Author: tianli

Rosen, G. M. published the artcileNeuromuscular blocking activity of a series of β-haloethylamines, Synthetic Route of 101-98-4, the publication is Archives Internationales de Pharmacodynamie et de Therapie (1973), 204(2), 242-51, database is CAplus and MEDLINE.

The degree of irreversible neuromuscular blockade caused by 6 β-haloethylamines that exist in equilibrium between the linear from RNMeCH2CH2Cl and the aziridinium chloride form I, depends on the stability of the aziridinium ion. Thus when the aziridinium ion is either conjugated with the aromatic ring, such as in 2-chloroethylmethylphenylamine [1669-85-8], or separated from it by methylene groups to minimize interaction with the aromatic/ring the compounds act as reversible blocking agents. Irreversible blockade is produced by compounds, such as benzyl(2-chloroethyl)methoxyethylamine [50283-06-2] in which the aziridinium ion is stabilized by interaction with the non-bonding electrons, the ether O, or with the π-electrons of the aromatic ring.

Archives Internationales de Pharmacodynamie et de Therapie published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Synthetic Route of 101-98-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Takeda, Kazuo published the artcileFe(II)/Cu(I)-dependent P-type ATPase activity in the liver of Long-Evans cinnamon rats, Quality Control of 85618-21-9, the publication is Life Sciences (2005), 76(19), 2203-2209, database is CAplus and MEDLINE.

This study examined Fe(II)-dependent ATPase activity in OTG (octylthioglucoside)-treated microsomes isolated from Wistar and LEC rats. The ATPase activity of the liver OTG-microsomes from Wistar rats increased sharply in the 5-150 μM range of Fe(II) with a K_0.5 value of 23.9 ± 3.6 μM, while the activity of LEC rat liver microsomes increased with increasing Fe(II) up to 500 μM with a K_0.5 value of 64.4 ± 8.1 μM. The K_0.5 values for Fe(II)-dependent ATPase activity of spleen OTG-microsomes were nearly identical at 59.3 μM in the Wistar rat and 63.7 μM in the LEC rats with a similar level of activity at each Fe(II) concentration in both strains of animals. These results indicated that there are two types of Fe(II)-dependent ATPase with different Fe(II) sensitivity, a high sensitive (H) and a low sensitive (L) type, and that the H-type activity was specific to the liver. The H-type activity was, however, deficient in the liver of LEC rats that accumulate copper and iron in hepatocytes as a result of mutations in the Wilson’s disease protein (WNDP). On the basis of these results, together with the similarity in optimal conditions required for full activity of the enzyme, we conclude that the Fe(II)-dependent ATPase (H-type) and WNDP may be identical.

Life Sciences published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H10O4S2, Quality Control of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hanack, M. published the artcileStudies on cyclopropane derivatives, SDS of cas: 50915-29-2, the publication is Angewandte Chemie (1962), 116-17, database is CAplus.

Dicyclopropylcarbinol (I) (Hart and Curtis, CA 50, 12839f) with PCl₅ or PCl₃ at — 15° gave only 1-cyclopropyl-4-chloro-1-butene (II), b₁₂ 60-2°, in 85% yield. With 3% HCl at 80° I gave 69% II and 11% cyclopropylbutadiene (III), b. 96-7°. With AcCl in Et₂O, I gave 10% acetate (IV) and 22% II. Pure IV was easily obtained with Ac₂O; alk. saponification gave only I. With PBr₃ in Et₂O or with 60% HBr at 0° I gave only 1-cyclopropyl-4-bromo-1-butene in 80% yield. Hydrolysis of II with 10% K₂CO₃ 3 hrs. at 80° gave 35% I. With Na amylate, II gave III, which easily formed a diene adduct, m. 84-5°, with maleic anhydride. Dicyclopropyl ketone (V) (Hart and C., loc. cit.) and MeMgI gave 70% dicyclopropylmethylcarbinol, b₁₅ 58°. With Na and EtOH the oxime of V easily gave the amine. Methylcyclopropylcarbinol (VI) with concentrated HCl and ZnCl₂ at 0° gave 5-chloro-2-pentene, which gave 10% VI when hydrolyzed with 10% K₂CO₃ 3 hrs. at 80°.

Angewandte Chemie published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, SDS of cas: 50915-29-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sparkes, Emily I. published the artcileBiocatalytic Silylation: The Condensation of Phenols and Alcohols with Triethylsilanol, Category: alcohols-buliding-blocks, the publication is Catalysts (2021), 11(8), 879, database is CAplus.

Silicatein-α (Silα), a hydrolytic enzyme derived from siliceous marine sponges, is one of the few enzymes in nature capable of catalyzing the metathesis of silicon-oxygen bonds. It is therefore of interest as a possible biocatalyst for the synthesis of organosiloxanes. To further investigate the substrate scope of this enzyme, a series of condensation reactions with a variety of phenols and aliphatic alcs. were carried out. In general, it was observed that Silα demonstrated a preference for phenols, though the conversions were relatively modest in most cases. In the two pairs of chiral alcs. that were investigated, it was found that the enzyme displayed a preference for the silylation of the S-enantiomers. Addnl., the enzyme′s tolerance to a range of solvents was tested. Silα had the highest level of substrate conversion in the nonpolar solvents n-octane and toluene, although the inclusion of up to 20% of 1,4-dioxane was tolerated. These results suggest that Silα is a potential candidate for directed evolution toward future application as a robust and selective biocatalyst for organosiloxane chem.

Catalysts published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C11H11BFNO4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Busev, A. I. published the artcileSpectroscopic study of the reaction products of Rhodamine 6Zh with naftamon during extraction by benzene, Product Details of C28H29NO4, the publication is Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya (1974), 17(9), 1367-70, database is CAplus.

Reaction products of the dye Rhodamine 6Zh (I) [7325-85-1] with Naftamon (II) [3818-50-6], and the dye itself were extracted with C6H6, and the spectra obtained from the extracts in the region 17,000-22,000 cm-1 were split into gauss constituents. Four gauss peaks were found in the extract corresponding to monomeric and dimeric forms of ionic associates of I with II and traces of the dye.

Izvestiya Vysshikh Uchebnykh Zavedenii, Khimiya i Khimicheskaya Tekhnologiya published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ji, Lei published the artcileExperimental and Theoretical Studies of Quadrupolar Oligothiophene-Cored Chromophores Containing Dimesitylboryl Moieties as π-Accepting End-Groups: Syntheses, Structures, Fluorescence, and One- and Two-Photon Absorption, Computed Properties of 239075-02-6, the publication is Chemistry – A European Journal (2014), 20(42), 13618-13635, database is CAplus and MEDLINE.

Quadrupolar oligothiophene chromophores composed of four to five thiophene rings with two terminal (E)-dimesitylborylvinyl groups (4 V-5 V), and five thiophene rings with two terminal aryldimesitylboryl groups (5 B), and an analog of 5 V with a central EDOT ring (5 VE), were synthesized via Pd-catalyzed cross-coupling reactions in high yields (66-89 %). Crystal structures of 4 V, 5 B, bithiophene 2 V, and five thiophene-derived intermediates are reported. Chromophores 4 V, 5 V, 5 B and 5 VE have photoluminescence quantum yields of 0.26-0.29, which are higher than those of the shorter analogs 1 V-3 V (0.01-0.20), and short fluorescence lifetimes (0.50-1.05 ns). Two-photon absorption (TPA) spectra were measured for 2 V-5 V, 5 B and 5 VE in the range 750-920 nm. The measured TPA cross-sections for the series 2 V-5 V increase steadily with length up to a maximum of 1930 GM. We compare the TPA properties of 2 V-5 V with the related compounds 5 B and 5 VE, giving insight into the structure-property relation for this class of chromophore. DFT and TD-DFT results, including calculated TPA spectra, complement the exptl. findings and contribute to their interpretation. A comparison to other related thiophene and dimesitylboryl compounds indicates that our design strategy is promising for the synthesis of efficient dyes for two-photon-excited fluorescence applications.

Chemistry – A European Journal published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Diez, Stefan J. published the artcileCrystallization at Solvent Interfaces Enables Access to a Variety of Cocrystal Polymorphs and Hydrates, HPLC of Formula: 86-48-6, the publication is Crystal Growth & Design (2018), 18(6), 3263-3268, database is CAplus.

A crystal growth technique, interfacial cocrystn., is demonstrated to be a simple and effective method for preparing multi-component crystal forms. The technique is based on the generation of a liquid-liquid interface between two immiscible solutions of cocrystal-forming compounds, and its utility is demonstrated through the preparation of polymorphs and hydrates of caffeine cocrystals, involving three different hydroxy-2-naphthoic acids, including the formation of some with unexpected compositions

Crystal Growth & Design published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, HPLC of Formula: 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wakamiya, Yuma published the artcileTotal Synthesis of Amphidinol 3: A General Strategy for Synthesizing Amphidinol Analogues and Structure-Activity Relationship Study, Recommanded Product: (R)-Oxiran-2-ylmethanol, the publication is Journal of the American Chemical Society (2020), 142(7), 3472-3478, database is CAplus and MEDLINE.

Amphidinol 3 (AM3) is a potent antifungal produced by the dinoflagellate Amphidinium klebsii. It was difficult to determine the absolute configuration of AM3 by using the scarce natural product due to the presence of numerous stereogenic centers on the acyclic carbon chain. Since the absolute configuration was partially determined on the basis of insufficient evidence, the originally proposed structure has been revised three times. Although recent progress on structure determination by computational anal. is remarkable, total synthesis is still the most reliable way to confirm structures. The first total synthesis of AM3 was achieved via expeditious assembly of three components in five steps, confirming the revised structure of AM3 after more than 20 years since its first discovery. The established synthetic route would be a general strategy for synthesizing amphidinol congeners. An artificial and simplified analog of AM3, which elicited antifungal activity comparable to that of AM3, was designed and synthesized. This is the first example of a biol. active artificial analog possessing a shorter polyol moiety, providing insight on the antifungal mode-of-action.

Journal of the American Chemical Society published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C23H43NP2, Recommanded Product: (R)-Oxiran-2-ylmethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bastien, Dominic published the artcileFragment-Based Design of Symmetrical Bis-benzimidazoles as Selective Inhibitors of the Trimethoprim-Resistant, Type II R67 Dihydrofolate Reductase, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol, the publication is Journal of Medicinal Chemistry (2012), 55(7), 3182-3192, database is CAplus and MEDLINE.

The continuously increasing use of trimethoprim as a common antibiotic for medical use and for prophylactic application in terrestrial and aquatic animal farming has increased its prevalence in the environment. This has been accompanied by increased drug resistance, generally in the form of alterations in the drug target, dihydrofolate reductase (DHFR). The most highly resistant variants of DHFR are known as type II DHFR, among which R67 DHFR is the most broadly studied variant. We report the first attempt at designing specific inhibitors to this emerging drug target by fragment-based design. The detection of inhibition in R67 DHFR was accompanied by parallel monitoring of the human DHFR, as an assessment of compound selectivity. By those means, small aromatic mols. of 150-250 g/mol (fragments) inhibiting R67 DHFR selectively in the low millimolar range were identified. More complex, sym. bis-benzimidazoles and a bis-carboxyphenyl were then assayed as fragment-based leads, which procured selective inhibition of the target in the low micromolar range (K_i = 2-4 μM). The putative mode of inhibition is discussed according to mol. modeling supported by in vitro tests.

Journal of Medicinal Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Recommanded Product: 2-(Benzyl(methyl)amino)ethanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Coles, G. C. published the artcileMechanism of action of the anthelmintic levamisole, SDS of cas: 3818-50-6, the publication is General Pharmacology (1975), 6(4), 309-13, database is CAplus.

In a solution of levamisole-HCl (I) [16595-80-5], the small round worm Nippostrongylus brasiliensis became paralyzed, but recovered on being left in the solution Both the rates of paralysis and recovery increased with increasing concentration of I. A small percentage of Ascaris suum also resumed movement in I, and were then protected against the effects of the anthelmintics bephenium hydroxynaphthoate [3818-50-6], methyridine [114-91-0], and pyrantel tartrate [33401-94-4]. The autonomic blocking agents mecamylamine and pempidine blocked I contractions in normal A. suum, and the results suggested that all 4 anthelmintics acted in a similar way.

General Pharmacology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, SDS of cas: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts