Category: 702-82-9

Adding a certain compound to certain chemical reactions, such as: 702-82-9, 3-Aminoadamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, name: 3-Aminoadamantan-1-ol, blongs to alcohols-buliding-blocks compound. name: 3-Aminoadamantan-1-ol

A solution of 66.90 g of 3-amino-1-adamantanol and 340 ml of anhydrous methanol was added successively to 500 ml of 3-necked flask. After stirring, 46.74 g of benzaldehyde was added dropwise, and the mixture was heated and refluxed.After 3 hours, TLC (thin layer chromatography) monitored the reaction until complete conversion of the starting material to form the intermediate.After cooling the reaction system to 0 C, 18.2 g of sodium borohydride was added in portions to the reaction system.After the addition is complete, the reaction is carried out at 0 C to 5 C for 1 to 2 hours.After completion of the reaction by TLC (thin layer chromatography), the solvent was removed by rotary evaporation.To the residue was added 200 ml of water and 300 ml of ethyl acetate, and the organic phase was separated.The organic phase was washed twice with 100 ml of saturated brine, dried over anhydrous sodium sulfate and concentrated to remove the solvent. The crude product was obtained as an oil (118.1 g), which was recrystallized from petroleum ether / ethyl acetate (Volume ratio = 1: 1) to give 95.5 g of a white solid in 92.8% yield

The synthetic route of 702-82-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shandong Weizhi Medicine Industry Co. Ltd.; Wei, yanjun; Wang, hua; Meng, zhoujun; (12 pag.)CN103980175; (2016); B;,
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Reference of 702-82-9, Adding some certain compound to certain chemical reactions, such as: 702-82-9, name is 3-Aminoadamantan-1-ol,molecular formula is C10H17NO, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 702-82-9.

EXAMPLESExample 1-1 (General procedure (A))4-(2,4-Dichloro-phenoxy)-N-((1 R,3S,5R,7S)-3-hvdroxy-adamantan-1-yl)-butyramideTo a stirred solution of 4-(2,4-dichloro-phenoxy)-butyric acid (0.8 g, 3.21 mmol) in dry THF (25 mL) was added HOBt (0.48 mg, 3.533 mmol) and EDAC (0.68 g, 3.533 mmol). After stirring for 10 min. at room temperature, DIPEA (0.62 mL) and 3-amino-adamantan-1- ol (0.59 g, 3.533 mmol) were added and the resulting mixture was stirred for 16 hrs. at room temperature. The volatiles were removed in vacuo and to the residue was added water (25 mL) followed by extraction with EtOAc (3×35 mL). The combined organic phases were washed with brine, dried (Na2SO4), filtered and the solvent evaporated in vacuo. The oily residue was crystallised from diethyl ether (5 mL) affording after drying at 50 0C in vacuo 800 mg (62 %) of the title compound as a solid. 1H NMR (400 MHz, DMSO-c/6) delta 1.35 – 1.58 (m, 6H), 1.70 – 1.85 (m, 6H), 1.91 (q, 2H) 2.09 (br.s., 2H), 2.21 (t, 2H), 4.04 (t, 2H), 4.48 (br.s., 1 H), 7.15 (d, 1 H), 7.36 (dd, 1 H), 7.40 (br.s., 1 H), 7.57 (d, 1 H).

According to the analysis of related databases, 702-82-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; TRANSTECH PHARMA, INC.; NOVO NORDISK A/S; WO2008/134221; (2008); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 702-82-9, name is 3-Aminoadamantan-1-ol. This compound has unique chemical properties. The synthetic route is as follows. 702-82-9

General procedure: For compounds 9-13, a mixture of 77-155mg (0.6-1.2mmol) of phthaldialdehyde 8 and equal molar amount of appropriately substituted adamantylamine or noradamantylamine (if utilized as the hydrochloride salt, potassium carbonate, 0.55-1.0eq, was added as appropriate) in 40-80mL tetrahydrofuran was stirred for 171.5-211.0h under a nitrogen atmosphere at room temperature. After removing solvent, the residues were purified by silica gel chromatography (EtOAc/Hex or MeOH/CH2Cl2)

At the same time, in my other blogs, there are other synthetic methods of this type of compound,702-82-9, 3-Aminoadamantan-1-ol, and friends who are interested can also refer to it.

Reference:
Article; Luo, Weiming; Tweedie, David; Beedie, Shaunna L.; Vargesson, Neil; Figg, William D.; Greig, Nigel H.; Scerba, Michael T.; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1547 – 1559;,
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702-82-9, Adding a certain compound to certain chemical reactions, such as: 702-82-9, 3-Aminoadamantan-1-ol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 702-82-9, blongs to alcohols-buliding-blocks compound.

Example-17: Preparation of 2-(3-hydroxyadamantan-l-yl-imino) acetic acid compound of formula 11:To the solution of l-aminoadamantane-3-ol (5 grams) in 50 ml of tetrahydrofuran 2-oxo acetic acid (2.25 grams) was added and stirred. The reaction mixture was heated to reflux for 3 hrs. The reaction mixture was cooled to room temperature and quenched with water. The reaction mixture was extracted with dichloromethane. The dichloromethane solvent was dried and distilled off to get the title compound.Yield: 6 grams.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,702-82-9, its application will become more common.

Reference:
Patent; MSN LABORATORIES LIMITED; SATYANARAYANA REDDY, Manne; ESWARAIAH, Sajja; VENKAT REDDY, Ghojala; KONDAL REDDY, Bairy; WO2011/101861; (2011); A1;,
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702-82-9, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 702-82-9, name is 3-Aminoadamantan-1-ol. This compound has unique chemical properties. The synthetic route is as follows.

Example 1 : Preparation of vildagliptin To the (S)-l-(2-chloroacetyl)pyrrolidine-2-carbonitrile (100 gm) was added FontWeight=”Bold” FontSize=”10″ isopropyl acetate (400 ml) and dimethylformamide (400 ml) at room temperature and then heated to 40C for 15 minutes to provide a solution. A mixture of 3-hydroxy-l- aminoadamantane (100 gm), 2-butanone (700 ml), potassium iodide (5 gm) and potassium carbonate (400 gm) were added to the solution. The reaction mixture was maintained for 1 hour at room temperature and then heated to 75 to 80C. The reaction mass was maintained for 1 hour at 75 to 80C, filtered and then concentrated to provide a residual solid. To the residual solid was added a mixture of diisopropyl ether (900 ml) and isopropyl acetate (100 ml) and then heated to 70C. The reaction mass was then cooled to room temperature and further cooled to 0 to 5C. The contents were maintained for 1 hour at room temperature and filtered. The solid thus obtained was dried to provide 100 gm of vildagliptin.

While traditionally a conservative industry, chemical producers will need to modernize their PR strategies to stay relevant.we look forward to future research findings about 702-82-9, 3-Aminoadamantan-1-ol.

Reference:
Patent; HETERO RESEARCH FOUNDATION; PARTHASARADHI REDDY, Bandi; RATHNAKAR REDDY, Kura; MURALIDHARA REDDY, Dasari; SUBASH CHANDER REDDY, Kesireddy; VAMSI KRISHNA, Bandi; WO2014/13505; (2014); A2;,
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702-82-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

General procedure: A mixture of 0.136 or 0.272 g (1 or 2 mmol) of 1-oxa-3,6-dithiacycloheptane (1) [3] in 5 mL of chloroform and 0.018 g (0.05 mmol) of SmCl3 ¡¤ 6 H2O was stirred for 30 min at room temperature under argon, and a solution of 1 mmol of the corresponding amine in 5 mL of ethanol was added dropwise. The mixture was stirred for 3 h at room temperature, treated with 2 mL of water, stirred for 30 min more, and extracted with chloroform (20 mL). The extract was evaporated, and the product (compound 2-17) was isolated from the residue by column chromatography on silica gel.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 702-82-9, 3-Aminoadamantan-1-ol, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Rakhimova; Ismagilov; Khalilov; Zainullin; Ibragimov; Dzhemilev; Russian Journal of Organic Chemistry; vol. 51; 7; (2015); p. 951 – 956; Zh. Org. Khim.; vol. 51; 7; (2015); p. 971 – 976,6;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 702-82-9, name is 3-Aminoadamantan-1-ol, the common compound, a new synthetic route is introduced below. 702-82-9

A mixture of 4.89 parts of Salt (I-9), 1.67 parts of a compound represented by the formula (IV-2) and 50 parts of acetonitrile was stirred at 23 C. for 5 hours. The mixture was concentrated and then, 30 parts of chloroform and 15 parts of ion-exchanged water were added to the residue obtained. The mixture obtained was separated to obtain an organic layer. The organic layer was washed with 15 parts of ion-exchanged water and then, concentrated. The residue obtained was dissolved in 20 parts of acetonitrile, and the solution obtained was concentrated. To the residue, 20 parts of ethyl acetate was added. The mixture obtained was concentrated.The residue obtained was mixed with 20 parts of tert-butyl methyl ether. The mixture obtained was stirred and then, the supernatant solution was removed. The residual layer was concentrated, and the residue obtained was mixed with 20 parts of ethyl acetate. The mixture obtained was stirred and the supernatant solution was removed. The residual layer was concentrated to obtain 4.75 parts of the salt represented by the formula (B1-22).Yield: 81% based on Salt (I-9)Yield: 81% based on the salt represented by the formula (II-1).

The synthetic route of 702-82-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; SUMITOMO CHEMICAL COMPANY, LIMITED; US2011/201823; (2011); A1;,
Alcohol – Wikipedia,
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702-82-9 , The common heterocyclic compound, 702-82-9, name is 3-Aminoadamantan-1-ol, molecular formula is C10H17NO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

In a 2L three-neck flask, 116.3 g (0.6954 moL) of 3-aminoadamantanol was added.70.2 g (0.6954 moL) of triethylamine, 4.8 g (0.02891 moL) of potassium iodide and 650.0 g of acetonitrile,Heat to 75-80C with stirring.100.0 g (0.5793 moL) of (S)-1-(2-chloroacetyl chloride)pyrrolidine-2-carbonitrile (dissolved in 500.0 g of acetonitrile) are added dropwise.2h drop is completed,Stir at 75-80 C for 1 h; TLC test is complete, and the reaction system is cooled to 20-30 C.The filter cake was rinsed with 400 g acetonitrile.Combine the filtrate and remove the solvent under reduced pressure (60C, -0.09–0.1MPa) to obtain an almost white solid.Add 211.0 g of a mixed solvent of ethanol and butanone in a mass ratio of 1:1 and heat to reflux to dissolve.Cool down to 20-30C, stir and crystallize for 1h, continue cooling to -5-5C,The crystals were stirred for 1 h. Filtration, 43g of butanone at 0C, and drying under reduced pressure (60C, -0.09–0.1MPa),127.3 g of white solid powder was obtained (yield 72.4%, HPLC purity 99.10%, Ia content 0.87%),Structural confirmation,

The synthetic route of 702-82-9 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Yantai Wanrun Pharmaceutical Co., Ltd.; Li Zhong; Hao Yu; Sun Baojia; Lin Peisen; Xiang Longming; Liu Zhigang; (10 pag.)CN104945299; (2017); B;,
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