Category: alcohols-buliding-blocks

Adding a certain compound to certain chemical reactions, such as: 5333-42-6, 2-octyldodecan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 2-octyldodecan-1-ol, blongs to alcohols-buliding-blocks compound. Recommanded Product: 2-octyldodecan-1-ol

Take 0.1g (452g/mol, 0.22mmol)Diisobutyl 3,9-nonanedicarboxylate in a round bottom flask, adding 1.63g(298 g/mol, 5.5 mmol) of 2-octyldodecanol was heated to 100 C,Add 0.01 g (10 wt%) of dihydroxybutyl tin chloride to the reaction flask,The temperature was raised to 170 C, and the reaction was heated for 3 h, and the plate was tracked during the reaction.After the reaction, the reaction was cooled to room temperature and the temperature was raised to 180 C.Vacuum distillation,Distilling off excess 2-octyldodecanol which acts as both a solvent for the reaction and a reactantDry in vacuum. The resulting product was cooled to room temperature and dissolved in petroleum ether.The wet method was purified by silica gel column to obtain a yellow dye. The conversion was calculated to be 90%.

The synthetic route of 5333-42-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shenzhen Guohua Optoelectric Technology Co., Ltd.; Shenzhen Guohua Optoelectric Institute; Zhou Guofu; Deng Yong; Li Shi; Ye Dechao; (8 pag.)CN109627802; (2019); A;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 52059-53-7, name is 2-(3-Fluorophenyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. category: alcohols-buliding-blocks

Example 149E (20 mg, 0.06 mmol) and 2-(3-fiuorophenyl)ethanol (9.3 mg, 0.066 mmol) were dissolved in 1 mL tetrahydrofuran. To this, PS-triphenylphosphine (58 mg, 0.18 mmol, 3.1 mmol/g) was added followed by di-tert-buty azodicarboxylate (20.9 mg, 0.09 mmol). The mixture was stirred at room temperature overnight. The resulting mixture was filtered, concentrated and purified by flash chromatography (0-50% ethyl acetate in hexane). To the material thus obtained was added 0.5 mL 4 MEtaC1 in dioxane. The reaction was stirred at 50 0C until completion. The mixture was concentrated to give the title compound as the hydrochloride salt. 1H NMR (500 MHz, DMSO-J6) delta ppm 9.44 (br, IH), 9.07 (br, 2H), 7.36 (dd, J = 14.4, 7.9 Hz, IH), 7.18 (t, J = 8.0 Hz, 2H), 7.05 (td, J = 8.8, 2.4 Hz, IH), 6.87 (d, J = 8.6 Hz, IH), 6.70 – 6.54 (m, 2H), 4.26 – 4.08 (m, 2H), 3.59 – 3.47 (m, IH), 3.30 (m, 4H), 3.11 – 2.85 (m, 4H), 2.60 (dd, J = 13.4, 7.0 Hz, IH), 1.97 (d, J = 13.5 Hz, IH).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 52059-53-7, 2-(3-Fluorophenyl)ethanol.

Reference:
Patent; ABBOTT LABORATORIES; ABBOTT GMBH &; CO. KG; WANG, Ying; BREWER, Jason, T.; AKRITOPOULOU-ZANZE, Irini; DJURIC, Stevan, W.; POHLKI, Frauke; BRAJE, Wilfried; RELO, Ana-Lucia; WO2010/124042; (2010); A2;,
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Related Products of 329218-12-4, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 329218-12-4, name is 3-Bromo-4-chlorobenzyl Alcohol. This compound has unique chemical properties. The synthetic route is as follows.

c. 3-Bromo-4-chloro-benzaldehyde To a solution of 3-bromo-4-chlorobenzyl alcohol (2.73 g, 12.34 mmol) in dichloromethane (75 mL) was added, at room temperature, pyridinium chlorochromate (2.66 g, 12.34 mmol). The reaction mixture was stirred at room temperature for 1 hr then filtered over celite. The solvent was removed under reduced pressure and the residue chromatographed on silica gel (10% ethyl acetate in hexane) to afford 2.52 g of 3-bromo-4-chloro-benzaldehyde (93% yield). 1H NMR (300 MHz; CDCl3) 1H NMR (300 MHz; CDCl3) 7.65 (d, J=8.1 Hz, 1H); 7.78 (dd, J1=8.4 Hz, J2=2.1 Hz, 1H); 8.12 (d, J=2.1 Hz, 1H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 329218-12-4, 3-Bromo-4-chlorobenzyl Alcohol.

Reference:
Patent; Maxia Pharmaceuticals, Inc.; US6515003; (2003); B1;,
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Electric Literature of 6240-11-5, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 6240-11-5, name is 1-Adamantaneethanol. A new synthetic method of this compound is introduced below.

A. A mixture of 2-(adamant-1-yl)ethanol (2.1 g, 12 mmoles), disuccinimidyl carbonate (3.3 g, 13 mmoles) and pyridine (0.86 ml, 10 mmoles) in acetonitrile (50 ml) was stirred at room temperature for 24 hours, then the solvent was evaporated off in the cold and the residue was dissolved in methylene chloride (100 ml). The solution was washed with water (50 ml), 1N HCl (50 ml) and water again (50 ml). The organic phase was dried over anhydrous sodium sulfate and the solvent was evaporated off to give 3 g (9 mmoles) of crude 2-(adamant-1-yl)ethyl-succinimidyl carbonate which was redissolved in THF (30 ml).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,6240-11-5, 1-Adamantaneethanol, and friends who are interested can also refer to it.

Reference:
Patent; Italfarmaco S.p.A.; US6034096; (2000); A;,
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Related Products of 111-90-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 111-90-0, name is Diethylene Glycol Monoethyl Ether. A new synthetic method of this compound is introduced below.

In a round bottom flask NaH (3.9 g, 0.163 mol) was dispersed in 150 ml of anhydrous THF. Anhydrous di(ethylene glycol) ethyl ether (20 g, 0.149 mol) was dissolved in THF (50 ml) and added dropwise to the NaH suspension. The reaction mixture was stirred for 2 hours. The solution of ethyl 3-bromopropionate (17.5 ml, 0.140 mol) in THF (20 ml) was added to a pre-cooled reaction mixture (t=-10 C.). The reaction mixture was stirred overnight, and the solvent was evaporated completely. [00150] Ethylacetate was added to the residue and a mixture was washed with a solution of 10% NaCl and deionized water. The ethylacetate solution was dried over MgSO4, filtered, and the solvent was evaporated. The residue was dried using a vacuum pump. The crude material was chromatographed on a silica gel column. Fractions containing the Compound III were collected, concentrated and characterized by TLC, HPLC, MS and NMR.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,111-90-0, its application will become more common.

Reference:
Patent; Nobex Corporation; US6713454; (2004); B1;,
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Application of 61439-59-6, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 61439-59-6, name is 2-(4-(Benzyloxy)phenyl)ethanol. A new synthetic method of this compound is introduced below.

To a mixture of 2-(4-benzyloxyphenyl)ethanol (1.19 g), triethylamine (700 mg), and ethyl acetate (30 ml), methanesulfonyl chloride (790 mg) was added dropwise at 0¡ãC, and the mixture was stirred at room temperature for two hours. The reaction mixture was washed with water, saturated aqueous sodium bicarbonate solution, 1 N hydrochloric acid, then, with saturated sodium chloride solution, and dried (MgSO4) and concentrated. To a mixture of the residue, ethyl (3-phenyl-1H-pyrazol-4-yl)acetate (1.0 g), and N, N-dimethylformamide (50 ml), sodium hydride (60percent, oily, 190 mg) was added at 0¡ãC, and the mixture was stirred at room temperature for one hour. The reaction mixture was poured into water, which was extracted with ethyl acetate. The ethyl acetate layer was washed with saturated aqueous sodium chloride solution, dried (MgSO4), and concentrated. The residue was subjected to silica gel column chromatography, and ethyl [1-[2-(4-benzyloxyphenyl)ethyl]-3-phenyl-1H-pyrazol-4-yl]acetate (0.45 g, yield: 24percent) was obtained as a colorless oily substance in the fraction eluted with diethyl ether-hexane (2:3, volume ratio). NMR(CDCl3) delta : 1.22(3H, t, J=7.0 Hz), 3.15(2H, t, J=7.4 Hz), 3.57(2H, s), 4.13(2H, q, J=7.0 Hz), 4.31(2H, t, J=7.4 Hz), 5.05(2H, s), 6.87-6.92(2H, m), 7.02-7.07(2H, m), 7.31-7.47(9H, m), 7.58-7.64(2H, m).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,61439-59-6, 2-(4-(Benzyloxy)phenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Takeda Chemical Industries, Ltd.; EP1228067; (2004); B1;,
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Synthetic Route of 41175-50-2 , The common heterocyclic compound, 41175-50-2, name is 1,2,3,5,6,7-Hexahydropyrido[3,2,1-ij]quinolin-8-ol, molecular formula is C12H15NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a screw-cap bottle, 8-hydroxyjulolidine 10 (0.60 g, 3.17 mmol) and trimellitic anhydride 11 (1.83 g, 9.51 mmol) were suspended in acetic acid (15 mL) and flushed with argon. Cone. H2 S O4 (1 drop) was added, and the reaction mixture was gradually heated in an oil bath (up to 100 C) and stirred for 2.5 h. The precipitate dissolved at about 80-90 C, and a red solution formed. After about 0.5 h, a “new” precipitate was formed. After cooling to room temperature, the purple suspension was transferred into centrifuge test-tubes, sonicated for several seconds in an ultrasonic bath, centrifuged, and the purple supernatant solution was discarded. The precipitate was washed with acetic acid (5 mL) ; the same sonication centrifugation cycles were repeated 5 – 6 times, until the supernatant solution became colorless. The solid residue was dried in vacuo to obtain 0.48 g (40%) of benzophenone 12a with traces of 12b (>95:<5). Beige solid; TLC: ACN/H20/DCM, 9:1:1. HPLC (Eurospher-100 C18 5 pm 250x4 mm, 1.2 mL/min; solvent A: water + 0.1% v/v trifluoroacetic acid (TFA) ; solvent B: MeCN + 0.1% v/v TFA). A/B: 30/70 - 100/0, 25 min, tR = 9.7 min (12a), 10.7 min (12b). NMR (400 MHz, DMSO-d6) delta 12.82 (s, 1H) , 8.09 (0228) (dd, J = 8.1, 1.7 Hz, 1H) , 8.02 (d, J = 8.1 Hz, 1H) , 7.76 (d, J = 1.7 Hz, 1H) , 6.39 (s, 1H) , 3.24 (td, J = 7.4, 4.8 Hz, 4H) , 2.58 (t, J = 6.4 Hz, 2H) , 2.40 (t, J = 6.2 Hz, 2H) , 1.91-1.78 (0229) (m, 2H) , 1.80-1.69 (m, 2H) . C2iHi9N06 (381.12124). MS (ESI): ml z (0230) (negative mode, %) = 380 (100) [M-H]-. The synthetic route of 41175-50-2 has been constantly updated, and we look forward to future research findings. Reference:
Patent; MAX-PLANCK-GESELLSCHAFT ZUR FOeRDERUNG DER WISSENSCHAFTEN E. V.; BUTKEVICH, Alexey; BELOV, Vladimir N.; HELL, Stefan W.; KAMIN, Dirk; SIDENSTEIN, Sven; SHOJAEI, Heydar; KOLMAKOV, Kirill; SOKOLOV, Viktor V.; (116 pag.)WO2018/46753; (2018); A1;,
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With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.14320-38-8, name is Cyclopent-3-enol, molecular formula is C5H8O, molecular weight is 84.12, as common compound, the synthetic route is as follows.category: alcohols-buliding-blocks

To an ice-cooled solution of 4-hydroxycyclopentene (50.0 g, 0.594 mol) and imidazole (80.9 g, 1.19 mol) in N,N-dimethylformamide (300 mL) was slowly added tert-butyldiphenylsilyl chloride (180 g, 0.65 mmol). The reaction mixture was warmed toroom temperature. After 16 h, the reaction mixture was diluted with water (1 L) and ethyl acetate (500 mL). The aqueous layer was extracted with ethyl acetate (2 x 200 mL). The combined organics were washed sequentially with water (3 x 300 mL) and saturated aqueous sodium chloride solution (2 x 200 mL). The collected organic was dried over anhydrous sodium sulfate, filtered, and concentrated. Purification by flash column chromatography(15:1 petroleum ether / ethyl acetate) providedtert-butyl(cyclopent-3-en-1-yloxy)diphenylsilane (188 g, 98 %) as a colorless oil. 1H NMR (400 MHz, CDC13): oe: 7.69 – 7.66 (m, 4H), 7.43 – 7.38 (m, 6H), 5.63 – 5.60 (m, 2H), 4.58 – 4.53 (m, 1H), 2.46 – 2.38 (m, 4H), 1.61 (s, 9H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,14320-38-8, Cyclopent-3-enol, and friends who are interested can also refer to it.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; GENENTECH, INC.; LYSSIKATOS, Joseph P.; LIU, Wen; SIU, Michael; ESTRADA, Anthony; PATEL, Snahel; LIANG, Guibai; HUESTIS, Malcolm; CHEN, Kevin; WO2015/91889; (2015); A1;,
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Reference of 702-82-9 ,Some common heterocyclic compound, 702-82-9, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

A solution of 5- (4-fluorophenyl) -7-trifluoromethylpyrazolo [1,5-a] pyrimidine-3-carboxylic acid (18, 3.08 mmol) obtained in the step 4) -dimethylaminopropyl) -3-ethylcarbodiimide (1.182 g, 6.18 mmol), 4-dimethylaminopyridine (0.3858, 3.08 mmol), 1-hydroxybenzotriazole (0.4158, 3.08 mmol ), 3-hydroxyamantanamine (4.62 mmol) and mixing to give a mixture I; sealing the vessel in which said mixture I is located, evacuating, passing nitrogen;After repeating the above steps three times, tetrahydrofuran and dimethylformamide were added to the mixture I under a nitrogen atmosphere to obtain a mixture; the tetrahydrofuran and TN, N-dimethylformamide were both dried and anhydrous ; Heating the mixture to a temperature of 40 C and heating for 6 hours, extracting, washing with water, combining and showing signs of drying to the mixture K; the extraction is carried out using a mixture of ethyl acetate Ester extraction, and the extraction process was repeated three times; the water washing process was repeated twice; and the drying was carried out using anhydrous sodium sulfate. The mixture K is subjected to distillation under reduced pressure to precipitate a solid; and the precipitated solid is filtered and washed to obtain a product. The washing was carried out using a mixed solution of ethyl acetate and n-hexane.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-82-9, 3-Aminoadamantan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Chongqing Medical College; SHI, LEI; NIU, YA HUI; (10 pag.)CN105884783; (2016); A;,
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Synthetic Route of 931-17-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 931-17-9, name is 1,2-Cyclohexanediol. A new synthetic method of this compound is introduced below.

EXAMPLE 77a Preparation of intermediate cyclopent-1-enecarbaldehyde To an acidic solution of sodium periodate (28.3 g, 0.13 mol) (Aldrich) in water (250 mL) was added the solution of 1,2-cycohexanediol (12 g, 0.10 mol) (Acros) in ethyl ether (150 mL). The mixture was stirred vigorously for 0.5 h at room temperature. After addition of KOH aqueous solution (20%, 38.4 mL), the reaction mixture was stirred for an additional 1 h. The mixture was extracted with ethyl ether. The organic layers were combined and dried. The solvent was removed to give cyclopent-1-enecarbaldehyde as yellow oil (Yield: 7.2 g, 75%)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,931-17-9, 1,2-Cyclohexanediol, and friends who are interested can also refer to it.

Reference:
Patent; Chen, Li; Ding, Qingjie; Liu, Jin-Jun; Yang, Song; Zhang, Zhuming; US2007/213341; (2007); A1;,
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