Author: tianli

Xu, Pin published the artcileEnantioselective Radical Trifluoromethylation of Benzylic C-H Bonds via Cooperative Photoredox and Copper Catalysis, Quality Control of 645-56-7, the publication is Journal of the American Chemical Society (2022), 144(30), 13468-13474, database is CAplus and MEDLINE.

The first enantioselective radical trifluoromethylation of benzylic C-H bonds has been established by a cooperative photoredox and copper catalysis system, providing straightforward access to structurally diverse benzylic trifluoromethylation products RCH(CF₃)CH₂R¹ [R = Ph, 2-phenyl-1,3-benzothiazol-6-yl, 4-cyclopropylphenyl, etc.; R¹ = H, n-Pr, 2-(1,3-dioxo-2,3-dihydro-1H-isoindol-2-yl)ethyl, 2-chloroethyl, etc.] in good yields with excellent enantioselectivities under mild conditions. A broad substrate scope and excellent functional group compatibility were reported. Merging the cooperative photoredox catalysis with copper catalysis is essential for the reaction, where the photoredox catalysis is used for the generation of benzylic radicals from alkyl arenes alkyl arenes RCH₂CH₂R¹ through a hydrogen atom transfer process and the copper catalysis is used for the enantioselective trifluoromethylation of the benzylic radicals.

Journal of the American Chemical Society published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C16H14O6, Quality Control of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang Teo, Alan Kay published the artcileA novel iron complex for highly efficient catalytic hydrogen generation from the hydrolysis of organosilanes, Name: Triethylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(54), 7191-7194, database is CAplus and MEDLINE.

Hydrolytic oxidation of organosilanes based on an iron catalyst is described for the first time. The novel iron complex, [Fe(C₆H₅N₂O)(CO)(MeCN)₃][PF₆], exhibits excellent mediating power in the catalytic hydrolysis of organosilanes to produce dihydrogen and organosilanols with turnover numbers approaching 10⁴ and turnover frequencies in excess of 10² min^-1 under ambient conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liang Teo, Alan Kay published the artcileA novel iron complex for highly efficient catalytic hydrogen generation from the hydrolysis of organosilanes, Application of Triisopropylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(54), 7191-7194, database is CAplus and MEDLINE.

Hydrolytic oxidation of organosilanes based on an iron catalyst is described for the first time. The novel iron complex, [Fe(C₆H₅N₂O)(CO)(MeCN)₃][PF₆], exhibits excellent mediating power in the catalytic hydrolysis of organosilanes to produce dihydrogen and organosilanols with turnover numbers approaching 10⁴ and turnover frequencies in excess of 10² min^-1 under ambient conditions.

Chemical Communications (Cambridge, United Kingdom) published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Application of Triisopropylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ding, Yue-He published the artcileIncreasing the Depth of Mass-Spectrometry-Based Structural Analysis of Protein Complexes through the Use of Multiple Cross-Linkers, Related Products of alcohols-buliding-blocks, the publication is Analytical Chemistry (Washington, DC, United States) (2016), 88(8), 4461-4469, database is CAplus and MEDLINE.

Chem. crosslinking of proteins coupled with mass spectrometry (CXMS) is a powerful tool to study protein folding and to map the interfaces between interacting proteins. The most commonly used cross-linkers in CXMS are BS³ and DSS, which have similar structures and generate the same linkages between pairs of lysine residues in spatial proximity. However, there are cases where no cross-linkable lysine pairs are present at certain regions of a protein or at the interface of two interacting proteins. In order to find the cross-linkers that can best complement the performance of BS³ and DSS, we tested seven addnl. cross-linkers that either have different spacer arm structures or that target different amino acids (BS²G, EGS, AMAS, GMBS, Sulfo-GMBS, EDC, and TFCS). Using BSA, aldolase, the yeast H/ACA protein complex, and E. coli 70S ribosomes, we showed that, in terms of providing structural information not obtained through the use of BS³ and DSS, EGS and Sulfo-GMBS worked better than the other cross-linkers that we tested. EGS generated a large number of cross-links not seen with the other amine-specific cross-linkers, possibly due to its hydrophilic spacer arm. We demonstrate that incorporating the cross-links contributed by the EGS and amine-sulfhydryl cross-linkers greatly increased the accuracy of Rosetta in docking the structure of the yeast H/ACA protein complex. Given the improved depth of useful information it can provide, we suggest that the multilinker CXMS approach should be used routinely when the amount of a sample permits.

Analytical Chemistry (Washington, DC, United States) published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Li, Xiaoman published the artcileCatalyst- and Metal-Free Photo-Oxidative Coupling of Thiols with BrCCl₃, Recommanded Product: 2-Phenylethanethiol, the publication is European Journal of Organic Chemistry (2022), 2022(23), e202200340, database is CAplus.

This paper reported a catalyst- and metal-free method to construct disulfide bond with BrCCl₃ under light irradiation This clean and mild reaction promoted the oxidative coupling of thiols with wide substrate scope, and was applicable to benzylic, aryl and aliphatic thiols, especially cysteine derivative The disulfides were obtained in high yields up to 98%, avoiding the use of heating, strong oxidant, metal reagent or catalyst. This facile strategy facilitated the synthesis of disulfide compounds

European Journal of Organic Chemistry published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C8H10S, Recommanded Product: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lin, Zechao published the artcileDesign, Synthesis, and Characterization of Binaphthalene Precursors as Photoactivated DNA Interstrand Cross-Linkers, Category: alcohols-buliding-blocks, the publication is Journal of Organic Chemistry (2018), 83(16), 8815-8826, database is CAplus and MEDLINE.

Most recently, alkylation via photo-generated carbocations has been identified as a novel mechanism for photo-induced DNA interstrand crosslink (ICL) formation by bifunctional aryl compounds However, most compounds showed a low efficiency for DNA crosslinking. Here, the authors have developed a series of new 1,1′-binaphthalene analogs that efficiently form DNA ICLs upon 350 nm irradiation via generated 2-naphthalenylmethyl cations. The DNA crosslinking efficiency depends on the substituents at the position-4 of the naphthalene moiety as well as the leaving groups. Compounds with NO2, Ph, H, Br, or OMe substituents led to 2-4 times higher DNA ICL yields than those with a boronate ester group. Compounds having tri-Me ammonium salt as a leaving group showed slightly better crosslinking efficiency than those with bromo as a leaving group. Some of these compounds showed a better crosslinking efficiency than that of traditional alkylating agents, such as nitrogen mustard analogs or quinone methide precursors. These highly efficient photo-activated carbocation precursors allow determination and characterization of the adducts formed between the photo-generated naphthalenyl cations and four natural nucleosides, indicating that the alkylation sites for these naphthalene analogs are dG, dA, and dC.

Journal of Organic Chemistry published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Koohmareh, Gholam Ali published the artcileSynthesis, characterization, and optical properties of poly[2-(4-(2,2′-bithiophen-5-yl)phenyl)-4-(4-alkoxyphenyl)-6-phenylpyridine|s, Related Products of alcohols-buliding-blocks, the publication is Designed Monomers and Polymers (2014), 17(5), 401-415, database is CAplus.

Two new copolymers, P₁ and P₂, composed of 4[4-(alkoxy)phenyl]-2, 6-bis(4-bromophenyl)pyridine and bithiophene units, have been synthesized via Suzuki cross-coupling reactions. 4[4-(alkoxy)phenyl]-2, 6-bis(4-bromophenyl)pyridines were synthesized starting from condensation reaction of 4-bromoacetophenone and 4-hydroxy benzaldehyde, and subsequent alkoxylation of hydroxyl groups. All of the polymers and intermediates were characterized using FTIR and NMR spectroscopies. The synthesized polymers exhibit good solubility in common organic solvents. The maximum absorption peak for P₁ and P₂ was 430 and 420 nm, resp. The optical band gap energy of the polymers was determined by absorption onset and found to be 2.17 eV for P₁ and 2.13 eV for P₂.

Designed Monomers and Polymers published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Esguerra, Kenneth Virgel N. published the artcileA biomimetic catalytic aerobic functionalization of phenols, Category: alcohols-buliding-blocks, the publication is Angewandte Chemie, International Edition (2014), 53(23), 5877-5881, database is CAplus and MEDLINE.

A biomimetic approach that converts phenolic C-H bonds into C-O, C-N, and C-S bonds at the sole expense of reducing O₂ to water (H₂O) was reported. This method hinges on a regio- and chemoselective Cu-catalyzed aerobic oxygenation to provide orthoquinones. Orthoquinones are versatile intermediates, whose direct catalytic aerobic synthesis from phenols enables a mild and efficient means of synthesizing polyfunctional aromatic rings.

Angewandte Chemie, International Edition published new progress about 27292-49-5. 27292-49-5 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Benzene,Phenol, name is 3-Morpholinophenol, and the molecular formula is C10H13NO2, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gotz, Tobias published the artcileMolecular Scissors for Tailor-Made Modification of Siloxane Scaffolds, Related Products of alcohols-buliding-blocks, the publication is Chemistry – A European Journal (2022), 28(2), e202103531, database is CAplus and MEDLINE.

The controlled design of functional oligosiloxanes is an important topic in current research. A consecutive Si-O-Si bond cleavage/formation using siloxanes that are substituted with 1,2-diaminobenzene derivatives acting as mol. scissors is presented. The method allows to cut at certain positions of a siloxane scaffold forming a cyclic diaminosilane or -siloxane intermediate and then to introduce new functional siloxy units. The procedure could be extended to a direct one-step cleavage of chlorooligosiloxanes. Both siloxane formation and cleavage proceed with good to excellent yields, high regioselectivity, and great variability of the siloxy units. Control of the selectivity is achieved by the choice of the amino substituent. Insight into the mechanism was provided by low temperature NMR studies and the isolation of a lithiated intermediate.

Chemistry – A European Journal published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gestin, J. F. published the artcileIntroduction of five potentially metabolizable linking groups between ¹¹¹In-cyclohexyl EDTA derivatives and F(ab’)₂ fragments of anti-carcinoembryonic antigen antibody–I. A new reproducible synthetic method, Category: alcohols-buliding-blocks, the publication is Nuclear Medicine and Biology (1993), 20(6), 755-62, database is CAplus and MEDLINE.

The purpose of this study was to synthesize new bifunctional linker-chelating agents for the modification of the in vivo distribution of ¹¹¹In-labeled antibodies. A general simple synthetic method of preparing cyclohexyl EDTA (CDTA) derivatives containing a linker/spacer group is described. Linkers prepared included a diester, a six carbon aliphatic chain, two thioethers and a disulfide group. The CDTA-linker compounds were coupled to F(Ab’)₂ fragments of anti-carcinoembryonic antigen monoclonal antibody and labeled with ¹¹¹In with good retention of immunoreactivity.

Nuclear Medicine and Biology published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts