Category: 62285-58-9

Synthetic Route of 62285-58-9 ,Some common heterocyclic compound, 62285-58-9, molecular formula is C9H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

Step C: Preparation of 2-(3-(2,6-Dimethylbenzyloxy)phenyl)-2-methylpropanenitrile:; A solution of 2,6-Dimethylbenzyl alcohol (2.76g, 20.3mmol) and diisopropyl azodicarboxylate (DIAD, 4.7g, 23.2mmol) in THF (20ml) was added drop wise to a solution of 2-(3-hydroxyphenyl)-2-methylpropanenitrile (Step B, 3.2g, 19.8mmol) and triphenylphosphine (5.28g, 20.1mmol) in THF (50ml) at O0C under argon. The reaction mixture was stirred at the same temperature for 16 hours, diluted with ether and washed with water. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate, 9:1) to give the title compound

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62285-58-9, its application will become more common.

Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; WO2009/151695; (2009); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 62285-58-9, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.62285-58-9, name is (2,6-Dimethylphenyl)methanol, molecular formula is C9H12O, molecular weight is 136.19, as common compound, the synthetic route is as follows.

A solution of 2,6-Dimethylbenzyl alcohol (7.71 g, 56.7 mmol) and diisopropyl azodicarboxylate (DIAD, 11.36 g, 56.18 mmol) in THF (30 ml) and DMF (13 ml) was added drop wise to a solution of Ethyl 3-(3-hydroxyphenyl)propanoate (Step A, 10.0 g, 51.5 mmol) and triphenylphosphine (14.73 g, 56.18 mmol) in THF (100 ml) at 00C. The reaction mixture was stirred at the same temperature for 4 hours, diluted with ether and washed with water. The organic layer was dried over Na2SO4, filtered, concentrated, and purified by flash chromatography on a silica gel column (hex: ethyl acetate 4:1) to give the title compound.1H NMR (270 MHz, CDCl3): 1.2 (t, 3H); 2.4 (s, 6H); 2.6 (t, 2H); 3.0 (t, 2H); 4.2 (q, 2H); 5.1 (s, 2H); 6.8 (m, 3H); 7.2-7.4 (m, 4H).

Statistics shows that 62285-58-9 is playing an increasingly important role. we look forward to future research findings about (2,6-Dimethylphenyl)methanol.

Reference:
Patent; WELLSTAT THERAPEUTICS CORPORATION; WO2007/56771; (2007); A2;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 62285-58-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 62285-58-9, name is (2,6-Dimethylphenyl)methanol. This compound has unique chemical properties. The synthetic route is as follows.

Step B Preparation of N- (2,6-Dimethylbenzyl)phthalimide: To a stirred solution of 2,6-Dimethylbenzyl Alcohol (Step A, 6.59 g, 48.4 mmol) in DMSO (20 ml) was added chlorotrimethylsilane (15.75 ml, 145 mmol) at room temperature, and the mixture was stirred for one hr. To this reaction mixture were added ethyl acetate and water, the organic layer was washed with brine, dried over Na2SO4, filtered and concentrated to give an oil. The oily residue was redissolved in DMF (100 ml) and potassium phthalimide (10.76 g, 58.1 mmol) was added. The reaction mixture was stirred for 16 hours at room temperature, ethyl acetate was added, and the organic layer was washed with 3% Na2CO3, 1 N HCl, dried over Na2SO4, filtered and concentrated to give white solid. The purification was done by flash chromatography on silica gel column (chloroform: methanol 95:5) to provide the title compound as white solid. 1H NMR (270 MHz, DMSO): 2.3 (s, 6H); 4.8 (s, 2H); 7.0 (m, 3H); 7.8 (s, 4H).

According to the analysis of related databases, 62285-58-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Sharma, Shalini; von Borstel, Reid W.; US2003/149107; (2003); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Application of 62285-58-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 62285-58-9 as follows.

Following the general intermolecular amination procedure, 2,6-dimethylbenzyl alcohol (7q: 54 mg, 0.4 mmol), Du Bois’ catalyst (6.1 mg, 8.0 mumol), and 32 TsONHMe (0.121 g, 0.6 mmol) were stirred in TFE (4 mL) at 0 C. for 2 h. Chromatographic purification of the crude product afforded 14 (2,6-dimethyl-3-(methylamino)phenyl)methanol (8q: 28 mg, 42%) as a solid, mp 78.6 C. TLC: Rf?0.4 (40% EtOAc/hexanes); 1H NMR (400 MHz, CDCl3) delta 7.00 (d, J=8.2 Hz, 1H), 6.56 (d, J=8.2 Hz, 1H), 4.74 (s, 2H), 2.88 (s, 3H), 2.35 (s, 3H), 2.20 (s, 3H); 13C NMR (101 MHz, CDCl3) delta 145.88, 136.50, 128.53, 125.51, 121.93, 109.72, 59.77, 31.30, 19.13, 12.57. HRMS (ESI+) Calcd. for [C10H15NO+H]+ 166.1232, Found 166.1228.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,62285-58-9, its application will become more common.

Reference:
Patent; The Board of Regents of the University of Texas System; William Marsh Rice University; FALCK, John R.; PAUDYAL, Mahesh P.; KUeRTI, Laszlo; (51 pag.)US2019/152892; (2019); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts