Author: tianli

Gokel, George W. published the artcileSulfur heterocycles. I. Use of 4,4-dimethyl-1,3-oxathiolane-3,3-dioxide as a carbonyl anion equivalent, Recommanded Product: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Tetrahedron Letters (1979), 3375-8, database is CAplus.

The oxathiolane I (R = H), acting as a carbonyl anion equivalent, was alkylated with BuLi and the appropriate reagent to give I [R = D, Me, PhCH₂, CH₂:CHCH₂, Me(CH₂)₅, 1-hydroxycyclopentyl, 1-hydroxycyclohexyl, 1-hydroxycyclododecyl, PhCH(OH), PhC(OH)Me, Me₃Si, Ph]. Thermal demasking of I (R ≠ H, D), with loss of Me₂C:CH₂ and SO₂, gave the corresponding aldehyde or α-silyl ketone. E.g., pyrolysis of I (R = PhCH₂) gave 100% PhCH₂CHO.

Tetrahedron Letters published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C4H10OS, Recommanded Product: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Capalbi, Antonio published the artcileSolution properties of alkyl glucosides, alkyl thioglucosides and alkyl maltosides, HPLC of Formula: 85618-21-9, the publication is Colloids and Surfaces, A: Physicochemical and Engineering Aspects (2004), 246(1-3), 99-108, database is CAplus.

Aqueous solutions containing sugar-based surfactants, alkyl glucosides, thioglucosides and maltosides, were studied in a wide concentration range, at different temperatures Colligative properties (f.p. and vapor pressure depression), volumetric, adiabatic compressibility, surface tension and calorimetric methods were used. The results give information on the Gibbs energy of transfer from H₂O to a micellar environment and on other thermodn. contributions to the overall aggregate stability. The thermodn. quantities derived from the above exptl. methods were interpreted by taking into account the role of polar head groups in modulating micelle formation. Use of a mass action approach allows determining micelle aggregation numbers, 〈N〉, from partial molal quantities. The differences between values obtained from calorimetric, colligative, compressibility, surface and volumetric properties were rationalized on proper grounds.

Colloids and Surfaces, A: Physicochemical and Engineering Aspects published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, HPLC of Formula: 85618-21-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Qingzhuo published the artcileBacterial mandelic acid degradation pathway and its application in biotechnology, Quality Control of 90-64-2, the publication is Journal of Applied Microbiology (2022), 133(2), 273-286, database is CAplus and MEDLINE.

A review. Mandelic acid and its derivatives are an important class of chem. synthetic blocks, which is widely used in drug synthesis and stereochem. research. In nature, mandelic acid degradation pathway has been widely identified and analyzed as a representative pathway of aromatic compounds degradation The most studied mandelic acid degradation pathway from Pseudomonas putida consists of mandelate racemase, S-mandelate dehydrogenase, benzoylformate decarboxylase, benzaldehyde dehydrogenase and downstream benzoic acid degradation pathways. Because of the ability to catalyze various reactions of aromatic substrates, pathway enzymes have been widely used in biocatalysis, kinetic resolution, chiral compounds synthesis or construction of new metabolic pathways. In this paper, the physiol. significance and the existing range of the mandelic acid degradation pathway were introduced first. Then each of the enzymes in the pathway is reviewed one by one, including the researches on enzymic properties and the applications in biotechnol. as well as efforts that have been made to modify the substrate specificity or improving catalytic activity by enzyme engineering to adapt different applications. The composition of the important metabolic pathway of bacterial mandelic acid degradation pathway as well as the researches and applications of pathway enzymes is summarized in this review for the first time.

Journal of Applied Microbiology published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C17H14N2O2, Quality Control of 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Song, Fengqin published the artcileGas chromatography-mass spectrometry profiling of volatile compounds reveals metabolic changes in a non-aflatoxigenic Aspergillus flavus induced by 5-azacytidine, SDS of cas: 622-40-2, the publication is Toxins (2020), 12(1), 57, database is CAplus and MEDLINE.

Aspergillus flavus is one of the most opportunistic pathogens invading many important oilseed crops and foodstuffs with such toxic secondary metabolites as aflatoxin (AF) and Cyclopiazonic acid. We previously used the DNA methylation inhibitor 5-azacytidine to treat with an AF-producing A. flavus A133 strain, and isolated a mutant (NT) of A. flavus, which displayed impaired abilities of AF biosynthesis and fungal development. In this study, gas chromatog.-mass spectrometry (GC-MS) anal. was used to reveal the metabolic changes between these two strains. A total of 1181 volatiles were identified in these two strains, among which 490 volatiles were found in these two strains in vitro and 332 volatiles were found in vivo. The NT mutant was found to produce decreasing volatile compounds, among which most of the fatty acid-derived volatiles were significantly downregulated in the NT mutant compared to the A133 strain, which are important precursors for AF biosynthesis. Two antioxidants and most of the amino acids derived volatiles were found significantly upregulated in the NT mutant. Overall, our results reveal the difference of metabolic profiles in two different A. flavus isolates, which may provide valuable information for controlling infections of this fungal pathogen.

Toxins published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C8H7NaO4S, SDS of cas: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhang, Youcan published the artcilePalladium-Catalyzed Carbonylative Four-Component Synthesis of β-Perfluoroalkyl Amides, HPLC of Formula: 20880-92-6, the publication is Chemistry – A European Journal (2021), 27(70), 17682-17687, database is CAplus and MEDLINE.

Transition-metal-catalyzed multicomponent carbonylation is one of the most efficient strategies to construct carbonyl-containing compounds Herein, a palladium-catalyzed four-component perfluoroalkylation/aminocarbonylation of unactivated alkenes with perfluoroalkyl halides, and amines was developed. A wide range of substrates, including anilines, alkylamines, sulfonamides, and hydrazines are all suitable reaction partners for this catalyst system, resulting in various β-perfluoroalkyl amides with good functional-group tolerance and excellent chemoselectivity. Furthermore, not only alkyl olefins, but also aliphatic alkynes, and even alkyl allenes can all be employed. Notably, several medical and bioactive related mols. are compatible here as well.

Chemistry – A European Journal published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C19H14O2, HPLC of Formula: 20880-92-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Segnitz, Bernd published the artcileSubunit structure of the nonactivated human estrogen receptor, COA of Formula: C18H20N2O12, the publication is Proceedings of the National Academy of Sciences of the United States of America (1995), 92(6), 2179-83, database is CAplus and MEDLINE.

The nonactivated estrogen receptor of human MCF-7 mammary carcinoma cells was investigated with respect to stoichiometry of protein subunits. The native receptor complex stabilized by molybdate had a mol. mass of ≈300 kDa. Chem. crosslinking with several bifunctional reagents resulted in complete stabilization of the same receptor form of ≈300 kDa and was achieved both in cell extracts and in intact cells. Incubation of the cross-linked receptor with a receptor-specific monoclonal IgG1 antibody increased the mol. mass by ≈135 kDa-i.e., no more than one Ig mol. bound to the complex. Partial and progressive crosslinking of affinity-labeled receptors revealed patterns of labeled bands upon denaturing gel electrophoresis indicative of a heteromeric structure. The completely cross-linked receptor was purified to homogeneity and analyzed for protein components. In addition to the receptor polypeptide of ≈65 kDa, the authors detected the heat shock proteins hsp90 and p59; the hsp90 band was roughly twice as intense as the p59 band. The heat shock protein hsp70 and the 40-kDa cyclophilin were not detected as components of the highly purified cross-linked receptor of ≈300 kDa. The authors suggest a heterotetrameric structure consisting of one receptor polypeptide, two hsp90 mols., and one p59 subunit, for which the mol. mass adds up to ≈300 kDa. Thus, the nonactivated estrogen receptor has a mol. architecture homologous to those of glucocorticoid and progesterone receptors, even though phylogenetically the estrogen receptor gene forms a distinct subgroup within the gene family of nuclear hormone receptors.

Proceedings of the National Academy of Sciences of the United States of America published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C12H6NNaO4, COA of Formula: C18H20N2O12.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Krasniqi, Besir published the artcileGeneral Transition Metal-Free Synthesis of NH-Pyrroles from Secondary Alcohols and 2-Aminoalcohols, Name: 2-Aminobutan-1-ol, the publication is Journal of Organic Chemistry (2019), 84(9), 5027-5034, database is CAplus and MEDLINE.

A novel, transition metal-free and one-pot methodol. to synthesize various substituted NH-pyrroles from readily available building blocks such as secondary alcs. and 2-aminoalcs. is described. The process is based on the venerable Oppenauer-Woodward oxidation, which uses benzophenone as an inexpensive reagent to achieve oxidation of secondary alcs. under mild condition to ketones, further in situ condensation with aminoalc., and oxidative cyclization to the target pyrrole ring. The reaction occurs under basic conditions, and features a broad substrate scope combined with very good tolerance for sensitive functional groups. This method can be used to synthesize various substituted pyrroles useful as a starting material for broad applications.

Journal of Organic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Name: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xiong, Xionghua published the artcileExpression, purification and characterization of a quinoprotein L-sorbose dehydrogenase from Ketogulonicigenium vulgare Y25, Category: alcohols-buliding-blocks, the publication is African Journal of Microbiology Research (2013), 7(24), 3117-3124, database is CAplus.

It is well known that Ketogulonicigenium vulgare Y25 could effectively oxidize L-sorbose to 2-keto-L-gulonic acid (2KGA), an industrial precursor of vitamin C. There in, L-sorbose dehydrogenase is one of the key enzymes responsible for the production of 2KGA. From this organism, the coding region of sdh gene was cloned into pET22b plasmid and its transcription product was overexpressed. This procedure allowed purification of L-sorbose dehydrogenase and production of polyclonal antibodies. In Western blot assays, the antibodies gave a pos. reaction against bacteria protein extract and purified L-sorbose dehydrogenase. The mol. mass of the enzyme was 60532 Da and the N-terminal amino acid sequence was determined to be QTAIT. The Native-PAGE and resting-cell reaction assay showed that purified L-sorbose dehydrogenase could convert L-sorbose to 2KGA and PQQ was found to be indispensable for its activity as prosthetic group. The enzyme showed broad substrates specificity and the K_m value for -sorbose and 1-propanol was 21.9 mM and 0.13 mM, resp. The optimum pH of the enzyme activity was 8.0 and the optimum temperature was 35°C. The activity of the L-sorbose dehydrogenase was greatly stimulated by Ca²⁺ and strongly inhibited by Co²⁺ and Cu²⁺. The results obtained from the present study showed that a PQQ-dependent L-sorbose dehydrogenase could oxidize -sorbose into 2-keto-L-gulonic acid in vitro.

African Journal of Microbiology Research published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C11H14O4, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Jia-Xin published the artcilePhotoredox-Catalyzed Allylic Defluorinative Alkoxycarbonylation of Trifluoromethyl Alkenes through Intermolecular Alkoxycarbonyl Radical Addition, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, the publication is Organic Letters (2022), 24(7), 1471-1475, database is CAplus and MEDLINE.

Herein, a photoredox-catalyzed allylic defluorinative alkoxycarbonylation of trifluoromethyl alkenes ArC(CF₃):CH₂ (Ar = 4-BrC₆H₄, naphthalen-2-yl, 6-methoxypyridin-3-yl, etc.) enabled by intermol. alkoxycarbonyl radical addition is disclosed. A wide variety of alc. oxalate derivatives ROC(O)CO₂H (R = Me, t-Bu, cyclopentyl, L-menthyl, N-Boc-piperidin-4-yl, etc.) was amenable, affording various β-gem-difluoroalkene esters ArC(:CF₂)CH₂COOR with excellent functional group tolerance. Notably, the potential synthetic value of this method is highlighted by successful late-stage modification for bioactive mols.

Organic Letters published new progress about 20880-92-6. 20880-92-6 belongs to alcohols-buliding-blocks, auxiliary class Other Aliphatic Heterocyclic,Chiral,Alcohol, name is ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol, and the molecular formula is C18H34N4O5S, Recommanded Product: ((3aS,5aR,8aR,8bS)-2,2,7,7-Tetramethyltetrahydro-3aH-bis([1,3]dioxolo)[4,5-b:4′,5′-d]pyran-3a-yl)methanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Khairullin, R. A. published the artcileSynthesis of O,O-Dialkyl S-(1,1-dimethyl-2-oxoethyl) dithiophosphates and their reactions with N-nucleophiles, Related Products of alcohols-buliding-blocks, the publication is Doklady Chemistry (2016), 467(2), 131-135, database is CAplus.

O,O-Dialkyl S-(1,1-dimethyl-2-oxoethyl) dithiophosphates, 2-(dialkoxythiophosphorylthio)-substituted aldehydes with branched carbon groups, were obtained by hydrolysis of phosphoryl-containing iminium salts. The reaction with primary amines results in imines containing acetal group in different positions. Tri- and tetra-substituted perhydro-1,3-diazoles and oxazoles containing a phosphorus atom in the side chain were prepared by reacting the aldehydes with O,Nand N,N-dinucleophiles.

Doklady Chemistry published new progress about 6346-09-4. 6346-09-4 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Ether, name is 4,4-Diethoxybutan-1-amine, and the molecular formula is C8H19NO2, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts