Author: tianli

John, Jubi published the artcileCatalytic Oxidation of Silanes by Carbon Nanotube-Gold Nanohybrids, Computed Properties of 17877-23-5, the publication is Angewandte Chemie, International Edition (2011), 50(33), 7533-7536, S7533/1-S7533/37, database is CAplus and MEDLINE.

Here reported an alternative strategy which has led to the discovery of the most efficient catalytic system to date for silane oxidation The approach involves layer-by-layer (LBL) assembly of gold nanoparticles on carbon nanotubes (CNT₅). Nanotubes provide high sp. surface area and excellent nanoparticle (NP) dispersion. In addition, nanotubes are electronically active and stabilization of transient higher oxidation states of gold are anticipated by collaborative interactions with the metal. To the best of authors knowledge, this is the first report on silane oxidation by CNT-supported catalysts. Thus, gold carbon nanotube catalyzed oxidation of PhSiMe₂H in THF/H₂O in the presence of air gave 98% PhSiMe₂OH in 45m at room temperature

Angewandte Chemie, International Edition published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Computed Properties of 17877-23-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Farah, Joseph published the artcileDirect integration of gold-carbon nanotube hybrids in continuous-flow microfluidic chips: A versatile approach for nanocatalysis, Category: alcohols-buliding-blocks, the publication is Journal of Colloid and Interface Science (2022), 359-367, database is CAplus and MEDLINE.

A carbon nanotube-based packed-bed microreactor was developed for the on-chip oxidation of silanes. The process is catalyzed by a heterogeneous gold-carbon nanotube hybrid that was embedded in the device using a micrometric restriction zone. Integration of the nanohybrid permitted efficient flow aerobic oxidation of the substrates into the corresponding silanols with high selectivity and under sustainable conditions.

Journal of Colloid and Interface Science published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Donck, Simon published the artcileMild and selective catalytic oxidation of organic substrates by a carbon nanotube-rhodium nanohybrid, Category: alcohols-buliding-blocks, the publication is Catalysis Science & Technology (2015), 5(9), 4542-4546, database is CAplus.

Rhodium nanoparticles were assembled on carbon nanotubes and the resulting nanohybrid was used for the catalytic aerobic oxidation of diverse substrates such as hydroquinones, hydroxylamines, silanes, hydrazines and thiols at room temperature The catalytic system was proved to be very efficient on the investigated substrates and demonstrated high selectivity. Furthermore, the catalyst operates under mild reaction conditions, with excellent yields and could be easily recycled without loss of activity.

Catalysis Science & Technology published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Alliot, Julien published the artcileA straightforward enantioselective synthesis of F17807, Quality Control of 57044-25-4, the publication is Tetrahedron (2015), 71(50), 9383-9387, database is CAplus.

An efficient approach for the enantioselective synthesis of the 1,4-benzodioxane F17807 drug is reported. The developed route relied on two key steps, namely S_NAr and Mitsunobu reactions, which permitted a straightforward access to the title compound with full preservation of the enantiomeric excess throughout the synthetic sequence.

Tetrahedron published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Quality Control of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pearl, Irwin A. published the artcileLignin and related products. XVI. Synthesis of lignin model compounds of the phenylglycerol β-ether and related series, SDS of cas: 70110-65-5, the publication is Journal of Organic Chemistry (1962), 2111-14, database is CAplus.

Substituted ethyl benzoylacetates have been employed for the preparation of lignin model compounds in the phenylpropane-1,3-diol and phenylpropane-1,2,3-triol series. Direct reduction of these esters with LiAlH₄ yields the corresponding phenylpropane-1,3-diol. Bromination followed by condensation with a phenol and reduction with LiAlH₄ of the resulting ether yields the phenylglycerol β-aryl ether. Bromination followed by acetylation and reduction yields the phenylpropane-1,2,3-triol. Models in the veratryl, 3,4,5-trimethoxyphenyl, 4-hydroxy-3,5-dimethoxyphenyl, 4-benzyloxy-3,5-dimethoxyphenyl, and 4-acetoxy-3,5-dimethoxyphenyl series were prepared Cf. Forest Prod. J. 11, 442(1961); CA 54, 385f.

Journal of Organic Chemistry published new progress about 70110-65-5. 70110-65-5 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Alcohol,Ether,Benzene Compounds, name is 2-Phenoxy-1-phenylpropane-1,3-diol, and the molecular formula is C15H16O3, SDS of cas: 70110-65-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Durcik, Martina published the artcileLast piece in the puzzle of bisphenols BPA, BPS and BPF metabolism: Kinetics of the in vitro sulfation reaction, Product Details of C12H10O4S, the publication is Chemosphere (2022), 303(Part_2), 135133, database is CAplus and MEDLINE.

Bisphenols are endocrine-disrupting chems. ubiquitously present in the environment, with the consequent exposure to humans. In humans, bisphenols are metabolized to glucuronide and sulfate conjugates. Recent studies indicate that sulfation represents an important bisphenol metabolic pathway for the most vulnerable humans, such as the growing fetus. Our aim was to evaluate sulfation kinetics of commonly detected bisphenols in biol. samples: bisphenol A (BPA), bisphenol S (BPS), and bisphenol F (BPF). Furthermore, we evaluated estrogenic agonist potencies and long-term stability of these bisphenol sulfates. BPS and BPF sulfates were prepared by chem. synthesis. Sulfation kinetics of the selected bisphenols were tested in pooled human liver cytosol, as a source for soluble phase II enzymes, including liver sulfotransferases, with quantification by LC-MS/MS. A validated transactivation assay using the hERα-Hela 9903 cell line was used to determine estrogenic agonist potencies. Moreover, BPA, BPS, and BPF sulfate stabilities were examined under various conditions and during storage. In vitro sulfation of BPA and BPS followed Michaelis-Menten kinetics; BPF sulfation followed a substrate inhibition model. Sulfation rates were comparable for these bisphenols, although their K_M values indicated some large differences in affinities. BPA and BPS sulfates are not hERα agonists. The bisphenol sulfates can be considered stable for at least 2 days under these tested media conditions. These data indicate that bisphenol sulfation is an important route in their biotransformation. Compared to glucuronidation, these bisphenols show slower sulfation rates but similar K_M values. BPA and BPS metabolic biotransformation by sulfation provides their detoxification as they are without estrogenic activities.

Chemosphere published new progress about 80-09-1. 80-09-1 belongs to alcohols-buliding-blocks, auxiliary class Ploymers, name is 4,4′-Sulfonyldiphenol, and the molecular formula is C12H10O4S, Product Details of C12H10O4S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Stec, Wojciech J. published the artcileDiastereomers of Nucleoside 3′-O-(2-Thio-1,3,2-oxathia(selena)phospholanes): Building Blocks for Stereocontrolled Synthesis of Oligo(nucleoside phosphorothioate)s, Name: 2-Methyl-2-sulfanylpropan-1-ol, the publication is Journal of the American Chemical Society (1995), 117(49), 12019-29, database is CAplus.

Diastereomerically pure 5′-O-DMT-nucleoside 3′-O-(2-thio-1,3,2-oxathiaphospholanes) I ( B = T, Ade^bz, Cyt^bz) were used for the synthesis of stereo-regular oligo(nucleoside phosphorothioate)s (S-Oligos). The oxathiaphospholane ring-opening condensation requires the presence of strong organic base, preferably DBU. The yield of a single coupling step is ca. 95% and resulting S-Oligos are free of nucleobase- and sugar-phosphorothioate backbone modifications. The diastereomeric purity of products was estimated on the basis of diastereoselective degradation with Nuclease P1 and a mixture of snake venom phosphodiesterase and Serratia marcescens endonuclease. Thermal dissociation studies of hetero-duplexes S-Oligos/DNA and S-Oligos/RNA showed that their stability is stereochem.- and sequence-dependent.

Journal of the American Chemical Society published new progress about 73303-88-5. 73303-88-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Aliphatic hydrocarbon chain,Alcohol, name is 2-Methyl-2-sulfanylpropan-1-ol, and the molecular formula is C5H10Cl3O3P, Name: 2-Methyl-2-sulfanylpropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mei, Jianguo published the artcileSynthesis of isoindigo-based oligothiophenes for molecular bulk heterojunction solar cells, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, the publication is Organic Letters (2010), 12(4), 660-663, database is CAplus and MEDLINE.

Isoindigo, as a new electron acceptor unit for organic electronic materials, was integrated into two low-energy gap oligothiophenes. Optical and electrochem. studies of the newly synthesized oligomers demonstrate broad absorption through the visible spectrum, along with appropriate energy levels, as desired for light harvesting donors for organic solar cells when blended with [6,6]-phenyl-C₆₁-butyric acid Me ester (PC₆₀BM). Mol. heterojunction solar cells were fabricated using these oligomers and exhibit a power conversion efficiency up to 1.76% with a V_oc of 0.74 V, I_sc of 6.3 mA/cm² and fill factor of 0.38.

Organic Letters published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Recommanded Product: 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Armbruster, Michael R. published the artcileIsobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC-MS/MS, Safety of 2-Hydroxy-2-phenylacetic acid, the publication is ACS Measurement Science Au (2022), 2(3), 287-295, database is CAplus and MEDLINE.

Isobaric labeling in mass spectrometry enables multiplexed absolute quantitation and high throughput, while minimizing full scan spectral complexity. Here, we use 4-plex isobaric labeling with a fixed pos. charge tag to improve quantitation and throughput for polar carboxylic acid metabolites. The isobaric tag uses an isotope-encoded neutral loss to create mass-dependent reporters spaced 2 Da apart and was validated for both single- and double-tagged analytes. Tags were synthesized inhouse using deuterated formaldehyde and Me iodide in a total of four steps, producing cost-effective multiplexing. No chromatog. deuterium shifts were observed for single- or double-tagged analytes, producing consistent reporter ratios across each peak. Perfluoropentanoic acid was added to the sample to drastically increase retention of double-tagged analytes on a C18 column. Excess tag was scavenged and extracted using hexadecyl chloroformate after reaction completion. This allowed for removal of excess tag that typically causes ion suppression and column overloading. A total of 54 organic acids were investigated, producing an average linearity of 0.993, retention time relative standard deviation (RSD) of 0.58%, and intensity RSD of 12.1%. This method was used for absolute quantitation of acid metabolites comparing control and type 1 diabetic urine. Absolute quantitation of organic acids was achieved by using one isobaric lane for standards, thereby allowing for anal. of six urine samples in two injections. Quantified acids showed good agreement with previous work, and six significant changes were found. Overall, this method demonstrated 4-plex absolute quantitation of acids in a complex biol. sample.

ACS Measurement Science Au published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Safety of 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Armbruster, Michael R. published the artcileIsobaric 4-Plex Tagging for Absolute Quantitation of Biological Acids in Diabetic Urine Using Capillary LC-MS/MS, Application In Synthesis of 621-37-4, the publication is ACS Measurement Science Au (2022), 2(3), 287-295, database is CAplus and MEDLINE.

Isobaric labeling in mass spectrometry enables multiplexed absolute quantitation and high throughput, while minimizing full scan spectral complexity. Here, we use 4-plex isobaric labeling with a fixed pos. charge tag to improve quantitation and throughput for polar carboxylic acid metabolites. The isobaric tag uses an isotope-encoded neutral loss to create mass-dependent reporters spaced 2 Da apart and was validated for both single- and double-tagged analytes. Tags were synthesized inhouse using deuterated formaldehyde and Me iodide in a total of four steps, producing cost-effective multiplexing. No chromatog. deuterium shifts were observed for single- or double-tagged analytes, producing consistent reporter ratios across each peak. Perfluoropentanoic acid was added to the sample to drastically increase retention of double-tagged analytes on a C18 column. Excess tag was scavenged and extracted using hexadecyl chloroformate after reaction completion. This allowed for removal of excess tag that typically causes ion suppression and column overloading. A total of 54 organic acids were investigated, producing an average linearity of 0.993, retention time relative standard deviation (RSD) of 0.58%, and intensity RSD of 12.1%. This method was used for absolute quantitation of acid metabolites comparing control and type 1 diabetic urine. Absolute quantitation of organic acids was achieved by using one isobaric lane for standards, thereby allowing for anal. of six urine samples in two injections. Quantified acids showed good agreement with previous work, and six significant changes were found. Overall, this method demonstrated 4-plex absolute quantitation of acids in a complex biol. sample.

ACS Measurement Science Au published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Application In Synthesis of 621-37-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts