Category: 3818-50-6

Bhatnagar, Madhu published the artcileThe in vitro effects of anthelmintics on phosphatases of sheep nodular worm, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Journal of Parasitology (1987), 11(2), 201-3, database is CAplus.

When tested in vitro, piperazine at 10 and 50 μg/mL inhibited acid phosphatase by 3.6 and 14.96%, resp., and activated alk. phosphatase by 2.35 and 5.9%, resp. Treatment with bephenium hydroxynaphoate at 10 and 50 μg/mL, inhibited acid phosphatase by 11.56 and 58.5%, resp., and increased alk. phosphatase by 11.8 and 55.3%, resp. Mebendazole at 10 and 50 μg/mL inhibited acid phosphatase by 64.6 and 93.87%, resp., and activated alk. phosphatase by 31.5 and 85.5%, resp. Thus, mebendazole showed the max inhibition of acid phosphatase and piperazine the least.

Indian Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gladkikh, V. F. published the artcileChanges in the stomach of small laboratory animals after oral administration of naphthamone and diphesyl, COA of Formula: C28H29NO4, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1972), 41(4), 423-8, database is CAplus and MEDLINE.

Rats, mice, guinea pigs, and cats, given orally repeated toxic doses of the antihelminthic compounds diphesyl (I) [34987-38-7] and naphthamone [3818-50-6] showed inflammation of the gastric mucosa, proliferation of the superficial squamous epithelium, and hyperkeratosis of the forestomach. These effects were reversible, and were probably due to the hydroxynaphthoate anion in the drugs.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, COA of Formula: C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dore, J. C. published the artcileInformation processing manipulation of developed formulas for structure-activity relation studies. Application to antiparasitic drugs, Computed Properties of 3818-50-6, the publication is Journal de Pharmacie de Belgique (1990), 45(6), 375-84, database is CAplus.

A method is described for structure-activity relationship studies using algorithms based on mol. connectivity matrixes of atoms, bonds, chem. functional groups, and mol. fragments. Common features of a group of different compounds with the same pharmacol. activity can be determined with this method. A network (Prim’s tree) relating chem. structures to activities can be designed from the data obtained. New compounds placed in the network can be tested for their expected activities. The method was applied to a group of 50 antiparasitic drugs.

Journal de Pharmacie de Belgique published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Computed Properties of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Krotov, A. I. published the artcileActivity of some quaternary salts of β-aryloxyethylaralkylammonium during the infection of mice by Nippostrongylus brasiliensis, Application In Synthesis of 3818-50-6, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1968), 37(3), 361-4, database is CAplus.

Some quaternary salts of β-aryloxyethylaralkylammonium were synthesized and tested in Nippostrongylus braziliensis exptl. infection in mice. The anthelmintic drug naphthamone (N-(β-phenoxyethyl)-N,N-dimethyl-N-benzylammonium β-hydroxynaphthoate) served as a standard. Changes in the cation portion of the napthamone mol. by introduction of various substitutes (e.g. CHO, OH) in the phenoxygroup, or substitution of the latter by the naphthoxy group, gave inactive compounds Introduction of naphthyl, imidazolyl, and other groups instead of the benzyl group results in reduction of the activity, whereas the presence of the thenyl group preserved the activity. The most active compound was bephenium salicylate; bephenium α-bromo-β-hydroxynaphthoate was inactive.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application In Synthesis of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Krotov, A. I. published the artcileActivity of some quaternary salts of β-aryloxyethylaralkylammonium during the infection of mice by Nippostrongylus brasiliensis, Application In Synthesis of 3818-50-6, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1968), 37(3), 361-4, database is CAplus.

Some quaternary salts of β-aryloxyethylaralkylammonium were synthesized and tested in Nippostrongylus braziliensis exptl. infection in mice. The anthelmintic drug naphthamone (N-(β-phenoxyethyl)-N,N-dimethyl-N-benzylammonium β-hydroxynaphthoate) served as a standard. Changes in the cation portion of the napthamone mol. by introduction of various substitutes (e.g. CHO, OH) in the phenoxygroup, or substitution of the latter by the naphthoxy group, gave inactive compounds Introduction of naphthyl, imidazolyl, and other groups instead of the benzyl group results in reduction of the activity, whereas the presence of the thenyl group preserved the activity. The most active compound was bephenium salicylate; bephenium α-bromo-β-hydroxynaphthoate was inactive.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application In Synthesis of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gladkikh, V. F. published the artcileChanges in the stomach of small laboratory animals after oral administration of naphthamone and diphesyl, COA of Formula: C28H29NO4, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1972), 41(4), 423-8, database is CAplus and MEDLINE.

Rats, mice, guinea pigs, and cats, given orally repeated toxic doses of the antihelminthic compounds diphesyl (I) [34987-38-7] and naphthamone [3818-50-6] showed inflammation of the gastric mucosa, proliferation of the superficial squamous epithelium, and hyperkeratosis of the forestomach. These effects were reversible, and were probably due to the hydroxynaphthoate anion in the drugs.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, COA of Formula: C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bhatnagar, Madhu published the artcileThe in vitro effects of anthelmintics on phosphatases of sheep nodular worm, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Journal of Parasitology (1987), 11(2), 201-3, database is CAplus.

When tested in vitro, piperazine at 10 and 50 μg/mL inhibited acid phosphatase by 3.6 and 14.96%, resp., and activated alk. phosphatase by 2.35 and 5.9%, resp. Treatment with bephenium hydroxynaphoate at 10 and 50 μg/mL, inhibited acid phosphatase by 11.56 and 58.5%, resp., and increased alk. phosphatase by 11.8 and 55.3%, resp. Mebendazole at 10 and 50 μg/mL inhibited acid phosphatase by 64.6 and 93.87%, resp., and activated alk. phosphatase by 31.5 and 85.5%, resp. Thus, mebendazole showed the max inhibition of acid phosphatase and piperazine the least.

Indian Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dore, J. C. published the artcileInformation processing manipulation of developed formulas for structure-activity relation studies. Application to antiparasitic drugs, Computed Properties of 3818-50-6, the publication is Journal de Pharmacie de Belgique (1990), 45(6), 375-84, database is CAplus.

A method is described for structure-activity relationship studies using algorithms based on mol. connectivity matrixes of atoms, bonds, chem. functional groups, and mol. fragments. Common features of a group of different compounds with the same pharmacol. activity can be determined with this method. A network (Prim’s tree) relating chem. structures to activities can be designed from the data obtained. New compounds placed in the network can be tested for their expected activities. The method was applied to a group of 50 antiparasitic drugs.

Journal de Pharmacie de Belgique published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Computed Properties of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Krotov, A. I. published the artcileActivity of some quaternary salts of β-aryloxyethylaralkylammonium during the infection of mice by Nippostrongylus brasiliensis, Application In Synthesis of 3818-50-6, the publication is Meditsinskaya Parazitologiya i Parazitarnye Bolezni (1968), 37(3), 361-4, database is CAplus.

Some quaternary salts of β-aryloxyethylaralkylammonium were synthesized and tested in Nippostrongylus braziliensis exptl. infection in mice. The anthelmintic drug naphthamone (N-(β-phenoxyethyl)-N,N-dimethyl-N-benzylammonium β-hydroxynaphthoate) served as a standard. Changes in the cation portion of the napthamone mol. by introduction of various substitutes (e.g. CHO, OH) in the phenoxygroup, or substitution of the latter by the naphthoxy group, gave inactive compounds Introduction of naphthyl, imidazolyl, and other groups instead of the benzyl group results in reduction of the activity, whereas the presence of the thenyl group preserved the activity. The most active compound was bephenium salicylate; bephenium α-bromo-β-hydroxynaphthoate was inactive.

Meditsinskaya Parazitologiya i Parazitarnye Bolezni published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application In Synthesis of 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shahar, Or David published the artcileA high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair, Product Details of C28H29NO4, the publication is Nucleic Acids Research (2014), 42(9), 5689-5701, database is CAplus and MEDLINE.

DNA double-strand breaks (DSBs) are the most severe type of DNA damage. DSBs are repaired by non-homologous end-joining or homol. directed repair (HDR). Identifying novel small mols. that affect HDR is of great importance both for research use and therapy. Mols. that elevate HDR may improve gene targeting, whereas inhibiting mols. can be used for chemotherapy, since some of the cancers are more sensitive to repair impairment. Here, the authors performed a high-throughput chem. screen for FDA approved drugs, which affect HDR in cancer cells. The authors found that HDR frequencies are increased by retinoic acid and Idoxuridine and reduced by the antihypertensive drug Spironolactone. The authors further revealed that Spironolactone impairs Rad51 foci formation, sensitizes cancer cells to DNA damaging agents, to Poly (ADP-ribose) polymerase (PARP) inhibitors and crosslinking agents and inhibits tumor growth in xenografts, in mice. This study suggests Spironolactone as a new candidate for chemotherapy.

Nucleic Acids Research published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C7H7IN2O, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts