221, database is CAplus.

Concise synthetic routes to 2H-benzo[b]thieno[3,2-b][1,5]oxazocin-6(3H)-one, and the new benzo[b]thieno[3,2-b][1,5]oxazonin-7(2H)-one and 2H-benzo[b]thieno[3,2-b][1,5]oxazecin-8(3H)-one systems, have been developed based on intramol. nucleophilic displacement in the key ring forming step.

Australian Journal of Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, COA of Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Radzki, Dominik published the artcileA Fresh Look at Mouthwashes-What Is Inside and What Is It For?, Quality Control of 70445-33-9, the publication is International Journal of Environmental Research and Public Health (2022), 19(7), 3926, database is CAplus and MEDLINE.

Mouthwashes are a very popular addnl. oral hygiene element and there are plenty of individual products, whose compositions are in a state of flux. The aim of our study was to investigate the compositions of mouthwashes and their functions, as well as to discuss their effectiveness in preventing and curing oral diseases and side effects. We searched for mouthwashes available on the market in Poland. We identified 241 individual mouthwash products. The extraction of compositions was performed and functions of the ingredients were assessed. Then, anal. was performed. The evaluation revealed that there are plenty of ingredients, but a typical mouthwash is a water-glycerin mixture and consists of addnl. sweetener, surfactant, preservative, and some colorant and flavoring agent, as well as usually having two oral health substances, anticaries sodium fluoride and antimicrobial essential oils. The effectiveness or side effects of several substances of mouthwashes were thoroughly discussed. We recommend not multiplying individual mouthwash products and their ingredients beyond medical or pharmaceutical necessity, especially without scientific proof.

International Journal of Environmental Research and Public Health published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Quality Control of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kleinmans, Roman published the artcilePhotoredox-enabled 1,2-dialkylation of α-substituted acrylates via Ireland-Claisen rearrangement, Safety of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, the publication is Chemical Science (2021), 12(8), 2816-2822, database is CAplus and MEDLINE.

The 1,2-dialkylation of simple feedstock acrylates RC(=CH₂)C(O)OR¹ [R = H, Me, F, i-Pr, naphthalen-1-yl, etc.; R¹ = prop-2-en-1-yl, 4-ethenyloxan-4-yl, 2-chloroprop-2-en-1-yl, 2-(4-oxocyclohexylidene)ethyl, etc.] for the synthesis of valuable tertiary carboxylic acids R²CH₂C(R)(R³)C(O)OH [R² = cyclohexyl, oxan-4-yl, 5-(2,5-dimethylphenoxy)-2-methylpentan-2-yl, etc.; R³ = prop-2-en-1-yl, 2-(oxan-4-ylidene)ethyl, 2-chloroprop-2-en-1-yl, etc.] by merging Giese-type radical addition with an Ireland-Claisen rearrangement have been reported. Key to success is the utilization of the reductive radical-polar crossover concept under photocatalytic reaction conditions to force the [3,3]-sigmatropic rearrangement after alkyl radical addition to allyl acrylates. Using readily available alkyl boronic acids as radical progenitors, this redox-neutral, transition-metal-free protocol allows the mild formation of two C(sp³)-C(sp³) bonds, thus providing rapid access to complex tertiary carboxylic acids in a single step. Moreover, this strategy enables the efficient synthesis of highly attractive α,α-dialkylated γ-amino butyric acids (GABAs) R⁴(CH₂)₂C(CH₃)(CH₂CH=CH₂)C(O)OH [R⁴ = dibutylaminyl, morpholin-4-yl, 4-[2-(morpholin-4-yl)-2-oxoethyl]piperazin-1-yl, etc.] when α-silyl amines R⁴CH₂Si(CH₃)₃ are used as radical precursors – a structural motif that was still inaccessible in related transformations. Depending on the nature of the radical precursors and their inherent oxidation potentials, either a photoredox-induced radical chain or a solely photoredox mechanism is proposed to be operative.

Chemical Science published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Safety of 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sherwood, Alexander M. published the artcileModular Approach to pseudo-Neoclerodanes as Designer κ-Opioid Ligands, SDS of cas: 57044-25-4, the publication is Organic Letters (2017), 19(19), 5414-5417, database is CAplus and MEDLINE.

Informed by previous semisynthetic work on salvinorin A, a modular total synthesis has been developed capable of producing novel compounds targeting the κ-opioid receptor. The strategy has permitted the deliberate simplification and introduction of functionality about the target mol. to provide access to mol. features on salvinorin A otherwise unattainable by semisynthesis. Using this approach, a potent pseudo-neoclerodane κ-opioid receptor ligand (I) has been realized.

Organic Letters published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C8H5F3N4, SDS of cas: 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Yiding published the artcileAn Aryne-Based Route to Substituted Benzoisothiazoles, Product Details of C6H9N3O2S, the publication is Organic Letters (2015), 17(19), 4786-4789, database is CAplus and MEDLINE.

The combination of arynes, generated using fluoride from the corresponding 2-(trimethylsilyl)aryl triflates, and 3-hydroxy-4-aminothiadiazoles leads to the selective formation of 3-amino-substituted benzo[d]isothiazoles. Variation of the substitution pattern of the aryne precursor, and of the thiadiazole, is possible, with the target heterocycles being obtained in good to excellent yields. In all cases, use of 3-hydroxy-4-aminothiadiazoles leads to incorporation of the amino-substituent in the product heterocycle.

Organic Letters published new progress about 30165-97-0. 30165-97-0 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Thiadiazole,Alcohol, name is 4-Morpholino-1,2,5-thiadiazol-3-ol, and the molecular formula is C6H9N3O2S, Product Details of C6H9N3O2S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Grimster, Neil P. published the artcileAlkynes to (E)-enolates using tandem catalysis: stereoselective anti-aldol and syn-[3,3]-rearrangement reactions, Computed Properties of 17877-23-5, the publication is Tetrahedron (2010), 66(33), 6429-6436, database is CAplus.

A new tandem catalysis strategy that transformed alkyne derivatives to (E)-enol-equivalent followed by either stereoselective anti-selective aldol coupling or syn-selective [3,3]-rearrangement transformations was reported. The mechanism was thought to proceed through an interchanging series of Lewis acid and Bronsted acid catalyzed reactions via the intermediacy of a ketiminum ion species. For example, the scandium(III) triflate-catalyzed reaction of alkyne I with Me₂CHCHO and triphenylsilanol afforded adduct II in 73% yield and dr >95:5, while zinc triflate-catalyzed reaction of (E)-PhCH:CHCH₂OH with I gave III in 88% yield and dr >95:5.

Tetrahedron published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fasano, Valerio published the artcileDivergent, Stereospecific Mono- and Difluoromethylation of Boronic Esters, Computed Properties of 608534-44-7, the publication is Angewandte Chemie, International Edition (2020), 59(22), 8502-8506, database is CAplus and MEDLINE.

There is considerable interest in incorporating fluorine into agrochems. and pharmaceuticals to improve their biol. properties. While a number of methods have been reported for installing CH₂F and CHF₂ groups, they are mainly limited to radical reactions, which are invariably racemic. Herein, we report the divergent, stereospecific reaction of fluoroiodomethyllithium with boronic esters to give α-fluoro-boronic esters. These unique intermediates can be readily transformed into the corresponding mono- or difluoromethylated compounds through proto- or fluorodeboronation, resp. The use of the highly unstable fluoroiodomethyllithium was key to allowing rapid 1,2-migration over competing decomposition of the carbanion. DFT calculations informed and supported the exptl. findings. Thus, e.g., homologation of I with FCH₂I/LDA → II (90%); protodeboronation using 4-tBu-catechol/TFA afforded III (90%).

Angewandte Chemie, International Edition published new progress about 608534-44-7. 608534-44-7 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic,Boronic acid and ester,Boronate Esters,Boronic Acids,Boronic acid and ester, name is 2-(2,3-Dihydro-1H-inden-2-yl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane, and the molecular formula is C15H21BO2, Computed Properties of 608534-44-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts