Category: alcohols-buliding-blocks

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 117284-59-0, name is 2-(2,2-Difluorocyclopropyl)ethanol. This compound has unique chemical properties. The synthetic route is as follows. SDS of cas: 117284-59-0

Methanesulfonyl chloride (1.35 mL) was added to a solution of 2- (2 , 2-difluorocyclopropyl) ethanol (1.42 g) and triethylamine (3.24 mL) in THF (20 mL) dropwise at 0 C. The mixture was stirred at room temperature overnight. Water was added, and the mixture was extracted with ethyl acetate. The organic layer was washed with brine, dried over anhydrous magnesium sulfate and concentrated under reduced pressure. The residue was purified by silica gel column chromatography(hexane/ethyl acetate) to give the title compound (1.31 g) as a pale yellow oil.XH NMR (300 MHz, DMSO-d6) delta 1.17-1.30 (1H, m) , 1.44-1.98 (4H, m) , 3.19 (3H,. s) , 4.16-4.36 (2H, m)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 117284-59-0, 2-(2,2-Difluorocyclopropyl)ethanol.

Reference:
Patent; TAKEDA PHARMACEUTICAL COMPANY LIMITED; YASUMA, Tsuneo; KAMATA, Makoto; YAMASHITA, Tohru; HIROSE, Hideki; MURAKAMI, Masataka; KINA, Asato; YONEMORI, Kazuko; MIZOJIRI, Ryo; FUJIMORI, Ikuo; FUJIMOTO, Takuya; IKEDA, Zenichi; WO2012/74126; (2012); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 2043-47-2, name is 1H,1H,2H,2H-Nonafluoro-1-hexanol. This compound has unique chemical properties. The synthetic route is as follows. HPLC of Formula: C6H5F9O

5.00 parts of a compound represented by the formula (I-1-b),Mix 20 parts of tetrahydrofuran and 8.98 parts of pyridine,After stirring for 30 minutes at 23 C., it was cooled at 5 C.In the resulting mixture, formula (I-7-a)9.74 parts of a compound represented byAfter stirring for 1 hour at 5 C.,Stir at 23 C. for 18 hours,Then, it cooled to 23 degreeC. In the reaction product obtained,50 parts and 10% ethyl acetateMix 30 parts of aqueous potassium carbonate solution and stir for 30 minutes atThe organic layer was obtained by liquid separation.In the collected organic layer,Mix 30 parts of deionized water and stir at 23 C. for 30 minutes,The organic layer was obtained by separation.After concentrating the obtained organic layer,The concentrated residue thus obtained was columned (silica gel 60 N (spherical, neutral) 100-210 mum; manufactured by Kanto Chemical Co.,Developing solvent: n-heptane / ethyl acetate = 1/3)By sorting,Compound Represented by Formula (I-7)I got 8.54 copies.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 2043-47-2, 1H,1H,2H,2H-Nonafluoro-1-hexanol.

Reference:
Patent; Sumitomo Chemical Co., Ltd.; Mashiyama, Tatsuro; Yasue, Takahiro Hamada; Ichikawa, Koji; (79 pag.)JP2019/52141; (2019); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 30379-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.30379-58-9, name is Benzyl 2-hydroxyacetate, molecular formula is C9H10O3, molecular weight is 166.17, as common compound, the synthetic route is as follows.

To a solution of 4-(methylsulfonamidomethyl)benzoic acid (0.4 g, 1.745 mmol) and benzyl 2-hydroxyacetate (0.290 g, 1.745 mmol) in a mixture of DCM and THF 1/1 (50 ml), EDC (0.334 g, 1.745 mmol) and DMAP (0.256 g, 2.094 mmol) were added in one portion. The reaction was stirred at RT for 3h. The solvent was removed under vacuum and the resulting crude was portioned between EtOAc and HC1 2N. The organic phase was separated, washed with brine and dried over Na2S04. The solvent was removed under vacuum affording 2-(benzyloxy)-2- oxoethyl 4-(methylsulfonamidomethyl) benzoate (0.4 g, 1.060 mmol, 60.7% yield, MS/ESr 377.9 [MH] +). This product was employed in the following step without any further purification.

The chemical industry reduces the impact on the environment during synthesis 30379-58-9, I believe this compound will play a more active role in future production and life.

Reference:
Patent; CHIESI FARMACEUTICI S.P.A.; ARMANI, Elisabetta; AMARI, Gabriele; CAPALDI, Carmelida; ESPOSITO, Oriana; PERETTO, Ilaria; WO2013/45280; (2013); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 96-35-5 ,Some common heterocyclic compound, 96-35-5, molecular formula is C3H6O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Example 1Reduction of Methyl Glycolate in Methanol to Ethylene Glycol The following example shows the positive effect of adding a promoter to the catalyst mixture. Run 1 in the table below is a comparative example. Runs 2-9 represent variants of the current invention.A 300-milliliter autoclave was charged with Ru(Acac)3 (0.10 mmole), TRIPHOS (0.50 mmole), and the promoter in the amount specified in the table. Methanol (32 milliliters) and methyl glycolate (0.156 mole) were added, and the reactor was sealed under N2. The reactor was pressurized to 250 psig (1.7 MPa) with H2 and heated to 200 C. Upon reaching 200 C., the H2 pressure was raised to 2000 psig (13.8 MPa). The autoclave was stirred and held at 200 C., 2000 psig (13.8 MPa) for a total of 3 hours. The autoclave was then cooled, excess gas vented, and the contents recovered. The contents were analyzed by the use of an internal standard gas chromatography method for the presence of methyl glycolate (?MG?) and ethylene glycol (?EG?). The results are shown in the table below. Catalyst Activity Rate Amount of Conversion of Selectivity to (moles EG per Promoter MG EG mole of Ru Run Promoter (mmole) (%) (%) per hr) 1 none none 39.5 88.4 205 2 Zn 0.25 49.3 88.9 228 Acetonylacetonate 3Me4NBF4 0.025 99.7 98.2 509 4Me4NBF4 0.001 96.8 98.2 394 5NH4PF6 0.025 100 96.9 504 6NH4OAc 0.150 67.8 94.8 334 7Ph4PBr 0.025 84.1 97.8 428 8NaPh4B 0.500 81.1 93.5 394 9BuN4PF6 0.025 97.8 95.8 487 Analysis of the run without a promoter showed a 39.5% conversion of the methyl glycolate with 88.4% selectivity to ethylene glycol. The catalyst activity rate for this experiment was 205 moles of EG per mole of ruthenium per hour. On the other hand, runs with a promoter showed MG conversions of 49-100%, EG selectivities of 89-98%, and catalyst activity rates of 230-510 moles of EG per mole of ruthenium per hour. This data show the positive effects of adding a promoter to the reaction mixture.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,96-35-5, its application will become more common.

Reference:
Patent; EASTMAN CHEMICAL COMPANY; US2009/143612; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 1454-85-9 , The common heterocyclic compound, 1454-85-9, name is Heptadecan-1-ol, molecular formula is C17H36O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 100 ml, 3 port reaction vessel equipped with a mechanical stirrer, mantle, thermowatch, short-column condenser, cow receiver, thermometers, and a nitrogen blanket, 27.68 grams of hydrophobe group containing compound and 4.34 grams of p-toluenesulfonic acid monohydrate were added. The reactants were heated to about 80° C. and 25 grams of the trithiocarbonate compound was added. A partial vacuum to 60 mmHg mercury was applied and the temperature was increased to about 110° C. for a period of five hours to produce the product shown above.

The synthetic route of 1454-85-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Lai, John Ta-Yuan; Hsu, Shui-Jen Raymond; Tamareselvy, Krishnan; US2006/39939; (2006); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 53463-68-6, name is 10-Bromodecanol, molecular formula is C10H21BrO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. HPLC of Formula: C10H21BrO

To 2.00 g of 10-bromo-1-decanol in 15 mL of chloroform (CHCl3) was added dropwise 16.9 mmol of 3,4-dihydro-2H-pyran (DHP) and catalytic amounts of p-toluenesulphonic acid (pTSA). The reaction mixture was stirred for 24 h at room temperature. The organic layer was washed with water (2 .x. 20 mL), NaHCO3 (2 .x. 20 mL), CHCl3 (1 .x. 20 mL), and dried over MgSO4, filtered, and evaporated in vacuo. The crude product was purified using silica gel column chromatography eluting with hexane/ether (9:1). The pure product 2 (Banaszak et al., 2009) was obtained as a colorless oil 2.35 g (7.32 mmol) for a 100percent yield.

With the rapid development of chemical substances, we look forward to future research findings about 53463-68-6.

Reference:
Article; Carballeira, Ne?stor M.; Montano, Nashbly; Cintro?n, Gabriel A.; Ma?rquez, Carmary; Rubio, Celia Ferna?ndez; Prada, Christopher Ferna?ndez; Balan?a-Fouce, Rafael; Chemistry and Physics of Lipids; vol. 164; 2; (2011); p. 113 – 117;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 2277-23-8, 2,3-Dihydroxypropyl decanoate, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Quality Control of 2,3-Dihydroxypropyl decanoate, blongs to alcohols-buliding-blocks compound. Quality Control of 2,3-Dihydroxypropyl decanoate

Compound 1, 100 mg, compound 2, 76 mg,120 mg of 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride (EDCI)42 mg of 1-hydroxybenzotriazole (HOBt) was dissolved in 2 ml of THF,The reactants were mixed and replaced with nitrogen three times,After stirring at room temperature for 1 hour.TLC detection (DCM: MeOH = 5: 1), the remaining starting material,The system was concentrated directly and scraped into large plates (DCM: MeOH = 10: 1) to give 51 mg of a light yellow oil.

The synthetic route of 2277-23-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Si Fenke Si Pharmaceutical Research And Development (Tianjin) Co., Ltd.; Yao Qingjia; Wu Simin; Xu Yangjun; (6 pag.)CN106749210; (2017); A;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Reference of 100-86-7, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 100-86-7, name is 2-Methyl-1-phenyl-2-propanol, molecular formula is C10H14O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

2.5.1 (1,1-Dimethyl-2-phenyl-ethoxy)-trimethylsilyl ether IR (neat): nu = 2950, 1450, 1255, 1095, 838, 740, 693 cm-1; 1H NMR (400 MHz, CDCl3): delta = 0.148 (s, 9H), 1.292 (s, 6H), 2.802 (s, 2H), 7.272-7.356 (m, 5H) ppm; MS (EI, 70 eV) m/z: 222 [M+], 207 [M+-CH3], 133 [M+-OTMS]; Anal. calcd for C13H22OSi: C, 70.27; H, 9.90. Found: C, 70.25; H, 9.87.

According to the analysis of related databases, 100-86-7, the application of this compound in the production field has become more and more popular.

Reference:
Article; Shirini, Farhad; Khaligh, Nader Ghaffari; Akbari-Dadamahaleh, Somayeh; Journal of Molecular Catalysis A: Chemical; vol. 365; (2012); p. 15 – 23;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Related Products of 5182-44-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 5182-44-5, name is 2-(3-Chlorophenyl)ethanol, molecular formula is C8H9ClO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Example 63-Chloro-7-[2-(3-chloro-phenyl)-ethoxymethyl]-6H-pyrimido[4,5-c]pyridazin-5-one6.1 [2-(3-Chloro-phenyl)-ethoxy]-acetic acid methyl ester; To a solution of 2-(3-chloro-phenyl)-ethanol (1.96 g, 12.51 mmol) in THF (55 ml) was added n-BuLi (8.8 ml, 1.6 M solution in hexane, 13.77 mmol) at -78 C. Then sodium iodoacetate (2.6 g, 12.51 mmol) was added and the mixture was allowed to warm to ambient temperature and was stirred overnight. The THF was then removed and 1 N HCl was added to the remaining residue to adjust the pH to 1. This mixture was extracted two times with dichloromethane and the combined extracts were dried (Na2SO4) and evaporated. The remaining red liquid was dissolved in MeOH (60 ml) and thionylchloride (1.56 ml, 21.5 mmol) was added dropwise at -15 C. The reaction mixture was then stirred for 1.5 h at ambient temperature. Then water was added and the mixture was extracted three times with ether. The combined extracts were washed with brine, dried (Na2SO4) and evaporated. The remaining residue was then purified by column chromatography (silica gel, heptane/ethyl acetate 95:5 to 88:12) to give the title compound (2.161 g, 9.45 mmol; 76%) as orange liquid. MS: m/e=229.2 [M+H+].

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 5182-44-5, 2-(3-Chlorophenyl)ethanol.

Reference:
Patent; Conte, Aurelia; Dehmlow, Henrietta; Grether, Uwe; Kratochwil, Nicole A.; Kuehne, Holger; Narquizian, Robert; Panousis, Constantinos G.; Peters, Jens-Uwe; Ricklin, Fabienne; US2008/234277; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Electric Literature of 33420-52-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 33420-52-9, name is 2,2-Difluoropropan-1-ol. A new synthetic method of this compound is introduced below.

General procedure: A mixture of 5-chloro-3-[(2-chlorophenyl)methyl]-7-(3,3-difluoropyrrolidin-l- yl)triazolo[4,5-d]pyrimidine (example 8, step a) (38.5 mg, 0.1 mmol), 2,2,2-Trifluoro- ethanol (99 mg, 1 mmol) and NaH (suspension in oil, 20 mg, 5 mmol) in DMF (1 mL) was stirred at 110 C for 6 h. After cooling to room temperature formic acid was added and the mixture was subjected to purification by preparative HPLC on reversed phase eluting with a gradient formed from acetonitrile, water and formic acid. After evaporation of the product containing fractions 29.3 mg (65 %) of the title compound was isolated. MS(m/e): 449.2 (MH+). Example 53; 3-[(2-Chlorophenyl)methyl]-5-(2,2-difluoropropoxy)-7-(3,3-difluoropyrrolidin-l- yl)triazolo[4,5-d]pyrimidine; In analogy to the procedure described for the synthesis of 3-[(2-chlorophenyl)methyl]-7- (3,3-difluoropyrrolidin-l-yl)-5-(2,2,2-trifluoroethoxy)triazolo[4,5-d]pyrimidine (example 40) the title compound was prepared from 5-chloro-3-[(2-chlorophenyl)methyl]-7-(3,3- difluoropyrrolidin-l-yl)triazolo[4,5-d]pyrimidine and 2,2-difluoropropan-l-ol with the use of Cs2C03 instead of NaH. MS(m/e): 445.3 (MH+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,33420-52-9, its application will become more common.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; HOFFMANN-LA ROCHE INC.; ROEVER, Stephan; ROGERS-EVANS, Mark; NETTEKOVEN, Matthias; SCHMITT, Sebastien; GRETHER, Uwe; KIMBARA, Atsushi; WO2015/32769; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts