Author: tianli

Kinzel, Olaf published the artcileSynthesis of a functionalized high affinity mannose receptor ligand and its application in the construction of peptide-, polyamide- and PNA-conjugates, Safety of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, the publication is Journal of Peptide Science (2003), 9(6), 375-385, database is CAplus and MEDLINE.

The synthesis of a high affinity mannose receptor ligand, appropriately functionalized for chemoselective ligation with an antigen or DNA-binding moieties is described. By a combination of solid- and solution-phase chem. a versatile synthesis of the target structure was accomplished. Examples of subsequent ligation reactions are described.

Journal of Peptide Science published new progress about 96345-79-8. 96345-79-8 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Gal and Man, name is (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C13H15NO6S, Safety of (2R,3S,4S,5S,6R)-2-(Hydroxymethyl)-6-(4-isothiocyanatophenoxy)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Afanasyev, Oleg I. published the artcileDirect Reductive Amination of Camphor Using Iron Pentacarbonyl as Stoichiometric Reducing Agent: Features and Limitations, HPLC of Formula: 6346-09-4, the publication is European Journal of Organic Chemistry (2020), 2020(39), 6289-6294, database is CAplus.

The method of direct reductive amination of camphor and fenchone was proposed. The most effective reducing agent is iron pentacarbonyl. No ligands or solvents are needed. The stereochem. of the corresponding products was determined by HMBC, HSQC, and NOESY spectra. The limitations of the method were shown. The reaction of camphor with primary amines led to exclusively exo product, while the reaction of fenchone led to exclusively endo product. The reaction of camphor with cyclic secondary amines led to the mixture of endo and exo isomers.

European Journal of Organic Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, HPLC of Formula: 6346-09-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Enache, Teodor Adrian published the artcileElectrochemical behavior of triflusal, aspirin and their metabolites at glassy carbon and boron doped diamond electrodes, Synthetic Route of 328-90-5, the publication is Combinatorial Chemistry & High Throughput Screening (2010), 13(7), 569-577, database is CAplus and MEDLINE.

The electrochem. behavior of triflusal (TRF) and aspirin (ASA), before and after hydrolysis in water and in alk. medium using two different electrode surfaces, glassy carbon and boron doped diamond, was studied by differential pulse voltammetry over a wide pH range. The hydrolysis products were 2-(hydroxyl)-4-(trifluoromethyl)-benzoic acid (HTB) for triflusal and salicylic acid (SA) for aspirin, which in vivo represent their main metabolites. The hydrolysis processes were also followed by spectrophotometry. The UV results showed complete hydrolysis after one hour for TRF and after two hours for ASA in alk. solution The glassy carbon electrode enables only indirect determination of TRF and ASA through the electrochem. detection of their hydrolysis products HTB and SA, resp. The oxidation processes of HTB and SA are pH dependent and involve different numbers of electrons and protons. Moreover, the difference between the oxidation peak potential of SA and HTB was equal to 100 mV in the studied pH range from 1 to 8 due to the CF₃ of the aromatic ring of HTB mol. Due to its wider oxidation potential range, the boron doped diamond electrode was used to study the direct oxidation of TRF and ASA, as well as of their resp. metabolites HTB and SA.

Combinatorial Chemistry & High Throughput Screening published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C8H5F3O3, Synthetic Route of 328-90-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

De Crozals, Gabriel published the artcileMethylene blue phosphoramidite for DNA labelling, Recommanded Product: 4-(Butylamino)butan-1-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2015), 51(21), 4458-4461, database is CAplus and MEDLINE.

We report the first synthesis of a methylene blue (MB) phosphoramidite derivative suitable for DNA solid-phase synthesis. The electrochem. and optical properties of the resulting MB modified oligonucleotides were confirmed. This new mol. is an important breakthrough in the design of new probes labeled with MB.

Chemical Communications (Cambridge, United Kingdom) published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, Recommanded Product: 4-(Butylamino)butan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Sorouraddin, Saeed Mohammad published the artcileDeep eutectic solvent-based air-assisted liquid-liquid microextraction of lead in gasoline samples followed by graphite furnace atomic absorption spectrometry, Formula: C8H8O3, the publication is Journal of the Iranian Chemical Society (2022), 19(6), 2591-2599, database is CAplus.

This paper describes determination of lead in gasoline by graphite furnace at. absorption spectrometry after application of an air-assisted liquid-liquid microextraction method using deep eutectic solvent. In this study, for the first time, a ternary deep eutectic solvent was synthesized from menthol, mandelic acid, and glycolic acid and was used as a complexing agent and an extraction solvent, simultaneously. Under optimized conditions, the proposed method made possible the determination of lead in the range of 5-50 ng L^-1 with a good linearity. The obtained detection and quantification limits were 1.6 and 5.0 ng L^-1, resp. Moreover, enrichment factor and extraction recovery values were 166 and 91.3%, resp. The optimized and developed method was successfully used for the determination of lead in various gasoline samples.

Journal of the Iranian Chemical Society published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C17H14F3N3O2S, Formula: C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kadirvel, Manikandan published the artcileInhibition of quorum sensing and biofilm formation in Vibrio harveyi by 4-fluoro-DPD; a novel potent inhibitor of AI-2 signalling, Product Details of C3H6O2, the publication is Chemical Communications (Cambridge, United Kingdom) (2014), 50(39), 5000-5002, database is CAplus and MEDLINE.

(S)-4,5-Dihydroxypentane-2,3-dione [(S)-DPD] is a precursor for AI-2, a quorum sensing signalling mol. for inter- and intra-species bacterial communication. The synthesis of its fluoro-analog, 4-fluoro-5-hydroxypentane-2,3-dione (4-fluoro-DPD) is reported. An intermediate in this route also enables a new, shorter synthesis of the native (S)-DPD. 4-Fluoro-DPD completely inhibited bioluminescence and bacterial growth of Vibrio harveyi BB170 strain at 12.5 μM and 100 μM, resp.

Chemical Communications (Cambridge, United Kingdom) published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Product Details of C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhong, Shuting published the artcileDNA-compatible diversification of indole π-activated alcohols via a direct dehydrative coupling strategy, Quality Control of 4410-99-5, the publication is Organic Letters (2022), 24(4), 1022-1026, database is CAplus and MEDLINE.

Indole-based diversification is highly desired in the DNA-encoded chem. library construction. Herein, we present a general strategy for on-DNA synthesis of diverse C3-functionalized indole derivatives via indole π-activated alc. formation followed by direct dehydrative coupling. Highly efficient bond linkages of C-C, C-N, and C-S were achieved to fuse building blocks that are widely com. available. DNA-encoding compatibility of the method has been further demonstrated to pave an avenue for application in constructing indole-focused three-dimensional libraries.

Organic Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C3H3Br2ClO, Quality Control of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Shengzheng published the artcileScaffold diversity inspired by the natural product evodiamine: discovery of highly potent and multitargeting antitumor agents, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid, the publication is Journal of Medicinal Chemistry (2015), 58(16), 6678-6696, database is CAplus and MEDLINE.

A critical question in natural product-based drug discovery is how to translate the product into drug-like mols. with optimal pharmacol. properties. The generation of natural product-inspired scaffold diversity is an effective but challenging strategy to investigate the broader chem. space and identify promising drug leads. Extending the efforts to the natural product evodiamine, a diverse library containing 11 evodiamine-inspired novel scaffolds and their derivatives were designed and synthesized. Most of them showed good to excellent antitumor activity against various human cancer cell lines. In particular, 3-chloro-10-hydroxyl thio-evodiamine I showed excellent in vitro and in vivo antitumor efficacy with good tolerability and low toxicity. Antitumor mechanism and target profiling studies indicate that compound I is the first-in-class triple topoisomerase I/topoisomerase II/tubulin inhibitor. Overall, this study provided an effective strategy for natural product-based drug discovery.

Journal of Medicinal Chemistry published new progress about 328-90-5. 328-90-5 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Carboxylic acid,Benzene,Phenol, name is 2-Hydroxy-4-(trifluoromethyl)benzoic acid, and the molecular formula is C14H17BFNO2, Recommanded Product: 2-Hydroxy-4-(trifluoromethyl)benzoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kaur, Gurpreet published the artcileSubstituent effect on anthracene-based bisboronic acid glucose sensors, Application In Synthesis of 673456-16-1, the publication is Tetrahedron (2006), 62(11), 2583-2589, database is CAplus.

Earlier the authors communicated an anthracene-based bisboronic acid sensor for glucose. Aimed at understanding the substituent effect, the authors have introduced various functional groups, such as the cyano, nitro, and fluoro group on the boronic acid moiety of this glucose sensor. Fluorescent binding studies indicated that the cyano-substituted sensor has the highest affinity (K 2540 M^-1) for glucose, but the lowest selectivity (three-fold over fructose); the fluoro-substituted compound shows the lowest affinity (630 M^-1) and a modest selectivity (15-fold over fructose); and the unsubstituted one shows the highest selectivity over fructose (43-fold) and a modest affinity (1472 M^-1).

Tetrahedron published new progress about 673456-16-1. 673456-16-1 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Bromide,Boronic acid and ester,Benzyl bromide,Benzene,Boronic Acids,Boronic acid and ester,, name is 2-(2-(Bromomethyl)-4-fluorophenyl)-5,5-dimethyl-1,3,2-dioxaborinane, and the molecular formula is C12H15BBrFO2, Application In Synthesis of 673456-16-1.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Jing published the artcileSynthesis of Nitrogen-doped Carbon Nanodots from Tri-isopropanolamine and the Application in Cell Imaging, Synthetic Route of 122-20-3, the publication is ChemistrySelect (2022), 7(27), e202201641, database is CAplus.

As an emerging nano-functional material, fluorescent carbon nanodots (CDs) have made breakthroughs in many fields. In our research, graphite-like nitrogen-doped carbon nanodots (N-CDs) with excellent down- and up-conversion fluorescent properties were synthesized by a facile one-step solvothermal method using tri-isopropanolamine (TIPA) as carbon and nitrogen sources. Mean particle diameter from 2.85 to 5.62 nm can be obtained by controlling the amount of HNO3 during synthesis. With low cytotoxicity and excellent fluorescence properties, the prepared N-CDs can well label HeLa cells, which has great potential in the field of cell imaging. This work could enrich the research on the preparation and application of N-CDs.

ChemistrySelect published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C5H10O2S, Synthetic Route of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts