Category: alcohols-buliding-blocks

Reference of 889884-94-0, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 889884-94-0, name is 7-Fluoronaphthalen-2-ol. A new synthetic method of this compound is introduced below.

General procedure: To a stirred solution of trichloroacetimidate glycosyl donor (0.6 mmol), and 2-naphthol derivative (0.5 mmol) in anhydrous MeCN (5 mL) was added trimethylsilyl trifluoromethanesulfonate (0.05 mL) dropwise at 0 C under argon atmosphere. The mixture was stirred at r.t. for 2 h, then cooled 0 C and the reaction was quenched with triethylamine and the mixture was concentrated under reduced pressure and purified by flash column chromatography on silica gel (EtOAc/ hexane) to afford the desired glycosides.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,889884-94-0, 7-Fluoronaphthalen-2-ol, and friends who are interested can also refer to it.

Reference:
Article; Chakraborty, Soumen; Mal, Dipakranjan; Synthesis; vol. 50; 7; (2018); p. 1560 – 1568;,
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Reference of 52273-77-5 , The common heterocyclic compound, 52273-77-5, name is 2-(3-Aminophenyl)ethanol, molecular formula is C8H11NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 4 A mixture of 9-chloro-3-methoxyacridine, (975 mg, 4 mmol), 3-aminophenethyl alcohol (549 mg, 4 ml) and methanesulfonic acid (0.32 ml, 5 mmol) in methanol (30 ml) is stirred under reflux for 2 hours. The mixture is concentrated in vacuo, and the residue is dissolved in methanol (10 ml). The solution is diluted with ether (150 ml). The precipitates are collected by filtration, washed with ether to give 9-[3′-(beta-hydroxyethyl)anilino]-3-methoxyacridine, as the methanesulfonate (1.15 g, 65%), mp 186-188 C. Microanalyses Calculated for C22 H20 N2 O2 –CH3 SO3 H: C, 2.71; H, 5.49; N, 6.36; S, 7.28%. Found: C, 62.79; H, 5.51; N, 6.14; S. 7.17%.

The synthetic route of 52273-77-5 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Sloan-Kettering Institute For Cancer Research; US5229395; (1993); A;,
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Reference of 6282-88-8 ,Some common heterocyclic compound, 6282-88-8, molecular formula is C9H11ClO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 502-[3-(4-chlorophenyl)propyl]-N-hydroxy-1-oxo-1,2-dihydroisoquinoline-7-carboxamide Compound I-131 Step 1: 1-(3-bromopropyl)-4-chlorobenzeneTo a solution of 3-(4-chlorophenyl)propan-1-ol (0.25 g, 1.46 mmol) in dichloromethane (5.5 mL) cooled at 0 C. was added triphenylphosphine (0.42 g, 1.6 mmol) and carbon tetrabromide (0.51 g, 1.5 mmol) and the reaction was stirred at rt overnight. The reaction was quenched with water and extracted with DCM (2¡Á). The combined organic phases were then washed with water, and brine, dried over anhydrous Na2SO4, filtered and concentrated. The residue was purified by flash silica gel chromatography (0% to 70% EtOAc/hexanes) to afford 1-(3-bromopropyl)-4-chlorobenzene (0.34 g, quant.). LC-MS: (FA) ES+234.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 6282-88-8, 3-(4-Chlorophenyl)propan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; Millennium Pharmaceuticals, Inc.; US2012/94997; (2012); A1;,
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Adding a certain compound to certain chemical reactions, such as: 1124-63-6, 3-Cyclohexylpropan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 1124-63-6, blongs to alcohols-buliding-blocks compound. SDS of cas: 1124-63-6

2.2 M diethyl azodicarboxylate (1.01 ml) and triphenylphosphine (581 mg) were added to a THF (20 ml) solution containing the resulting compound (450 mg) and 3-cyclohexyl-1-propanol (315 mg), followed by heating at 50C for 22 hours. Water was added to the reaction solution, followed by extracttion with chloroform. The organic layer was washed with saturated brine and dried over anhydrous magnesium sulfate. The solvent was evaporated under reduced pressure, and the residue was purified by silica gel column chromatography (eluent: hexane:EtOAc = 2:1 (v/v)) to obtain methyl 5-[({4-[4[(3-cyclohexylpropoxy)phenoxy]piperidin-1-yl}carbonyl)oxy]nicotinate (242 mg).

The synthetic route of 1124-63-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Astellas Pharma Inc.; EP1849773; (2007); A1;,
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Electric Literature of 599-67-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 599-67-7, name is 1,1-Diphenylethanol, molecular formula is C14H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: Iodine (5.1 mg, 0.02 mmol) was added to phenol 1l (0.148 g, 1 mmol) or alcohol 3h (0.242 g, 1 mmol), followed by addition of HMDS (0.089 g, 0.55 mmol); the mixture was stirred at room temperature until the complete consumption of the starting material (TLC check). The crude reaction mixture was dissolved in 4 mL of hexane/TBME and stirred with the finely powdered Na2S2O3 until the disappearance of iodine. From this point on, two different scenarios are possible: a) The solids were filtered off and the solvent evaporated under the reduced pressure, yielding the crude product. In numerous cases, such products were practically pure; column chromatography and/or distillation improved their quality only slightly. b) A solution of a product in hexane/TBME mixture could be directly subjected to the column chromatography, without filtration of the solids. Caution: Although we experienced no problems when performing these reactions, care should taken due to the potential formation of NI3.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 599-67-7, 1,1-Diphenylethanol.

Reference:
Article; Jereb, Marjan; Tetrahedron; vol. 68; 20; (2012); p. 3861 – 3867;,
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Synthetic Route of 756520-66-8, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 756520-66-8, name is 1-(2,6-Dichloro-3-fluorophenyl)ethanol. A new synthetic method of this compound is introduced below.

A solution of 1- (2,6-dichloro-3-fluorophenyl) ethanol (5 g, 23.9 mmol) in hydrobromic acid (30 ml) When cooled to room temperature. Extracted with ethyl acetate. The combined organic phases were washed with water, dried over anhydrous sodium sulfate and concentrated to give the product (5.2 g, Yield: 80%).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,756520-66-8, 1-(2,6-Dichloro-3-fluorophenyl)ethanol, and friends who are interested can also refer to it.

Reference:
Patent; Tianjin Binjiang Pharmaceutical Inc.; Tian, Hongqi; Huang, Gongchao; (33 pag.)CN103497177; (2017); B;,
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Synthetic Route of 25574-11-2, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 25574-11-2, name is 3-(4-Bromophenyl)propan-1-ol, molecular formula is C9H11BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

A mixture of 3-(4-bromophenyl)propanol (8.15 g, 37.9 mmol), potassium acetate (11.2 g, 113.7 mmol), bis(pinacolato)diboron (10.6 g, 41.7 mmol), dimethyl sulfoxide (150 mL) and 1, l ‘-bis(diphenyl-phosphino) ferroncene-palladium dichloride dichloromethane complex (1:1) (1.55 g, 1.89 mmol) was heated at 800C under nitrogen overnight. Upon cooling, the reaction mixture was poured into water (-300 mL), and the product was extracted with Et2O-hexanes (1:1) (3x300mL). The combined organic extracts were washed with water (~300 mL), brine, dried (Na2SO4) and concentrated to afford 3-[4-(4,4,5,5-tetramethyl-l,3,2-dioxaborolan-2- yl)phenyl]propanol, which was used without further purification.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 25574-11-2, 3-(4-Bromophenyl)propan-1-ol.

Reference:
Patent; MERCK & CO., INC.; WO2008/51405; (2008); A1;,
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Application of 7589-27-7, Adding some certain compound to certain chemical reactions, such as: 7589-27-7, name is 2-(4-Fluorophenyl)ethanol,molecular formula is C8H9FO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 7589-27-7.

A mixture of 2,5-dichloronicotinic acid (0.30 g, 1.6 mmol), 2-(4- fluorophenyl)ethanol (0.23 mL, 1.9 mmol), and sodium hydride in oil (0.15 g, 3.7 mmol) in N, N-dimethylforamide (2 mL) was heated at 90 ¡ãC in an oil bath for 3 hours. The reaction mixture was poured into 10percent citric acid aqueous solution (50 mL), and extracted with ethyl acetate (50 mL x 2). The combined organic layers were washed with water (50 mL x 2) and brine (50 mL), dried (magnesium sulfate), and evaporated. The crude solids were washed with hexane/ether (10/1), and dried in vacuo to afford 0.31 g (68percent) of the title compound as white solids: (at)H-NMR (CDCI3) 8 8.41 (1 H, d, J = 2.8 Hz), 8.31 (1 H, d, J = 2.8 Hz), 7.27-7.20 (2H, m), 7.08-6.98 (2H, m), 4.78 (2H, t, J = 6.8 Hz), 3.15 (2H, t, J = 6.8 Hz) ; MS (ESI) m/z 294 (M – H)-

According to the analysis of related databases, 7589-27-7, the application of this compound in the production field has become more and more popular.

Reference:
Patent; PFIZER PRODUCTS INC.; WO2005/102389; (2005); A2;,
Alcohol – Wikipedia,
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Reference of 722-92-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 722-92-9 as follows.

A solution of [2- (4-AMINOPHENYL)-1,] 1,1, 3,3, 3-hexafluoropropan-2-ol (Oakwoood, [1] g, 3.9 [MMOL)] and 2, [4-DICHLOROBENZALDEHYDE] in methanol (21 mL) was stirred at ambient temperature. After 18 hours, glacial acetic acid (0.24 mL, 4.25 [MMOL)] and sodium [CYANOBOROHYDRIDE] (388 mg, 4.25 [MMOL)] were added. After stirring an additional 18 hours, the mixture was [CONCENTRATED IN VACUO] and the residue dissolved in EtOAc. The organic layer was washed several times with brine, dried [(NA2SO4),] filtered, and concentrated. Purification by flash chromatography (4: 1 hexanes/EtOAc) afforded the title compound as a white waxy solid (1.6 g, 99percent). MS (ES+) [M/Z] 418 (M+), 420 (M+2).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,722-92-9, its application will become more common.

Reference:
Patent; PHARMACIA CORPORATION; WO2003/99769; (2003); A1;,
Alcohol – Wikipedia,
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As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1805-32-9

General procedure: A mixture of the substrate (1 mmol), hexamethyldisilazane (0.70 mmol), and/or 3,4-dihydro-2H-pyran (1.4 mmol) and BiPy(SO3H)2(HSO4)2 (10 mg, 1.95 mol%) in CH3CN(3 mL) and/or CH2Cl2 (3 mL) was stirred at room temperature. The progress of thereaction was monitored by TLC (n-hexane: EtOAc; 10:1) and/or GC. After completion ofthe reaction, the mixture was filtered to separate the solid catalyst. Then the solution wasfiltered through a silica gel pad and washed with CH3CN (2 ¡Á 3 mL) and/or CH2Cl2 (2 ¡Á3 mL). Evaporation of the solvent gave the desired products in high purity.

With the rapid development of chemical substances, we look forward to future research findings about 1805-32-9.

Reference:
Article; Shirini, Farhad; Abedini, Masoumeh; Mahmoodi, Nosratollah; Biglari, Mohammad; Safarpoor Nikoo Langrudi, Mohaddeseh; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 11; (2015); p. 1912 – 1921;,
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