Author: tianli

Arriaga Alba, M. published the artcileMutagenicity of urine from mice exposed orally to nitrite and various aminated antiparasitic drugs, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Environmental and Molecular Mutagenesis (1989), 14(1), 13-19, database is CAplus and MEDLINE.

The mutagenic activity of mouse urine was determined after oral administration of sodium nutrite and pyrantel pamoate, chloroquine, piperazine, dehydroemetine, iodochlorhydroxyquin, and bephenium hydroxynaphthoate. The simultaneous administration of piperazine or chloroquine with sodium nitrite produced urinary mutagens that appeared conjugated as glucuronides, whereas pyrantel pamoate and dehydroemetine in the presence of nitrite caused only slight mutagenic urine. No mutagenic activity was detected in the urine of mice to which halogenated derivatives of tertiary amines (iodochlorhydroxyquin) or quaternary ammonium salts (bephenium hydroxynaphthoate) were administered together with nitrite.

Environmental and Molecular Mutagenesis published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Dindarloo Inaloo, Iman published the artcileNickel-Catalyzed Synthesis of N-(Hetero)aryl Carbamates from Cyanate Salts and Phenols Activated with Cyanuric Chloride, Application of Thiophen-3-ol, the publication is ChemCatChem (2020), 12(21), 5486-5491, database is CAplus.

A simple and efficient domino reaction has been designed and employed for the one-pot synthesis of N-(hetero)aryl carbamates ArNHC(O)OR (Ar = Ph, thiophen-2-yl, pyridin-3-yl, etc.; R = Pr, cyclohexyl, allyl, etc.) through the reaction between alcs. ROH and in-situ produced (hetero)aryl isocyanates in the presence of a nickel catalyst. The phenolic C-O bond was activated via the reaction of phenol with cyanuric chloride (2,4,6-trichloro-1,3,5-triazine (TCT)) as an inexpensive and readily available reagent. This strategy provides practical access to N-(hetero)aryl carbamates in good yields with high functional groups compatibility.

ChemCatChem published new progress about 17236-59-8. 17236-59-8 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Alcohol, name is Thiophen-3-ol, and the molecular formula is C4H4OS, Application of Thiophen-3-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Omran, Anahid published the artcileSynthesis of 3-(3-hydroxyphenyl)pyrrolidine dopamine D₃ receptor ligands with extended functionality for probing the secondary binding pocket, Category: alcohols-buliding-blocks, the publication is Bioorganic & Medicinal Chemistry Letters (2018), 28(10), 1897-1902, database is CAplus and MEDLINE.

A series of 3-(3-hydroxyphenyl)pyrrolidine analogs which incorporate N-alkyl groups and N-butylamide-linked benzamide functionality were synthesized and their in vitro binding affinities at human dopamine receptors were evaluated. The authors’ ligand design strategy was to take the 3-(3-hydroxyphenyl)pyrrolidine scaffold and extend functionality from the orthosteric binding site to the secondary binding pocket for enhancing affinity and selectivity for the D₃ receptor. The N-alkyl analogs constitute a homologous series from N-pentyl to N-decyl to probe the length/bulk tolerance of the secondary binding pocket of the D₃ receptor. Enantiomeric 3-(3-hydroxyphenyl)pyrrolidine analogs were also prepared to test the chirality preference of the orthosteric binding site for this scaffold. Benzamide analogs were prepared to enhance affinity and/or selectivity based upon the results of the homologous series.

Bioorganic & Medicinal Chemistry Letters published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Troutman, Jerry M. published the artcileTuning the Production of Variable Length, Fluorescent Polyisoprenoids Using Surfactant-Controlled Enzymatic Synthesis, Application of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Biochemistry (2015), 54(18), 2817-2827, database is CAplus and MEDLINE.

Bactoprenyl diphosphate (BPP), a two-E eight-Z configuration C₅₅ isoprenoid, serves as a critical anchor for the biosynthesis of complex glycans central to bacterial survival and pathogenesis. BPP is formed by the polymerase undecaprenyl pyrophosphate synthase (UppS), which catalyzes the elongation of a single farnesyl diphosphate (FPP) with eight Z-configuration isoprene units from eight isopentenyl diphosphates. In vitro anal. of UppS and other polyprenyl diphosphate synthases requires the addition of a surfactant such as Triton X-100 to stimulate the release of the hydrophobic product from the enzyme for effective and efficient turnover. Here using a fluorescent 2-nitrileanilinogeranyl diphosphate analog of FPP, we have found that a wide range of surfactants can stimulate release of product from UppS and that the structure of the surfactant has a major impact on the lengths of products produced by the protein. Of particular importance, shorter chain surfactants promote the release of isoprenoids with four to six Z-configuration isoprene additions, while larger chain surfactants promote the formation of natural isoprenoid lengths (8Z) and larger. We have found that the product chain lengths can be readily controlled and coarsely tuned by adjusting surfactant identity, concentration, and reaction time. We have also found that binary mixtures of just two surfactants can be used to fine-tune isoprenoid lengths. The surfactant effects discovered do not appear to be significantly altered with an alternative isoprenoid substrate. However, the surfactant effects do appear to be dependent on differences in UppS between bacterial species. This work provides new insights into surfactant effects in enzymol. and highlights how these effects can be leveraged for the chemoenzymic synthesis of otherwise difficult to obtain glycan biosynthesis probes. This work also provides key reagents for the systematic anal. of structure-activity relationships between glycan biosynthesis enzymes and isoprenoid structure.

Biochemistry published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C15H20O6, Application of (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Qudrat-i-Khuda, M. published the artcileInvestigations on Ocimum gratissimum. II. Characterization of gratissimin and gratissimic acid, Related Products of alcohols-buliding-blocks, the publication is Sci. Res. (Dacca, Pakistan) (1965), 2(1/2), 8-10, database is CAplus.

cf. CA 62, 81191g. Reduction of gratissimum C₂₀H₂O₄ (I) with Li-AlH₄ has given a diol, C₁₈H₂₀O₂, m.p. 104 °, which forms ditoluene-p-sulfonyl derivative, m.p. 184°, confirms the mol. formula and evidence the presence of 2 COOCH₃ groups in the mol. Acetic anhydride converts gratissimic acid (II) into a crystalline anhydride, m.p. 187°. Oxidation of II with KMnO₄ has afforded a high yield of benzoic acid. Results indicate that I is dimethyl ester of α-truxillic acid (III) and II is identical with this acid, which has been confirmed by comparing these compounds with III and its dimethyl ester prepared from trans-cinnamic acid.

Sci. Res. (Dacca, Pakistan) published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Finkel’shtein, E. Sh. published the artcileElectrophilic addition to methylenecyclobutane and bicyclobutylidene, HPLC of Formula: 20117-47-9, the publication is Neftekhimiya (1985), 25(1), 48-57, database is CAplus.

Title reaction of methylenecyclobutane (I) with ROH (R = Me, Et, Bu, 1-methylcyclobutyl, Ph, Ac, ClCH₂CO, FCH₂CO, CCl₃CO, CF₃CO) in the presence or absence of hexane or cyclohexane and/or 80% H₂SO₄ gave the corresponding ethers and esters II. PhOH gave 4-R¹C₆H₄OH (R¹ = 1-methylcyclobutyl) and 2,4,6-R¹₃C₆H₂OH (same R¹) as the major products. Analogous reactions of bicyclobutylidene with ROH (R = H, Me, Ac, CF₃CO, Ph) gave bicyclo[3.3.0]octanes III (R² = OH, OMe, OAc, O₂CCF₃, C₆H₄OH-4, resp.). I reacted with aqueous HCHO under these conditions to give 5,7-dioxaspiro[3.5]nonane, methanolysis which gave diol IV (R = H) (V) and IV (R = Me). Dehydrating V gave 1-vinylcyclobutene . The NMR and mass spectra of the products were interpreted.

Neftekhimiya published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, HPLC of Formula: 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wasin, Tuchinda published the artcileFabrication of “Clickable” Polyfluorene Nanowires with High Aspect Ratio as Biological Sensing Platforms, Related Products of alcohols-buliding-blocks, the publication is ACS Sensors (2016), 1(6), 766-774, database is CAplus.

“Clickable” nanowires with well-defined and uniform structures made of conjugated polyfluorene polymers were successfully fabricated by single particle nanofabrication technique (SPNT). Poly[(9,9-dihex-5-yn-1-ylfluorenyl-2,7-diyl)-co-(9,9′-di-n-octylfluorenyl-2,7-diyl)] (F6E8) and poly[(9,9-dihex-5-yn-1-ylfluorenyl-2,7-diyl)-co-(2,2′-bithiophene)] (F6E2T) underwent an efficient crosslinking reaction upon irradiation, resulting in formation of one-dimensional nanostructures with high and desired aspect ratio reaching up to 200. Alkyne groups on the surface of nanowires were functionalized effectively by click reaction with fluorescent 5-TAMRA-PEG3-azide, which was confirmed by confocal microscopy. Substrates functionalized with the nanowires provide dramatic expansion of “clickable” surface area immobilized directly with TAMRA, and the fluorescence resonance energy transfer (FRET) processes between TAMRA and nanowire backbones are demonstrated as biol. sensing platforms.

ACS Sensors published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C6H8O3, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kaufmann, Thomas C. published the artcileA novel method for detergent concentration determination, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Biophysical Journal (2006), 90(1), 310-317, database is CAplus and MEDLINE.

A fast and precise method for detergent concentration determination is presented. A small droplet of the detergent solution is deposited on a piece of Parafilm M and side views are recorded by two orthogonally arranged TV cameras. The droplet contours are then approximated by ellipses to determine the contact angles. Comparison of the observed contact angle values to calibrated standard curves of known detergent concentrations gives the concentration of the detergent assessed. A range of commonly used detergents was studied to demonstrate the reproducibility and precision of this simple method. As a first application, the detergent binding capacity of the Escherichia coli galactose/proton symporter (GalP) was assessed. Aggregation of GalP was observed when <260±5 dodecyl-β-D-maltoside mols. were bound to one GalP mol. These measurements document the efficacy of the drop-shape based detergent concentration determination described.

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Brody, Gerald published the artcileComparative activity of 29 known anthelmintics under standarized drug-diet and gavage medication regimens against four helminth species in mice, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Journal of Parasitology (1971), 57(5), 1068-77, database is CAplus and MEDLINE.

Of 29 reference anthelmintics (21 aromatic-heterocyclic and 8 organophosphate compounds) tested at an initial concentration of 1000 ppm in the diet of mice for 18 days against 4 mouse helminths, parbendazole (I) [14255-87-9] was the only compound exhibiting activity against all 4 helminths and the effectiveness of I was .sim.100% against the 4 helminths. However, in experiments using the 29 compounds at an initial dose of 200 mg/kg/day by gavage for 3 days, significant differences were observed in the effectiveness of a number of the anthelmintics in the 2 different medication regimens. The data below refers to the effectiveness of the compounds when given in the diet. Against Nematospiroides dubius, I, pyrantel (II) [15686-83-6], dl-tetramisole [5036-02-2], l-tetramisole (III) [14769-73-4], and thiabendazole (IV) [148-79-8] were the most effective. Against Hymenolepis nana (tapeworm), I and Ro-2-9009 (1,4-bis(2-diethylaminoethoxy)anthraquinone-2HCl (V) [18272-48-5] were the most effective. Against Syphacia obvelata, I, II, III, IV, V, dithiazanine (VI) [7187-55-5] (at 250 ppm), pyrvinium (VII) [7187-62-4], stilbazium (VIII) [3784-99-4], coumaphos (IX) [56-72-4], haloxon (X) [321-55-1], mercaptophos (XI) [55-38-9], and Ruelene (XII) [299-86-5] were the most effective. Against Aspiculuris tetraptera, I, II, VI, VII, VIII, IX, X, XI, XII, and dichlorvos [62-73-7] were the most effective.

Journal of Parasitology published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Recommanded Product: N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Abdel-Razek, A. S. published the artcileBioelimination of phenanthrene using degrading bacteria isolated from petroleum soil: safe approach, Safety of 1-Hydroxy-2-naphthoic acid, the publication is Desalination and Water Treatment (2020), 131-140, database is CAplus.

Polyaromatic hydrocarbon contamination is considered as serious pollution resulted from industrial activities. Phys. or chem. methods used for remediation of hydrocarbons might cause the transfer of the remediated compounds from the polluted sites into other clean locations. Our study is concerned by the bioremediation of phenanthrene, using microbial degraders that will eventually, result in the release of non-toxic structures, as end products. Successfully, three bacterial isolates; Enterobacter cloacae, Bacillus sp. and Bacillus thuringiensis with accession numbers; MK559694, MK561601 and MK559693, resp., showed higher phenanthrene biodegradation ability. The examined conditions indicated that the isolates were active in a wide range of temperatures, pH and hydrocarbon concentrations The gas chromatog.-mass spectrum anal. of the formed byproducts showed the existence of intermediate structures with varied carbon values, ranged from C4H8O2 to C12H22O11. However, these byproducts did not show cytotoxic effect against Vero cell lines, compared with the tested undegraded phenanthrene. The obtained results revealed that these bacterial isolates can be used as potent phenanthrene degraders with safe and non-toxic end products, which allow the treated water to be used for non-potable water applications.

Desalination and Water Treatment published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Safety of 1-Hydroxy-2-naphthoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts