Author: tianli

Kiskan, Baris published the artcileSynthesis and characterization of pyrrole and thiophene functional polystyrenes via “click chemistry”, Safety of 4-(1H-Pyrrol-1-yl)phenol, the publication is Polymer Bulletin (Heidelberg, Germany) (2011), 67(4), 609-621, database is CAplus.

Novel side-chain pyrrole or thiophene functional polystyrenes (PS-Py and PS-Th) were synthesized by using “click chem.” strategy. First, approx. 40% of chloro groups of poly(styrene-co-chloromethylstyrene) P(S-co-CMS), prepared by nitroxide mediated radical polymerization (NMRP), were converted to azido groups by using NaN₃ in N,N-dimethylformamide. Propargyl pyrrole was prepared by etherification of 4-(1H-pyrrol-1-yl)phenol prepared by Clauson-Kaas reaction using propargylbromide. Propargyl thiophene was synthesized by heterogeneous esterification reaction between 3-thiophenecarboxylic acid and propargylbromide. Finally, azido-functionalized polystyrene was coupled to these propargyl functional heterocyclics with high efficiency by click chem. The intermediates at various stages and final polymers were characterized by spectral anal. and cyclic voltammetry.

Polymer Bulletin (Heidelberg, Germany) published new progress about 23351-09-9. 23351-09-9 belongs to alcohols-buliding-blocks, auxiliary class Pyrrole,Benzene,Alcohol, name is 4-(1H-Pyrrol-1-yl)phenol, and the molecular formula is C10H9NO, Safety of 4-(1H-Pyrrol-1-yl)phenol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Breyton, Cecile published the artcileMicellar and biochemical properties of (hemi)fluorinated surfactants are controlled by the size of the polar head, Category: alcohols-buliding-blocks, the publication is Biophysical Journal (2009), 97(4), 1077-1086, database is CAplus and MEDLINE.

Surfactants with fluorinated and hemifluorinated alkyl chains have yielded encouraging results in terms of membrane protein stability; however, the mols. used hitherto have either been chem. heterogeneous or formed heterogeneous micelles. A new series of surfactants whose polar head size is modulated by the presence of one, two, or three glucose moieties has been synthesized. Anal. ultracentrifugation and small-angle neutron scattering show that fluorinated surfactants whose polar head bears a single glucosyl group form very large cylindrical micelles, whereas those with two or three glucose moieties form small, homogeneous, globular micelles. We studied the homogeneity and stability of the complexes formed between membrane proteins and these surfactants by using bacteriorhodopsin and cytochrome b₆f as models. Homogeneous complexes were obtained only with surfactants that form homogeneous micelles. Surfactants bearing one or two glucose moieties were found to be stabilizing, whereas those with three moieties were destabilizing. Fluorinated and hemifluorinated surfactants with a two-glucose polar head thus appear to be very promising mols. for biochem. applications and structural studies. They were successfully used for cell-free synthesis of the ion channel MscL.

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hirano, Tomohiro published the artcileSyndiotactic- and heterotactic-specific radical polymerizations of N-n-propyl-α-fluoroacrylamide and phase-transition behaviors of aqueous solutions of poly(N-n-propyl-α-fluoroacrylamide), Formula: C9H22OSi, the publication is Journal of Polymer Science, Part A: Polymer Chemistry (2012), 50(12), 2471-2483, database is CAplus.

Radical polymerization of N-n-propyl-α-fluoroacrylamide (NNPFAAm) was studied in several solvents at low temperatures in the presence or absence of Lewis bases, Lewis acids, alkyl alcs., silyl alcs., or fluorinated alcs. Different effects of solvents and additives on stereospecificity were observed in the radical polymerizations of NNPFAAm and its hydrocarbon analogs such as N-isopropylacrylamide (NIPAAm) and N-n-propylacrylamide (NNPAAm); for instance, syndiotactic (and heterotactic) specificities were induced in radical polymerization of NNPFAAm in polar solvents (and in toluene in the presence of alkyl and silyl alcs.), whereas isotactic (and syndiotactic) specificities were induced in radical polymerizations of the hydrocarbon analogs under the corresponding conditions. In contrast, heterotactic specificity induced by fluorinated alcs. was further enhanced in radical polymerization of NNPFAAm. The effects of stereoregularity on the phase-transition behaviors of aqueous solutions of poly(NNPFAAm) were also studied. Different tendencies in stereoregularity were observed in aqueous solutions of poly(NNPFAAm)s from those in solutions of the hydrocarbon analogs such as poly(NIPAAm) and poly (NNPAAm). The polymerization behavior of NNPFAAm and the phase-transition behavior of aqueous poly(NNPFAAm) are discussed based on possible fluorine-fluorine repulsion between the monomer and propagating chain-end, and neighboring monomeric units. © 2012 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem, 2012.

Journal of Polymer Science, Part A: Polymer Chemistry published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Formula: C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salat, Kinga published the artcileThe microglial activation inhibitor minocycline, used alone and in combination with duloxetine, attenuates pain caused by oxaliplatin in mice, Quality Control of 23828-92-4, the publication is Molecules (2021), 26(12), 3577, database is CAplus and MEDLINE.

The antitumor drug, oxaliplatin, induces neuropathic pain, which is resistant to available analgesics, and novel mechanism-based therapies are being evaluated for this debilitating condition. Since activated microglia, impaired serotonergic and noradrenergic neurotransmission and overexpressed sodium channels are implicated in oxaliplatin-induced pain, this in vivo study assessed the effect of minocycline, a microglial activation inhibitor used alone or in combination with ambroxol, a sodium channel blocker, or duloxetine, a serotonin and noradrenaline reuptake inhibitor, on oxaliplatin-induced tactile allodynia and cold hyperalgesia. To induce neuropathic pain, a single dose (10 mg/kg) of i.p. oxaliplatin was used. The mech. and cold pain thresholds were assessed using mouse von Frey and cold plate tests, resp. On the day of oxaliplatin administration, only duloxetine (30 mg/kg) and minocycline (100 mg/kg) used alone attenuated both tactile allodynia and cold hyperalgesia 1 h and 6 h after administration. Minocycline (50 mg/kg), duloxetine (10 mg/kg) and combined minocycline + duloxetine influenced only tactile allodynia. Seven days after oxaliplatin, tactile allodynia (but not cold hyperalgesia) was attenuated by minocycline (100 mg/kg), duloxetine (30 mg/kg) and combined minocycline and duloxetine. These results indicate a potential usefulness of minocycline used alone or combination with duloxetine in the treatment of oxaliplatin-induced pain.

Molecules published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Quality Control of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hayashi, Yoshiyuki published the artcilePreparation of tertiary amines having different substituents from quaternary 2-hydroxyethylammonium salts, Related Products of alcohols-buliding-blocks, the publication is Yukagaku (1987), 36(6), 409-12, database is CAplus.

N,N-Disubstituted ethanolamines readily and quant. reacted with alkyl halides to give quaternary 2-hydroxyethylammonium halides. The quaternary salts, when treated with a small excess of KOH at 120°, afforded tertiary amines in high yields, accompanied by the evolution of ethylene oxide. Thus, Me(CH₂)₉NMeCH₂CH₂OH was treated with PhCH₂Cl to give 93% PhCH₂[Me(CH₂)₉]N⁺MeCH₂CH₂OH Cl^–, which was heated at 120° with KOH to give 90% Me(CH₂)₉NMeCH₂Ph. N,N-Dimethylalkylamines were also prepared quant. in a one-pot reaction procedure from N,N-dimethylethanolamine and alkyl halides.

Yukagaku published new progress about 101-98-4. 101-98-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Benzene,Alcohol, name is 2-(Benzyl(methyl)amino)ethanol, and the molecular formula is C10H15NO, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Hirose, Yuta published the artcileStereoselective synthesis of the A-ring of armatol A from a bromo-substituted chiral building block based on Ireland-Claisen rearrangement and ring-closing olefin metathesis, Product Details of C9H22OSi, the publication is Heterocycles (2015), 91(1), 76-103, database is CAplus.

The stereoselective synthesis of the A-ring (I) of armatol A, a natural polycyclic ether triterpene from the red alga Chondria armata, was achieved in a non-biomimetic way. The synthesis employed Ireland-Claisen rearrangement of an ester, prepared from a bromo-substituted chiral building block, for the construction of C6 and C7 stereocenters and a relay ring-closing olefin metathesis for the seven-membered ring formation.

Heterocycles published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Product Details of C9H22OSi.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeong, Jaeyoung published the artcileSelective Synthesis of Bisdimethylamine Derivatives from Diols and an Aqueous Solution of Dimethylamine through Iridium-Catalyzed Borrowing Hydrogen Pathway, Quality Control of 111-29-5, the publication is ChemCatChem (2022), 14(3), e202101499, database is CAplus.

A new system was developed for the selective synthesis of bisdimethylamine derivatives using a diol and dimethylamine as starting materials and an iridium complex bearing an N-heterocyclic carbene ligand as catalyst. The starting materials were easily available, less toxic, inexpensive and easy to handle. The reaction proceeded efficiently through a borrowing hydrogen pathway under aqueous conditions, without any addnl. organic solvent, to afford various bisdimethylamine derivatives in good to excellent yields.

ChemCatChem published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, Quality Control of 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nagasawa, Shota published the artcileChromium-Salen Complex/Nitroxyl Radical Cooperative Catalysis: A Combination for Aerobic Intramolecular Dearomative Coupling of Phenols, Product Details of C9H11NO4, the publication is Journal of Organic Chemistry (2021), 86(9), 6952-6968, database is CAplus and MEDLINE.

We describe an aerobic intramol. dearomative coupling reaction of tethered phenols such as I using a catalytic system consisting of a chromium-salen (Cr-salen) complex combined with a nitroxyl radical. This novel catalytic system enables formation of various spirocyclic dienone products such as II including those unable to be accessed by previously reported methods efficiently under mild reaction conditions.

Journal of Organic Chemistry published new progress about 528594-30-1. 528594-30-1 belongs to alcohols-buliding-blocks, auxiliary class Nitro Compound,Benzene,Phenol,Ether, name is 2-Methoxy-4-(2-nitroethyl)phenol, and the molecular formula is C9H11NO4, Product Details of C9H11NO4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Satoh, Yasushi published the artcileA catalyst- and additive-free synthesis of alkoxyhydrosiloxanes from silanols and alkoxyhydrosilanes, Safety of Triethylsilanol, the publication is Chemical Communications (Cambridge, United Kingdom) (2020), 56(59), 8218-8221, database is CAplus and MEDLINE.

A convenient method for the selective synthesis of alkoxyhydrosiloxanes that bear SiH and SiOR² groups on the same silicon atom, R¹₃Si-O-SiR³_2-n(OR²)_nH (n = 0, 1, or 2), via a simple catalyst- and additive-free dealcoholization reaction between silanols and alkoxyhydrosilanes has been developed. These alkoxyhydrosiloxanes can be easily converted into Si(OR²)₃-containing siloxanes by zinc catalyzed alkoxylation and alkoxy-containing silphenylene polymers by platinum catalyzed hydrosilylation.

Chemical Communications (Cambridge, United Kingdom) published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Safety of Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Haitao published the artcileHighly and homogeneously conductive conjugated polyelectrolyte hole transport layers for efficient organic solar cells, Computed Properties of 239075-02-6, the publication is Journal of Materials Chemistry A: Materials for Energy and Sustainability (2017), 5(28), 14689-14696, database is CAplus.

High mobility, stable and thick hole-transporting layer (HTL) materials are highly desirable for organic solar cells (OSCs). Two pH neutral conjugated polyelectrolytes (CPEs), PCPDT-T and PCPDT-2T, based on 3,4-dithia-7H-cyclopenta[a]pentalene and thienyl units with a self-doping effect were designed and synthesized. Between the 2 CPEs, the PCPDT-T exhibits higher, more homogeneous mobility and appropriate work function, which makes it an ideal HTL material for OSCs. The single-junction OSCs modified with the PCPDT-T HTL showed an outstanding power conversion efficiency of 9.3%, which is much higher than that of the PEDOT:PSS-modified devices (8.0%). Notably, the PCPDT-T HTL exhibits excellent thickness insensitivity in fabricating OSC devices, i.e. OSC devices with very thick PCPDT-T interlayers over 50 nm still demonstrated high power conversion efficiencies over 7.1%, which is very compatible to meet the requirement for future roll-to-roll printing.

Journal of Materials Chemistry A: Materials for Energy and Sustainability published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is Al2H32O28S3, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts