Category: 3637-61-4

Electric Literature of 3637-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.

General procedure: Ionic liquid [Dsim]HSO4 (6.5 mg, ?0.02 mmol) was added to a stirred mixture of alcohol, phenol or naphthol (1.0 mmol) and HMDS (80 mg, 0.5 mmol) at room temperature under solvent free conditions. After completion of the reaction (monitored by TLC, It should be noted that when addition of HMDS is finished stirring of the mixture is stopped after 1 min. TLC showed that in most of the cases the reaction is completed immediately after the addition of HMDS), the product was extracted with Et2O and the ionic liquid was recovered and was dried at 65 ?C under vacuum to remove moisture, and then reused. Evaporation of the solvent under reduced pressure gave the highly pure product without further purification. The desired pure products were characterized by comparison of their IR, NMR and MS data as well as boiling poin twith those of known compounds

The chemical industry reduces the impact on the environment during synthesis 3637-61-4, I believe this compound will play a more active role in future production and life.

Reference:
Article; Shirini, Farhad; Khaligh, Nader Ghaffari; Akbari-Dadamahaleh, Somayeh; Journal of Molecular Catalysis A: Chemical; vol. 365; (2012); p. 15 – 23;,
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Reference of 3637-61-4 ,Some common heterocyclic compound, 3637-61-4, molecular formula is C6H12O, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc., below Introduce a new synthetic route.

The toluene 4-sulfonic acid cyclopentyl methyl ester was prepared by adding p- Toluenesulfonyl chloride (3.6 mmol, 684 mg) to a solution of CYCLOPENTANEMETHANOL (3 mmol, 300mg) and pyridine (3ml) in dichloromethane (3ml). The resulting mixture was stirred for 2 1/2 hours at room temperature, then diluted with DICHLOROMETHANE and washed sequentially with HCI (1 M solution) and a saturated solution of NA2CO3. The organic layer was then dried over MgSO4 and evaporated to give the TOLUENE-4-SULFONIC acid cyclopentyl methyl ester.1H NMR (CDCI3) delta 1.17 (2H, m), 1.53 (4H, m), 1.69 (2H, m), 2.20 (1H, m), 2.45 (3H, s), 3.89 (2H, d), 7.34 (2H, d), 7.78 (2H, d).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles. 3637-61-4, Cyclopentanemethanol, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; GLAXO GROUP LIMITED; WO2004/39753; (2004); A2;,
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Related Products of 3637-61-4, With the rapid development and complex challenges of chemical substances, the synthesis of new drugs is usually one of the most effective ways to increase yield.3637-61-4, name is Cyclopentanemethanol, molecular formula is C6H12O, molecular weight is 100.16, as common compound, the synthetic route is as follows.

(A) 3-Cyclopentyl-2-(3,4-dichloro-phenyl)-N-pyridin-2-yl-propionamide: A solution of triphenylphosphine (28.80 g, 109.8 mmol) and imidazole (14.9 g, 219.6 mmol) in methylene chloride (160 mL) was cooled to 0 C. and then slowly treated with iodine (27.87 g, 109.8 mmol). The reaction mixture was then treated dropwise with a solution of cyclopentylmethanol (10.0 g, 99.8 mmol) in methylene chloride (10 mL). The resulting reaction mixture was allowed to warm to 25 C., where it was stirred for 4 h. The reaction mixture was then diluted with water (50 mL), and the reaction mixture was further extracted with methylene chloride (3*20 mL). The combined organic layers were dried over sodium sulfate, filtered and concentrated in vacuo at 25 C. The resulting solid was washed with pentane (4*50 mL) and filtered through a silica gel plug. The filtrate was concentrated in vacuo at 25 C. to afford iodomethylcyclopentane (18.48 g, 88%) as a clear colorless liquid: EI-HRMS m/e calcd for C6H11I1 (M+) 209.9906, found 209.9911.

Statistics shows that 3637-61-4 is playing an increasingly important role. we look forward to future research findings about Cyclopentanemethanol.

Reference:
Patent; Bizzarro, Fred Thomas; Corbett, Wendy Lea; Grippo, Joseph Francis; Haynes, Nancy-Ellen; Holland, George William; Kester, Robert Francis; Sarabu, Ramakanth; US2001/39344; (2001); A1;,
Alcohol – Wikipedia,
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Synthetic Route of 3637-61-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3637-61-4, name is Cyclopentanemethanol. A new synthetic method of this compound is introduced below.

To a suspension of Nail (98 rng, 2.5 mmol, 5 eq) in THF (5 mL) at 0C cyclopentanernethanol (263 iL, 2.5 mrnol, 5 eq) was added. The reaction was stirred at 0C for 30 mm and 6-(6-bromopyridin-2-yl)-3 -[(2-chloro-4-fluorophenyl)sulfanyl]- 6-(thiophen-3-yI)piperidine-2,4-dione (250 mg, 0.49 mmol, I eq) was added. The reaction was then stirred overnight under reflux and quenched by the addition of water (10 mL) and HCI 1M (5 mL). The aqueous phase was extracted with ethyl acetate (3 x 15 mL) and the combined organic phases were dried with Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by flash chromatography on silica gel (eluent: heptane/ ethyl acetate: 75/25) to give 3- [(2-chloro-4-fluorophenyl)sulfanyl]-6-[6-(cyclopentylmethoxy)pyridin-2-yl] -6- (thiophen-3-yl)piperidine-2,4-dione (192 mg, 0.36 mmol) in 74 % yield.?H NMR (MeOD-d4, 400 MHz): 6 7.71 (dd, .1 8.0, 7.6 Hz, 1H), 7.44 (dd, J 8.8, 7.2 Hz, I H), 7.27 (dd, .1 = 2.8, 1 .2 Hz, 1 H), 7.1 5-7.1 1 (m, 2H), 7.09 (dd, J 4.8, 2.8 Hz. 11-1), 6.75 (d,.J= 8.4 Hz, IH), 6.54 (td,.J= 8.4, 2.8 Hz, IH), 5.99 (dd,J= 8.8, 6.0 Flz, IF). 4.27-4.18 (rn, 21-1). 3.87 (d,.J= 16.4 l-lz, IH), 3.45 (d,.1 16.4 Hz, 1H), 2.36-2.28 (111, 11-1), l.83-l.74(rn, 2H), 1.66-1.53 (m, 4H), 1.39-1.29 (m, 2H).?3C NMR (MeOD-d4, 100 MHz): 6 166.9, 161.6, 158.6 (d,J 245 Hz), 157.2, 143.5, 138.2, 130.7 (d, J= 4 Hz), 124.8 (d, J 8.5 Hz), 124.7, 124.5, 120.1, 114.7 (d, J= 25 Hz), 112.3 (d, .J= 21 Hz), 111.8, 108.0, 100.0, 68.3, 59.3, 39.1, 37.3, 27.5,23.4.

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3637-61-4, Cyclopentanemethanol, and friends who are interested can also refer to it.

Reference:
Patent; SPERMATECH AS; GOLDING, Louise; SIENG, Bora; LUNDVALL, Steffi; B?EN, Claudia Alejandra; HNIDA, Kathrin; (68 pag.)WO2018/211276; (2018); A1;,
Alcohol – Wikipedia,
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Application of 3637-61-4, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 3637-61-4, name is Cyclopentanemethanol. A new synthetic method of this compound is introduced below.

To a suspension of NaH (61 mg, 1.5 mmol) in THF (3 mL) at 0C was added CpMeOH (0.16 mL, 1.5 mmol). After 30 min at 0C, 6-(6-bromopyridin-2-yl)-3-((2- chlorophenyl)thio)-6-(thiophen-3-yl)piperidine-2,4-dione (150 mg, 0.30 mmol) was added and the reaction mixture was stirred for 18 hr at reflux. The reaction was stopped by the addition of water (10 mL) and HC1 1 M (3 mL). The aqueous phase was extracted with ethyl acetate (3 x 10 mL) and the combined organic phases were dried over Na2S04, filtered and concentrated under reduced pressure. The crude material was purified by flash column chromatography (silica gel, eluent: heptane/ethyl acetate: 8/2 to 7/3 to 1/1) to give 3-((2-chlorophenyl)thio)-6-(6- (cyclopentylmethoxy)pyridin-2-yl)-6-(thiophen-3-yl)piperidine-2,4-dione in 62 % yield. 1H NMR (400 MHz, MeOH-d4): delta = 7.70 (t, J = 7.8 Hz, 1H), 7.43 (dd, J = 5.0, 3.0 Hz, 1 H), 7.28 (br s, 1 H), 7.22 (d, J= 7.9 HZ, 1 H), 7.15-7.12 (m, 2H), 6.94 (t, J= 7.8 Hz, 1 H), 6.77-6.73 (m, 2H), 5.98 (d, J= 8.0 Hz, 1H), 4.22 (m, 2H9, 3.91 (d, J= 16.4 Hz, 1 H), 3.45 (d, J= 16.4 Hz, 1H), 3.45 (s, 1H), 2.35-2.28 (m, 1H), 1.82-1.73 (m, 2H), 1.64-1.51 (m, 4H), 1.38-1.30 (m, 2H).

At the same time, in my other blogs, there are other synthetic methods of this type of compound,3637-61-4, Cyclopentanemethanol, and friends who are interested can also refer to it.

Reference:
Patent; ARCTIC PHARMA AS; GOLDING, Louise; KLAVENESS, Jo; SIENG, Bora; LUNDVALL, Steffi; B?EN, Claudia Alejandra; HNIDA, Kathrin; (128 pag.)WO2018/211277; (2018); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 3637-61-4, Cyclopentanemethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, SDS of cas: 3637-61-4, blongs to alcohols-buliding-blocks compound. SDS of cas: 3637-61-4

Preparation E Cyclopentylmethyl Iodide Methanesulfonyl chloride (25.5 mL) was added dropwise to a solution of cyclopentanemethanol (32.4 mL) and triethylamine (46 mL) in dichloromethane (500 ml) at 0 C. After stirring overnight at room temperature, the mixture was sequentially washed with water, 2% hydrochloric acid, 4% aqueous sodium bicarbonate and water again. Following drying over sodium sulfate, the solvent was removed under vacuum, affording crude cyclopentylmethyl methanesulfonate (ca. 50 g) as a colourless oil.

The synthetic route of 3637-61-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Pharmacia & Upjohn S.p.A.; US6482827; (2002); B1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Adding a certain compound to certain chemical reactions, such as: 3637-61-4, Cyclopentanemethanol, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound, Recommanded Product: Cyclopentanemethanol, blongs to alcohols-buliding-blocks compound. Recommanded Product: Cyclopentanemethanol

Methanesulfonyl chloride (13.8 mL, 178 mmol) was added drop wise and at 0 C. to a solution of cyclopentanemethanol (16.2 g, 162 mmol) in anhydrous pyridine (35 mL). The mixture was stirred at 0 C. for 5 h, poured into water (200 mL), and extracted with methylene chloride (3¡Á50 mL). The combined organic layers were washed with 1 M HCl (3¡Á20 mL) and brine (2¡Á20 mL), dried with anhydrous magnesium sulphate, and evaporated in vacuo. The residue was dissolved in anhydrous acetone (20 mL), and a solution of sodium iodide (24 g, 162 mmol) in acetone (50 mL) was added. The mixture was refluxed for 5 h. The formed precipitate was filtered off, and the filtrate was evaporated in vacuo. The residue was distilled and the fraction boiling at 71-75 C. (110 Torr) was collected to give iodomethylcyclopentane. Yield: 13.8 g (41%). 1H-NMR (CDCl3, delta ppm): 3.21 (d, J=6.9 Hz, 2H); 2.18 (hept, J=7.5 Hz, 1H); 1.95-1.45 (m, 6H); 1.35-1.11 (m, 2H).

The synthetic route of 3637-61-4 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Novo Nordisk A/S; US2008/139562; (2008); A1;,
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts