Author: tianli

Price, David A. published the artcileHigh throughput synthesis of functionalized 1,3-diones and subsequent heterocycle formation, Recommanded Product: 3,3,3-Trifluoropropan-1-ol, the publication is Synlett (2002), 1170-1172, database is CAplus.

Treatment of 3,5-heptanedione with iodosylbenzene followed by reaction with aliphatic and benzylic alcs. ROH [R = F₃CCH₂CH₂, EtCMe₂, 3-MeOC₆H₄CH₂, PhO(CH₂)₃, cyclopropylmethyl, etc.] gave the corresponding 4-alkoxy-3,5-heptanediones, which in situ underwent heterocyclization with hydrazine to afford alkoxy-substituted pyrazoles I in 10-40% total yields.

Synlett published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Recommanded Product: 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Rubert, Josep published the artcileA Screening of Native (Poly)phenols and Gut-Related Metabolites on 3D HCT116 Spheroids Reveals Gut Health Benefits of a Flavan-3-ol Metabolite, Product Details of C8H8O3, the publication is Molecular Nutrition & Food Research, database is CAplus and MEDLINE.

Epidemiol. evidence suggests that a reduced risk of colorectal cancer (CRC) is correlated with high consumption of fruits and vegetables, which are major sources of fiber and phytochems., such as flavan-3-ols. However, it remains unknown how these phytochems. and their specific gut-related metabolites may alter cancer cell behavior. A focused screening using native (poly)phenols and gut microbial metabolites (GMMs) on 3D HCT116 spheroids is carried out using a high-throughput imaging approach. Dose-responses, IC50, and long-term exposure are calculated for the most promising native (poly)phenols and GMMs. As a result, this research shows that (poly)phenol catabolites may play a key role in preventing cancer propagation. Indeed, μM concentration levels of (4R)-5-(3′,4-dihydroxyphenyl)-γ-valerolactone significantly decrease spheroid size at early stages of spheroid aggregation and gene expression of matrix metalloproteinases. A chronic exposure to (4R)-5-(3,-d4ihydroxyphenyl)-γ-valerolactone may lead to a reduced CRC risk. Daily intake of monomeric, oligomeric, and polymeric flavan-3-ols may increase the colonic concentrations of this metabolite, and, in turn, this compound may act locally interacting with intestinal epithelial cells, precancerous and cancer cells.

Molecular Nutrition & Food Research published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Bruusgaard-Mouritsen, Maria A. published the artcileFacial contact dermatitis caused by cosmetic-relevant allergens, Synthetic Route of 70445-33-9, the publication is Contact Dermatitis (2021), 85(6), 650-659, database is CAplus and MEDLINE.

Facial allergic contact dermatitis caused by cosmetic products is common. New allergens in cosmetics continuously emerge. To investigate characteristics of patients with facial dermatitis (FD) between 2010 and 2019 including patch test results from cosmetic-related allergens and a new test series with cosmetic-relevant natural ingredients (CRNIs). This is a retrospective study analyzing demographics, clin. characteristics according to MOAHLFA index (male; occupation; atopic dermatitis; hand; leg; face; age ≥ 40 years), and patch test results to 27 cosmetic-relevant allergens in FD patients. A prospective study evaluating a screening test series with CRNIs in consecutive FD patients for 1 yr was also conducted. These patients received a questionnaire for collecting extra characteristics (eg, concerning quality of life). Of 8740 tested patients, 2292 (26.2%) had FD. Of these, 30.6% had cosmetic-induced FD. The most common cosmetic-related allergens were fragrances and preservatives. The most common patch test-pos. CRNIs were hydroperoxides of limonene and linalool, and propolis. Potato and peanut were rare, but the most common prick test-pos. CRNIs, however, without any relation to the use of cosmetic products. FD affected nearly all patients′ quality of life and caused limitations to their daily life. Updated management and quick diagnosis of FD is important to avoid neg. impact on patients′ quality of life.

Contact Dermatitis published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Synthetic Route of 70445-33-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Salaun, J. published the artcileSmall rings. XXX. Ring expansion of cyclopropanols. 1-(Halomethyl)-, 1-(hydroxymethyl)-, 1-vinyl-, 1-acylcyclopropanols, and oxaspiropentanes to cyclobutanones, Safety of (1-Bromocyclopropyl)methanol, the publication is Tetrahedron (1974), 30(11), 1413-21, database is CAplus.

1-(Hydroxymethyl)-, 1-(tolysulfonyloxymethyl)-, 1-(bromomethyl)cyclopropanol, and oxaspiropentane (I), prepared from methylenecyclopropane, underwent ring expansion to form cyclobutanones. 1-Vinyl-, 1-(1-cyclopentenyl)- and 1-(1-cyclohexenyl)cyclopropanol, prepared from (ClCH2)2CO underwent similar ring expansion. 1-Cyclopropylcyclopropanol under similar conditions gave cyclopropyl Et ketone. II with NaOMe followed by treatment with ClSiMe3, gave cyclobutanone III.

Tetrahedron published new progress about 50915-29-2. 50915-29-2 belongs to alcohols-buliding-blocks, auxiliary class Cyclopropanes, name is (1-Bromocyclopropyl)methanol, and the molecular formula is C4H7BrO, Safety of (1-Bromocyclopropyl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Katiyar, R. D. published the artcileThiabendazole as an anthelmintic of outstanding efficiency, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, the publication is Indian Veterinary Journal (1964), 41(12), 803-9, database is CAplus.

Four trials are described in which thiabendazole [2-(4-thiazolyl)benzimidazole] (I) efficiency is tested against nematodes. Frantin (bephenium hydroxynaphthoate) (II), Promintic (Methrydine) (III), and phenothiazine (IV) were used as comparisons. Lambs naturally parasitized with Haemonchus, Trichostrongyles, Ostertagia, Nematodirus, Oesophagostomum, Cooperia, and Bunostomum spp. were treated with I (50 mg./kg. body weight), II (4 g./lamb), III (200 mg./kg. body weight), IV (600 mg./kg.) and no treatment. The reductions in egg counts were 95.7, 82.1, 78.7, 76.2, and 39.2%, resp. Against individual nematode species in sheep, I was 85-100% effective. It was 97.7% effective against nematodes causing gastroenteritis in crossbred Angora kids, while IV was only 76.5% effective. Romney Marsh rams with a heavy infestation of Strongloides papillosus were treated with IV with no effect, while treatment with I reduced the ova count by 91-95% over 15 days. In all trials, treatment with I increased the body weight

Indian Veterinary Journal published new progress about 3818-50-6. 3818-50-6 belongs to alcohols-buliding-blocks, auxiliary class Anti-infection,Antiparasitic, name is N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate, and the molecular formula is C28H29NO4, Application of N-Benzyl-N,N-dimethyl-2-phenoxyethanaminium 3-hydroxy-2-naphthoate.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Berger, Bryan W. published the artcileRelating surfactant properties to activity and solubilization of the human adenosine A₃ receptor, Synthetic Route of 85618-21-9, the publication is Biophysical Journal (2005), 89(1), 452-464, database is CAplus and MEDLINE.

The effects of various surfactants on the activity and stability of the human adenosine A₃ receptor (A₃) were investigated. The receptor was expressed using stably transfected HEK293 cells at a concentration of 44 pmol functional receptor per mg membrane protein and purified using over 50 different nonionic surfactants. A strong correlation was observed between a surfactant’s ability to remove A₃ from the membrane and the ability of the surfactant to remove A₃ selectively relative to other membrane proteins. The activity of A₃ once purified also correlates well with the selectivity of the surfactant used. The effects of varying the surfactant were much stronger than those achieved by including A₃ ligands in the purification scheme. Notably, all surfactants that gave high efficiency, selectivity and activity fall within a narrow range of hydrophile-lipophile balance values. This effect may reflect the ability of the surfactant to pack effectively at the hydrophobic transmembrane interface. These findings emphasize the importance of identifying appropriate surfactants for a particular membrane protein, and offer promise for the development of rapid, efficient, and systematic methods to facilitate membrane protein purification

Biophysical Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Synthetic Route of 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Gonzalez, Tania published the artcileCatalytic CO₂ hydrosilylation with [Mn(CO)₅Br] under mild reaction conditions, Name: Triethylsilanol, the publication is Polyhedron (2021), 115242, database is CAplus.

