Author: tianli

Sugimoto, Kanta published the artcileVersatile tensile and fracture behaviors of dual crosslinked elastomers by postpreparation photo tuning of local crosslink density, COA of Formula: C5H12O2, the publication is Polymer (2021), 124089, database is CAplus.

This study demonstrates the postpreparation easy tuning of the Young’s modulus of elastomers by using polyesters bearing thermal and photo crosslinkable groups. In the first crosslinking step, only thermoreactive groups form crosslinks, resulting in a highly deformable soft elastomer. In the second step, photoreactive groups are crosslinked by UV irradiation, and controlling the UV irradiation time can tune the crosslink d., resulting in modulus tuning over two orders of magnitude at room temperature The use of photo reaction enables precise modulus patterning using photomasks with a series of slits. In horizontally patterned samples, the dually crosslinked stiff section shows negligible deformation, whereas large elongation is observed selectively in the single crosslinked soft sections. In vertically patterned samples, interestingly, crack propagation and complete fracture are significantly suppressed, compared with the fully dually crosslinked sample. The present data can thus provide important insight for developing new methodologies for controlling the tensile and fracture behavior of elastomers.

Polymer published new progress about 111-29-5. 111-29-5 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic hydrocarbon chain,Alcohol,Ploymers, name is Pentane-1,5-diol, and the molecular formula is C13H15NO6S, COA of Formula: C5H12O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Golombek, Florian published the artcileThree Steps, Two Enzymes, One Pot, but a Multitude of Nanocompartments: Combined Cycles of Kinetic Resolutions and Re-racemization with Incompatible Biocatalysts, Product Details of C8H8O3, the publication is ACS Omega (2021), 6(43), 29192-29200, database is CAplus and MEDLINE.

Deracemizations are clearly preferable to kinetic resolutions in the production of chiral mols. from racemates, as they allow up to 100% chem. and optical yield. Here we present a new process route for multienzymic deracemizations that is relevant for reaction systems with incompatible reaction conditions of the biocatalysts. This often applies to combinations of lipases used for stereoselective acylation and solvent-sensitive racemases. By encapsulating a model racemase in polymeric vesicles, it was protected from inactivation by the organic solvent up to phase proportions of 99%. As high yields in the lipase reaction required either water proportions well below 1% or racemase-denaturating acyl donor concentrations, a one-pot reaction was implemented through the sequential use of lipase and racemase-containing nanocompartments. This strategy allowed us to perform two kinetic resolutions with intermittent re-racemization in one pot yielding 72% (0.72 mM after 120 h) of an enantiopure product.

ACS Omega published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Product Details of C8H8O3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Levesque, Jean Pierre published the artcileA mitogenic fibrinogen receptor that differs from glycoprotein IIb-IIIa. Identification by affinity chromatography and by covalent cross-linking, Computed Properties of 70539-42-3, the publication is Journal of Biological Chemistry (1990), 265(1), 328-33, database is CAplus and MEDLINE.

The mitogenic effect of human fibrinogen on the hemopoietic cell lines Raji and JM is mediate by a specific receptor with biochem. and functional properties different from those of the platelet fibrinogen receptor, the glycoprotein complex IIb-IIIa. This work describes the identification of the mitogenic fibrinogen receptor (MFR) by 2 independent methods, affinity chromatog. and covalent crosslinking. Affinity chromatog. of surface-labeled cell extracts on fibrinogen-Sepharose revealed a 94-kDa membrane protein that bound specifically to fibrinogen-Sepharose only on cells that expressed the MFR. Its mol. mass was not modified after reduction This was confirmed by crosslinking fibrinogen to surface-labeled Raji cells using the cleavable crosslinkers, ethyleneglycolbis(succinimidyl succinate) and dithiobis(succinimidyl propionate). Complexes between fibrinogen and iodinated cell membrane proteins were immunoprecipitated by anti-fibrinogen antibodies. The biochem. cleavage of these immunoprecipitated conjugates gave rise to a 92-kDa membrane protein whose mol. mass was not modified after reduction Thus, fibrinogen binds specifically to a 92-94-kDa MFR which does not belong to the integrin family.

Journal of Biological Chemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C18H20N2O12, Computed Properties of 70539-42-3.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Kurogome, Yuji published the artcileSynthesis of Decytospolide A, B and Their C-3 Epimers Using Stereoselective Oxypalladation, Quality Control of 57044-25-4, the publication is Synthesis (2016), 48(5), 765-771, database is CAplus.

Stereoselective synthesis of decytospolide A and B (I and II, resp.) and their C-3 epimers, which have a 2,6-cis-tetrahydropyran ring, has been achieved in high stereoselectivity and yield. The oxypalladation of single diastereomers of 6-(benzyloxy)-7-hydroxydodec-2-enyl 2-naphthoates was optimized to give products with a 2,6-cis-tetrahydropyran ring with high diastereoselectivity and yield.

Synthesis published new progress about 57044-25-4. 57044-25-4 belongs to alcohols-buliding-blocks, auxiliary class Epoxides,Chiral,Aliphatic hydrocarbon chain,Alcohol, name is (R)-Oxiran-2-ylmethanol, and the molecular formula is C3H6O2, Quality Control of 57044-25-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Yamaguchi, Mutsuo published the artcileMitochondrial NADH:ubiquinone oxidoreductase (complex I): Proximity of the subunits of the flavoprotein and the iron-sulfur protein subcomplexes, Related Products of alcohols-buliding-blocks, the publication is Biochemistry (1993), 32(8), 1935-9, database is CAplus and MEDLINE.

The proximities of the three subunits (51, 24, and 9 kDa) of the flavoprotein subcomplex (FP) and five subunits (75, 49, 30, 18, and 13) of the iron-sulfur protein subcomplex (IP) of the bovine NADH: ubiquinone oxidoreductase (complex I) were investigated by crosslinking studies. The crosslinking reagents used were disuccinimidyl tartrate and ethylene glycol bis(succinimidyl succinate). The cross-linked products were identified by sodium dodecyl sulfate gel electrophoresis and immunoblotting with antibodies specific for each subunit. Results showed that the three FP subunits are juxtaposed to one another, and only the 51 kDa subunit of FP is in close proximity to only the 75-kDa subunit of IP. The 75-kDa subunit cross-linked to the 30- and the 13-kDa subunits, the 49-kDa subunit cross-linked to the 30-, 18-, and 13-kDa subunits, and the 30-kDa subunit cross-linked to the 18- and the 13-kDa subunits. No cross-linked products of 75+49-, 75+18-, or 18+13-kDa subunits were detected. These results are consistent with the occurrence of potential electron carriers in FP and IP subunits. These electron carriers are FMN and one iron-sulfur cluster in the 51-kDa subunit, one iron-sulfur cluster in the 24-kDa subunit, and apparently two iron-sulfur clusters in the 75-kDa subunit.

Biochemistry published new progress about 70539-42-3. 70539-42-3 belongs to alcohols-buliding-blocks, auxiliary class pyrrolidine,Ester,Amide,Inhibitor,Inhibitor, name is Bis(2,5-dioxopyrrolidin-1-yl) O,O’-ethane-1,2-diyl disuccinate, and the molecular formula is C5H10N2OS, Related Products of alcohols-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Doura, Tomohiro published the artcileAn adhesive ¹⁹F MRI chemical probe allows signal off-to-on-type molecular sensing in a biological environment, Application of 3,3,3-Trifluoropropan-1-ol, the publication is Chemical Communications (Cambridge, United Kingdom) (2013), 49(97), 11421-11423, database is CAplus and MEDLINE.

We report a new strategy for designing a signal off-to-on-type ¹⁹F MRI chem. probe that operates in biol. environments. The present strategy is based on the control of adherence of a ¹⁹F MRI chem. probe to certain blood proteins, accompanied by a change in transverse relaxation time of ¹⁹F nuclei.

Chemical Communications (Cambridge, United Kingdom) published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C3H5F3O, Application of 3,3,3-Trifluoropropan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

El-Sayed, Heba M. published the artcileQuality by Design Strategy for Simultaneous HPLC Determination of Bromhexine HCl and Its Metabolite Ambroxol HCl in Dosage Forms and Plasma, Application In Synthesis of 23828-92-4, the publication is Chromatographia (2020), 83(9), 1075-1085, database is CAplus.

Abstract: The quality by design strategy was applied for the simultaneous chromatog. quantification of a binary mixture of bromhexine HCl and its pharmacol. active metabolite ambroxol HCl in dosage forms as well as in human plasma. In this study, five independent parameters were screened by fractional factorial design to specify the critical ones. The optimal conditions were determined by a response surface methodol. using a central composite design. Response surface methodol. enabled the best separation in minimal run time, as well as, prediction of separation and retention parameters with min. error. Separation and quantitation were carried out on BDS Hypersil C₈ (250 × 4.6 mm, 5μm) RP-column at 1.1 mL min^-1 flow rate, 25 mM of KH₂PO₄ (pH 3.5) in aqueous mobile phase, 65% MeOH, 210 nm wavelength of detection and 10μL injection volume After optimization of the chromatog. parameters, validation of the method was achieved according to ICH guidelines. Linearity ranged from 0.195 to 100μg mL^-1 ambroxol HCl, and 0.391-100μg mL^-1 bromhexine HCl, with R² values of 0.9998 and 0.9999 and limits of detection of 0.098 and 0.195μg mL^-1, resp. Recovery results ranged from 98.06 to 100.18 and 97.88 to 100.68 for bromhexine HCl and ambroxol HCl, resp., with RSD less than 1.80.

Chromatographia published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Application In Synthesis of 23828-92-4.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Zhao, Pinjing published the artcileInsertions of Ketones and Nitriles into Organorhodium(I) Complexes and β-Hydrocarbyl Eliminations from Rhodium(I) Alkoxo and Iminyl Complexes, Formula: C19H14O2, the publication is Organometallics (2008), 27(18), 4749-4757, database is CAplus.

Tris(triethylphosphine)-ligated organorhodium(I) complexes were prepared, and their reactions with electron-poor arylnitriles and diaryl ketones were studied. [(PEt₃)₃Rh(Ar)] (Ar = Ph (1a) or o-anisyl (1e)) reacted with an excess of electron-poor arylnitriles Ar’CN (Ar’ = p-CF₃C₆H₄ or 3,5-bis(CF₃)C₆H₃) to form Rh(I) iminyl complexes {(PEt₃)₃Rh[N:C(Ar)(Ar’)]} (2h–j). In contrast, 3,5-(CF₃)₂C₆H₃CN did not insert into the M-C bond of the arylrhodium(I) complexes [(PEt₃)₃Rh(Ar)] (Ar = p-CF₃C₆H₄ (1f) or 3,5-(CF₃)₂C₆H₃ (1g)), containing more electron-poor aryl groups. The kinetic data for nitrile insertions were most consistent with a pathway involving initial ligand dissociation, followed by a classic migratory insertion. Some iminyl complexes decomposed at higher temperatures via β-aryl eliminations with selective migration of the more electron-poor aryl Group 3,5-(CF₃)₂C₆H₃ to form 1g and the corresponding nitriles. Migratory aptitudes of various aryl groups were assessed by studying β-aryl eliminations from a variety of iminyl complexes. Kinetic data for these β-aryl eliminations were most consistent with initial phosphine dissociation and C-C bond cleavage of the resulting 14-electron intermediate. Insertions of diaryl ketones Ar(Ar’)C:O (Ar = 3,5-(CF₃)₂C₆H₃, Ar’ = Ph or 3,5-(CF₃)₂C₆H₃) into 1a also occurred, although the resulting Rh(I) alkoxides {(PEt₃)₂Rh[OC(Ph)(Ar)(Ar’)]} (3f–g) were not stable under the reaction conditions and could not be directly identified. Instead, a mixture of {(PEt₃)₃Rh[3,5-(CF₃)₂C₆H₃]} (1g) and the ketone Ph(Ar’)C:O (Ar’ = Ph or 3,5-(CF₃)₂C₆H₃) were detected as the major products, indicating that decomposition of alkoxides 3f–g occurred by β-elimination of the more electron-poor aryl group. Independent preparation of 3f–g and studies on their thermal decomposition with added PEt₃ confirmed that selective β-aryl elimination occurs to generate aryl complex 1g and the corresponding ketones. Analogous β-aryl eliminations from bis-phosphine Rh(I) alkoxo complexes 3a–e and trisphosphine Rh(I) alkoxo complexes 4b–e were also studied, and the kinetic results were most consistent with irreversible β-Ph elimination from bis(phosphine) alkoxo complexes. Insertion of 3,5-(CF₃)₂C₆H₃CN into an alkylrhodium(I) complex [(PEt₃)₃Rh(Me)] did not occur; however, the electron-poor ketone Ar₂C:O (Ar = 3,5-(CF₃)₂C₆H₃) inserted into 1h, as judged by the detection of the corresponding alc. HOC(Me)[3,5-(CF₃)₂C₆H₃]₂ as the major organic product after quenching with Et₃N·HCl. Vinylrhodium(I) complex [(PEt₃)₃Rh(CH:CH₂)] also reacted with ketones Ar₂C:O (Ar = 3,5-(CF₃)₂C₆H₃) to form a Rh(I) alkoxo complex (PEt₃)₂Rh{OC(CH:CH₂)[3,5-(CF₃)₂C₆H₃]₂} (3h), which was stabilized by the intramol. coordination of the vinyl moiety to the Rh center. The alkynylrhodium(I) complex [(PEt₃)₃Rh(CCPh)] (1j) did not react with ketones or nitriles. Instead, the propargylic alkoxides {(PEt₃)₂Rh[OC(R)₂(CCPh)]} (R = Me or Ph) that would have resulted from insertion react rapidly in the presence of added PEt₃ to form the alkynyl complex 1j and the corresponding ketones via β-alkynyl eliminations. The crystal and mol. structures of [(PEt₃)₃Rh(2-MeOC₆H₄)] and [(PEt₃)₂Rh(OCPh₃)] were determined by x-ray crystallog.

Organometallics published new progress about 596-38-3. 596-38-3 belongs to alcohols-buliding-blocks, auxiliary class Other Aromatic Heterocyclic,Benzene,Alcohol, name is 9-Phenyl-9H-xanthen-9-ol, and the molecular formula is C6H13N3O2, Formula: C19H14O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ghosh, Kousik published the artcileA triple alkoxo bridged dinuclear cobalt(III) complex mimicking phosphatase and showing ability to degrade organic dye contaminants by photocatalysis, COA of Formula: C4H11NO, the publication is Journal of Organometallic Chemistry (2019), 52-64, database is CAplus.

A dinuclear Co(III) complex, [(N₃)L¹Co^IIIL²Co^IIIL¹] (1), was synthesized and characterized {H₂L¹ = 2-((1-hydroxybutan-2-ylimino)methyl)-4-bromophenol and HL² = 2-amino-1-butanol}. Single crystal x-ray diffraction anal. confirmed its structure. Extended supra-mol. architectures were generated in the complex through weak noncovalent interactions. The energetic features of significant supramol. interactions were studied using DFT calculation and further corroborated with NCI plot index computational tool. The complex was found to mimic the role of phosphatase enzyme efficiently by transforming 4-nitrophenylphosphate to 4-nitrophenolate at room temperature The reaction follows Michaelis-Menten enzymic reaction kinetics with turnover numbers of ∼1.4 s^-1 in aqueous DMF (98% DMF, volume/volume) medium. The complex also acts as an efficient photocatalyst for degradation of organic pollutants. Methylene blue (MB), a widely used dye in various industries, was selected as a model pollutant in aqueous media to evaluate the photocatalytic effectiveness of the complex.

Journal of Organometallic Chemistry published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C4H11NO, COA of Formula: C4H11NO.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Shi, Da-Hua published the artcileSynthesis of 3-(alkylamino)-, 3-(alkoxy)-, 3-(aryloxy)-, 3-(alkylthio)-, and 3-(arylthio)-1,2,4-triazines by using a unified route with 3-(methylsulfonyl)-1,2,4-triazine, COA of Formula: C3H5F3O, the publication is European Journal of Organic Chemistry (2016), 2016(16), 2842-2850, database is CAplus.

In our attempts to synthesize 3-(alkylthio)- and 3-(alkoxy)-1,2,4-triazines without substituents at the 5- or 6-position, the synthesis of their anticipated precursor 3-(methylsulfonyl)-1,2,4 triazine was also optimized. The reactivity of 3-(methylsulfonyl)-1,2,4-triazine towards alkyl and aryl thiols, primary and secondary alkylamines, phenols, and alcs. was explored, and the reactions were optimized to maximize the isolation of the corresponding 3-substituted 1,2,4-triazine. Good yields were obtained for the products of the reactions with all of the aforementioned nucleophiles, with the exception of alcs., by using alkali metal carbonates. Higher yields of 3-(alkoxy)-1,2,4-triazines were obtained by using the appropriate magnesium alkoxide as the nucleophile.

European Journal of Organic Chemistry published new progress about 2240-88-2. 2240-88-2 belongs to alcohols-buliding-blocks, auxiliary class Trifluoromethyl,Fluoride,Aliphatic hydrocarbon chain,Alcohol, name is 3,3,3-Trifluoropropan-1-ol, and the molecular formula is C16H12O, COA of Formula: C3H5F3O.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts