Category: alcohols-buliding-blocks

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 534-03-2, name is 2-Aminopropane-1,3-diol. A new synthetic method of this compound is introduced below., Product Details of 534-03-2

General procedure: Amine (1 mmol) and Fmoc-Cl (1.1 mmol) were placed in a glass tube under neat conditions and were sonicated for a suitable time (as indicated in Tables 1, 2 and 3). All reactions were performed in a water bath at room temperature. After completion of the reaction (as indicated by TLC), 5 cm3 of diethyl ether was added to the mixture. The N-Fmoc derivatives were crystallized and were obtained in good to excellent yields. Purification of the product was accomplished by recrystallization from diethyl ether.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 534-03-2, 2-Aminopropane-1,3-diol.

Reference:
Article; Mansouri, Rachida; Aouf, Zineb; Lakrout, Salah; Berredjem, Malika; Aouf, Nour-Eddine; Journal of the Brazilian Chemical Society; vol. 27; 3; (2016); p. 546 – 550;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 30379-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 30379-58-9 as follows.

10129] l3enzyl glycolate (30 g, 0.25 mol) and Hoc anhydride (39.1 g, 0.19 mol) were dissolved in 30 ml of dichloromethane. 5 ml of DMAP (4.62 g, 0.038 mol) in dichloromethane solution was added dropwise into the resultant reaction liquid at 80 C. Afier that, the reaction liquid was reacted at 15 C. for 0.5 h. Afier completion of the reaction, the reaction liquid was poured into ice water, extracted with ethyl acetate, the combined resultant organic phase was washed with water and saturated salt water successively. The organic phase was concentrated and recrystallized with petroleum ether/ethyl acetate in a ratio of 10:1 to give a white solid (32.5 g, 66%).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,30379-58-9, its application will become more common.

Reference:
Patent; JIANGSU TASLY DIYI PHARMACEUTICAL CO., LTD.; Zhou, Wei; Jing, Yunrong; Wang, Yongfeng; Wang, Guocheng; (81 pag.)US2016/340365; (2016); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 62285-58-9, name is (2,6-Dimethylphenyl)methanol. A new synthetic method of this compound is introduced below., Application In Synthesis of (2,6-Dimethylphenyl)methanol

Step C: Preparation of 3-(3-(2,6-dimethylbenzyloxy)phenyl)propanenitrile: A solution of 3-(3-hydroxyphenyl)propanenitrile (Step B, 1.25 g, 8.5 mmol) and diisopropyl azodicarboxylate (DIAD, 1.87 g, 9.26 mmol) in dry THF (10 ml) was added drop wise to a solution of 2.6-Dimethylbenzyl alcohol (1.27 g, 9.3 mmol) and triphenylphosphine (TPP. 2.43 g, 9.26 mmol) in dry THF (30 ml) at 0C under argon. The reaction mixture was warmed to room temperature for 4 hours or until all the starting material is consumed, diluted with ether and washed with water (2X). The organic layer was dried over Na3SO4. filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate 2:1) to give the title compound.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 62285-58-9, (2,6-Dimethylphenyl)methanol.

Reference:
Patent; Wellstat Therapeutics Corporation; O’NEIL, James, Dennen; SHARMA, Shalini; ARUDCHANDRAN, Ramachandran; EP2282736; (2015); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 10488-69-4, name is Ethyl 4-chloro-3-hydroxybutanoate, the common compound, a new synthetic route is introduced below. Safety of Ethyl 4-chloro-3-hydroxybutanoate

(1) Ethyl S-4-chloro-3-hydroxybutyrate was stirred with 60percent by weight of DMSO and 1-fold by weight of sodium azide at 60 ° C for 5 hours, The solvent is DMF, n-propanol, isopropanol, n-butanol, tert-butanol, toluene or cyclopentanol and so on to get the intermediate I, and the reaction is complete, stop the reaction, direct concentration to remove the solvent,

The synthetic route of 10488-69-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Chongqing East Ze Pharmaceutical Technology Development Co., Ltd.; Yuan, Huajie; Dai, Liping; Xie, Lingling; Ye, Lei; (24 pag.)CN105330581; (2016); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.495-76-1, name is Benzo[d][1,3]dioxol-5-ylmethanol, molecular formula is C8H8O3, molecular weight is 152.1473, as common compound, the synthetic route is as follows.Computed Properties of C8H8O3

General procedure: In a typical reaction, the catalyst was weighed into a screw-capped glass pressure vessel containing a stir bar. The required amounts of alcohol (0.5 mmol) and amine (0.6 mmol), pre-dissolved in solvent (2 mL), were added and the vessel was filled with oxygen, sealed, and heated to the desired temperature in an oil bath with stirring. The products of the reaction were analyzed by gas chromatography (GC, Agilent 7890A) and GC-mass spectrometry (MS, Agilent 7890A/5975C).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,495-76-1, Benzo[d][1,3]dioxol-5-ylmethanol, and friends who are interested can also refer to it.

Reference:
Article; Zhang, Zhixin; Wang, Yehong; Wang, Min; Lue, Jianmin; Li, Lihua; Zhang, Zhe; Li, Mingrun; Jiang, Jingyang; Wang, Feng; Chinese Journal of Catalysis; vol. 36; 9; (2015); p. 1623 – 1630;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 109-83-1, name is 2-(Methylamino)ethanol, molecular formula is C3H9NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. category: alcohols-buliding-blocks

4-Methoxy-2,6-dimethylbenzenesulfonyl chloride (12 g, 51 mmol) is added to a solution of 2- (methylamino)ethanol (4.6 mL, 61 mmoi), diisopropyl ethyl amine (22 mL, 130 mmol), and CH2Cl2 (130 mL) under N2. The reaction vessel is sealed and left to stir for 21 h. The solution is washed with 1 :1 sat. aq. NH4C.: H2O (2 X 200 mL) and brine (200 mL). The aqueous layers are extracted with CH2Cl2 (200 mL). The combined organic layers are dried over Na2SO4, filtered, and concentrated to afford the title compound as a pale yellow oil. LC-MS m/? (M + Na~): 296.06 (§).

With the rapid development of chemical substances, we look forward to future research findings about 109-83-1.

Reference:
Patent; NEUROGEN CORPORATION; WO2007/140383; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 6920-22-5, Adding some certain compound to certain chemical reactions, such as: 6920-22-5, name is Hexane-1,2-diol,molecular formula is C6H14O2, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 6920-22-5.

General procedure: Glycerol (0.3 mmol, 42 mg), NH4ReO4 (0.03 mmol, 8 mg), 2,4-dimethyl-3-pentanol (0.43-0.86 mmol, 60-120 muL), and 1 mL anhydrous toluene were added to a thick-walled Ace glass reactor tube. The Teflon seal was closed and the reactor was placed in a heating mantle connected with a Digi Troll (Glas-Col) digital temperature controller equipped with a thermocouple at 140-165 C for 5-48 h while stirring. After cooling to room temperature, the solution was filtered to remove the precipitated NH4ReO4 and analyzed with GC-MS

According to the analysis of related databases, 6920-22-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Gossett, Justin; Srivastava, Radhey; Tetrahedron Letters; vol. 58; 39; (2017); p. 3760 – 3763;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 5456-63-3, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.5456-63-3, name is trans-2-Aminocyclohexanol hydrochloride, molecular formula is C6H14ClNO, molecular weight is 151.6345, as common compound, the synthetic route is as follows.

To a suspension of l-(2,4-dichlorophenyl)-4-hydroxymethyl-5-[4-(3,3,3-trifluoropropane- l-sulfonyloxy)phenyl]-lH-pyrazole-3-carboxylic acid (0.70 g, 1.30 mmol) in dichloromethane (90 ml) was added c-2-aminocyclohexanol hydrochloride (200 mg, 1.32 mmol) followed by triethylamine (0.37 ml, 2.63 mmol) and BOP (708 mg, 1.60 mmol). The reaction mixture was stirred at room temperature overnight, poured into ice- water and extracted with EtOAc (x3). The combined organic extracts were dried (Na2SO4), filtered and concentrated. Flash chromatography (heptane : EtOAc 50 : 50 – EtOAc) and CH2Cl2 : MeOH 99 : 1 – 95 : 5) afforded 200 mg (24%) of the title compound as a colorless solid. HPLC: 89%. MS: 658 (M+Na).

The chemical industry reduces the impact on the environment during synthesis 5456-63-3, I believe this compound will play a more active role in future production and life.

Reference:
Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/148061; (2007); A1;; ; Patent; ASTRAZENECA AB; ASTRAZENECA UK LIMITED; WO2007/148062; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 4152-92-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 4152-92-5, name is (2-(Aminomethyl)phenyl)methanol, molecular formula is C8H11NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 1(3R,6f?)-3-(2,3-Dihydro-1 H-inden-2-yl)-6-(1 -ethylpropyl)-1 -[2(hydroxymethyl)- benzyI]piperazine-2,5-dione [2-(Aminomethyl)phenyl]methanol (4.12g, 30 mmol) was dissolved in methanol (30ml) and 2-ethylbutanal (3.7ml, 30 mmol) added followed by (2R)-2,3-dihydro-1H-inden-2- yl({[(1 ,1-dimethylethyl)oxy]carbonyl}amino)ethanoic acid (8.74g, 30 mmol). The mixture was stirred for 15 minutes before 4-chlorophenylisonitrile (4.13g, 30 mmol) was added. The mixture was stirred for 2.25 hours and then left to stand at room temperature overnight (16.3 hours) before it was cooled in an ice / water bath. Then acetyl chloride (12.75ml, 179.5 mmol) was added dropwise, keeping the reaction temperature below 200C. Then the mixture was stirred in the cooling bath for a further 10 minutes before it was stirred at room temperature. After 5 hours the mixture was evaporated under reduced pressure to leave a dark brown gum. The gum was stirred in chloroform (75ml) and saturated aqueous sodium bicarbonate solution (75ml) for 20 minutes before it was diluted with chloroform (75ml) and the phases separated. The aqueous phase was extracted with chloroform (3 * 75ml). The combined organic phase was dried (MgSO4) and concentrated under reduced pressure to ca. 75ml. The chloroform solution was treated with glacial acetic acid (3ml) and left to stand, at room temperature over the weekend. Then the reaction mixture was washed with 2M hydrochloric acid (75ml), followed by saturated aqueous sodium bicarbonate solution (75ml). The organic phase was dried (MgSO4) and evaporated under reduced pressure and dried to leave a brown foam. The foam was loaded in dichloromethane onto a 33Og flash silica chromatography column (pre-eluted with 20% ethyl acetate in cyclohexane). The column was eluted with 20% to 100% ethyl acetate in cyclohexane to afford (3f?,6R)-3-(2,3-dihydro-1H-inden-2- yl)-6-(1-ethylpropyl)-1-[2-(hydroxymethyl)benzyl]piperazine-2,5-dione (4.12g) as a pale brown solid. HPLC (A) Rt = 3.26 minutes; m/z [M+H]+ = 421. EPO 1H NMR (CDCI3) delta 7.37 (m, 1 H), 7.30 (m, 2H), 7.21 (m, 5H), 6.84 (br d,1 H), 5.45 (d, 1 H), 4.74 and 4.63 (d, 2H), 4.16 (d, 1 H), 4.08 (dd, 1 H), 4.04 (d, 1 H), 3.15 (m, 3H), 2.92 (m, 1H), 2.78 (m, 2H), 1.76 (m, 1 H), 1.62 (m, 3H), 1.31 (m, 1 H), 0.92 (m, 6H).

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 4152-92-5, (2-(Aminomethyl)phenyl)methanol.

Reference:
Patent; GLAXO GROUP LIMITED; WO2006/67462; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 23377-40-4, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 23377-40-4, name is 3-(Hexadecyloxy)propan-1-ol, molecular formula is C19H40O2, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a mixture of adefovir (1.36 g, 5 mmol) and 3-hexadecyloxy-l-propanol (1.8 g, 6 nunol) in dry pyridine was added DCC (2.06 g, 10 mmol). The mixture was heated to reflux and stirred 18 h then cooled and filtered. The filtrate was concentrated under reduced pressure and the residue was applied to a short column of silica gel. Elution of the column with 9:1 dichloromethane/methanol yielded hexadecyloxypropyl-adefovir (HDP-ADV) as a white powder.

According to the analysis of related databases, 23377-40-4, the application of this compound in the production field has become more and more popular.

Reference:
Patent; CHIMERIX, INC.; WO2006/110656; (2006); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts