Category: 1805-32-9

As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below. Product Details of 1805-32-9

General procedure: A mixture of the substrate (1 mmol), hexamethyldisilazane (0.70 mmol), and/or 3,4-dihydro-2H-pyran (1.4 mmol) and BiPy(SO3H)2(HSO4)2 (10 mg, 1.95 mol%) in CH3CN(3 mL) and/or CH2Cl2 (3 mL) was stirred at room temperature. The progress of thereaction was monitored by TLC (n-hexane: EtOAc; 10:1) and/or GC. After completion ofthe reaction, the mixture was filtered to separate the solid catalyst. Then the solution wasfiltered through a silica gel pad and washed with CH3CN (2 ¡Á 3 mL) and/or CH2Cl2 (2 ¡Á3 mL). Evaporation of the solvent gave the desired products in high purity.

With the rapid development of chemical substances, we look forward to future research findings about 1805-32-9.

Reference:
Article; Shirini, Farhad; Abedini, Masoumeh; Mahmoodi, Nosratollah; Biglari, Mohammad; Safarpoor Nikoo Langrudi, Mohaddeseh; Phosphorus, Sulfur and Silicon and the Related Elements; vol. 190; 11; (2015); p. 1912 – 1921;,
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Synthetic Route of 1805-32-9, Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps,and cheap raw materials. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. A new synthetic method of this compound is introduced below.

General procedure: Ionic liquid [Dsim]HSO4 (6.5 mg, ?0.02 mmol) was added to a stirred mixture of alcohol, phenol or naphthol (1.0 mmol) and HMDS (80 mg, 0.5 mmol) at room temperature under solvent free conditions. After completion of the reaction (monitored by TLC, It should be noted that when addition of HMDS is finished stirring of the mixture is stopped after 1 min. TLC showed that in most of the cases the reaction is completed immediately after the addition of HMDS), the product was extracted with Et2O and the ionic liquid was recovered and was dried at 65 ?C under vacuum to remove moisture, and then reused. Evaporation of the solvent under reduced pressure gave the highly pure product without further purification. The desired pure products were characterized by comparison of their IR, NMR and MS data as well as boiling poin twith those of known compounds

At the same time, in my other blogs, there are other synthetic methods of this type of compound,1805-32-9, 3,4-Dichlorobenzyl alcohol, and friends who are interested can also refer to it.

Reference:
Article; Shirini, Farhad; Khaligh, Nader Ghaffari; Akbari-Dadamahaleh, Somayeh; Journal of Molecular Catalysis A: Chemical; vol. 365; (2012); p. 15 – 23;,
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Electric Literature of 1805-32-9, The major producers of chemicals have been the Europe, Japan and China. Due to the growing call for a cleaner, greener environment, people will have to find innovative ways to maintain their relevance. Here is a compound 1805-32-9, name is 3,4-Dichlorobenzyl alcohol. This compound has unique chemical properties. The synthetic route is as follows.

To a mixture of 3,4-dichlorobenzyl alcohol (0.21 g, 1.20 mmol) in DMSO (5 mL) was added potassium rt-butoxide (0.29 g, 2.58 mmol). The mixture was stirred at ambient temperature for 5 minutes and 5-chloro-N-(N,N-dimethylsulfamoyl)-2,4-difluorobenzamide (Preparation 3) (0.30 g, 1.01 mmol) was added. After 0.5 h, the reaction mixture was diluted with ethyl acetate (150 mL), washed with IN hydrochloric acid (2 chi 150 mL), brine (150 mL), dried over anhydrous sodium sulfate and filtered. The filtrate was concentrated in vacuo to provide a residue which was purified by HPLC using Method A. The title compound was obtained as a white solid (0.03 g, 7%): NMR (300 MHz, DMSO-de) 6 11.78 (s, 1H), 7.75-7.66 (m, 3H), 7.43 (d, J= 8.2 Hz, 1H), 7.31 (d, J= 12.1 Hz, 1H), 5.28 (s, 2H), 2.83 (s, 6H); MS (ES-) m/z 453.0, 455.0 (M – 1).

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; DEHNHARDT, Christoph Martin; CHOWDHURY, Sultan; FOCKEN, Thilo; GRIMWOOD, Michael Edward; HEMEON, Ivan William; SAFINA, Brian; SUTHERLIN, Daniel, P.; WO2014/8458; (2014); A2;,
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Synthetic Route of 1805-32-9, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 1805-32-9, name is 3,4-Dichlorobenzyl alcohol, molecular formula is C7H6Cl2O, The compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

(3,4-Dichlorophenyl)methanol 7a (500 mg, 2.84 mmol) and triethylamine (860 mg, 8.52 mmol) were dissolved in 10 mL of dichloromethane, and methanesulfonyl chloride (481 mg, 4.26 mmol) was added dropwise at 0 C. ), react at room temperature for 6 hours. Add 50mL of 10% citric acid solution, extract with dichloromethane (50mL ¡Á 3), and combine the organic phase, wash with saturated sodium bicarbonate solution (50mL) and saturated sodium chloride solution (50mL ¡Á 1), the organic phase is anhydrous Drying over sodium sulfate and concentrating under reduced pressure afforded 3,4-dichlorobenzyl methanesulfonate 7b (724 mg, white solid).

According to the analysis of related databases, 1805-32-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Zhejiang Haizheng Pharmaceutical Co., Ltd.; Guan Dongliang; Wang Zhongli; Bai Hua; Liu Zhubo; Meng Lichen; Zhao Weifeng; Ling Long; Wang Yan; (78 pag.)CN109574927; (2019); A;,
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Synthetic Route of 1805-32-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1805-32-9 as follows.

To a solution of (3,4-dichlorophenyl)methanol (350 mg, 1.98 mmol) in DMF (3 mL) was added sodium hydride (60%, 80 mg, 4.00 mmol) at 0 C. After stirring at 0 C for 30 minutes, 5-chloro-2,4-difluorobenzonitrile (345 mg, 1.99 mmol) was added in portions. The reaction mixture was stirred at room temperature for 6 h, quenched by saturated NH4Cl (10 mL) and extracted with ethyl acetate (5 mL x 3). The combined organic layers were washed with brine, dried over MgSO4, filtered and concentrated in vacuo to afford 5-chloro-4-(3,4-dichlorobenzyloxy)-2-fluorobenzonitrile as a yellow solid. The residue was used in the next step without further purification. LCMS (ESI) m/z: 329.9 [M-H]-

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route,1805-32-9, its application will become more common.

Reference:
Patent; GENENTECH, INC.; XENON PHARMACEUTICALS INC.; CHEN, Chien-An; CHOWDHURY, Sultan; DEHNHARDT, Christoph Martin; SUN, Shaoyi; WO2014/144545; (2014); A2;,
Alcohol – Wikipedia,
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1805-32-9, In the chemical reaction process,reaction time,type of solvent,can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product.An updated downstream synthesis route of 1805-32-9 as follows.

General procedure: Cu/OMS-2 (10 mg, 0.25 mol%), benzyl alcohol (2 mmol), N-arylamidine (0.5 mmol), toluene (2 mL) were added to a flask with a bar. The flask was stirred at 90 C for 20 h under air. After cooling to room temperature, the mixture was diluted with ethyl acetate and filtered. The filtrate was removed under reduced pressure to get the crude product, which was further purified by silica gel chromatography (petroleum/ethyl acetate = 40/1-50/1 as eluent) to yield corresponding product. The identity and purity of the products were confirmedby 1H, 13C NMR spectroscopic and HRMS analysis.

The chemical industry reduces the impact on the environment during synthesis 1805-32-9, I believe this compound will play a more active role in future production and life.

Reference:
Article; Meng, Xu; Bi, Xiuru; Wang, Yanmin; Chen, Gexin; Chen, Baohua; Jing, Zhenqiang; Zhao, Peiqing; Catalysis Communications; vol. 89; (2017); p. 34 – 39;,
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