Author: tianli

O’Brien, Anne Marie published the artcileChemical stabilization of recombinant horseradish peroxidase, Product Details of C18H20N2O12, the publication is Biotechnology Techniques (1996), 10(12), 905-910, database is CAplus.

Unglycosylated recombinant horseradish peroxidase (HRP C°) had a half life of 21 min at 65° compared with only 5 min for the plant enzyme (HRP). The half life of HRP C^* at 65° increased by 5-fold following modification with ethylene glycol bis(succinic acid N-hydroxysuccinimide ester). Tolerance to 60% 1,4-dioxan also increased while tolerance to 30% DMF was unchanged.

Biotechnology Techniques published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Product Details of C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Murphy, Ann published the artcileChemically stabilized trypsin used in dipeptide synthesis, Application In Synthesis of 70539-42-3, the publication is Biotechnology and Bioengineering (1998), 58(4), 364-373, database is CAplus and MEDLINE.

Bovine pancreatic trypsin was treated with ethylene glycol bis(succinic acid N-hydroxysuccinimide ester), such that approx. 8 out of 14 lysines per trypsin mol. were modified. This derivative (EG trypsin) was more stable than native between 30° and 70°: T₅₀ values were 59° and 46°, resp. EG trypsin’s half-life of 25 min at 55° was fivefold greater than native’s. EG trypsin had a decreased rate of autolysis and retained more activity in aqueous mixtures of 1,4-dioxan, DMF, dimethylsulfoxide, and acetonitrile. EG trypsin had lower K_m values for both amide and ester substrates; its k_cat values for two amides (PhCO-Arg-NHC₆H₄NO₂-4 and Cbz-Gly-Gly-Arg-NMC; NMC = 7-amino-4-methylcoumarin) increased, whereas its k_cat value for an ester (Cbz-Lys-SCOPh) decreased slightly. The specific activity (k_cat/K_m) of EG trypsin was increased for both amide and ester substrates. EG trypsin gave higher yields and reaction rates than the native trypsin in kinetically controlled synthesis of PhCO-Arg-Leu-NH₂ in acetonitrile and in t-butanol. Highest peptide yields occurred with EG trypsin in 95% acetonitrile, where 90% of the substrate was converted to product. No peptide synthesis occurred in 95% DMF with either form of trypsin.

Biotechnology and Bioengineering published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Application In Synthesis of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Donnelly, Liam J. published the artcileC-H Borylation Catalysis of Heteroaromatics by a Rhenium Boryl Polyhydride, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is ACS Catalysis (2021), 11(12), 7394-7400, database is CAplus.

Transition metal complexes bearing metal-boron bonds are of particular relevance to catalytic C-H borylation reactions, with iridium polyboryl and polyhydrido-boryl complexes the current benchmark catalysts for these transformations. Herein, we demonstrate that polyhydride boryl phosphine rhenium complexes are accessible and catalyze the C-H borylation of heteroaromatic substrates. Reaction of [K(DME)(18-c-6)][ReH₄(Bpin)(η²-HBpin)(κ²-H₂Bpin)] 1 with 1,3-bis(diphenylphosphino)propane (dppp) produced [K(18-c-6)][ReH₄(η²-HBpin)(dppp)] 2 through substitution of two equivalent of HBpin, and protonation of 2 formed the neutral complex [ReH₆(Bpin)(dppp)] 3. Combined X-ray crystallog. and DFT studies show that 2 is best described as a σ-borane complex, whereas 3 is a boryl complex. Significantly, the boryl complex 3 acted as a catalyst for the C(sp²)-H borylation of a variety of heteroarenes (14 examples including furan, thiophene, pyrrole and indole derivatives) and displayed similar reactivity to the iridium analogs.

ACS Catalysis published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Application of 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Jianjun published the artcileTotal Synthesis of (-)-Melanthioidine by Copper-Mediated Cyclodimerization, Product Details of C9H11NO4, the publication is Organic Letters (2016), 18(15), 3542-3545, database is CAplus and MEDLINE.

An efficient asym. total synthesis of the dimeric macrocyclic diaryl ether phenethyltetrahydroisoquinoline alkaloid (-)-melanthioidine is reported. Key steps of the synthesis include an efficient Noyori asym. transfer hydrogenation to access the enantioenriched phenethyltetrahydroisoquinoline monomeric subunit and a copper-mediated cyclodimerization to form the two diaryl ether linkages with concomitant macrocyclization.

Organic Letters published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C6H16OSi, Product Details of C9H11NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Deldaele, Christopher published the artcileRoom-Temperature Practical Copper-Catalyzed Amination of Aryl Iodides, Formula: C8H19NO2, the publication is ChemCatChem (2016), 8(7), 1319-1328, database is CAplus.

An efficient and highly practical procedure was reported for the Ullmann-Goldberg-type copper-catalyzed amination of aryl iodides. By using a combination of copper iodide and proline in the presence of an excess of an amine, a wide range of aryl iodides were readily aminated at room temperature The reaction proceeded well regardless of the electronic properties of the starting aryl iodide and the amination products were obtained without the need for purification by column chromatog. in most cases. Owing to its efficiency and the mildness of the reaction conditions, this amination was extended to the amination of complex aryl iodides at room temperature

ChemCatChem published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Formula: C8H19NO2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pospisil, Jan published the artcileOxidation of catechol. IV. Oxidation of 4-tert-octylcatechol, HPLC of Formula: 1139-46-4, the publication is Chemicke Listy pro Vedu a Prumysl (1958), 939-47, database is CAplus.

cf. C.A. 52, 4546g. Oxidation of 4-tert-octylcatechol (I) (tert-octyl = R = Me₃CCH₂CMe₂) with O or alk. H₂O₂ gave 2-hydroxy-5-tert-octyl-1,4-benzoquinone (II), also obtained by oxidation of 4-tert-octyl-1,2-benzoquinone (III). The oxidation of I is assumed to proceed through intermediate 1,2,4-trihydroxy-5-tert-octylbenzene (IV) to II. A similar mechanism is proposed for the oxidation of catechol (V) to 2,5-dihydroxy-1,4-benzoquinone (VI). Alkylation of pyrogallol (VII) with di-isobutylene (VIII) gave 5-tert-octylpyrogallol (IX) whose oxidation with Ag₂O yielded 6-hydroxy-4-tert-octyl-1,2-benzoquinone (X). Dissolving 110 g. resublimed V in 448 g. hot VIII, treating the solution with 0.2 ml. concentrated H₂SO₄, stirring the mixture 2.5 hrs. at 105-15°, cooling, filtering off the product with suction, and washing with H₂O yielded 167.6 g. I, m. 108° (ligroine). Adding a solution of 4.5 g. I in 220 ml. Et₂O to a mixture of 100 ml. Et₂O, 5 g. anhydrous Na₂SO₄, and Ag₂O prepared from 135 g. AgNO₃, shaking 5 min., filtering, and evaporating gave 4.29 g. III, m. 121-1.5° (Et₂O). Acetylation of 2.2 g. I by heating with 6 ml. Ac₂O and 0.1 ml. concentrated H₂SO₄ 20 min. on the steam-bath gave 1.8 g. 1,2-diacetoxy-4-tert-octylbenzene, m. 49.5°. The same compound was also obtained by boiling for 10 min. a mixture of 0.44 g. III, 1 g. anhydrous NaOAc, 1.0 g. Zn dust, and 12 ml. Ac₂O. To oxidize I, O was passed into a solution of 68 g. KOH in 300 ml. 75% MeOH at a rate of 0.2-0.3 l./min. at 30°. After 15 min., 10 g. I in 100 ml. 75% MeOH was added over a period of 2.5 hrs. The initial blue color turned red. The red clear solution was diluted with 300 ml. H₂O, 300 g. ice was added, and the mixture acidified with concentrated HCl. The solution turned yellow and a yellow product precipitated Evaporation of the MeOH in vacuo yielded another crop of II, m. 133.5-4.5° (decomposition) (petr. ether) (7.45 g., 70.1% total). Dissolving 4.5 g. I in 50 ml. 5% solution of KOH in 50% MeOH, treating this solution at 40° with 7 ml. 40% H₂O₂ for 30 min., stirring the mixture 1.5 hrs., decanting the red solution from resinous material, diluting it to a 10-fold volume with ice and H₂O, and acidifying with HCl gave 69.8% II. The same compound was obtained also by oxidation of 0.22 g. III in methanolic solution of KOH (containing 4.5 g. KOH in 45 ml. 75% MeOH) by passing 0.15-0.2 l./min. O through the solution 1.5 hrs. (yield 41.3%) or by treating 0.5 g. III in 2.2 ml. MeOH with 2.5 ml. 40% aqueous KOH and 1.4 ml. 40% H₂O₂ 1 hr. at 40° (yield 15.3%, 0.08 g.). Absorption of II in 0.1N aqueous KOH showed log ε 4.086 at 285 mμ, and log ε 3.216 at 495 mμ. Heating 1 g. II with 5 ml. Ac₂O and 0.1 ml. concentrated H₂SO₄ 2 hrs. at 45° and diluting the mixture after 20 hrs. with 20 ml. H₂O yielded 0.95 g. 2-acetoxy-5-tert-octyl-1,4-benzoquinone (XI), m. 89.5-90° (petr. ether). Dissolving 0.2 g. XI in 5 ml. Ac₂O, adding 0.5 g. Zn dust and 0.5 g. anhydrous NaOAc, refluxing the mixture 30 min., filtering off the Zn, and diluting the filtrate with 25 ml. H₂O and 25 g. ice gave 0.22 g. triacetate (XII) of IV, m. 88.5° (petr. ether). The same compound was obtained by treating similarly 2 g. II in 25 ml. Ac₂O with 2.5 g. Zn dust and 2.5 g. NaOAc; yield 2.62 g. Hydrogenation of 0.11 g. II in 20 ml. glacial AcOH and 40 ml. Ac₂O over PtO₂ and heating the mixture with 0.2 ml. concentrated H₂SO₄ 20 min. under H gave XII. If the hydrogenation was carried out in MeOH, the colorless solution of IV formed was reoxidized in contact with air. Heating 30 g. VII with 172 g. VIII and 0.1 ml. concentrated H₂SO₄ 3 hrs. at 105-15° gave 30.7 g. (51.7%) IX, m. 104° (ligroine). Shaking 1.2 g. IX in 100 ml. Et₂O with 12 g. Ag₂O and 10 g. anhydrous Na₂SO₄ in 50 ml. Et₂O for 10 min. gave a red solution of X whose reductive acetylation by heating with 5 ml. Ac₂O, 0.5 g. NaOAc, and 0.5 g. Zn dust in 30 ml. C₆H₆ gave 1,2,3-triacetoxy-5-tert-octylbenzene, m. 71° (petr. ether). The same compound was also obtained by allowing 0.37 g. III to stand 24 hrs. at 20° with 10 ml. Ac₂O and 0.1 ml. H₂SO₄ or by heating 1 g. IX with 8 ml. Ac₂O and 0.1 ml. H₂SO₄ 10 min. on the steam bath (yield 1.25 g.). Heating 0.28 g. VI, 6 ml. Ac₂O, and 0.1 ml. H₂SO₄ 2 hrs. at 50° and diluting the mixture after 20 hrs. with ice and H₂O gave 0.27 g. 2,5-diacetoxy-1,4-benzoquinone (XIII), m. 151-2° (decomposition) (AcOH). Hydrogenation of 0.14 g. VI in 40 ml. MeOH over PtO₂ at 18° gave impure 1,2,4,5-tetrahydroxybenzene whose acetylation with 5 ml. Ac₂O and 1 drop H₂SO₄ gave tetraacetate, m. 226° (AcOH).

Chemicke Listy pro Vedu a Prumysl published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, HPLC of Formula: 1139-46-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Luk’yanov, S. M. published the artcileConversion of 1,3-benzodioxans into xanthene derivatives, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol, the publication is Zhurnal Organicheskoi Khimii (1978), 14(2), 399-401, database is CAplus.

Treatment of dioxanes I (R = Ph, Me) with Ph₃C⁺ClO^–₄ in HOAc gave 21-62.8% II, which was also prepared by reaction of o-HOC₆H₄CPh₂OH with Ph₃C⁺ClO₄^– or HClO₄. Treatment of II with BrCH₂CO₂Et and Zn gave 93% III (R¹ = CH₂CO₂Et) III (R¹ = p-H₂NC₆H₄, p-Me₂NC₆H₄, EtO) were also prepared

Zhurnal Organicheskoi Khimii published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C19H14O2, Recommanded Product: 9-Phenyl-9H-xanthen-9-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bolano, Tamara published the artcileAn Acyl-NHC Osmium Cooperative System: Coordination of Small Molecules and Heterolytic B-H and O-H Bond Activation, Name: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, the publication is Organometallics (2015), 34(15), 3902-3908, database is CAplus.

The hexahydride complex OsH₆(PⁱPr₃)₂ (1) activates the C-OMe bond of 1-(2-methoxy-2-oxoethyl)-3-methylimidazolium chloride (2), in addition to promoting the direct metalation of the imidazolium group, to afford a five-coordinate OsCl(acyl-NHC)(PⁱPr₃)₂ (3) compound The latter coordinates carbon monoxide, oxygen, and mol. hydrogen to give the corresponding carbonyl (4), dioxygen (5), and dihydrogen (6) derivatives Complex 3 also promotes the heterolytic bond activation of pinacolborane (HBpin), using the acyl oxygen atom as a pendant Lewis base. The hydride ligand and the Bpin substituent of the Fischer-type carbene of the resulting complex 7 activate the O-H bond of alcs. and water. As a consequence, complex 3 is a metal ligand cooperating catalyst for the generation of mol. hydrogen, by both the alcoholysis and hydrolysis of pinacolborane, via the intermediates 7 and 6.

Organometallics published new progress about 25240-59-9. 25240-59-9 belongs to alcohols-buliding-blocks, auxiliary class Boronic acid and ester,Boronic Acids,Boronate Esters, name is 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol, and the molecular formula is C6H13BO3, Name: 4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cortinas de Nava, C. published the artcileMutagenicity of antiamebic and anthelmintic drugs in the Salmonella typhimurium microsomal test system, Product Details of C28H29NO4, the publication is Mutation Research, Genetic Toxicology Testing (1983), 117(1-2), 79-91, database is CAplus and MEDLINE.

Amebicides (chloroquine (I) [54-05-7], diiodohydroxyquin  [83-73-8], iodochlorohydroxyquin  [130-26-7] and dehydroemetine  [4914-30-1]) and anthelmintics (bephenium hydroxynaphthoate  [3818-50-6], 4-hexylresorcinol  [136-77-6], mebendazole  [31431-39-7], niclosamide  [50-65-7], pyrantel pamoate  [22204-24-6] and pyrvinium pamoate  [3546-41-6]) were tested for mutagenicity in the S. typhimurium microsomal test system. Frameshift mutations were induced by dehydroemetine and niclosamide following activation by microsomal enzymes, while pyrvinium pamoate induced both frameshift and base-pair substitution mutations with or without metabolic activation. The urine of mice treated with dehydroemetine or pyrvinium pamoate showed no mutagenic activity. However, urine obtained from mice treated with niclosamide was mutagenic in strains TA98 and TA1538. The fluctuation assay showed I to be mutagenic in TA1537, a strain which detects frameshift mutations.

Mutation Research, Genetic Toxicology Testing published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Product Details of C28H29NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Arriaga Alba, M. published the artcileMutagenicity of products generated by the reaction between several antiparasitic drugs and nitrite, HPLC of Formula: 3818-50-6, the publication is Environmental and Molecular Mutagenesis (1988), 12(1), 65-73, database is CAplus and MEDLINE.

Drugs containing secondary aliphatic amines, heterocyclic N, or secondary aliphatic amido groups (chloroquine, dihydroemetine, mebendazole, and piperazine) and pyrimidine derivatives such as pyrantel pamoate were reacted in vitro with NaNO₂ at pH 3.7 and became mutagenic for Salmonella typhimurium strain TA1535. The products derived from the nitrosation of chloroquine and dehydroemetine required metabolic activation by mammalian hepatic S9 to be mutagenic. The N-nitroso derivatives of mebendazole, piperazine, and pyrantel pamoate were mutagenic with and without S9, although more activity was noted in the presence of S9 with the nitrosated compounds formed from mebendazole and piperazine. Under identical conditions, no mutagenic products were detected from quaternary ammonium salts such as bephenium hydroxynaphthoate or drugs containing tertiary heterocyclic amino groups, such as iodochlorhydroxyquin.

Environmental and Molecular Mutagenesis published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, HPLC of Formula: 3818-50-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts