Author: tianli

Brady, Stephen F. published the artcileSome novel, acid-labile amine protecting groups, SDS of cas: 20117-47-9, the publication is Journal of Organic Chemistry (1977), 42(1), 143-6, database is CAplus and MEDLINE.

RO2C-Phe-OH [I; R = cyclopropylmethyl (CP), 1-methylcyclobutyl (MCB), cyclobutyl, 1-methylcyclohexyl, 1-cyclopropylethyl] and R1O2C-Phe-Ala-OMe (R1 = CP, MCB) were prepared After 48 hr in 50% HOAc, >99% of MCBO2C-Phe-OH (II) remained unchanged, whereas under the same conditions 10-15% of BOC was cleaved from BOC-Phe-OH. However, the complete removal of MCBO2C was achieved by treating II with CF3CO2H at 25° for 30 min. ROH were treated with COCl2 to give RO2CCl which were treated with phenylalanine or with H-Phe-OMe and saponified to give I.

Journal of Organic Chemistry published new progress about 20117-47-9. 20117-47-9 belongs to alcohols-buliding-blocks, auxiliary class Aliphatic cyclic hydrocarbon,Alcohol, name is 1-Methylcyclobutan-1-ol, and the molecular formula is C5H10O, SDS of cas: 20117-47-9.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Fuwa, Haruhiko published the artcileSynthesis of biotinylated photoaffinity probes based on arylsulfonamide γ-secretase inhibitors, Synthetic Route of 120103-18-6, the publication is Bioorganic & Medicinal Chemistry Letters (2006), 16(16), 4184-4189, database is CAplus and MEDLINE.

Synthesis and biol. evaluation of arylsulfonamide inhibitors of γ-secretase are described. Design, synthesis, and biol. evaluation of multifunctional mol. probes harboring a benzophenone photophore as a crosslinking group and a biotin tag are also reported.

Bioorganic & Medicinal Chemistry Letters published new progress about 120103-18-6. 120103-18-6 belongs to alcohols-buliding-blocks, auxiliary class Fluoride,Nitro Compound,Benzene,Phenol, name is 2,5-Difluoro-4-nitrophenol, and the molecular formula is C6H3F2NO3, Synthetic Route of 120103-18-6.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Xu, Shibo published the artcileNickel-Catalyzed Regio- and Stereospecific C-H Coupling of Benzamides with Aziridines, Application of 2-Aminobutan-1-ol, the publication is Organic Letters (2021), 23(14), 5471-5475, database is CAplus and MEDLINE.

A nickel-catalyzed C-H coupling of 8-aminoquinoline-derived benzamides with aryl- and alkyl-substituted aziridines was disclosed. The current strategy provided direct access to benzolactams by the C-H alkylation-intramol. amidation cascade event with the concomitant removal of the aminoquinoline auxiliary. The regioselectivity of ring opening of aziridines was controlled by the substituents. The reaction with chiral aziridines proceeded with inversion of configuration, thus suggesting an SN²-type nucleophilic ring-opening pathway.

Organic Letters published new progress about 96-20-8. 96-20-8 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 2-Aminobutan-1-ol, and the molecular formula is C11H24O3, Application of 2-Aminobutan-1-ol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Asahara, Teruzo published the artcileTelomerization of ethylene and carbon tetrachloride initiated by amines, Quality Control of 4543-95-7, the publication is Bulletin of the Japan Petroleum Institute (1965), 35-40, database is CAplus.

cf. CA 62, 1554a. In this reaction, strongly basic amines are excellent initiators. Primary amines are more effective than secondary or tertiary structures, and branched amines are inferior to n-amines. Alkanolamines are also excellent initiators. The experiments were carried out in a stainless steel autoclave in the absence of metallic salts. tert-Butanol is a preferred solvent for this reaction. Generally, the higher the dielec. constant of the hydroxylic solvent, the greater the yield of telomer. Aprotic solvents show no such regular influence. 13 references.

Bulletin of the Japan Petroleum Institute published new progress about 4543-95-7. 4543-95-7 belongs to alcohols-buliding-blocks, auxiliary class Amine,Aliphatic hydrocarbon chain,Alcohol, name is 4-(Butylamino)butan-1-ol, and the molecular formula is C8H19NO, Quality Control of 4543-95-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Nagasawa, Yoshiyuki published the artcileHydrogenation of 4-Propylphenol over Carbon-supported Palladium Catalyst without External Hydrogen: Effect of Carbon Support and Palladium Loading, Computed Properties of 645-56-7, the publication is Chemistry Letters (2021), 50(3), 431-434, database is CAplus.

The ring hydrogenation of 4-propylphenol in aqueous ethanol solution was studied over graphite- and activated carbon-supported palladium catalysts (Pd/G and Pd/C) with 0.1-5 wt% of palladium loadings without using external hydrogen. Decomposition of ethanol produced hydrogen which was responsible for the hydrogenation of 4-propylphenol over palladium metal particles on both the supports in aqueous medium. The different hydrogenation behaviors were discussed based on surface properties of supports.

Chemistry Letters published new progress about 645-56-7. 645-56-7 belongs to alcohols-buliding-blocks, auxiliary class Liquid Crystal &OLED Materials, name is 4-Propylphenol, and the molecular formula is C9H12O, Computed Properties of 645-56-7.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Huber, Verena published the artcileUncovering the curcumin solubilization ability of selected natural deep eutectic solvents based on quaternary ammonium compounds, Recommanded Product: 2-Hydroxy-2-phenylacetic acid, the publication is Journal of Molecular Liquids (2022), 119661, database is CAplus.

The solubility of curcumin in ethanolic solutions can be increased twentyfold through the addition of natural deep eutectic solvents (NADES). Instead of only screening nine different NADES based on choline chloride, betaine, and carnitine mixed with lactic, levulinic, and pyruvic acid in terms of their solving ability, they were investigated regarding the mechanism of solvation as well. The curcumin solubility enhancement was assessed via UV/Vis measurements, while the investigation of the intermol. effects was performed theor. by COSMO-RS predictions of the chem. potential and exptl. via 1H and NOESY NMR measurements. The addition of the quaternary ammonium compounds to ethanol resulted in a solubility increase regardless of addnl. functionalities, which was not the case for the acids, where functionalities showed a significant influence. A solubility synergy in the levulinic acid NADES was reached, which could be explained through the combination of COSMO-RS and NMR experiments, yielding indications that an interplay of non-specific and directed intermol. interactions was the responsible driving force for an efficient solubility enhancement of curcumin. Thus, the NADES based on levulinic acid achieved the best results.

Journal of Molecular Liquids published new progress about 90-64-2. 90-64-2 belongs to alcohols-buliding-blocks, auxiliary class Carboxylic acid,Benzene,Alcohol,Natural product, name is 2-Hydroxy-2-phenylacetic acid, and the molecular formula is C8H8O3, Recommanded Product: 2-Hydroxy-2-phenylacetic acid.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Pedersen, R. T. published the artcileIdentification of novel metabolites of the xenoestrogen 4-tert-octylphenol in primary rat hepatocytes, COA of Formula: C14H22O2, the publication is Chemico-Biological Interactions (2000), 128(3), 189-209, database is CAplus and MEDLINE.

A number of environmental pollutants, including 4-tert-alkylphenols, can mimic the actions of endogenous steroids and have the potential to disrupt the endocrine function in humans and animals. The biotransformation of a 4-tert-alkylphenol in isolated rat hepatocytes was studied in order to determine the possible fate and activity of these xenoestrogens in higher vertebrates. Hepatocytes were incubated with 30 μM 4-(1′,1′,3′,3′-tetramethylbutyl)[U-¹⁴C]phenol (4-tert-octylphenol; t-OP) for up to 60 min. Radiolabeled metabolites were detected by radio-HPLC and the structures determined by gas chromatog.-mass spectrometry (GC-MS) anal. of the conjugated or aglycon products. After a 15 min incubation, over 97% of t-OP was metabolized to a complex mixture of metabolites. The initial metabolites formed were identified as products of hydroxylation of the aromatic ring to form catechols and methylated catechols, as well as glucuronide conjugates of the catechol metabolites or parent phenol. These products were further metabolized by hydroxylation of the alkyl chain followed by glucuronide conjugation of the alkoxy group. The conjugated metabolites of t-OP are unlikely to retain estrogen receptor activity; however t-OP is metabolized by some pathways that are similar to that of estrogen catabolism, namely by ortho-hydroxylation to form catechols, methylation by catechol O-methyltransferases and ring conjugation by uridine diphosphoglucuronosyl transferases. Further investigations are needed to determine whether 4-tert-alkylphenols can alter circulating sex steroid profiles by acting as substrates of enzymes determining estrogen metabolism and excretion.

Chemico-Biological Interactions published new progress about 1139-46-4. 1139-46-4 belongs to alcohols-buliding-blocks, auxiliary class Benzene,Phenol, name is 4-(2,4,4-Trimethylpentan-2-yl)benzene-1,2-diol, and the molecular formula is C14H22O2, COA of Formula: C14H22O2.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Mannanovna, Yunusova Kholida published the artcileResearch on the selection of a certain content of “Ambronat” juice syrup, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, the publication is International Journal of Pharmacy and Pharmaceutical Research (2021), 20(4), 62-71, database is CAplus.

This article presents several experiments on the selection of a specific composition of Ambronat syrup. These selected several excipients in the selection of the sweetness and consistency and consistency of the syrup, based on which the ingredients were considered, and the result was the result of the selection of a moderate content.

International Journal of Pharmacy and Pharmaceutical Research published new progress about 23828-92-4. 23828-92-4 belongs to alcohols-buliding-blocks, auxiliary class Membrane Transporter/Ion Channel,Sodium Channel, name is trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride, and the molecular formula is C13H19Br2ClN2O, Recommanded Product: trans-4-((2-Amino-3,5-dibromobenzyl)amino)cyclohexanol hydrochloride.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Ruiz, C. Carnero published the artcileInteraction between n-octyl-β-D-thioglucopyranoside and bovine serum albumin, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, the publication is Open Macromolecules Journal (2008), 6-18, database is CAplus.

The binding of the nonionic surfactant n-octyl-β-D-thioglucopyranoside (OTG) to the globular protein bovine serum albumin (BSA) has been investigated by using exptl. techniques such as surface tension, steady-state fluorescence and dynamic light scattering. It was observed that the surfactant micellization is delayed in the presence of protein; this was interpreted as a consequence of the fact that part of the surfactant is not available for the formation of micelles, because it is partitioned into the protein hydrophobic sites. This was taken as an evidence of the interaction between surfactant and protein. The fluorescence emission spectra of intrinsic tryptophans revealed that the protein is partially denatured in the presence of high surfactant concentrations The anal. of the binding features as obtained by two different methods, (i) one based on surface tension measurements, and (ii) another based on the behavior of the intrinsic BSA fluorescence, indicated that the binding process is non-cooperative at low surfactant concentration, but becomes cooperative when it is high enough. The reduction of the average aggregation number in the presence of protein interpreted as a sign of the formation of clusters of surfactant adsorbed on the protein surface. A slight conformational change in the protein structure at low surfactant concentration was revealed by resonance energy transfer from tryptophan residues to 8-anilinonaphthalene-1-sulfonate. A treatment of the autocorrelation functions as obtained by dynamic light scattering measurements, based on the application of appropriate fitting techniques, allowed for the discrimination between two kinds of structures in the OTG/BSA system: surfactant-protein complexes, with a “pearl necklace” structure, in equilibrium with the free micelles of OTG.

Open Macromolecules Journal published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Recommanded Product: (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts

Molina-Bolivar, J. A. published the artcileEffect of NaCl on the Self-Aggregation of n-Octyl β-D-Thioglucopyranoside in Aqueous Medium, Product Details of C14H28O5S, the publication is Journal of Physical Chemistry B (2006), 110(24), 12089-12095, database is CAplus and MEDLINE.

This report investigates the effect of sodium chloride (NaCl) on the micellization, surface activity, and the evolution in the shape and size of n-octyl β-D-thioglucopyranoside (OTG) aggregates. By using surface tension measurements, information was obtained on both changes in the critical micelle concentration and adsorption behavior in the air-liquid interface with the electrolyte concentration These data were used to obtain the thermodn. properties of micellization along with the corresponding adsorption parameters in the air-liquid interface. From extended static and dynamic light scattering measurements, the micelle mol. weight, the mean aggregation number, and the second virial coefficient, the apparent diffusion coefficient and the mean hydrodynamic radius of micelles in a range of NaCl concentrations were obtained. The light scattering data have shown that when the surfactant concentration is lower to 4.5 g/L, only spherical micelles are formed. However, an increase in the surfactant concentration induces an increase in micellar size, suggesting a rodlike growth of the micelles. This deviation of micelle geometry from spherical to rodlike is supported both by the ratio between the hydrodynamic radius and the radius of gyration and by the angular dependence of light scattering. On the other hand, the studies performed in the presence of high NaCl concentration (0.2 and 0.5 M) provide strong support for the view that the micelles may overlap together to form an entangled network above certain crossover concentration

Journal of Physical Chemistry B published new progress about 85618-21-9. 85618-21-9 belongs to alcohols-buliding-blocks, auxiliary class Tetrahydropyran,Chiral,sulfides,Alcohol, name is (2R,3S,4S,5R,6S)-2-(Hydroxymethyl)-6-(octylthio)tetrahydro-2H-pyran-3,4,5-triol, and the molecular formula is C14H28O5S, Product Details of C14H28O5S.

Referemce:
https://en.wikipedia.org/wiki/Alcohol,
Alcohols – Chemistry LibreTexts