Category: 12080-32-9

The preparation of ester heterocycles mostly uses heteroatoms as nucleophilic sites, which are achieved by intramolecular substitution or addition reactions. Compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ) is researched.Category: alcohols-buliding-blocks.Gholivand, Khodayar; Maghsoud, Yazdan; Kahnouji, Mohammad; Hosseini, Mahdieh; Satari, Mohammad; Abdolmaleki, Parviz; Roe, Stephen Mark published the article 《Platinum(II) complexes containing hydrazide-based aminophosphine ligands: Synthesis, molecular structures, computational investigation and evaluation as antitumour agents》 about this compound( cas:12080-32-9 ) in Applied Organometallic Chemistry. Keywords: DFT FMO platinum chloride diphenylphosphinoamino complex; antitumor activity platinum chloride diphenylphosphinoamino complex; crystal structure platinum chloride diphenylphosphinoamino complex preparation. Let’s learn more about this compound (cas:12080-32-9).

Four new N,N-bis(diphenylphosphino)amine ligands (amine = 1-amino-4-methylpiperazine (L1), N-aminophthalimide (L2), 4-aminomorpholine (L3) and hydrazine dihydrochloride (L4)) and their Pt(II) complexes C1, C2, C3 and C4 were synthesized and characterized using IR and NMR spectroscopies. The crystal structures of C1, C2 and C3 were determined using single-crystal x-ray diffraction techniques. The antitumor activities of the synthesized complexes determined using MTT assay on MDA-MB-231 cell line revealed that the studied complexes, especially C2, significantly suppressed the proliferation of these cancer cells in a dose- and time-dependent manner (e.g. at a complex concentration of 100 μg ml-1, in 24 h, the reduction of the cell viability was 88.00, 38.89, 83.35 and 64.28% for C1-C4, resp.). Theor. approaches were also used to investigate the energy and the nature of metal-ligand and metal-chlorine interactions in the complexes, which could explain their biol. activities. The interaction between ligand and Pt is stronger in C2, while the Pt-Cl interaction is weaker in this complex in comparison with the other complexes.

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Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Article, Chemistry – A European Journal called Bright Luminescent Platinum(II)-Biaryl Emitters Synthesized Without Air-Sensitive Reagents, Author is Wakasugi, Chuei; Yoshida, Masaki; Sameera, W. M. C.; Shigeta, Yasuhiro; Kobayashi, Atsushi; Kato, Masako, which mentions a compound: 12080-32-9, SMILESS is C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-], Molecular C8H12Cl2Pt, HPLC of Formula: 12080-32-9.

Transition-metal complexes bearing biaryl-2,2′-diyl ligands tend to show intense luminescence. However, difficulties in synthesis have prevented their further functionalization and practical applications. Herein, a series of platinum(II) complexes bearing biaryl-2,2′-diyl ligands, which have never been prepared in air, were synthesized through transmetalation and successive cyclometalation of biarylboronic acids. This approach does not require any air- or moisture-sensitive reagents and features a simple synthesis even in air. The resulting (Et4N)2[Pt(m,n-F2bph)(CN)2] (m,n-F2bph=m,n-difluorobiphenyl-2,2′-diyl) complexes exhibit intense green emissions with high quantum efficiencies of up to 0.80 at 298 K. The emission spectral fitting and variable-temperature emission lifetime measurements indicate that the high quantum efficiency was achieved because of the tight packing structure and strong σ-donating ability of bph.

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In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called Ditopic dithiocarbamate ligands for the production of trinuclear species, published in 2020-01-31, which mentions a compound: 12080-32-9, Name is Dichloro(1,5-cyclooctadiene)platinum(II), Molecular C8H12Cl2Pt, Related Products of 12080-32-9.

Reactions of group 10 transition metals with the ditopic ligand dipicolyldithiocarbamate (DPDTC) were performed. Thus, 1:2 reactions of [Ni(CH3COO)2], [Pd(COD)Cl2] or [Pt(COD)Cl2] with DPDTC produced monomeric complexes of the type [M(κ2-SCS-DPDTC)2, M = Ni (1), Pd (2) or Pt (3)] with the dithiocarbamate ligand (DTC) coordinated in a typical chelate κ2-SCS fashion. Interestingly, the reaction of [NiCl2] with DPDTC, under similar conditions, afforded the organic compound 2-(pyridin-2-ylmethyl)imidazo[1,5-a]pyri-dine-3(2 H)-thione (4) as unique product. In order to prove the ditopic nature of the ligand DPDTC, complex [Pd(κ2-SCS-DPDTC)2] (2) was further reacted with [ZnCl2] in a 1:2 M ratio to yield the trinuclear complex [Cl2Zn(κ2-NN-DPDTC-SCS-κ2)Pd(κ2-SCS-DPDTC-NN-κ2)ZnCl2] (5). The mol. structures of all compounds were determinate by typical anal. techniques including the unequivocal determination of all structures by single crystal x-ray diffraction anal. As expected, complexes 1-3 are isostructural, and the metal centers exhibiting slightly distorted square-planar geometries. While in 5, the trinuclear nature of the complex in confirmed exhibiting a nice combination of tetrahedral-square planar-tetrahedral geometries for the Zn-Pd-Zn centers resp.

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Hu, Di; Yang, Chen; Lok, Chun-Nam; Xing, Fangrong; Lee, Pui-Yan; Fung, Yi Man Eva; Jiang, Haibo; Che, Chi-Ming published the article 《An Antitumor Bis(N-Heterocyclic Carbene)Platinum(II) Complex That Engages Asparagine Synthetase as an Anticancer Target》. Keywords: platinum heterocyclic carbene synthesis anticancer asparagine synthetase proteome; N-heterocyclic carbenes; antitumor agents; asparagine synthetase; platinum complexes; thermal proteome profiling.They researched the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9 ).Name: Dichloro(1,5-cyclooctadiene)platinum(II). Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:12080-32-9) here.

New anticancer platinum(II) compounds with distinctive modes of action are appealing alternatives to combat the drug resistance and improve the efficacy of clin. used platinum chemotherapy. Herein, we describe a rare example of an antitumor PtII complex targeting a tumor-associated protein, rather than DNA, under cellular conditions. Complex [(bis-NHC)Pt(bt)]PF6 (1a; Hbt=1-(3-hydroxybenzo[b]thiophen-2-yl)ethanone) overcomes cisplatin resistance in cancer cells and displays significant tumor growth inhibition in mice with higher tolerable doses compared to cisplatin. The cellular Pt species shows little association with DNA, and localizes in the cytoplasm as revealed by nanoscale secondary ion mass spectrometry. An unbiased thermal proteome profiling experiment identified asparagine synthetase (ASNS) as a mol. target of 1a. Accordingly, 1a treatment reduced the cellular asparagine levels and inhibited cancer cell proliferation, which could be reversed by asparagine supplementation. A bis-NHC-ligated Pt species generated from the hydrolysis of 1 a forms adducts with thiols and appears to target an active-site cysteine of ASNS.

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Application In Synthesis of Dichloro(1,5-cyclooctadiene)platinum(II). The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Room-Temperature Phosphorescent Platinum(II) Alkynyls with Microsecond Lifetimes Bearing a Strong-Field Pincer Ligand. Author is Liska, Tadeas; Swetz, Anna; Lai, Po-Ni; Zeller, Matthias; Teets, Thomas S.; Gray, Thomas G..

The use of organometallic triplet emitters in organic light emitting diodes (OLEDs) is motivated by the premise of efficient intersystem crossing leading to unit internal quantum efficiencies. However, since most devices are based on solid-state components, an inherent limitation to square-planar Pt(II) phosphors is their tendency toward aggregation-based quenching. Here, a new class of emissive, four-coordinate Pt(II) species based on the bisimidazolyl carbazolide (BIMCA) ligand is introduced, which displays highly efficient, long-lived solid-state phosphorescence at room temperature A set of four BIMCAPt Ph acetylides were synthesized that emit in the green (λmax=507-540 nm) with >60% quantum yield and millisecond lifetimes. The structures of the resulting species reveal a nonplanar structure imposed by steric clashes between BIMCA and the iodo or alkynyl co-ligand. Ground-state and photophys. characterization are presented. D. functional theory calculations indicate that the BIMCA ligand dominates the frontier orbitals along with the 1st Franck-Condon singlet and triplet excited states.

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In organic chemistry, atoms other than carbon and hydrogen are generally referred to as heteroatoms. The most common heteroatoms are nitrogen, oxygen and sulfur. Now I present to you an article called Multinuclear Ag Clusters Sandwiched by Pt Complex Units: Fluxional Behavior and Chiral-at-Cluster Photoluminescence, published in 2021-05-10, which mentions a compound: 12080-32-9, mainly applied to silver cluster platinum complex fluxional rearrangement isomerization chiral luminescence; crystal structure mol silver cluster sandwiched platinum preparation optimized; Ag cluster; Pt complex; fluxional behavior; photoluminescence; sandwich complex, Recommanded Product: Dichloro(1,5-cyclooctadiene)platinum(II).

Multinuclear Ag clusters sandwiched by Pt complex units were synthesized and characterized by single crystal X-ray diffraction and NMR studies. The sandwich-shaped multinuclear Ag complexes showed two different types of fluxional behavior in solution: rapid slippage of Pt complex units on the Ag3 core and a reversible demetalation-metalation reaction by the treatment with Cl anion and Ag ion, resp. The Ag2 complex obtained by demetalation reaction from the Ag3 complex displayed U to Z isomerization. These multinuclear Ag complexes showed strong photoluminescence whose properties depended on the existence of Pt→Ag dative bonds. The Ag3 complex, identified to be “”chiral-at-cluster””, was optically resolved by the formation of a diastereomeric salt with a chiral anion. The enantiomers show CD (CD) and circularly polarized luminescence (CPL) properties which is unprecedented for compounds based on a chiral sandwich structure. Theor. calculations allow to understand their structural features and photophys. properties.

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The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Confined Spaces in [n]Cyclo-2,7-pyrenylenes, the main research direction is cyclo pyrenylene inclusion reaction crystal mol structure; cycloparaphenylenes; host-guest systems; macrocycles; molecular recognition; supramolecular chemistry.Computed Properties of C8H12Cl2Pt.

A set of strained aromatic macrocycles based on [n]cyclo-2,7-(4,5,9,10-tetrahydro)pyrenylenes is presented with size-dependent photophys. properties. The K-region of pyrene was functionalized with ethylene glycol groups to decorate the outer rim and thereby confine the space inside the macrocycle. This confined space is especially pronounced for n=5, which leads to an internal binding of up to 8.0×104 M-1 between the ether-decorated [5]cyclo-2,7-pyrenylene and shape-complementary crown ether-cation complexes. Both the ether-decorated [n]cyclo-pyrenylenes as well as one of their host-guest complexes have been structurally characterized by single-crystal X-ray anal. In combination with computational methods the structural and thermodn. reasons for the exceptionally strong binding have been elucidated. The presented rim confinement strategy makes cycloparaphenylenes an attractive supramol. host family with a favorable, size-independent read-out signature and binding capabilities extending beyond fullerene guests.

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Sutton, Ryan B.; Henderson, William published an article about the compound: Dichloro(1,5-cyclooctadiene)platinum(II)( cas:12080-32-9,SMILESS:C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-] ).Related Products of 12080-32-9. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:12080-32-9) through the article.

The synthesis of the platinum(II) μ2-sulfide complex [Pt2(μ2-S)2(PTA)4] (PTA = phosphatriazaadamantane), as a water-soluble analog of the known triphenylphosphine complex [Pt2(μ2-S)2(PPh3)4], was explored through a range of synthetic routes. A direct synthesis, from cis-[PtCl2(PTA)2] and Na2S·9H2O in benzene is the most effective, while attempted ligand substitution of the PPh3 ligands of [Pt2(μ2-S)2(PPh3)4] with PTA resulted in rearrangement of the {Pt2S2} core, and formation of a series of PTA-substituted trinuclear species of the general composition [Pt3(μ3-S)2(PPh3)x(PTA)6-x]2+. The fully-substituted complex [Pt3(μ3-S)2(PTA)6]2+ was also obtained when cis-[PtCl2(PTA)2] was reacted with a sulfide ion-exchange resin. Reaction of [PtCl2(cod)] (cod = 1,5-cyclooctadiene) with Na2S·9H2O in benzene gave a red solid identified as crude [Pt2(μ2-S)2(cod)2]. Reaction of this labile {Pt2S2} precursor with PTA gave [Pt2(μ2-S)2(PTA)4] along with PTA -oxide and -sulfide. ESI mass spectrometry was widely employed as a convenient tool for exploring this chem., in conjunction with 31P{1H} NMR spectroscopy. These PTA-Pt-sulfide species, especially those containing {Pt2S2} cores, have a tendency to decompose in solution Addnl. confirmation of the formation of [Pt2(μ2-S)2(PTA)4] was provided by its reaction with [Rh2(μ2-Cl)2(cod)2], giving the adduct [Pt2(μ3-S)2(PTA)4Rh(cod)]+, identified using ESI MS.

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Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 12080-32-9, is researched, SMILESS is C1=CCC/C=CCC/1.[Pt+2].[Cl-].[Cl-], Molecular C8H12Cl2PtJournal, Journal of Coordination Chemistry called Synthesis, reactivity and transition metal complexes of 1,1′-bis(diethynylphosphino)ferrocene, Author is Sonawane, Sachin C.; Kunchur, Harish S.; Pandey, Sameer Prasad; Balakrishna, Maravanji S., the main research direction is ferrocenyl bisphosphine preparation oxidation reaction transition metal complex; diethynylphosphinoferrocene preparation crystal mol structure reactivity transition metal complex; crystal mol structure diethynylphosphinoferrocene sulfide platinum copper complex.Formula: C8H12Cl2Pt.

The synthesis, oxidation reactions and transition metal complexes of a new ferrocenyl-bisphosphine, [Fe{C5H4P(CH)2}2] (1), are described. The reaction of bis(dichlorophosphino)ferrocene with four equivalent of ethynylmagnesium bromide resulted in the formation of 1 in 76% yield. The reaction between 1, aqueous H2O2 or elemental sulfur produced bis(oxide) and bis(sulfide) derivatives, [Fe{C5H4P(E)(CCH)2}2] (2 E = O, 3 E = S). Reaction of with [Ru(η6-p-cymene)Cl2]2 yielded a diruthenium complex [Fe{C5H4P(CCH)2}2{RuCl2(η6-p-cymene)}2] (4). Treatment of 1 with [M(COD)Cl2] (M = Pd, Pt) resulted in [Fe{C5H4P(CCH)2}2{MCl2}] (5 M = Pd, 6 M = Pt). Equimolar reactions between 1 and CuX produced binuclear complexes, [Fe{C5H4P(CCH)2}2{CuX}2] (7 X = Cl, 8 X = Br, 9 X = I).

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Recommanded Product: 12080-32-9. The protonation of heteroatoms in aromatic heterocycles can be divided into two categories: lone pairs of electrons are in the aromatic ring conjugated system; and lone pairs of electrons do not participate. Compound: Dichloro(1,5-cyclooctadiene)platinum(II), is researched, Molecular C8H12Cl2Pt, CAS is 12080-32-9, about Transition metal decorated soft nanomaterials through modular self-assembly of an asymmetric hybrid polyoxometalate. Author is Hampson, Elizabeth; Cameron, Jamie M.; Watts, Julie A.; Newton, Graham N..

An asym. functionalised Wells-Dawson organic-inorganic hybrid polyoxometalate has been post-functionalised by Pt2+ coordination, and demonstrates self-assembly into surface-decorated micellar nanostructures. This multifunctional hybrid material is found to be a redox-active soft nanomaterial and demonstrates a new mol. design strategy with potential for applications in photo- or electro-catalysis.

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