Category: 4461-39-6

Application of 4461-39-6, Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 4461-39-6, Name is N-(2-Hydroxyethyl)-1,3-propanediamine, SMILES is NCCCNCCO, belongs to alcohols-buliding-blocks compound. In a article, author is Nandrino, Jean-Louis, introduce new discover of the category.

Training emotion regulation processes in alcohol-abstinent individuals: A pilot study

The study aimed to assess whether abstinent individuals with alcohol use disorders (AUD) would benefit from enhanced emotional regulation (ER) strategies using the affect regulation training (ART) program based on weekly sessions comprising psycho-education, muscle and respiratory relaxation, awareness, acceptance and tolerance, compassionate personal support, emotion analysis and modification. Seventy-two participants with AUD benefited from ART and were compared on their ER ability, mindfulness, and their experience of abstinence to 40 participants not receiving the program, before it, at the end, and 6 months after. Improvements in ER were observed, particularly in positive centration, action centration or self-blame and in mindfulness abilities after the program and six months later. In addition, by comparing participants who received the program with a short ( < 18 months) or long ( > 18 months) abstinence duration, the results showed a greater decrease in the use of non-adaptive strategies, a greater increase in adaptive strategies and mindfulness abilities in short-term abstinent individuals. These results demonstrate improvement in ER skills after training in people who were abstinent from alcohol. ART is effective for consolidating abstinence and should be used especially at the beginning of withdrawal to promote the rapid implementation of new ER strategies.

Application of 4461-39-6, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 4461-39-6.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 4461-39-6, Name is N-(2-Hydroxyethyl)-1,3-propanediamine, molecular formula is , belongs to alcohols-buliding-blocks compound. In a document, author is Hamidullah, Shahnaza, HPLC of Formula: C5H14N2O.

Effects of vapourized THC and voluntary alcohol drinking during adolescence on cognition, reward, and anxiety-like behaviours in rats

Cannabis and alcohol co-use is prevalent in adolescence, but the long-term behavioural effects of this co-use remain largely unexplored. The aim of this study is to investigate the effects of adolescent alcohol and Delta(9)-tetrahydracannabinol (THC) vapour co-exposure on cognitive- and reward-related behaviours. Male Sprague-Dawley rats received vapourized THC (10 mg vapourized THC/four adolescent rats) or vehicle every other day (from post-natal day (PND) 28-42) and had continuous voluntary access to ethanol (10% volume/volume) in adolescence. Alcohol intake was measured during the exposure period to assess the acute effects of THC on alcohol consumption. In adulthood (PND 56+), rats underwent behavioural testing. Adolescent rats showed higher alcohol preference, assessed using the two-bottle choice test, on days on which they were not exposed to THC vapour. In adulthood, rats that drank alcohol as adolescents exhibited short-term memory deficits and showed decreased alcohol preference; on the other hand, rats exposed to THC vapour showed learning impairments in the delay-discounting task. Vapourized THC, alcohol or their combination had no effect on anxiety-like behaviours in adulthood. Our results show that although adolescent THC exposure acutely affects alcohol drinking, adolescent alcohol and cannabis co-use may not produce long-term additive effects.

If you are hungry for even more, make sure to check my other article about 4461-39-6, HPLC of Formula: C5H14N2O.

Reference:
Alcohol – Wikipedia,
,Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4461-39-6, N-(2-Hydroxyethyl)-1,3-propanediamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: 4461-39-6, blongs to alcohols-buliding-blocks compound. Recommanded Product: 4461-39-6

General procedure: A suspension oftert-butyl 4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-formyl-5a,5b,8,8,11a-pentamethyl-1-(prop-1-en-2-yl)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a,13b-octadecahydro-1H-cyclopenta[a]chrysen-9-yl)benzoate5(1 eq.), the corresponding amine (2 eq.) and acetic acid (2 – 5 eq.) in DCE (2 ml) was stirred at RT for 30 min.To this suspension was added sodium triacetoxyborohydride (5 eq.).The resulted mixture was stirred at RT for 18 – 72 hrs.The reaction mixture was diluted with 5 ml of saturated sodium carbonate and extracted with DCM (3 x 10 ml).The combined organic layers were dried over sodium sulfate, filtered and concentratedinvacuo.The crude product was purified by Biotage flash chromatography or was used directly in the next step without further purification.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,4461-39-6, N-(2-Hydroxyethyl)-1,3-propanediamine, and friends who are interested can also refer to it.

Reference:
Article; Chen, Yan; Sit, Sing-Yuen; Chen, Jie; Swidorski, Jacob J.; Liu, Zheng; Sin, Ny; Venables, Brian L.; Parker, Dawn D.; Nowicka-Sans, Beata; Lin, Zeyu; Li, Zhufang; Terry, Brian J.; Protack, Tricia; Rahematpura, Sandhya; Hanumegowda, Umesh; Jenkins, Susan; Krystal, Mark; Dicker, Ira D.; Meanwell, Nicholas A.; Regueiro-Ren, Alicia; Bioorganic and Medicinal Chemistry Letters; vol. 28; 9; (2018); p. 1550 – 1557;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 4461-39-6, name is N-(2-Hydroxyethyl)-1,3-propanediamine. A new synthetic method of this compound is introduced below., category: alcohols-buliding-blocks

To a round-bottom flask (250 mL) containing 3-(benzyloxy)benzaldehyde (3.50 g, 16.5 mmol) dissolved in methanol (100 ml), N-(2-Hydroxyethyl)-1,3-propanediamine (3.50 g, 16.5 mmol) was added. The resulting mixture was stirred for 2 h at ambient temperature. Then carbon disulfide (1.00 mL, 16.5 mmol) was slowly mixed to the reaction, which was kept under stirring for about 40 min. Cu(O2CCH3)2H2O (1.50 g, 8.25 mmol) was then added and a brown solid was formed. After stirring for 4 h, the formed brown precipitate was filtrated and re-crystallized in a 4:1 mixture of CH2Cl2 and toluene. Yield 81%. Mp. 93.6-95.0 C. IR (cm-1, KBr): 1496 (nuN-CS); 980 {nuasym(C-S)}; 601 {nusym(C-S)}. Analysis of C, H and N, respectively for C40H48N4O4S4Cu found% (calc.%): 56.95 (57.15); 5.67 (5.76); 6.58 (6.66).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it, 4461-39-6, N-(2-Hydroxyethyl)-1,3-propanediamine.

Reference:
Article; Ferreira, Isabella P.; Lima, Geraldo M. De; Paniago, Eucler B.; Takahashi, Jacqueline A.; Krambrock, Klaus; Pinheiro, Carlos B.; Wardell, James L.; Visentin, Lorenzo C.; Journal of Molecular Structure; vol. 1048; (2013); p. 357 – 366;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 4461-39-6, N-(2-Hydroxyethyl)-1,3-propanediamine, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, 4461-39-6, blongs to alcohols-buliding-blocks compound. Safety of N-(2-Hydroxyethyl)-1,3-propanediamine

In a nitrogen purged glove box, a 3-Liter, 4-neck round-bottom flask, fitted with a mechanical stirrer, thermocouple, nitrogen inlet adapter and septum, was charged with 2-(3- aminopropylamino)ethanol (144 g; 1.22 mol) and sulfolane (1.00 L; 10.5 mol). This was brought to a fume hood where it was attached to a nitrogen line and the septum was replaced with an adapter holding a 1/8 inch diameter Teflon tube attached to a HBr lecture bottle. While stirring, the hydrogen bromide (HBr) gas was admitted subsurface at a rate that allowed the temperature to rise to about 1300C. Addition was discontinued after heat evolution ceased and HBr was no longer absorbed; two equivalents had reacted, giving the dihydrobromide salt of the starting alcohol. The adapter on the reaction flask was replaced with a pressure-equalized dropping funnel containing phosphorus tribromide (PBr3) (132 g, 0.487 mol, 1.2 equiv) which was added over about 10 minutes at a temperature of between about 110 to about 130C. The solution was then stirred under nitrogen at 1200C for 20 minutes, after which time the product had crystallized into a thick cake. Additional sulfolaiie (380 mL) was added, resulting in a slurry which could be stirred at 120C. After a period of time, the hot slurry was transferred through a 3/8 ” polypropylene tube and was dropped into 2 L of acetone, stirring in a 4 L beaker (in three approximately equal portions) to precipitate the product. After each portion, the solid was filtered and rinsed with acetone and the beaker was charged with 2 L of fresh acetone for the next portion. Finally, the round bottom flask was rinsed with acetone and the resulting solid was combined with other portions. The solid was dried by passing nitrogen through the filtration bed overnight, giving 391 g (1.14 mol, 94%) of pale yellow hygroscopic powder. The 1H NMR showed that it contained residual sulfolane in a 0.023:1 mol ratio (Figure 1).[00032] Subsequent studies showed that less PBr3 is needed for this reaction, the 0.33:1 mol ratio required by the stoichiometry is nearly adequate and excess PBr3 contributes to the formation of colored impurities which are removed from the final product as described below. It was also found that the buildup of product cake after PBr3 addition can be prevented by increasing the initial sulfolane charge and by maintaining the reactor temperature at about 120C.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,4461-39-6, its application will become more common.

Reference:
Patent; ALBEMARLE CORPORATION; WO2007/53730; (2007); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts