Author: tianli

Ervin, Samantha M. published the artcileTargeting Regorafenib-Induced Toxicity through Inhibition of Gut Microbial β-Glucuronidases, SDS of cas: 622-40-2, the publication is ACS Chemical Biology (2019), 14(12), 2737-2744, database is CAplus and MEDLINE.

Regorafenib (Stivarga) is an oral small mol. kinase inhibitor used to treat metastatic colorectal cancer, hepatocellular carcinomas, and gastrointestinal stromal tumors. Diarrhea is one of the most frequently observed adverse reactions associated with regorafenib. This toxicity may arise from the reactivation of the inactive regorafenib-glucuronide to regorafenib by gut microbial β-glucuronidase (GUS) enzymes in the gastrointestinal tract. We sought to unravel the mol. basis of regorafenib-glucuronide processing by human intestinal GUS enzymes and to examine the potential inhibition of these enzymes. Using a panel of 31 unique gut microbial GUS enzymes derived from the 279 mapped from the human gut microbiome, we found that only four were capable of regorafenib-glucuronide processing. Using crystal structures as a guide, we pinpointed the mol. features unique to these enzymes that confer regorafenib-glucuronide processing activity. Furthermore, a pilot screen identified the FDA-approved drug raloxifene as an inhibitor of regorafenib reactivation by the GUS proteins discovered. Novel synthetic raloxifene analogs exhibited improved potency in both in vitro and ex vivo studies. Taken together, these data establish that regorafenib reactivation is exclusively catalyzed by gut microbial enzymes and that these enzymes are amenable to targeted inhibition. Our results unravel key mol. details of regorafenib reactivation in the GI tract and provide a potential pathway to improve clin. outcomes with regorafenib.

ACS Chemical Biology published new progress about 622-40-2. 622-40-2 belongs to alcohols-buliding-blocks, auxiliary class Morpholine,Alcohol, name is 2-Morpholinoethanol, and the molecular formula is C6H13NO2, SDS of cas: 622-40-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jiang, Minghui published the artcileInhibition effect of different corrosion inhibitors on steel bars corrosion and improvement effect after double doped, Application In Synthesis of 122-20-3, the publication is Science Journal of Chemistry (2021), 9(4), 105-112, database is CAplus.

Reinforced concrete structures are easily corroded in the Salt Lake areas of China, especially in harsh environmental circumstance, such as freezing-thawing cycles, wetting-dry, et al, thus causing a lot of damage problems (concrete deterioration and steel bars corrosion). This research investigation was a research study which was to solve the corrosion problem of reinforced concrete structures under the chloride environmental circumstance through the electrochem. performance and mech. properties test of the reinforced mortar specimens, the effect of single or compound doping of two organic and two inorganic corrosion inhibitors to the electrode potential, electrochem. impedance spectroscopy and mech. properties of the reinforced mortar were investigated. The exptl. conclusion demonstrated that the organic or inorganic corrosion inhibitors after single and compound doping showed some degree influence on the electrode potential and mech. properties of the reinforced mortar specimens. Meanwhile, when the ratio of triethanolamine (TEA):triisopropanolamine (TIPA) was 7:3, sodium monofluorophosphate (MFP):sodium molybdate was 5:5, the compressive strength and flexural strength of mortar after curing for 28 days were greater than 90, it indicated that these proportions showed the best corrosion resistance performance of steel bars. Therefore, these proportions of corrosion inhibitors could be used in reinforced concrete structures. The significant was that these results could provide theor. guidance and tech. basis for the study of corrosion damage of reinforced concrete structures in the future.

Science Journal of Chemistry published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, Application In Synthesis of 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Cui, Lei published the artcileExperimental study on multi-component corrosion inhibitor for steel bar in chloride environment, SDS of cas: 122-20-3, the publication is Construction and Building Materials (2021), 125533, database is CAplus.

This paper investigates one type of multi-component corrosion inhibitor for steel bars in chloride environment. Triethanolamine (TEA), tri-isopropanolamine (TIPA), sodium monofluorophos-phate (MFP) and sodium molybdate (T-4) were proportioned to prepare this multi-component corrosion inhibitor. Corrosion behavior of steel bar was evaluated using the polarization curve, electrochem. impedance spectroscopy (EIS) and SEM (SEM). The polarization curves were fitted using the adsorption isotherm models. Exptl. results indicated that the steel bar corrosion in chloride solution can be reduced by the addition of either organic or inorganic corrosion inhibitors. This is attributed to the fact that organic corrosion inhibitor can form an adsorption film on the steel bar surface and inorganic corrosion inhibitor abates electrochem. reaction of steel bars. Compared to single component corrosion inhibitors, the corrosion rate of steel bars in simulated pore solution was significantly restrained by the multi-component corrosion inhibitor. The adsorption of multi-component corrosion inhibitor on the surface of steel bar can significantly reinforce the passive film by means of phys. (organic) or chem. (inorganic) process. For all the investigated corrosion inhibitors, the adsorption isotherms were in good agreement with exptl. results. The EIS result and equivalent electrochem. circuit confirmed the chem. reaction and phys. adsorption process of the multi-component corrosion inhibitor. Therefore, the chloride induced corrosion of steel bars can be effectively controlled by the multi-component corrosion inhibitor.

Construction and Building Materials published new progress about 122-20-3. 122-20-3 belongs to alcohols-buliding-blocks, auxiliary class Organic Pigment, name is Triisopropanolamine, and the molecular formula is C9H21NO3, SDS of cas: 122-20-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Song, Chengwen published the artcileRole of carboprost tromethamine in laparoscopic myomectomy, COA of Formula: C25H47NO8, the publication is Xuzhou Yixueyuan Xuebao (2013), 33(2), 139-140, database is CAplus.

Hemostatic effect of carboprost tromethamine in laparoscopic myomectomy was discussed. One hundred patients with uterine fibroids were randomly divided into treatment group and control group, they were injected with 1 mL carboprosttromethamine (250 μg) and oxytocin 20 U during operation to prevent bleeding. Bleeding amount, operation time and abdominal drainage in treatment group were less than those in control group (P<0.05). Temperature recovery time and evacuation time by anus had no statistical significance. Application of carboprost tromethamine in laparoscopic myomectomy could significantly decrease bleeding time, shorten operation time, with less adverse reaction and worth popularizing.

Xuzhou Yixueyuan Xuebao published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C8H10N2O2, COA of Formula: C25H47NO8.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Chen, Xincheng published the artcileTheoretical study on the reaction of Et₃GeCH:CH₂ with Et₃SiOH, Recommanded Product: Triethylsilanol, the publication is Advanced Materials Research (Durnten-Zurich, Switzerland) (2012), 301-304, database is CAplus.

The reaction of Et₃GeCH:CH₂ + Et₃SiOH → Et₃SiO-Ge-Et₃ + CH₂:CH₂ has been studied using quantum chem. methods. Geometries of reactants, transition states, and products have been optimized resp. at the B3LYP/6-311+g(2d,2p) level. The rate constants were evaluated using canonical variational transition state theory (CVT) and canonical variational transition state theory with small-curvature tunneling contributions (CVT/SCT) over the temperature range of 200-3500K. The CVT/SCT rate constants exhibit typical non-Arrhenius behavior, and a three-parameter rate-temperature formula has been fitted as follows: k(T)=1.43 × 10^-38T^5.41exp(-13200/T) (in units of cm³ mol.^-1s^-1).

Advanced Materials Research (Durnten-Zurich, Switzerland) published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Recommanded Product: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Xianxian published the artcileExtraction of honokiol from Artemisia argyi and in vitro and in vivo investigation of its antifungal activity, SDS of cas: 90-64-2, the publication is Natural Product Research, database is CAplus and MEDLINE.

Extracts from plants used in Chinese medicine can be good sources of fungicides for agricultural applications. In this study, we separated and identified antifungal compounds from four traditional Chinese medicine extracts and evaluated their antifungal activities in vitro and in vivo. In vitro, honokiol extracted from Artemisia argyi showed broad-spectrum antimicrobial and mycelial inhibitory activity with EC50 in the range 3.56 – 33.85 μg/mL against eight plant pathogens. q-PCR indicated that honokiol might induce cell cancerisation and inhibit cellular respiration, which provided significant insights into honokiol function in tobacco resistance to mol. mechanisms of the phytopathogenic fungus Phytophthora nicotianae. In vivo, honokiol significantly decreased the rate of fungal infection in eggplants, potatoes, grapes, cherry tomatoes, and cucumbers, and enhanced disease resistance in tobacco. Overall, our results indicate that honokiol has the potential to control a variety of fungal and oomycete diseases, and A. argyi could be a source of honokiol.

Natural Product Research published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C20H21ClN4O4, SDS of cas: 90-64-2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Wang, Rui-jiao published the artcileStudy on effect of oxytocin combined with carboprost tromethamine in preventing postpartum hemorrhage in high-risk women, Category: alcohols-buliding-blocks, the publication is Zhongguo Fuyou Baojian (2016), 31(15), 3033-3035, database is CAplus.

Objective: To analyze the preventive effect of the combination of carboprost tromethamine and oxytocin on postpartum hemorrhage in cesarean section of high-risk women, and observe the occurrence of adverse reactions after maternal medication. Methods: A total of 120 high-risk pregnant women who were scheduled for cesarean delivery at the Obstetrics Department of Liaobu Hospital in Dongguan City were collected, and randomly divided into 3 groups. 40 cases in group A, who were given oxytocin alone. 40 patients in group B were treated with oxytocin combined with carboprost methylate suppository. 40 patients in group C were given oxytocin combined with carboprost tromethamine. The intraoperative and postoperative bleeding volume, postpartum hemorrhage, treatment and adverse reactions of the three groups were compared. Results: The intraoperative and postoperative 2 h bleeding volume of group B and group C were significantly lower than that of group A (P < 0.05), among which the difference of group C was more significant. The bleeding volume in group C was significantly lower than that in group A and group B at 2-24 h after operation (P < 0.05). The incidence of postpartum hemorrhage, blood transfusion rate, and treatment rate of other hemostatic measures in group B and group C were significantly lower than those in group A (P < 0.05). Conclusion: The combination of carboprost tromethamine and oxytocin can effectively reduce the amount of postpartum hemorrhage and the incidence of postpartum hemorrhage in high-risk women, and it is safe and worthy of further promotion.

Zhongguo Fuyou Baojian published new progress about 58551-69-2. 58551-69-2 belongs to alcohols-buliding-blocks, auxiliary class Chiral,Alkenyl,Amine,Aliphatic cyclic hydrocarbon,Ester,Alcohol,Inhibitor,, name is 2-Amino-2-(hydroxymethyl)propane-1,3-diol (Z)-7-((1R,2R,3R,5S)-3,5-dihydroxy-2-((S,E)-3-hydroxy-3-methyloct-1-en-1-yl)cyclopentyl)hept-5-enoic acid, and the molecular formula is C11H19N, Category: alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, Weichao published the artcileA plate method for rapid screening of Ketogulonicigenium vulgare mutants for enhanced 2-keto-L-gulonic acid production, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, the publication is Brazilian Journal of Microbiology (2017), 48(3), 397-402, database is CAplus and MEDLINE.

A new plate method was developed for rapid screening of Ketogulonicigenium vulgare mutants overproducing 2-keto-L-gulonic acid (2-KLG). The screening methodol. took the advantage of the acidity caused by 2-KLG, which changes the color of bromothymol blue (pH indicator) from blue to yellow. Using the proposed method, a mutant, K. vulgare 65, was selected from 20,000 colonies produced by a strain subjected to spaceflight mutagenesis. When co-cultured with Bacillus megaterium 2980 in 20-L fermenters, K. vulgare 65 showed a high conversion rate (94.45%) of l-sorbose to 2-KLG. In contrast to the traditional screening method, this one significantly improved the frequency of obtaining pos. mutants. Theproposed plate screening method is cost-effective and easy to run and is thus useful for the isolation and screening of K. vulgare mutants overproducing 2-KLG.

Brazilian Journal of Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C8H5F3N4, Name: (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yang, W. published the artcileSpaceflight-induced enhancement of 2-keto-L-gulonic acid production by a mixed culture of Ketogulonigenium vulgare and Bacillus thuringiensis, Formula: C6H10O7, the publication is Letters in Applied Microbiology (2013), 57(1), 54-62, database is CAplus and MEDLINE.

Two bacterial strains used for industrial production of 2-keto-L-gulonic acid (2-KLG), Ketogulonigenium vulgare 2 and Bacillus thuringiensis 1514, were loaded onto the spacecraft Shenzhou VII and exposed to space conditions for 68 h in an attempt to increase their fermentation productivities of 2-KLG. An optimal combination of mutants B. thuringiensis 320 and K. vulgare 2194 (KB2194-320) was identified by systematically screening the pH and 2-KLG production of 16 000 colonies. Compared with the coculture of parent strains, the conversion rate of L-sorbose to 2-KLG by KB2194-320 in shake flask fermentation was increased significantly from 82·7% to 95·0%. Furthermore, a conversion rate of 94·5% and 2-KLG productivity of 1·88 g l^-1 h^-1 were achieved with KB2194-320 in industrial-scale fermentation (260 m³ fermentor). An observed increase in cell number of K2194 (increased by 47·8%) during the exponential phase and decrease in 2-KLG reductase activity (decreased by 46·0%) were assumed to explain the enhanced 2-KLG production The results suggested that the mutants KB2194-320 could be ideal substitutes for the currently employed strains in the 2-KLG fermentation process and demonstrated the feasibility of using spaceflight to breed high-yielding 2-KLG-producing strains for vitamin C production Significance and Impact of the Study : KB2194-320, a combination of two bacterial strains bred by spaceflight mutation, exhibited significantly improved 2-KLG productivity and hence could potentially increase the efficiency and reduce the cost of vitamin C production by the two-step fermentation process. In addition, a new pH indicator method was applied for rational screening of K2, which dramatically improved the efficiency of screening.

Letters in Applied Microbiology published new progress about 526-98-7. 526-98-7 belongs to alcohols-buliding-blocks, auxiliary class Sugar Units,Other Sugar Units, name is (3S,4R,5S)-3,4,5,6-Tetrahydroxy-2-oxohexanoic acid, and the molecular formula is C18H23N3O4S, Formula: C6H10O7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Jeon, Mina published the artcileTransformation of Silanes into Silanols using Water and Recyclable Metal Nanoparticle Catalysts, Name: Triethylsilanol, the publication is ChemCatChem (2012), 4(4), 521-524, database is CAplus.

The highly selective and efficient transformation of organosilanes into silanols was achieved using readily available heterogeneous metal nanoparticle catalysts on an Al oxyhydroxide support [M/AlO(OH), M = Pd, Au, Rh, Ru, and Cu]. The transformation was performed under ambient conditions with H₂O. Among the catalysts studied, the Pd catalyst showed the highest activity; it was highly recyclable and applicable for large-scale reactions. The Pd catalyst was effective for a wide range of silanes, although small amounts of hydrogenated side products were formed in some cases for alkynyl silanes. The hydrogenation reaction was suppressed by using an O atm. or by using a gold catalyst. The Au catalyst could be reused at least ten times without any loss in activity.

ChemCatChem published new progress about 597-52-4. 597-52-4 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic Chain, name is Triethylsilanol, and the molecular formula is C6H16OSi, Name: Triethylsilanol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts