Author: tianli

Martins, Marcia S. published the artcileOccurrence of Allergens in Cosmetics for Sensitive Skin, Formula: C11H24O3, the publication is Cosmetics (2022), 9(2), 32, database is CAplus.

Sensitive skin is characterized by symptoms such as stinging and tingling in response to stimuli that usually do not cause unpleasant sensations. Epidemiol. studies show that individuals with sensitive skin are more prone to developing skin allergies, although the link between both conditions is unknown. Aiming to evaluate the presence of allergens in facial-skin products for sensitive skin, a pool of 88 cosmetic products from international brands marketed in pharmacies and parapharmacies was analyzed. A list of allergens identified in product labels was compiled and grouped according to their function. Fragrances were the most common allergens, followed by skin-conditioning agents, surfactants, and preservatives. Fragrances presenting the highest use percentages were linalool, benzyl alc., geraniol, and citronellol. Overall, the majority of cosmetic formulations were absent of fragrance allergens, being present only in 7% of products. Other allergens were found in most products (95%). This finding should be interpreted with caution, since many of these compounds are rare sensitizers and studies demonstrating their risk for individuals with sensitive skin are lacking. With this study, useful information for health professionals is provided to support their advice and to help consumers choosing cosmetic products.

Cosmetics published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Formula: C11H24O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Martins, Marcia S. published the artcileOccurrence of Allergens in Cosmetics for Sensitive Skin, Quality Control of 111-29-5, the publication is Cosmetics (2022), 9(2), 32, database is CAplus.

Sensitive skin is characterized by symptoms such as stinging and tingling in response to stimuli that usually do not cause unpleasant sensations. Epidemiol. studies show that individuals with sensitive skin are more prone to developing skin allergies, although the link between both conditions is unknown. Aiming to evaluate the presence of allergens in facial-skin products for sensitive skin, a pool of 88 cosmetic products from international brands marketed in pharmacies and parapharmacies was analyzed. A list of allergens identified in product labels was compiled and grouped according to their function. Fragrances were the most common allergens, followed by skin-conditioning agents, surfactants, and preservatives. Fragrances presenting the highest use percentages were linalool, benzyl alc., geraniol, and citronellol. Overall, the majority of cosmetic formulations were absent of fragrance allergens, being present only in 7% of products. Other allergens were found in most products (95%). This finding should be interpreted with caution, since many of these compounds are rare sensitizers and studies demonstrating their risk for individuals with sensitive skin are lacking. With this study, useful information for health professionals is provided to support their advice and to help consumers choosing cosmetic products.

Cosmetics published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Beliaev, Alexandre published the artcileSynthesis and structure-activity relationships of ionizable 1,3,4-oxadiazol-2(3H)-ones as peripherally selective FAAH inhibitors with improved aqueous solubility, Product Details of C10H15NO, the publication is Pure and Applied Chemistry (2016), 88(4), 341-347, database is CAplus.

Novel 5-(2,4-difluorophenoxy)-3-aryl-1,3,4-oxadiazol-2(3H)-ones were prepared and in vivo SAR were discussed. Ionizable substituents on the N-Ph ring provided compounds with significantly improved aqueous solubility In addition, these analogs retained equivalent or improved potency against FAAH enzyme compared to the parent phenols. FAAH inhibition by the 2-(piperazin-1-yl)ethyl and 3-(piperazin-1-yl)propyl derivatives was confined to the periphery in mice (30 mg/kg), whereas hepatic FAAH activity was inhibited by over 90%.

Pure and Applied Chemistry published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Product Details of C10H15NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pagola, G. I. published the artcileCould Electronic Anapolar Interactions Drive Enantioselective Syntheses in Strongly Nonuniform Magnetic Fields? A Computational Study, COA of Formula: C3H6O2, the publication is Journal of Chemical Theory and Computation, database is CAplus and MEDLINE.

It is shown that the anapolar interaction of the electrons of a mol. with an external uniform magnetic field B and a uniform curl C = ∇ × B′ determines different thermodn. stabilization of the ground state for the enantiomers and diastereoisomers of a chiral mol. A series of potential candidates for enantioselective syntheses have been investigated in a computational study via SCF-HF, B3LYP, and various coupled cluster approaches to determine the difference in energy between different enantiomers and diastereoisomers. The calculations show that these differences are very small for B and C presently available but approx. 3 orders of magnitude larger than those determined by parity violation effects. The chances that enantioselective synthesis may be attempted in the future are discussed. Recognition of anapolar interaction in chiral mols. via measurements of an induced magnetic dipole moment in the ordered phase may become possible in the presence of a nonuniform magnetic field with a strong gradient.

Journal of Chemical Theory and Computation published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, COA of Formula: C3H6O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mitini-Nkhoma, Steven C. published the artcileIon transport modulators differentially modulate inflammatory responses in THP-1-derived macrophages, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is Journal of Immunology Research (2021), 8832586, database is CAplus and MEDLINE.

Ion transport modulators are most commonly used to treat various noncommunicable diseases including diabetes and hypertension. They are also known to bind to receptors on various immune cells, but the immunomodulatory properties of most ion transport modulators have not been fully elucidated. We assessed the effects of thirteen FDA-approved ion transport modulators, namely, ambroxol HCl, amiloride HCl, diazoxide, digoxin, furosemide, hydrochlorothiazide, metformin, omeprazole, pantoprazole, phenytoin, verapamil, drug X, and drug Y on superoxide production, nitric oxide production, and cytokine expression by THP-1-derived macrophages that had been stimulated with ethanol-inactivated Mycobacterium bovis BCG. Ambroxol HCl, diazoxide, digoxin, furosemide, hydrochlorothiazide, metformin, pantoprazole, phenytoin, verapamil, and drug Y had an inhibitory effect on nitric oxide production, while all the test drugs had an inhibitory effect on superoxide production Amiloride HCl, diazoxide, digoxin, furosemide, phenytoin, verapamil, drug X, and drug Y enhanced the expression of IL-1β and TNF-α. Unlike most immunomodulatory compounds currently in clin. use, most of the test drugs inhibited some inflammatory processes while promoting others. Ion pumps and ion channels could therefore serve as targets for more selective immunomodulatory agents which do not cause overt immunosuppression.

Journal of Immunology Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Garces, Karin published the artcileIridium-Catalyzed Hydrogen Production from Hydrosilanes and Water, Formula: C6H16OSi, the publication is ChemCatChem (2014), 6(6), 1691-1697, database is CAplus.

The iridium(III) complex [Ir(H)(CF₃SO₃)(NSiN)(coe)] (NSiN=fac-coordinated bis(pyridine-2-yloxy)methylsilyl, coe=cyclooctene) has been proven to be an effective catalyst precursor for hydrogen production from the hydrolysis of hydrosilanes at room temperature The reaction performance depends both on the nature of the silane and the solvent. Interestingly, high turnover frequencies of around 10⁵ h^-1 were obtained by using Et₂SiH₂ or (Me₂HSi)₂O as hydrogen sources and THF as the solvent. Moreover a mechanistic insight into this Ir-catalyzed hydrogen generation process, based on both theor. calculations and NMR spectroscopy, is reported. The overall catalytic cycle can be viewed as a two-stage process that involves water-promoted Si-H bond activation followed by water splitting by a proton transfer.

ChemCatChem published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Formula: C6H16OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Seguin, Jean-Christophe published the artcileChemical Composition of the Unexplored Volatile Fraction of Betula glandulosa, a Prevalent Shrub in Nunavik, Quebec, Formula: C10H18O, the publication is Chemistry & Biodiversity (2022), 19(2), e202100871, database is CAplus and MEDLINE.

The volatile fraction of the leaves of Betula glandulosaICHX. has been investigated for its secondary metabolite composition by GC/MS and GC/FID. The rapid expansion of this shrub species in subarctic landscapes, like the ones found in Nunavik (Northern Quebec, Canada), highly impacts ecosystem dynamics. Yet, despite its abundance, few phytochem. investigations have yet been conducted on this species. In this study, we present the first phytochem. investigation of the volatile metabolites of B. glandulosa leaves. Although no essential oil was isolated, volatile compounds were extracted from the hydrosol by steam distillation The main metabolites observed were linalool (14.6-19.0 %), C6 oxylipins (known as green leaf volatiles, GLV; total of 18.2-40.2 %), eugenol (1.6-8.6 %) and α-terpineol (3.3-4.8 %). Dwarf birch is an important food source for insects and herbivores, so knowledge of its metabolite composition could help understand parts of its functional role in subarctic ecosystems. The composition of the volatile fraction could serve as marker for differentiating B. glandulosa from other dwarf birch species like Betula nana L.

Chemistry & Biodiversity published new progress about 106-25-2. 106-25-2 belongs to alcohols-buliding-blocks, auxiliary class Natural product, name is cis-3,7-Dimethyl-2,6-Octadien-1-Ol, and the molecular formula is C17H20ClN3, Formula: C10H18O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morisaki, Yasuhiro published the artcileXanthene-Based Oligothiophene-Layered Polymers, SDS of cas: 239075-02-6, the publication is Macromolecular Chemistry and Physics (2010), 211(22), 2407-2415, database is CAplus.

We synthesized xanthene-based oligothiophene-layered polymers containing bithiophenes, terthiophenes, quaterthiophenes and quinquethiophenes by the Suzuki-Miyaura coupling reaction. The polymers were characterized by various spectroscopic and electrochem. methods. They were well soluble in common organic solvents and thermally stable. Effective π-π interactions among the layered oligothiophene units in the polymer backbone were not observed in the ground state as well as in the excited state. A possible application of the polymers in opto-electronic devices such as hole transporting materials is expected.

Macromolecular Chemistry and Physics published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, SDS of cas: 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Morisaki, Yasuhiro published the artcileNaphthalene-based oligothiophene-stacked polymers, Product Details of C20H28B2O4S2, the publication is Polymer Journal (Tokyo, Japan) (2010), 42(12), 928-934, database is CAplus.

We report the synthesis and properties of π-stacked polymers consisting of oligothiophene and naphthalene as the stacked π-system and the scaffold, resp. The titled polymers were obtained by the Suzuki-Miyaura coupling reaction. Oligothiophene units were layered in proximity, ∼3.0 Å from each other. Contribution of the quinoidal structure of the oligothiophene units involving the naphthalene scaffolds in the excited state resulted in relatively high photoluminescence quantum efficiencies. The polymers have potential application to optoelectronic devices such as hole-transporting materials. Polymer Journal (2010) 42, 928-934; doi:10.1038/pj.2010.101; published online 27 Oct. 2010.

Polymer Journal (Tokyo, Japan) published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Product Details of C20H28B2O4S2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Reis, Joel S. published the artcileOxazoline as acceptor moiety for excited-state intramolecular proton transfer, Quality Control of 86-48-6, the publication is Tetrahedron (2018), 74(48), 6866-6872, database is CAplus.

Excited state intramol. proton transfer (ESIPT) is a widespread phenomenon that has been exploited in several anal. and technol. applications. Here we describe the synthesis of two ESIPT-active halogen-substituted naphthol-oxazolines that can be conveniently functionalized to develop tailored sensors, and a bis-oxazoline that showcases the potential of oxazolines to undergo double ESIPT. The photophys. properties of these compounds in solution were investigated using polar aprotic solvents and the results were rationalized using DFT/TD-DFT calculations

Tetrahedron published new progress about 86-48-6. 86-48-6 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment,Natural product, name is 1-Hydroxy-2-naphthoic acid, and the molecular formula is C11H8O3, Quality Control of 86-48-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts