Author: tianli

Jeon, Mina published the artcileTransformation of Silanes into Silanols using Water and Recyclable Metal Nanoparticle Catalysts, Category: alcohols-buliding-blocks, the publication is ChemCatChem (2012), 4(4), 521-524, database is CAplus.

The highly selective and efficient transformation of organosilanes into silanols was achieved using readily available heterogeneous metal nanoparticle catalysts on an Al oxyhydroxide support [M/AlO(OH), M = Pd, Au, Rh, Ru, and Cu]. The transformation was performed under ambient conditions with H₂O. Among the catalysts studied, the Pd catalyst showed the highest activity; it was highly recyclable and applicable for large-scale reactions. The Pd catalyst was effective for a wide range of silanes, although small amounts of hydrogenated side products were formed in some cases for alkynyl silanes. The hydrogenation reaction was suppressed by using an O atm. or by using a gold catalyst. The Au catalyst could be reused at least ten times without any loss in activity.

ChemCatChem published new progress about 17877-23-5. 17877-23-5 belongs to alcohols-buliding-blocks, auxiliary class Protection and Derivatization Reagent, name is Triisopropylsilanol, and the molecular formula is C9H22OSi, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Liu, Caiping published the artcileDiscovery of Salidroside Glycoside Analogs as Novel Angiogenesis Agents to Treat Diabetic Hind Limb Ischemia, Name: 3-Hydroxyphenylacetic acid, the publication is Journal of Medicinal Chemistry (2022), 65(1), 135-162, database is CAplus and MEDLINE.

Therapeutic angiogenesis is a potential therapeutic strategy for hind limb ischemia (HLI); however, currently, there are no small-mol. drugs capable of inducing it at the clin. level. Activating the hypoxia-inducible factor-1 (HIF-1) pathway in skeletal muscle induces the secretion of angiogenic factors and thus is an attractive therapeutic angiogenesis strategy. Using salidroside, a natural glycosidic compound as a lead, we performed a structure-activity relationship (SAR) study for developing a more effective and drug angiogenesis agent. We found a novel glycoside scaffold compound (C-30) with better efficacy than salidroside in enhancing the accumulation of the HIF-1α protein and stimulating the paracrine functions of skeletal muscle cells. This in turn significantly increased the angiogenic potential of vascular endothelial and smooth muscle cells and, subsequently, induced the formation of mature, functional blood vessels in diabetic and non-diabetic HLI mice. Together, this study offers a novel, promising small-mol.-based therapeutic strategy for treating HLI.

Journal of Medicinal Chemistry published new progress about 621-37-4. 621-37-4 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Phenol,Natural product, name is 3-Hydroxyphenylacetic acid, and the molecular formula is C8H8O3, Name: 3-Hydroxyphenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yu, Wangzhi published the artcilePalladium-Catalyzed Linear Hydrothiocarbonylation of Unactivated Terminal Alkenes: Synthesis of Aliphatic Thioesters, Name: 2-Phenylethanethiol, the publication is Organic Letters, database is CAplus and MEDLINE.

A Pd-catalyzed hydrothiocarbonylation of unactivated terminal alkenes is presented. According to this protocol, aliphatic thioesters were synthesized with exclusive linear selectivity under mild reaction conditions. Good to excellent yields (up to 91% yield), broad substrate scope, broad functional group tolerance, and utility of the method demonstrated the advantages of this protocol.

Organic Letters published new progress about 4410-99-5. 4410-99-5 belongs to alcohols-buliding-blocks, auxiliary class Thiol,Benzene, name is 2-Phenylethanethiol, and the molecular formula is C29H24FN7O, Name: 2-Phenylethanethiol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Byun, Jaewon published the artcileImpact of uncertainty in technological cycle on circular economy: Bio-based jet fuel range alkenes and pentanediols production, HPLC of Formula: 111-29-5, the publication is Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) (2021), 356-361, database is CAplus.

In terms of circular economy (CE), the coprodn. of biofuels and bio-based chems. could be a feasible strategy to improve the biorefinery economics. However, this approach is significantly affected by the variation of the techno-economic parameters. Thus, we evaluated the techno-economic feasibility of an integrated strategy through deterministic and stochastic models for the coprodn. of biofuels (jet fuel range alkenes (JFA)) and bio-based chems. (pentanediols and pentane) to identify the impact of uncertainty in technol. cycle on the CE action plan. The deterministic anal. estimated the min. JFA selling price (MJSP) expressed per gasoline gal equivalent (GGE) and led to the identification of six major techno-economic parameters having a significant impact on the economics. Stochastic anal. was performed based on the Monte Carlo simulation, leading to probabilistic results on the economic feasibility of the integrated strategy, taking into account the uncertainty in the six identified parameters. In five of the six scenarios developed considering each uncertainty, the chances of MJSP being lower than the maximum biofuel price (USD 3.10 GGE^-1) in the last three years (2017-2019) were higher than 50% (53.2-88.1%), implying that, despite the uncertainties reflected in the major techno-economic parameters, the integrated strategy could be a risk-averse investment.

Journal of Industrial and Engineering Chemistry (Amsterdam, Netherlands) published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C5H12O2, HPLC of Formula: 111-29-5.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wu, Xia published the artcileApplication of urapidil in prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, the publication is Nanjing Yike Daxue Xuebao, Ziran Kexueban (2015), 35(9), 1305-1307, database is CAplus.

The application effect of urapidil on prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section was observed A total of 60 full-term pregnant patients who needed cesarean section of lower uterine segment were randomly divided into urapidil group (U group) and normal saline group (N group), 30 cases in each group. After fetal childbirth, based on injection of carboprost tromethamine 250 μg, urapidil of 12.5 mg was i.v. injected in U group, and 20 mL normal saline was injected in N group. The mean arterial blood pressure (MAP), heart rate (HR) and pulse oxygen saturation (SPO₂) were recorded in both groups before anesthesia (T₀), at fetal childbirth (T₁), 10 min after injection of carboprost tromethamine (T₂) and 30 min after injection of carboprost tromethamine (T₃). And the adverse reactions in both groups were observed There were no statistically significant differences in MAP, HR and SPO₂ at T₀ between both two groups (P>0.05). Compared with T₀, MAP and HR in N group were increased at T₂ (P<0.05), while SPO₂ was decreased (P<0.05). Compared with N group, MAP and HR in U group were decreased at T₂ (P<0.05), while SPO₂ was increased (P<0.05). The incidences of headache and chest tightness were higher in N group than in U group (P<0.05). Urapidil can be effectively used in the prevention and treatment of adverse reactions caused by carboprost tromethamine in cesarean section, which is conducive to the stability of circular breathing.

Nanjing Yike Daxue Xuebao, Ziran Kexueban published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C11H8O3, Recommanded Product: 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Lee, Junghoon published the artcileSiloxane-Based Hybrid Semiconducting Polymers Prepared by Fluoride-Mediated Suzuki Polymerization, Computed Properties of 239075-02-6, the publication is Angewandte Chemie, International Edition (2015), 54(15), 4657-4660, database is CAplus and MEDLINE.

Siloxane-containing materials are a large and important class of organic-inorganic hybrids. In this report, a practical variation of the Suzuki polymerization to generate semiconducting polymeric hybrids based on siloxane units, which proceeds under essentially nonbasic conditions, is presented. This method generates solution-processable poly(diketopyrrolopyrrole-alt-benzothiadiazole) (PDPPBT-Si) consisting of the hybrid siloxane substituents, which could not be made using conventional methods. PDPPBT-Si exhibits excellent ambipolar transistor performance with well-balanced hole and electron FET mobilities. The siloxane-containing DPP-thiophene polymer classes (PDPP3T-Si and PDPP4T-Si), synthesized by this method, exhibit high hole mobility of up to 1.29 cm² V^-1 s^-1. This synthetic approach should provide access to a variety of novel siloxane-containing conjugated semiconductor classes by using a variety of aryldihalides and aryldiboronic acids/esters.

Angewandte Chemie, International Edition published new progress about 239075-02-6. 239075-02-6 belongs to alcohols-buliding-blocks, auxiliary class Thiophene,Boronic acid and ester,Boronate Esters, name is 5,5′-Bis(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-2,2′-bithiophene, and the molecular formula is C20H28B2O4S2, Computed Properties of 239075-02-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Novotny, Chris J. published the artcileFarnesyltransferase-Mediated Delivery of a Covalent Inhibitor Overcomes Alternative Prenylation to Mislocalize K-Ras, Application In Synthesis of 57044-25-4, the publication is ACS Chemical Biology (2017), 12(7), 1956-1962, database is CAplus and MEDLINE.

Mutationally activated Ras is one of the most common oncogenic drivers found across all malignancies, and its selective inhibition has long been a goal in both pharma and academia. One of the oldest and most validated methods to inhibit overactive Ras signaling is by interfering with its post-translational processing and subsequent cellular localization. Previous attempts to target Ras processing led to the development of farnesyltransferase inhibitors, which can inhibit H-Ras localization but not K-Ras due to its ability to bypass farnesyltransferase inhibition though alternative prenylation by geranylgeranyltransferase. Here the authors present the creation of a neo-substrate for farnesyltransferase that prevents the alternative prenylation by geranylgeranyltransferase and mislocalizes oncogenic K-Ras in cells.

ACS Chemical Biology published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Application In Synthesis of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Tan, Y. L. published the artcileDeoxygenation of pyrolysis vapour derived from durian shell using catalysts prepared from industrial wastes rich in Ca, Fe, Si and Al, Product Details of C4H11NO, the publication is Science of the Total Environment (2020), 134902, database is CAplus and MEDLINE.

Catalysts prepared from industrial wastes rich in Fe, Ca, Si, and Al were used in catalytic upgrading of pyrolysis vapor derived from durian shell and their effect on product yield and properties were compared. With same SiO₂-to-alumina ratio, catalyst prepared from oil palm ash (AS-OPA) with lower Fe and Ca contents gave higher liquid yield (8.32%) with alcs. (28.90%), hydrocarbons (46.00%), and N-containing compounds (21.46%) while catalyst prepared from elec. arc furnace slag (AS-EAF) with higher Fe and Ca contents produced lower liquid yield (50.21%) with high amount of esters (25.80%) and hydrocarbons (72.82%). The presence of AS-OPA and AS-EAF catalysts enhanced deoxygenation degree of bio-oil to 81.13% and 85.49%, resp. The catalytic performance of AS-EAF at different temperatures (400-600°) and AS-EAF/durian shell ratios (1:30, 2:30, 3:30) was studied. Increasing catalytic temperature enhanced production of bio-oil, reduced oxygenates and enhanced formation of esters. The liquid yield and yield of esters decreased with increasing catalyst loading. Hydrocarbons (mainly neopentane) were the major chem. compounds found in bio-oil produced over AS-EAF. Besides that, AS-EAF showed good deoxygenation performance with highest selectivity of hydrocarbons at 500° and AS-EAF/durian shell ratio of 2:30. Catalytic fast pyrolysis of durian shell using waste-derived catalysts is an effective waste management strategy as the bio-oil produced can be a potential alternative source of energy or chem. feedstocks.

Science of the Total Environment published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C10H9NO, Product Details of C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Karpati, Levente published the artcileThe sequenced structure of amino-alcohol-based random poly(ester amide)s, Recommanded Product: 2-Aminobutan-1-ol, the publication is Journal of Thermal Analysis and Calorimetry (2019), 136(2), 737-747, database is CAplus.

Random amino-alc.-based poly(ester amide)s were synthesized using adipic acid and differently substituted amino-alcs., namely 2-amino-ethan-1-ol, 1-amino-propan-2-ol, 2-amino-butan-1-ol and 2-amino-2-methyl-propan-1-ol. The effect of substitution on the yield and fine structure was investigated using residual functional group anal., SEC and NMR. The functional group anal. and SEC proved the blocking effect of small substituents on direct polycondensation. The NMR data suggested a sequenced structure that could cause the formation of different crystalline phases in linear amino-alc.-based poly(ester amide)s. Three different crystalline phases with different thermal stability and crystallization rate were observed with DSC and WAXS. The crystalline nature of the poly(ester amide)s proves the sequenced organization along the backbone.

Journal of Thermal Analysis and Calorimetry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, Recommanded Product: 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Smoum, Reem published the artcileFenchone Derivatives as a Novel Class of CB2 Selective Ligands: Design, Synthesis, X-ray Structure and Therapeutic Potential, Application In Synthesis of 645-56-7, the publication is Molecules (2022), 27(4), 1382, database is CAplus and MEDLINE.

A series of novel cannabinoid-type derivatives was synthesized by the coupling of (1S,4R)-(+) and (1R,4S)-(-)-fenchones I (R = H, Me, n-pentyl, 2-methylbutan-2-yl, etc.; R¹ = H, hexyl; R² = H, OMe) with various resorcinols RC₆H₃(OH)₂/phenols RC₆H₄OH. The fenchone-resorcinol derivatives I were fluorinated using Selectfluor and demethylated using sodium ethanethiolate in DMF (DMF). The absolute configurations of four compounds were determined by X-ray single crystal diffraction. The fenchone-resorcinol analogs I possessed high affinity and selectivity for the CB2 cannabinoid receptor. One of the analogs synthesized, I (R = 2-methyloctan-2-yl, R¹ = H, R² = OMe (II)), had a high affinity (K_i = 3.51 nM) and selectivity for the human CB2 receptor (hCB2). In the [³⁵S]GTPγS binding assay, the lead compound was found to be a highly potent and efficacious hCB2 receptor agonist (EC₅₀ = 2.59 nM, E_(max) = 89.6%). Two of the fenchone derivatives I were found to possess anti-inflammatory and analgesic properties. Mol.-modeling studies elucidated the binding interactions of (II) within the CB2 binding site.

Molecules published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C3H6BrNaO3S, Application In Synthesis of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts