Category: 5299-60-5

Application of 5299-60-5 ,Some common heterocyclic compound, 5299-60-5, molecular formula is C8H16O3, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

General procedure: To a stirred solution of esters 2a-2j (70 mmol) in MeOH (30 mL) cooled in an ice-water bath was added dropwise 80% aqueous hydrazine hydrate (6.26 g, 100 mmol). The resulting solution was stirred at room temperature (2a-2b or 2d-2j), or reflux (2c), until the completion of reaction as indicated by TLC analysis (typically within 5 h). The reaction mixture was evaporated on a rotary evaporator to give a residue, which was purified by column chromatography through a short silica gel column to yield 3a-3k after trituration with n-hexane if possible.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 5299-60-5, Ethyl 6-hydroxyhexanoate, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Tian, He; Liu, Wei; Zhou, Zhixing; Shang, Qian; Liu, Yuqiang; Xie, Yafei; Liu, Changying; Xu, Weiren; Tang, Lida; Wang, Jianwu; Zhao, Guilong; Molecules; vol. 21; 11; (2016);,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. A new synthetic method of this compound is introduced below., Safety of Ethyl 6-hydroxyhexanoate

1.4 Synthesis of ethyl 6-[(2-cyanoethyl)( V, V-diisopropylamino)phosphino] oxyhexanoate. Ethyl 6-hydroxyhexanoate (2.44 mL, 15.0 mmol) and diisopropylethylamine (10.4 mL, 60.0 mmol) were dissolved in CH2C12 (60 mL). 2-Cyanoethyl-N,N- diisopropylchlorophosphoramidite (3.51 mL, 15.8 mmol) was added dropwise, and the reaction was stirred for 2 h. The reaction was washed with ice-cold saturated aqueous NaHC03, dried over Na2S04, filtered and concentrated under reduced pressure. The crude material was purified by flash chromatography (Si02, 9: 1 hexane/EtOAc with 0.1%> Et3N) to yield the product (4.20 g, 1 1.7 mmol, 78%) as a colorless liquid. i? 0.80 (2: 1 hexane/EtOAc). Spectral data matched those reported previously (Raddatz et al. , 2002, Nucleic Acids Res. 30, 4793).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5299-60-5, Ethyl 6-hydroxyhexanoate.

Reference:
Patent; THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA; LAMBRIS, John D.; RICKLIN, Daniel; WO2015/142701; (2015); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 5299-60-5, name is Ethyl 6-hydroxyhexanoate. This compound has unique chemical properties. The synthetic route is as follows. Recommanded Product: 5299-60-5

This was synthesized essentially following the procedurereported previously.30 Briefly, a mixture of tert-butyldimethylsilylchloride(1.84 g, 12.21 mmol), imidazole (816 mg, 11.99 mmol)and ethyl 6-hydroxyhexanoate (640 mg, 3.99 mmol) in DMF (10mL) was stirred under nitrogen at 20 C. After 24 h, the reactionmixture was diluted with ether (50 mL) and the ethereal solutionwashed with brine (150 mL 3). The ether solution was separated,dried over Na2SO4, and the ether removed by rotary evaporation toobtain a yellow oil. A methanolic solution of Triton B (40% w/w, 10mL) was added to this and the mixture stirred at 20 C for an hour.Methanol was removed under vacuum, water (20 mL) was addedto the residue and the pH adjusted to 4 using 1 M HCl. The aqueousphase was then extracted with ether (100 mL 3) and the combinedether solution was dried over Na2SO4. Ether was evaporatedto yield 609 mg (2.47 mmol, 61.9%) of compound 3 as a yellow oil:1H NMR (CDCl3) d 0.04 (s, 6H), 0.89 (s, 9H), 1.40 (dd, 2H), 1.53 (m,2H), 1.65 (m, 2H), 3.61 (t, 2H)

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 5299-60-5, Ethyl 6-hydroxyhexanoate.

Reference:
Article; Zhou, Zhengyuan; Chitneni, Satish K; Devoogdt, Nick; Zalutsky, Michael R.; Vaidyanathan, Ganesan; Bioorganic and Medicinal Chemistry; vol. 26; 8; (2018); p. 1939 – 1949;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Synthetic Route of 5299-60-5, Adding some certain compound to certain chemical reactions, such as: 5299-60-5, name is Ethyl 6-hydroxyhexanoate,molecular formula is C8H16O3, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 5299-60-5.

To astirred solution of 60 mL dry DCM and DMSO (17.3 mL 0.243 mol) was added oxalylchloride (11.84 mL, 0.138mol) at -78oC dropwise and stirred for 15minutes, then added a solution of compound 20(4.5 g, 0.021 mol) in 10 mL dry DCM slowly and maintained the -78oCtemperature for another 1.5h, added Et3N (17.5 mL, 0.125mol) at -78oCand stirred for another 30 minutes,added icecold water and worked up with DCM, washed with brine, dried over MgSO, solvent evaporated and residue was directlyused for next step without any further purification.THF was added in themixture of solid methyltriphenylphosphonium iodide (22.23g, 0.056 mol) andpotassium t-butoxide (6.22g, 0.056mol)at 0oC and stirred for 15 minutes, it was observed that the reactionmass turned yellow colour, a solution of aldehyde of alcohol 20 (4g, 0.0187mol) in dry THF was added to this yellow reaction mass and stirred for1h at 0oC, before being quenched with saturated NH4Clsolution, extracted with ether, washed with brine, dried on MgSO4,solvent evaporated on reduced pressure followed by column chromatography toafforded olefin 21 (2.9 g, 78%) as colorless liquid; IR (KBr): 2927, 2857, 1734, 1461, 1271, 1161, 1034 cm-1; 1H NMR (300 MHz, CDCl3): delta= 5.70-5.83 (m, 1H), 4.90-5.02 (m, 2H), 4.10 (q, J= 7.55 Hz, 2H), 2.28 (t, J= 7.54 Hz, 2H), 1.96-2.10 (m, 2H), 1.55-1.68(m, 3H), 1.34-1.45 (m, 2H), 1.23 (t, J=6.78 Hz, 4H); 13C NMR (75 MHz, CDCl3): delta= 173.6, 138.3, 114.6, 60.1, 34.1, 33.3,28.3, 24.3, 14.2; MS (ESI) (m/z): 157 [M+H]+.

According to the analysis of related databases, 5299-60-5, the application of this compound in the production field has become more and more popular.

Reference:
Article; Dachavaram, Soma Shekar; Kalyankar, Kondbarao Balasaheb; Das, Saibal; Tetrahedron Letters; vol. 55; 41; (2014); p. 5629 – 5631;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts