Category: 124-76-5

Arulprakasam, Karthick Raja published the artcileGenome mining of biosynthetic gene clusters intended for secondary metabolites conservation in actinobacteria, Category: alcohols-buliding-blocks, the main research area is genome mining secondary metabolite actinobacteria; Anti-microbial resistance; Biosynthetic gene cluster; Genome mining; Non-ribosomal peptide synthetases; Polyketide synthases; Secondary metabolites.

Evolution of genome sequencing technol., on the one hand, and advancement of computational genome mining tools, on the other hand, paves way for improvement in predicting secondary metabolites. In past, numerous efforts were made concerning genome mining for recognizing secondary metabolites within the genus, but only a negligible quantity of comparative genomic reports had carried out among species of different genera. In this study, we explored potential of 24 actinobacteria species belonging to the genera, including Streptomyces, Nocardia, Micromonospora, and Saccharomonospora, to traverse diversity and distribution of Biosynthetic Gene Clusters (BGCs). Investigating results obtained from antiSMASH (Antibiotics and Secondary Metabolites Anal. Shell), NaPDoS (Natural Product Domain Seeker), and NP.searcher revealed conservation of genus-specific gene clusters among various species. E.g., NAGGN (n-acetyl glutaminyl glutamine amide) is present in Micromonospora, furan in Nocardia, melanin, and lassopeptide occur in Streptomyces. Bioactive compounds like alkyl-O-dihydro geranyl methoxy hydroquinone, SapB, desferrioxamine E, 2-Methylisoborneol, mayamycin, cyclodipeptide synthase, diisonitrile, salinichelin, hopene, ectoine and isorenieratene are highly conserved among diverse genera. Furthermore, pharmacol. activity of actinobacterial derived metabolites against bacterial and fungal pathogens were illustrated. We need to accomplish large-scale anal. of natural products, including various genera of actinobacteria to deliver comprehensive intuition to overcome antibiotic resistance.

Microbial Pathogenesis published new progress about Actinobacteria. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Category: alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

El Ouahdani, Khadija published the artcileThymus algeriensis and Artemisia herba-alba Essential Oils: Chemical Analysis, Antioxidant Potential and In Vivo Anti-Inflammatory, Analgesic Activities, and Acute Toxicity, Related Products of alcohols-buliding-blocks, the main research area is Thymus Artemisia essential oil antiinflammatory analgesic agent acute toxicity; Artemisia herba-alba; Thymus algeriensis; analgesic; anti-inflammatory; antioxidant; toxicity.

The study of bioactive mols. of natural origin is a focus of current research. Thymus algeriensis and Artemisia herba-alba are two medicinal plants widely used by the Moroccan population in the traditional treatment of several pathologies linked to inflammation. This study aimed to evaluate the single and combined antioxidant, anti-inflammatory and analgesic effects of the essential oils extracted from these two medicinal plants, and also their potential toxicity. Essential oils were extracted using hydro-distillation in a Clevenger-type apparatus The antioxidant activity was evaluated by two methods: the scavenging of the free radical DPPH, and the reduction in iron. Anti-inflammatory activity was evaluated by evaluating the edema development induced by carrageenan injecting, while the analgesic power was evaluated according to the number of abdominal contortions induced by the i.p. injection of acetic acid (0.7%). The acute oral toxicity was performed to assess the potential toxicity of the studied EOs, followed by an anal. of the blood biochem. parameters. The results of the two antioxidant tests indicated that our extract mixture exhibits good iron reduction capacity and very interesting DPPH free radical scavenging power, with an IC50 of around 4.38 ± 0.98 μg/mL higher than that of the benchmark antioxidant, BHT. The anti-inflammatory test demonstrated that the mixture administered orally at a dose of 150 mg/kg has a better activity, exceeding that of 1% Diclofenac, with a percentage of maximum inhibition of the edema of 89.99 ± 4.08. The number of cramps in the mice treated with the mixture at a dose of 150 mg/kg is significantly lower (29.80 ± 1.92) than those of the group treated with Tramadol (42.00 ± 2.70), resp. The toxicity results show no signs of toxicity with an LD50 greater than 150 mg/Kg. These interesting results show that the two plants′ EOs had an important anti-inflammatory, analgesic, and antioxidant activity, and also a powerful synergistic effect, which encourages further in-depth investigations on their pharmacol. proprieties.

Molecules published new progress about Acute toxicity. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Related Products of alcohols-buliding-blocks.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Zhao, Yiping published the artcileThree-stage microwave extraction of cumin (Cuminum cyminum L.) Seed essential oil with natural deep eutectic solvents, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Cuminum tricyclene seed essential oil natural deep eutectic solvent.

As a class of promising green media, natural deep eutectic solvents (NADESs) have attracted more and more attention in recent years. In this paper, a novel method based on microwave-assisted natural deep eutectic solvents pretreatment coupled with microwave hydrodistillation (MA-NADES-MHD) was used for the extraction of essential oil from Cuminum cyminum L. seed. NADESs were used as pretreatment solvents for adsorbing microwaves and dissolving cellulose. The maximum yield of essential oil obtained with this three-stage microwave extraction technol. was 2.22% (weight/weight) when the natural deep eutectic solvent composed of choline chloride and L-lactic acid (with 1:3 of molar ratio) with 40% (weight/weight) of water. Compared with microwave hydrodistillation (MHD) and ultrasound-assisted natural deep eutectic solvents pretreatment combined with microwave hydrodistillation (UA-NADES-MHD) in which essential oil yield of 1.13% (weight/weight) and 1.57% (weight/weight) were obtained, resp., the MA-NADES-MHD naturally brought more essential oil. Notably, a total of 45, 48, and 58 volatile components were identified by using gas chromatog.-mass spectrometry with MHD, UA-NADES-MHD, and MA-NADES-MHD, resp. Hence, NADESs had a significant impact on the extraction of essential oil with higher yield, premium quality, and more quantity, especially when it was combined with microwave technol. Moreover, the MA-NADES-MHD as an economical and eco-friendly technique had the potential to be applied to other plant materials.

Industrial Crops and Products published new progress about Cuminum cyminum. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Chen, Jingjing published the artcileDetermination and Correlation of Solubility of Borneol, Camphor, and Isoborneol in Different Solvents, Computed Properties of 124-76-5, the main research area is correlation solubility borneol camphor isoborneol solvent.

The solubility of borneol, camphor, and isoborneol in four solvents (i.e., acetone, ethanol, p-cymene, and p-xylene) was measured by the static equilibrium method within the temperature range of 296.65-348.85 K under the atm. The fusion points and fusion enthalpies of borneol and isoborneol were determined by differential scanning calorimetry. The Apelblat equation, Wilson model, and NRTL model were employed to correlate the measured solubility data, and the NRTL model fits the measured data better. Mixing properties of each solute-solvent pair are calculated by the NRTL model.

Journal of Chemical & Engineering Data published new progress about Fusion enthalpy. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Computed Properties of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Almadiy, Abdulrhman A. published the artcileBioactivity of Deverra tortuosa essential oil, its nanoemulsion, and phenylpropanoids against the cowpea weevil, a stored grain pest with eco-toxicological evaluations, HPLC of Formula: 124-76-5, the main research area is Callosobruchus maculatus Deverra tortuosa essential oil nanoemulsion phenylpropanoid ecotoxicol; Biosafety; Deverra tortuosa; Ecofriendly pesticides; Essential oil; Nanoemulsion; Phenylpropanoids.

The essential oil (EO) was hydrodistd. from of Deverra tortuosa aerial parts. Fifty-six components amounting 99.3% were identified in EO through using gas chromatog.-fame ionization detection (GC-FID) and (GC-MS). Phenylpropanoids, dillapiole (41.6%), elemicin (7.3%) and myristicin (5.1%), and the monoterpene, sabinene (4.2%) were identified as the major terpenes. An oil-in-water nanoemulsion (particle size 70.3 nm) was developed from EO adopting a low-energy method. The EO products showed insecticidal and biochem. effects against the cowpea weevil Callosobruchus maculatus. Based on a 48-h exposure period, the oil nanoemulsion exhibited a superior contact bioactivity (LC50=10.3μg/cm2), followed by EO (LC50=23.1μg/cm2), dillapiole (LC50=27.8μg/cm2), and myristicin (LC50=37.1μg/cm2). Upon fumigation, nanoemulsion and EO were superior as fumigants (LC50 after 48 h were 6.9 and 14.3μl/l, resp.). Test materials showed a residual bioactivity against C. maculatus, where EO, dillapiole, and myristicin showed the strongest grain protecting activity. EO products significantly inhibited acetylcholinesterase (AChE) activity of C. maculatus adults. Test products were safe toward the non-target earthworms and did not alter the viability of cowpea seeds. There are evidences for the potential of using EO of D. tortuosa and its nanoemulsion and phenylpropanoids as natural grain protectants against C. maculatus.

Environmental Science and Pollution Research published new progress about Bioavailability. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Shao, Liangyu published the artcileEffects of Borneol on the Release of Compound Danshen Colon-Specific Osmotic Pump Capsule In Vitro and Pharmacokinetics Study in Beagle Dogs, Synthetic Route of 124-76-5, the main research area is borneol compound danshen colon osmotic pump capsule pharmacokinetics dog; borneol; colon-specific osmotic pump capsule; compound Danshen; in vitro release; in vivo pharmacokinetics.

Borneol can enhance the bioavailability of several other drugs by opening the blood-brain barrier and inhibiting P-glycoprotein (P-gp) efflux. However, whether borneol will impact the bioavailability and the mechanism of compound Danshen colon-specific osmotic pump capsule (CDCOPC) remains unclear. This study aimed to determine the effects of borneol on the in vitro release and in vivo pharmacokinetic characteristics of CDCOPC. Besides, the in vitro release behavior of CDCOPC was further assessed by chromatog. fingerprints. The in vitro release studies showed that borneol followed the zero-order release and hardly impacted the in vitro release of Salvia miltiorrhiza and Panax notoginseng in CDCOPC. Moreover, as revealed from the similarity results of fingerprints, the in vitro release of different components of CDCOPC was almost simultaneous. Compared with the com. available tablets, the pharmacokinetics studies suggested that both CDCOPCs containing and lacking borneol could significantly prolong the retention time of these effective components; their average relative bioavailability values increased to 448.70% and 350.97%, resp. Notably, borneol significantly improved the relative bioavailability of some components of CDCOPC, such as salvianolic acid B (SAB), tanshinone IIA (Tan IIA), notoginsenoside R1 (R1), ginsenoside Rg1 (Rg1), and ginsenoside Re (Re) from CDCOPC, while it slightly impacted ginsenoside Rb1 (Rb1) and ginsenoside Rd (Rd). Summarily, borneol is capable of improving the bioavailability of some effective components in CDCOPC, which is critical to design with CDCOPC for enhanced bioavailability. This study could also help reveal the composition principle of the compound Danshen formula (CDF).

AAPS PharmSciTech published new progress about Bioavailability. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Huang, Yaling published the artcileVariation of Volatile Compounds and Corresponding Aroma Profiles in Chinese Steamed Bread by Various Yeast Species Fermented at Different Times, HPLC of Formula: 124-76-5, the main research area is volatile aroma Chinese steamed bread yeast; Chinese steamed bread; GC−MS; GC−O; aroma-active compounds; sensory evaluation.

To control the fermentation process of yeast-Chinese steamed bread (CSB), the volatile compounds and odor profiles of yeast-CSBs during fermentation were comprehensively investigated by sensory evaluation, gas chromatog.-mass spectrometry, gas chromatog.-olfactometry (GC-O), and odor activity value (OAV). Eight sensory attributes were established, and quant. descriptive anal. results showed that CF1303-CSB had intense sweet and sweet aftertaste attributes, CF1318-CSB was characterized by milky, wheaty, and yeasty attributes, while CL10138-CSB presented distinct sour, winy, and floury attributes. A total of 41 key aroma-active compounds were detected, and phenylethyl alc. was the most potent aroma compound with a flavor dilution (FD) of 1024. CF1303-CSB, CF1318-CSB, and CL10138-CSB contained 24, 22, and 21 key aroma compounds, resp., based on the OAV. These key aroma compounds can be used as the potential markers to monitor the yeast-CSBs during the fermentation process. Five compounds, including β-myrcene, 2-phenoxyethanol, Me cinnamate, guaiacol, and o-cresol, were first identified in CSB. These results provide theor. basis for processing and quality control of yeast-CSBs.

Journal of Agricultural and Food Chemistry published new progress about Bread (steamed). 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, HPLC of Formula: 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Al-Ansari, Mysoon M. published the artcileInsecticidal, antimicrobial and antioxidant activities of essential oil from Lavandula latifolia L. and its deterrent effects on Euphoria leucographa, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is Euphoria Lavandula essential oil insecticide antimicrobial antioxidant.

Lavandula latifolia L. is a medicinal plant has fungicidal, antibacterial and antioxidant properties. The aim of this study was to determine the chem. composition, antioxidant and antimicrobial activities of essential oil (EO) of L. latifolia L. extracted by hydrodistillation method. A total of 22 constituents were identified in L. latifolia L. using Gas chromatog.-mass spectrometry anal. The compounds such as, gamma-terpinene (26.8%), camphor (13.8%), 1,8-cineole (10.2%), lavandulol (9.3%), terpinen-4-ol (9.1%), linalool (8.9%), b-elemene (3.2%), b-pinene (3.1%), 1,4-cineole (3.07%), camphene (2.32%), a-terpineol (2.3%), and a-copaene (2.2%) were determined The antifungal activity of this EO against five phytopathogenic fungi revealed their broad-spectrum and strong antifungal properties. Notably, the EO showed potent activity on Trichophyton mentagrophytes (31 ± 1 mm) and the min. inhibitory concentration value was 0.125 ± 0.05μg/mL. The oil, analyzed for its DPPH (1,1-diphenyl-2-picrylhydrazyl) and ABTS [2,2_-azinobis-(3-ethylbenzothiazoline-6- sulfonic acid)] free radical scavenging activity. Hydrodistd. EO had higher ABTS scavenging capacity than DPPH free radical scavenging power. Essential oil was used to test pesticide activity against Euphoria leucographa (Order: Coleoptera; Family: Scarabaeidae) infected in custard apple (Annona muricata) fruit. Results indicated that the spike lavender EO had contact toxicity on E. leucographa upon topical treatment. The effective concentration at 50% (EC50) value of EC of L. latifolia L. was 0.37% revealed considerable fumigant activity mainly due to the presence of fragrant compounds Interestingly, custard apple (A. muricata) treated with EO effectively controlled the growth of T. mentagrophytes. Overall, antifungal and insecticidal properties of lavender EO, as a natural choice to preserve the harvested fruits thereby protecting the industrial crops.

Industrial Crops and Products published new progress about Annona muricata. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Application of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Niteeshkumar published the artcileChemical analysis and antibacterial activity of Black turmeric (Curcuma caesia Roxb.) genotypes, Synthetic Route of 124-76-5, the main research area is Curcuma Bacillus Streptococcus Pseudomonas Shigella.

Curcuma caesia Roxb. is an important, lesser known, non-conventional medicinal plant belonging to Zingiberaceae family. The eight genotypes selected were GKM-1, GKM-2, GKB-3, GKB-4, GKJ-5, GMV-6, GKT-29 and GKK-30 were collected from different regions as presented in (Table 1). The Rhizomes of black turmeric genotypes were extracted with methanol at room temperature for 18 h. Preliminary phytochem. anal. revealed the presence of tannins, flavonoid and phenol. The highest phenol GMV-6 (1.46 mg-1g), tannin GKT-29 (0.69 mg-1g) and flavonoid GMV-6 (1.64 mg-1g) was recorded. The bioactive compounds of Curcuma caesia Roxb have been evaluated using GC-MS. Totally 19 major compounds were identified from eight genotypes. The major constituents were identified in the methanolic rhizome extracts were Curcumenol in GKM-1(20.35%), GKB-3(12.96%), GKB-4(15.67%) and in GKT-29(16.17%), Curcumenone in GKM-1(16.07%), GKM-2(25.03%), GKB-3(29.30%) and in GKT-29(22.25%), Epicurzerenone in GKM-1(12.93%) and GKM-2(21.82%), 9-12, Octadecadionic acid in GKM-1(5.54%), GKB-3(2.81%) and in GKB-4(3.59%), 2-Bornanone in GKM-2(4.38%) and in GKB3(5.38%), 4H-Pyran-4-one, 2,3-dihydro-3,5-dihydroxy-6-methyl- in GKB-3(8.91%), GKB-4(24.44%), GKJ-5(19.82%) and GKT-29(9.88%), Isoborneol in GKM-2(1.54%) and GKB-3(3.67%) and Eucalyptol in GKM-2(1.17%). The research findings have shown that the rhizome of C. caesia is extensively rich in secondary metabolites. The extracts were assessed for their potential antibacterial activity against Gram pos. and Gram neg. bacteria viz., Bacillus cereus, Bacillus subtilis, Streptococcus agalactiae, Escherichia coli, Pseudomonas aeruginosa and Shigella flexneri. The rhizome extracts of black turmeric genotypes exhibit pos. results against the Gram pos. bacteria.

Pharma Innovation published new progress about Bacillus cereus. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Synthetic Route of 124-76-5.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts

Salomon, Lysanne published the artcileComparison of the phenolic compound profile and antioxidant potential of Achillea atrata L. and Achillea millefolium L, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, the main research area is phenolic compound antioxidant Achillea atrata millefolium; Achillea atrata L.; Achillea millefolium L.; DPPH; antioxidant activity; phenolic metabolome.

In the present study, Achillea atrata L. and A. millefolium L. were compared for the first time with regard to their phenolic compound profile and antioxidant activity by applying the 2,2-diphenyl-picryl hydrazyl radical assay. For this purpose, aerial plant parts were consecutively extracted with solvents of increasing polarity (dichloromethane, n-butanol, Et acetate), revealing that the A. atrata Et acetate fraction showed the highest antioxidant activity with an IC50 value of 12.2 ±0.29 μg/mL compared to 17.0 ± 0.26 μg/mL for A. millefolium. Both species revealed the presence of luteolin, apigenin, centaureidin, and nevadensin exclusively in this most polar fraction, which are known as effective 2,2-diphenyl-picryl hydrazyl radical scavengers. The antioxidant capacity of the aforementioned fractions strikingly correlated with their total phenolic contents, which was highest in the Et acetate fraction of A. atrata. Characterization of the metabolite profiles of both Achillea species showed only marginal differences in the presence of key compounds, whereas the concentrations of individual compounds appeared to be species-specific. Our results suggest that A. atrata, based on its compound pattern and bioactivity characteristics, has similar qualities for phytotherapy as A. millefolium.

Molecules published new progress about Achillea atrata. 124-76-5 belongs to class alcohols-buliding-blocks, name is rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol, and the molecular formula is C10H18O, Safety of rel-(1R,2R,4R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-ol.

Referemce:
Alcohol – Wikipedia,
Alcohols – Chemistry LibreTexts