Carbon dioxide hydrosilylation with earth-abundant transition-metal catalysts is an attractive alternative for the design of greener and cost-effective synthetic strategies. Herein, simple [Mn(CO)₅Br] is an efficient precatalyst in the hydrosilylation of carbon dioxide with Et₃SiH under mild reaction conditions. Using THF as a solvent, triethylsilylformate Et₃SiCH(O)O was obtained in 67% yield after 1 h at 50°C and 4 bar of CO₂ pressure. The selectivity of the reaction was tuned by changing the solvent to a mixture of THF and toluene producing bis(triethylsilyl)acetal (Et₃SiO)₂CH₂ in 86% yield. The CO₂ hydrosilylation was also effective at room temperature and atm. pressure using either THF or the mixture THF/toluene as the solvent resulting in high Et₃SiH conversion (92%-99%) but with a decrease in the selectivity. Radical trapping experiments indicated the participation of radical species in the catalytic mechanism. To the best of our knowledge, this is the first report on CO₂ hydrosilylation catalyzed by transition-metal radical intermediates.

Polyhedron published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Perales, Eduardo published the artcileEcotoxicity and QSAR studies of glycerol ethers in Daphnia magna, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol, the publication is Chemosphere (2017), 277-285, database is CAplus and MEDLINE.

Glycerol is currently considered a raw, renewable material, which can be used to synthesize new glycerol derivatives that may be used as green solvents. However, these compounds must be environmentally evaluated before their use. The acute ecotoxicity of a series of mono-, di-, and trialkyl ethers synthesized from glycerol for the crustacean Daphnia magna has been studied. The EC₅₀ values of these ethers after 24 h of exposure were determined according to the OECD 202 protocol. Their possible structural-toxicity relationships according to different alkyl substituents have been discussed after applying different QSAR models (with the DARC-PELCO approach and topol. parameters). The results of the immobilization test show that most of the glycerol derivatives studied exhibit relatively low ecotoxicity. There is a correlation between the lipophilicity and the increase of the toxic effect in the crustacean biomodel. Furthermore, the length and the number of the alkyl substituents and ecotoxicity are highly related.

Chemosphere published new progress about 70445-33-9. 70445-33-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is 3-((2-Ethylhexyl)oxy)propane-1,2-diol, and the molecular formula is C11H24O3, Name: 3-((2-Ethylhexyl)oxy)propane-1,2-diol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Tongfei published the artcileCopper-catalyzed thioketalization of enones featuring trifluoromethyl groups, Computed Properties of 4410-99-5, the publication is RSC Advances (2021), 11(32), 19832-19835, database is CAplus and MEDLINE.

Here, a copper-catalyzed thioketalization of enones bearing CF₃ groups and various mercaptans was developed, thioketal mols. I [R = Et, i-Pr, allyl, etc.; RR = (CH₂)₂; R² = Me, Ph] had been obtained with moderate to excellent yield. Meanwhile, a preparative scale experiment had been performed giving over 95% yield. This work allowed the straightforward formation of thioketals I containing CF₃ groups and unsaturated double bonds.

RSC Advances published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C7H15NO, Computed Properties of 4410-99-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xuerong published the artcileTransition Metal-Free Aerobic Oxidation of Aryl Secondary and Primary Alcohols to Carbonyl Compounds in Open Air, Synthetic Route of 90-64-2, the publication is ChemistrySelect (2022), 7(3), e202103502, database is CAplus.

Here, an efficient and practical oxidation of aryl secondary and primary alcs. R¹CH(OH)R² (R¹ = Ph, biphenyl-4-yl, 2-naphthyl, etc., R² = H, ME, Et, CO₂H, 4-ClC₆H₄, etc.) to the corresponding carbonyl compounds using NaOtBu in open air at room temperature has been developed. By utilizing NaOtBu/air/toluene, a series of ketones R¹C(O)R² or benzoic acids were obtained in high yields, resp. More importantly, most of the substrates with electron-withdrawing or electron-donating groups could be converted to the corresponding products in high to excellent yields. Furthermore, the practicality of the reaction was demonstrated through a 1.0 g-scale reaction with excellent yield.

ChemistrySelect published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C24H29N5O3, Synthetic Route of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts